대한의용생체공학회:학술대회논문집 (Proceedings of the KOSOMBE Conference) (Proceedings of the KOSOMBE Conference)
대한의용생체공학회 (The Korean Society of Medical and Biological Engineering)
- 기타
과학기술표준분류
- 보건의료 > 기능복원/보조/복지기기
대한의용생체공학회 1997년도 춘계학술대회
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Poly(acrylic acid) 와 poly(vinyl alcohol) 을 이용하여 온도와 pH 에 감응성을 가지는 상호침투 가교 고분자 히드로겔을 합성하고 약물의 투과도를 측정하였다. 이 히드로겔은 고분자 구조 내에 이온기를 포함하고 있으므로 팽윤 시에 외부의 pH 와 이온 세기의 영향을 크게 받았으며 이온기와 용액과의 상호작용이 증가할수록 팽윤도가 감소하였다. 히드로겔을 이용한 약물의 투과실험에서 비이온성 약물의 경우 약물 입자의 크기에 따른 분리가 가능하였으며 이온성 약물의 경우 고분자 히드로겔의 구조차 외부 pH, 약물의 구조에 따른 상호작용에 의하여 투과가 이루어짐을 알 수 있었다.
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We used the photoreactive poly(allylamie) (PPA) as the hydrophilic membrane to control the release of drug from polyurethane(PU). PPA was covalently bonded onto PU surface through the highly reactive nitrene intermediate upon UV light irradiation
$(3.3mW/cm^2)$ at 254nm for 5min. Thus the release rate of rifampicin from PU surface was controlled. To know the characteristics of PU surface bonded with PPA, we measured the ATR-FTIR, ESCA, Static Contact Angle and SEM. From these, we suggest that PPA as a hydrophilic membrane is enable to control the release rate of a hydrophobic drug from polymer without the change of bulk property. -
The adhesion of stimulated and unstimulated platelet to fibrinogen requires the receptor binding site of GPIIb/IIIa. These recognition sites are existed in the Au chain(RGDS at positions 572-575 and RGDF at 95-98) and the carboxyterminal
$\gamma$ chain (HHLGGAKQAGDV at 400-411) of fibrinogen. The unstimulated platelet does not adhered on the fragment E-coated surface containing RGDF sequence. In this study, we developed RGDF-immobilized surface to detect the functional state of platelet. RGDF-immobilized surface was prepared on the glass using photolithographic technology. Platelet adhesion to petide(RGDF)-immobilized surface was observed by the fluorescence microscope using mepacrine. -
In exposuring x-rays, we can adjust three variables of kVp, mA and sec. The kVp is one of main factors affecting x-ray quality -peneterability. And miliampere-seconds is directly proportional to x-ray quantity. In this paper, we detected voltage variation of CdS, II-VI group semiconductor compounds, by kVp as the fundamental experiments of designing x-ray dosimeter. We exposured x-ray on the material from 40 to 100 kVp by increasing 2kVp using Shimadazu TH-500-125 Radio-Tex cx-s x-ray machine. We fixed miliampere -seconds to 100mA and 0.2 sec. After acquiring the raw data, we plotted the graph of kVp and voltage variation and figured slope value of 0.093 by regression. The standard deviation of voltage to kVp was 0.22. For the future study, the mAs variation study will be needed to investigate the connections between kVp and mAs in order to design x-ray dosimeter.
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As the fundamental study of designing x-ray dosimeter , we measured the voltage variation of CdS, II-VI group semiconductor compound, by mAs variation. We obtained data in the condition of 50, 70 kVp, by increasing the tube current as 1, 2, 2.5, 3.2, 4, 5, 10, 20, 32, 50 and 80 mAs. The output time of CdS was increased as mAs increased. We figured the slope value of 50kVp as 0.0088 and 0.0081 of 70 kVp. And by regression method, we obtained the standard deviation of time, Y axis, at 50 and 70kVp as 0.00268 and 0.00333. The result of this ssudy is so important to design x-ray dosimeter.
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A new method for the prevention of foreign body-associated infections by controlled release of antibiotic was developed. The polyurethane (PU) matrix containing rifampicin was immobilized with hydrophilic photoreactive polyallylamine (PPA) containing azidophenyl groups. The rifampicin release characteristics and the long-lasting antimicrobial activities of the new material was compared with rifampicin-containing PU matrix without PPA membrane. The release rate of antibiotic from rifampicin-containing PU with PPA membrane significantly decreased as the thickness of PPA membrane was increased. The PPA-immobilized rifampicin-containing PU discs immersed in the PBS for 47 days had an efficient antimicrobial activity against both S. aureus and S. epidermidis.
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The interfacial bonding energy between laser surface treated HA layer and Ti alloy substrate was investigated using a mechanical push-out tester. The initial slope of shear-stress and reduced displacement curves, maximum interfacial bond strength and bonding energy were calculated from results of the push-out test. The calculated initial slpoes are 38 MPa for the Ti alloy(A), 65 MPa for the sandblast finished specimen(B), 95 MPa for the HA plasma spray coated specimen and 49 MPa for the laser surface treated specimen(D). The maximum interfacial bonding strength are 3 MPa for the A, 19 MPa for the B, 20 MPa for the C, 10 MPa for the D. The interfacial bonding energies are
$3.3\times10^{-9}J/mm^2$ for the A,$15.5\times10^{-9}J/mm^2$ for the B,$15.6\times10^{-9}J/mm^2$ for the C and$18.3\times10^{-9}J/mm^2$ for the D. Microscopic observation shows that the breaking of the laser treated specimen had been occured through the boundary between HA layer and polymer resin, but the untreated specimen had been occured through the inside of HA coating layer. -
Biostabilities of the iron oxide MRI contrast agent were evaluated using the cytotoxicity test and the animal test. Six experimental groups (35, 17, 5, 3.4, 1.7, 0.9 mg of iron oxide/10ml) and a control group were prepared for the cytotoxicity test. The cell count of higher concentration than 5 mg/10m1 become decrease significantly after 4-days incubation. Iron oxide was injected into the right vein of the two fully grown rabbits with the concentration of 0.5 or 0.9mg/kg of body weight respectively. Blood samples were collected and analyzed in turn after 30min, 1, 2, 4, 8, 16, 30, 60, 90days injection. The body temperature and weight of rabbits were measured simultaneously. The result of blood and serum analyses and the body temperature shows that there was no significant variation with respect to the sampling term and the dosage within this experimental conditions.
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The interfacial bond strength and microstructural analysis of pre-heat treated porcelain-fused-metal (PFM) were investigated using a mechanical three-point bending tester and scanning electron microscope(SEM). Four kinds of heat treated samples were prepared as follows; A: heating
$1200^{\circ}F\rightarrow1600^{\circ}F$ , holding 1min, reheating$\rightarrow1850^{\circ}F$ , hold 3min under vacuum, B: heating$1200^{\circ}F\rightarrow1600^{\circ}F$ holding 1min, reheating$\rightarrow1850^{\circ}F$ under vacuum condition, C: heating$1200^{\circ}F\rightarrow1600^{\circ}F$ , holding 1min, reheating$\rightarrow1850^{\circ}F$ , holding 3min in the air, repeat same heat treatment process under vacuum condition, D: heating$1200^{\circ}F\rightarrow1600^{\circ}F$ , holding 1min, reheating$\rightarrow1850^{\circ}F$ , holding 1min in the air. The three-point bending test results shows that the interfacial bond strength of specimen B and C were higher than that of A and B. The SEM study reveals that Specimen C shows the highest surface density. -
We synthesized N-Hydroxysuccinimidyl (NHS) azidobenzoate as a cross-linking reagent for immobilization of peptide onto the solid surface. Thin polystyrene(PS) films spin-coated with a NHS azidobenzoate solution were exposed with ultraviolet light at 245nm
$(3.3mW/cm^2)$ for 5 min. The NHS active ester groups became covalently attached to the polymer via photogenerated, highly reactive nitrene intermediates derived from NHS azidobenzoate. Using this technique, it is demonstrated that well-defined surface regions can be functionalized with a minimum observable feature size of 1mm for UV exposure. Through reaction of this functionalized PS surface with primary amine-containing biomolecules, biological molecule had been immobilized on the polymer surface. -
Lumbrokinase, potent fibrinolytic enzyme purified from earthworm, was immobilized onto the total artificial heart valves using photoreaction. This valve were implanted into the lamb for three days. After experiments, thrombus was observed in the untreated valves whereas no thrombus was observed in the lumbrokinase immobilized valves. The fibrinolytic activity and proteolytic activity of the implanted valve was examined. The fibrinolytic activity of the valve was remained after the implantation. The lumbrokinase could be a suitable fibrinolytic agents in the vascular contacting devices to reduce the thrombus.
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In this paper we reviewed and stated the present state of our team's research of the moving-actuator type total artificial heart (MA-TAH). Especially, this paper showed new direction of researches. The integrated research of battery, telemetry, TET is required. And the real-time supervisory of the state of hemodynamic variables and MA-TAH is also needed. These requirement made us to think the supervisory control system (SCS). As functional abilities of the SCS require very high computational cost, the digital signal processor is an appropriate choice for our need.
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It is needless to say that the hemodynamic variables estimation is a very important study for the artificial heart. Even though its importance there have not been satisfactory results which can be applied to the real-world situations. This paper surveys and recommends how to cope with the problem of hemodynamic variable estimation for the moving-actuator type total artificial heart (MA-TAH).
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In the total artificial heart(TAH), a transcutaneous information transmission system(TITS) is vely important to monitor the TAH status and detect the device failure, and repair the possible problems. First of all, the communication channel(skin) and method were simulated in terms of transmittance, scattering, reflection and absorption, then the system was designed with size reduction including low power consumption and reliability compared to the previous one. The informations are transmitted through the skin(approximately 1cm in depth) by frequency modulated near infrared(NIR) pulses using 780nm laser diodes as transmitters and photodiode as receiver with high speed and high spectral sensitivity. The logic high and low frequencies are 3MHz, 1MHz respectively. The system is a bidirectional data link for more than 38.4Kbps data rate, full-duplex with a bit error rate of less than
$10^{-5}$ . -
The early detection of brest cancer is clearly a key ingredient for any strategy designed to reduce breast cancer mortality. Microcalcification(MCC) is one of the primary signatures to discriminate between normal and cancerous tissue. The detection and locating procedures can be automated by digital image processing, however, MCCs have various sizes, shapes, and intensity levels in film images, so it is difficult to find accurate locations and sizes. Firstly, we made quantitative analysis for many characteristic features of mammograms that can be used to segment MCCs from normal tissues. Secondly, we developed algorithms proper to segmentation like pattern matching. The performance was evaluated with TP and FP rates.
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We have developed a 3-D image processing and display technique that include image resampling, modification of MIP, and fusion of MIP image and volumetric rendered image. This technique facilitates the visualization of the three-dimensional spatial relationship between vasculature and surrounding organs by overlapping the MIP image on the volumetric rendered image of the organ. We applied this technique to a MR brain image data to produce an MRI angiogram that is overlapped with 3-D volume rendered image of brain. MIP technique was used to visualize the vasculature of brain, and volume rendering was used to visualize the other structures of brain. The two images are fused after adjustment of contrast and brightness levels of each image in such a way that both the vasculature and brain structure are well visualized either by selecting the maximum value of each image or by assigning different color table to each image. The resultant image with this technique visualizes both the brain structure and vasculature simultaneously, allowing the physicians to inspect their relationship more easily. The presented technique will be useful for surgical planning for neurosurgery.
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In the accessment of the performance of a magnetic resonance imaging unit, there are many parameters to be measured. Such measured parameters are not often meaning by itself. Namely, it need to be compared with some standard. Since there is no gold standard MRI, only can be compared with a worldly renowned product. In this report, we attempted to compare a few MRI parameters for the accessment of the performance of 1 Tesla MRI unit which is domestically developed. Though we did not measure all the parameters related to hardware aspects and software aspects for the full comparison, there few parameters may elucidate some important aspects of MRI unit.
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A new computation algorithm to detect the intimal and adventitial contours from the intravascular images was developed. An image processing on gray level image was used. It uses arrays of pixels in each radial lines on the images. A Low-Pass filters was adopted at first step for one dimensional image processing. Some other calculations techniques were developed to increase the accuracy of automatically detected contours. The program implemented in C++ as a window95-base application.
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In this study, for the coding of stereoscopic video sequence, two approaches are presented based on simulcast mathod and sidefield image format. The field sequential method for stereoscopic visualization have been specified. Also, camera parameter and shooting conditions for each test sequence are studied. Coding method based on sidefield format structure revealed better performance over simulcast in PSNR.
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One of the most significant feature of diagnostic ultrasonic instrument is to display information on the soft tissues in the body in real time. In this paper we carried out basic study on the digital moving image processing for tracing the movement of heart valves in echocardiograms. Digital moving image file was made from analog echocardiograms and it was remade as 256 gray-level images on each frame. The ROI(Region of interest) was placed on a heart valve region to process images efficiently. Images were processed by the use of image enhancement filters and morphology filters. The result shows that the processed images were more enhanced than original images. When a moving image is reconstructed by using these enhanced images, we can trace the movement of heart valves more easily. In this study we proposed the availability of the moving image reconstruction using enhancement images.
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By measuring the increase of regional cerebral blood flow (rCBF) during the activation tasks, we can describe the brain regions that participate in certain specific functions. In this study, we composed the functional maps of verbal and nonverbal memory by performing the rCBF positron emission tomography (PET) activation studies and analyzing the differences between control and each activation state. Successive four tasks, which consist of one control state and three different activation tasks, were performed on 6 normal volunteers. All images were spatially normalized on standard atlas and the differences between control and activation states were statistically analyzed. The verbal memory activated predominantly left-sided structures, especially left superior temporal cortex, and the nonverbal short-term memory activated the right frontal cortex. Also, some regions ,where is thought to be related with short-term memory system, such as cingulate gyrus and hippocampus were activated. We conclude that biological validity of the brain regions for verbal and nonverbal memory could be tested using rCBF PET imaging technique and statistical analysis.
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In this paper, we propose a coding method to improve compression efficiency for MR image. This can be achieved by combining coding and segmentation scheme which removes noisy background region, which is meaningless for diagnosis, in MR image. The wavelet coder encodes only diagnostically significant foreground regions refering to segmentation map. Our proposed algorithm provides about 15% of bitrate reduction when compared with the same coder which is not combined with segmentation scheme. And the proposed scheme shows better reconstructed image Qualify than JPEG at the same compression ratio.
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In-vivo and in-vitro MR Microscopy has been performed to investigate any differences in-between the normal and the abnormal skin layers. Noninvasively acquired images could provide the skin histology. Also, it was found that the epidermis of the abnormal skin was thickened more than that of normal skin. MR Microscopy utilized for the present study may be applicable to the noninvasive investigation of skin pathology and this technique may be of use in the development of cosmetics.
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A medical teleconferencing and medical image transmision system has been developed for diagnosis of the medical images between the medical doctors who are far away. The medical teleconferencing system transmits the voice and image of the doctors using the video and audio capture boards. The medical image transmission system software uses the medical image standard DICOM 3.0 for the future expansibility and the open system interconectivity. The medical images usually use CR images.
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In MRI, gradient coils are needed for spatial selection and position coding to obtain the position information of the NMR signal. In this paper, a new design scheme for actively-shielded x, y-gradient coils, namely, a minimum-power and/or minimum-inductance design scheme using current-loop elements, has been proposed. Its utility in designing MRI gradient coils has been shown by using simulation. An actively-shielded x-gradient coil has been designed as an example and the results are presented. The design scheme seems to be useful for actively-shielded transverse gradient coils, even of non-cylindrical or of arbitrarily -selected shapes.
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The objective of present study is to obtain information about stenosis effects on the blood flow in the coronary artery bifurcation. The three dimensional steady of blood in the coronary artery bifurcation with stenosis and without stenosis are simulated using the finite volume method. Apparent viscosity of blood is represented as a function of shear rate by the Carreau models. Velocities vectors and wall shear stresses along the branch tubes with stenosis are compared with those of without stenosis for steady flows. Flow phenomena in the stenosed branch tubes are discussed extensively.
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In hippocampal morphology Abnormalities, including unilateral or bilateral volume loss, are known to occur in epilepsy, Alzheimer's disease, and in certain amnestic syndromes. To detect such abnormalities in hippocampal morphology, we present a method that combines region growing and dynamic contour model to detect hippocampus from MRI brain data. The segmentation process is performed two steps. First region growing with a seed point is performed in the region of hippocampus and the initial contour of dynamic contour model is obtained. Second, the initial contour is modified on the basis of criteria that integrate energy with contour smoothness and the image gradient along the contour. As a result, this method improves fairly sensitivity to the choice of the initial seed point, which is often seen by conventional contour model. The power and practicality of this method have been tested on two brain datasets. Thus, we have developed an effective algorithm to extract hippocampus from MRI brain data.
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In this paper, we represented the variation of heart cavity area in the space domain by 3-d rendering. We arranged the 2-d sequence of ultrasonic image acquired in the time domain as volumetric data, and extracted heart cavity region from 3-d data. For the segmentation of 3-d volume data, we extracted the cavity region using the method of expanding the cavity region that is same statistical property. By shading which is using light and object normal vector, we visualized the volume data on image plane.
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We present a method for the estimation of 3D solid angle assessment of the acetabular coverage of the femoral head in 3D space. At first, femoral head and acetabulum is segmented from the original CT scan images. The slice thickness is 1.5mm and the number of slices is usually 30-40 to cover the entire acetabulum. The superior half of the femoral head is modeled as part of a sphere. Thus, the axial cross sections of the upper half of the femoral head are also modeled as circles. A set of points from each outline image of femoral head is fitted recursively into a circle by minimizing root-mean-square (RMS) error. With these fitted circles, a center point of the femoral head model is evaluated. This is a reference point for calculating the solid angle of the acetabular inner surface. Next, the tangent lines connecting from a set of points of the acetabular edge to the center of the fitted sphere are obtained. The lines pass through the unit sphere whose center is the same as that of the femoral head. With the points on the unit sphere, we calculate area and estimate the solid angle. Based on this solid angle, the deformity of the acetabulum is analyzed. In case of normal subject, the solid angle is about 4.3 (rad) and acetabular coverage is 68%.
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Phase-contrast(PC) methods have been used for quantitative measurements of velocity and volume flow rate. In addition, phase contrast cine magnetic resonance imaging (MRI) combines the flow dependent contrast of PC MRI with the ability of cardiac cine imaging to produce images throughout the cardiac cycle. In this method, the through-plane velocity has been encoded generally. However, the accuracy of the flow data can be reduced by the effect of flow direction, finite slice thickness, resolution, pulsatile flow pattern, and so on. In this study we calculated the error caused by misalignment of tomographic plane and flow directon. To reduce this error and encode the velocity for more complex flow, we suggested 3 directional velocity encoding method.
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We implementated an ultrasonic wave cane for the blind. The cane detect walking obstacle and provide a walking direction. The cane used time of flight method of ultrasonic-wave for a measurement of obstacle distance and fluxgate geomagnetic sensor for guidance of walking direction. This system can detect an obstacle of upward, forward, downward and that warn to the blind with vibration, pitch sound. And the blind can know walking direction to voice output. As a result, the blind could efficiently avoid a exposed obstacle, obstacles beyond knee, an exposed street obstacle, a branch of tree person's height and it is usable search for surrounding land mark.
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In this paper, we proposed a implantable middle ear system using FM transmission and receiving method which has higher detection efficiency than that of AM method. And a new shape of vibrating transducer which is more efficiently vibrate than the conventional type is designed. This tranducer consist of coil and small T-type cylindrical permanent magnet. We investigated and compared the differences between conventional methods and proposed methods by quantitive analysis. We proved them by experiment.
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Femoral neck anteversion is the angle between the neck and the knee axis projected on a plane perpendicular to the longitudinal axis. Conventional methods that use cross-sectional Computed Tomography(CT) images to estimate femoral anteversion have several problems because of the complex 3D structure of the femur. These are the ambiguity of defining the longitudinal axis, the femoral neck axis and condylar line, and the dependence on patient positioning. Especially the femoral neck axis that is known as a major source of error is hard to determine from a single or multiple 2D transverse images. So we developed a new method for measuring femoral anteversion by 3D modeling method. In this method, femoral head is modeled as a sphere. The center of femoral neck is the mid-point of the 2D reconstructed oblique image in the femoral neck part. Then neck axis is a line connecting foregoing two centers. We model the longitude of femur as a cylinder, and the long axis is defined from the fitted cylinder. The knee axis which is tangent to the back of the femoral condyles is easily determined by table-top method. By the definition of femoral anteversion, the femoral anteversion is easily calculated from this model.
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This paper describes a methodology for the development of models of discrete event system. The methodology is based on transformation of continuous state space into discrete one to homomorphically represent dynamics of continuous processes in discrete events. This paper proposes a formal structure which can coupled discrete event system models within a framework. The structure employs the discrete event specification formalism for the discrete event system models. The proposed formal structure has been applied to develop a discrete event specification model for the complex spectral density analysis of strip for urin analyzer system. For this, spectral density data of strip is partitioned into a set of Phases based on events identified through urine spectrophotometry. For each phase, a continuous system of the continuous model for the urine spectral density analysis has been simulated by programmed C++. To validate this model, first develop the discrets event specification model, then simulate the model in the DEVSIM++ environment. It has the similar simulation results for the data obtained from the continuous system simulation. The comparison shows that the discrete event specification model represents dynamics of the urine spectral density at each phase.
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Modelling and Simulation of the activation process for the myocardium is meaningful to understand special excitation conduction system in the heart and to study cardiac functions. In this paper, we propose two dimensional cellular automata model for the activation process of the myocardium and simulated by means of discrete time and discrete event algorithm. In the model, cells are classified into anatomically similar characteristic parts of heart; SA node, internodal tracks, AV node, His bundle, bundle branch and four layers of the ventricular muscle, each of which has a set of cells with preassigned properties, that is, activation time, refractory duration and conduction time between neighbor cell. Each cell in this model has state variables to represent the state of the cell and has some simple state transition rules to change values of state variables executed by state transition function. Simulation results are as follows. First, simulation of the normal and abnormal activation process for the myocardium has been done with discrete time and discrete event formalism. Next, we show that the simulation results of discrete time and discrete event cell space model is the same. Finally, we compare the simulation time of discrete event myocardium model with discrete time myocardium models and show that the discrete event myocardium model spends much less simulation time than discrete time myocardium model and conclude the discrete event simulation method Is excellent in the simulation time aspect if the interval deviation of event time is large.
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In this paper, the control scheme is proposed that PI controller parameter used for TAH speed control is adapted by fuzzy logic method using only the motor current waveform. By scheduling PI parameters, minimization of the vibration and the energy consumption and overcoming AoP loads becomes possible. In in vitro tests experimental results show our approach is a good scheme that is adapted to changing afterloads well.
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It is very useful to perform the surgery simulation before implanting TAH(Total Artificial Heart} in a patient. The space of chest and the shape of vessels are different from patient to patient. So, It is desirable to customize a TAH design to the anatomy structure of a patient. Several studies are performed to visualize and explain the 3D structure of heart. These studies are performed using 2-dimensional ref or mated images and simple measurement. Anatomy structure of a human heart is not so simple. It is 4dimensional structure ; 3-dimensional plus time, heart beating. 3-dimensional reconstruction schemes of medical images developed for about 10 years are usually categorized into two types of rendering technique ; surface rendering and volume rendering. Volume rendering is preferable in medical image processing field because this technique can be applied without considering the complexity of geometry and change of field of interest. The usable space in the chest of patient can be measured by 3D volume matching of patient trunk and TAH model. This space changes with time. In this research we have developed the 4-dimensional volume match program of patient and TAH model. 3-dimensional rendered set of volumes along time were used to simulate TAH fitting trial. The quantitative measurement from this simulation could be applied to customize TAH design.
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In this paper, we consider the aortic sinus baroreceptor, which is the most representative baroreceptors sensing the variance of pressure in the cardiovascular system(CVS), and propose heart activity control model to observe the effect of delay time in heart period and stroke volume under the regulation of baroreflex in arotic sinus. The proposed heart activity baroreflex regulation model contains CVS electric circuit sub-model, baroreflex regulation sub-model and time delay sub-model. In these models, applied electric circuit sub-model is researched by B.C.Choi and the baroreflex regulation sub-model transforms the input, the arotic pressure of CVS electric circuit sub-model, to outputs, heart period and stroke volume by mathematical nonlinear feedback. We constituted the time delay sub-model to observe sensitivity of heart activity baroreflex regulation model by using the variable value to represent the control signal transmission time from the output of baroreflex regulation model to efferent nerve through central nervous system. The simulation object of this model is to observe variability of the CVS by variable value in time delay sub-model. As simulation results, we observe three patterns of CVS variability by the time delay. First, if the time delay is over 2.5 sec, arotic pressure, stroke volume and heart rate is observed nonperiodically and irregularly. Second, if the time delay is from between 0.1 sec and 0.25 sec, the regular oscillation is observed. Finally, if time delay is under 0.1 sec, then heart rate and arotic pressure-heart rate trajectory is maintained in stable state.
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We have developed a remote diagnosis system using the LAN and MODEM which enables a routine check for a patient remotely. We used
$LabVIEW^{TM}$ as the programing development tool and DAQ (Data Aquisition) board from National Instrument for data aquisition. The LAN card and MODEM are used for the transmission of patient's data. A patient data are aquired by DAQ board and signal processing is done by$LabVIEW^{TM}$ , which is a graphical prgamming language. Two methods for the data of transmission. One is the Client-Server model using TCP/IP (Transmission Control Protocol / Internet Address) in the LAN (Local Area Network) Another is using MODEM to transmit the measured data from a patient. In this case, the data transmission is accomplished by the FTP (File Transfer Protocol). -
We are exposed to the various types of external stimuli, and many researches have been conducted to analyze the emotional changes to the stimuli quantitatively. In this paper, changes of human emotion was studied by analyzing HRV from ECG signals which were varied by the auditory stimulus. Power contents for each frequency bands were calculated from HRV waveforms. Two peak values representing autonomic nervous system status, HF and LF, were used to extract the parameters. An analysis on the normalized HF/LF to the subjective rating of the subject were performed. It was assumed that the positive emotional changes evoked by the auditory stimuli, the HF values representing activation of the parasympathetic nervous system, are increased much higher than the LF values, activation of the sympathetic nervous system. Results showed that the parasympathetic nervous system works more actively than the sympathetic nervous system to the stimuli which cause the positive emotional changes.
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The objective of this study was to develop an FES exercise protocol that can enhance muscle force and fatigue resistance and to evaluate the resulting effects. We investigated contraction and fatigue properties of vasti of 10 normal subjects and 4 paraplegics by applying different types of electrical stimulation. Based on the results, we have been training quadriceps of a male paraplegic patient. The results suggested that the exercise be applied 7 days a week, and confirmed that low frequency and intermittent stimulation delays fatigue. After the two-year FES exercise, the patient's knee extensor torque increased by about ten folds and the fatigue index decreased to half of the preFES value.
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In terms of a system identification, we present a method for autoregressive(AR) modelling of variious biomedical signal. Model order is estimated fly low rank approximation and coefficients are determined by innovation processes of Kalman filter derivation. An application of the method is given for visual evoked potentials.
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In this paper, we present a real-time remote patient monitoring service through world-wide web, which allows the medical doctor to monitor his patients in remote sites using popular web browsers. The real-time service consists of two services: Patient Locator Service (PLS) and Vital Sign Monitoring Service (VSMS). The PLS provides the information of patients currently being monitored. The VSMS allows the user to observe a stream of vital sign data of a specific patient. The vital sign data include ECG, respiration, temperature,
$SPO_2$ , invasive blood pressure and non-invasive blood pressure. -
A medical information management system for small to medium sized clinics and hospitals is developed. The system is designed to process, analyze and manage each patient's clinical record using database technique. The structure of the database was determined and implemented through careful and rigorous study of medical practices in Korea and, therefore, reflects the needs of information management in Korean medical community. Furthermore, a sophisticated inference engine that can deduce possible diseases from the result of medical examination is added to the system to provide doctors with a guideline in medical diagnoses.
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We are developing computer integrated polysomnography system. This system integrates conventional polysomnography with computer for data management, automatic analysis, scoring, and data transmission. In the first stage, we have developed the signal interface and user interface for the manual scoring and data management. For the automatic scoring of sleep stage, we have developed the protocol and have applied the analytic method in its primitive form. In the second stage we will develope a partially automatic scoring system, and finalize the fully automatic system in the final third stage.
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본 연구는 G7 의료공학기술개발사업의 1차년도 연구결과이다. 본 연구의 최종목표는 청각계통중 내이의 손상에 의한 감각성 난청환자에게 소리를 인식할 수 있게 하는 한국형 인공와우의 개발, 전 음성 난청환자의 음성인식 효율을 높일 수 있는 한국형 인공이소골의 개발 그리고 인공와우 시술환자에게 적합한 재활용 프로그램을 개발하는데 있다. 이를 위하여 지난 1차년도에는 코클리어의 전기생리학적 현상을 규명하고, 이식전극시스템과 그 주변장치를 설계, 평가하였다. 그리고 한국인의 성인사체의 16귀를 측정하여 한국인 체형에 적합한 인공이소골의 설계기준을 확립하였다. 또한, 인공와우 시술 후 청력회복에 필요한 한국형 재활프로그램의 개발을 위하여 인공와우의 coding strategy에 따른 언어분별력 조사, 유소아의 어음특성분석등을 행하였다. 이 연구결과를 토대로 차기년도에는 상용화에 근접한 프로토타잎의 제품개발과 임상실험이 진행되리라 생각된다.
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We are developing a portable multipurpose gamma counting and imaging probe that will be useful for many applications in nuclear medicine including radioimmunoguided surgery in the detection and treatment of malignant tumors. Any diagnostic information provided by CT, MRI, PET, SPECT or gamma camera imaging prior to surgery obviously is very important, but current techniques are limited in many instances. To overcome some of these limitations, the portable multipurpose gamma probe is being developed. The gamma probe consists of NaI(Tl) crystal with 1" dia
$\times$ 0.5" thick and singlechannel photomultiplier tube (SC-PMT) for counting, and 3" dia$\times$ 0.375" and multichannel photomultiplier tube (MC-PMT) for imaging, nuclear instrument module (NIM), position circuits, interface, and PC. The energy resolution using Tc-99m was measured as 14% and the spatial resolution using 3mm dia green LED was measured as 2.9mm. These priliminary results indicate that the currently developing probe is very promising and could be very useful for many applications in nuclear medicine. -
X-Ray Angiography has been gold standard for imaging of blood flow. However, patients have to take many risks such as catheterization procedure, iodine contrast agent and ionizing X-rays. MR Angiography has been suggested as a substitute for its non-hazard to patient. But the resolution and contrast was inferior to that of X-ray Angiography. Recently the resolution and the contrast have been much improved due to the development of fast imaging technique. Here we report some preliminary results of the MR Angiography we have implemented on 1 Tesla MRI unit.
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A new phased-array quadrature RF coil for one or two RF acquisition channels is developed for spine MR imaging. Quadrature RF coils for MRI have been useful to improve the signal-to-noise ratio (SNR) by
$"\sqrt{2}"$ using two orthogonal RF coils in combination [1]. More recently, the phased-array RF coil has been proposed for more improvement of SNR by using an array of RF coil elements with a reduced size and coverage for each element. Two new schemes are proposed for the new phased-array quadrature RF coil as follows : (1) Proper overlapping of two quadrature RF coils thus removing the mutual inductance and (2) Attaching preamplifiers right after the coil section and combining the signal with proper phase delays. The coil has been implemented for receive- only mode. It has been tested through phantom and volunteer imaging. The experimental results show the utility of the proposed RF coil. -
The matching pursuit (MP) algorithm developed by S. Mallat and Z. Zhang is applied to magnetic resonance (MR) imaging. Since matching pursuit is a greedy algorithm to find waveforms which are the best match for an object-signal, the signal can be decomposed with a few iterations. In this paper, we propose an application of the MP algorithm to the MR imaging to reduce imaging time. Inner products of residual signals and selected waveforms in the MP algorithm are derived from the MR signals by excitation of RF pulses which are fourier transforms of selected waveforms. Results from computer simulations demonstrate that the imaging time is reduced by using the MP algorithm and further a progressive reconstruction can be achieved.
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The Graphical User Interface (GUI) software is developed for 0.3 Tesla Permanent Magnet Resonance Imaging (MRI) system and the state of art of designing GUI system is discussed in this paper. The Object-Oriented concepts are applied for designing GUI software utilizing Interbase ODBC Database layer. Also, Multimedia concepts such as voice, sound and music are integrated in GUI system to enhance the efficiency of MRI operation.
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23 hallux valgus patients were evaluated with clinical examinations and plantar pressure distribution measurements. A masking method for detailed plantar pressure distribution analyses was suggested. With higher grade of hallux valgus, pressure, contact length & area, and impulse on metartasus were significantly increased. Localized pressure concentration is very important in foot diseases and appropriate plantar pressure distributions should be considered on any shoe design.
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Excessive stress on the bone-stem interface may cause local micromotion that could produce midthigh pain, interface bone resorption and prevent bony ingrowth. It is important for clinician and prosthetic designer to develop an understanding of the load transfer mechanism, its associated stress pattern and its relationships with the particular mechanical characteristics of the femoral stem designs. Finite element method (FEM) is preeminently suited to provide information in this respect. The authors developed 3-dimensional numerical finite element models implanted with the straight stem which is composed of total 1170 elements of 8 nodes and with the curved stem which is composed of total 885 elements of 8 node, and analysed the relative micromotions between the straight stem and the curved stem in immediate postoperative stage of an uncemented total hip replacement in load simulating the single leg stance. The results showed that the rotational displacement was occupied over 90% of total micromotion in both types of stem and was peak at the proximal medial portion of the stem, but markedly less distally. The curved stem was more stable especially in terms of rotational stability. It is recommended that surgeons do not allow the patient weight bearing until bony ingrowth was achieved. In the future more attention should be drawn to increase initial rotational stability of the two types of femoral stem to prevent loosening from excessive micromotion.
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A study on static and dynamic socket pressure distributions on a trans-femoral amputee with a suction socket was performed in order to assess an optimal socket fitting and function. Even for the amputee's static neutral position, pressure concentrations were observed in the lateral, medial, and posterior planes of the socket. During free walking, a significant movement of pressure concentration areas was observed. Large socket pressure was observed in the lateral, medial-anterior and posterior walls during mid-stance or push-off period. Socket pressure measurement will be one of the good tool to determine the optimal socket-limb interface.
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KESF-1 foot conceptually provides storage of potential energy and is converted to kinetic energy throughout the weight - bearing phase of the gait cycle. This stored energy is progressively released as the foot continues through the toe-off phase to rebound and propel the body forward. A weight deflects the keel through a predetermined range, then the keel "springs back" as weight is removed. Foot designs criteria were selected to guide development beyond the proof-of concept composite material keels; 1) store and return energy (1-3/4 " metatarsal deflection at 435 pounds vertical load), 2) natural feel and stability; 3) useful life of 3-years: 4) lightweight; 5) reduced production costs. The purpose of this study is developed the comfortable stable foot that fitted with Korean lifestyle and road condition. The results produced the realistic cosmetic foot cover with polyurethane form and the keel composed with composite materials of both glass fiber and carbon fiber.
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In this paper, we studied about the EMG of sternohyoid muscle(SH) during articulation. we selected /ki/ as the word that use subaxial a little, and /pa/, /pan/ as the word that use subaxial very much. The subjects were 4 persons with normal larynx. We indicated them to unify the amplitude of SH EMG during /ki/, /pa/, /pan/ phonation, and measured the amplitude of SH EMG between a phoneme and a phoneme.3 At the results, we found that the subjects can not control to unify the amplitude of EMG during articulation.
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The purpose of this paper is the development of Integrated Bio-signal Management System. (IBMS) using the network. IBMS is the system to manage the medical signals that measured from the each independent medical measurement system module. Each has a LAN Card. We developed the Network Application using Socket Library. Also, we developed the Graphic User Interface software for IBMS using Visual C++ on Windows 95.
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Oxygen saturation is an important parameter in clinical fields; fetal monitoring, apnea, emergency medicine etc. Because of monitoring patients continuously, pulse oximeter that measures oxigen saturation non-invasively is regarded attentively. But, though research about accuracy of signal extraction has been developed, it actually plays a supplementary part in hospital for not trusting the principle of measurement by clinicians. In this paper focusing on these things, first we suggested simple mathematical modelling on separating do components, ac components andnoise components in optical signal transmitted from fingertip or earlobe, and then we considered oxygen saturation computing algorithm using integral ratio of pulsating components. Last, we analyzed its effect by comparing received data.
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Skin temperatures, heart rates and skin conductance levels were tested in order to extract the biological characteristics of the physical constitutional types in according to the Lee's 4 type physical constitutional theory. The subjects of this experiment were 14 ; 5 Macro-Negative subjects, 5 Micro-Negative subjects, 3 Micro-Positive subjects and 1 Macro-Positive subject. All subjects were stimulated with 2.5Hz 30V peak-peak pulses for 2 minutes. As the results, in normal prestimulation state the skin temperatures of the trunk in Micro-Positive and Macro-Positive subjects were higher than those of Macro-Negative and Micro-Negative subjects. In Macro-Negative subjects the reflected skin temperature of lever was the highest in the anterior trunk. In Micro-Negative subjects the reflected skin temperature of kidney was the highest in the trunk. In Micro-Positive subjects the reflected skin temperature of stomach was the highest in the trunk. In Macro-Positive subject the reflected skin temperature of lung was the highest in the trunk. In transient poststimulation state, heart rate was decreased in 7 cases among of 10 Macro-Negative and Micro-Negative subjects, but it was iscreased in 3 cases among of 4 Micro-Positive and Macro-Positive subjects. And the hand temperature was increased in 8 cases among of 10 Macro-Negative and Micro-Negative subjects, but it was decreased in 3 cases among of 4 Micro-Positive and Macro-Positive subjects.
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Standard methods estimating the power spectral density(PSD) from an irregularly sampled cardiac event series require deriving a new evenly-spaced signal applicable to those methods. To avoid that requirement, in this study, the power spectrum of heart rate variability was estimated by Lomb-Scargle's algorithm, which is a means of obtaining PSD estimates directly from irregularly sampled timeseries observed in astronomy. To assess the performance of Lomb-Scargle algorithm in the power spectral analysis of heart rate variability, it was applied to various cardiac event series derived through integral pulse frequency modulation model(IPFM) simulation and from real ECG signals, and the resultant power spectra was compared with those obtained by a conventional method based on the FFT. In result, it is concluded that Lomb-Scargle's periodogram is very effective in the power spectral analysis of heart rate variability, especially in the presence of arrhythmia and/or dropouts of cardiac events.
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Bayesian reconstruction methods for emission computed tomography have been a topic of interest in recent years, partly because they allow for the introduction of prior information into the reconstruction problem. Early formulations incorporated priors that imposed simple spatial smoothness constraints on the underlying object using Gibbs priors in the form of four-nearest or eight-nearest neighbors. While these types of priors, known as "membrane" priors, are useful as stabilizers in otherwise unstable ML-EM reconstructions, more sophisticated prior models are needed to model underlying source distributions more accurately. In this work, we investigate whether the "thin plate" model has advantages over the simple Gibbs smoothing priors mentioned above. To test and compare quantitative performance of the reconstruction algorithms, we use Monte Carlo noise trials and calculate bias and variance images of reconstruction estimates. The conclusion is that the thin plate prior outperforms the membrane prior in terms of bias and variance.
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In this paper, we describe the intrabed and interbed network in a developed patient monitoring system. Intrabed network handles data communication among the main unit of a bedside monitor and parameter modules plugged in it. Interbed network deals with a higher level data communication among many bedside monitors, central stations, DB servers, and clinical workstations. Analyzing the data communication requirements in each stage of the system, we designed the intrabed network based upon RS-485 and HDLC protocol with 1Mbps data rate. Interbed network is designed to utilize the industry standard 10Base-T Ethernet with TCP/IP and UDP protocol. We present the specifications and the performances of the developed data communication networks in the patient monitoring system.
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Chromosomes, as the genetic vehicles, provide the basic material for a large proportion of genetic investigations. The human chromosome analysis is widely used to diagnose genetic disease and various congenital anomalies. Many researches on automated chromosome karyotype analysis has been carried out, some of which produced commercial systems. However, there still remains much room for improving the accuracy of chromosome classification. In this paper, we propose an optimal pattern classifier by neural network to improve the accuracy of chromosome classification. The proposed pattern classifier was built up of two-step multi-layer neural network(TMANN). We are employed three morphological feature parameters ; centromeric index(C.I.), relative length ratio(R.L.), and relative area ratio(R.A.), as input in neural network by preprocessing twenty human chromosome images. The results of our experiments show that our TMANN classifier is much more useful in neural network learning and successful in chromosome classification than the other classification methods.
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We developed the system that enables patients to be treated at home during their daily life through digital telemetry and public communication line. This system records and transfers ECG signals through wireless digital telemetry unhindering the patient's normal activities in long-term recording, and transmits the processed data, which enables real-time remote examination via ISDN phone line. Patient's image, voice, and transmitted signals are transferred to medical experts in remote medical center interactively.
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Recently, many people are interested in the electromagnetic fields(EMF), so we measured the strength of electromagnetic fields in the carriages of national railways and subways. We also measured on the platforms of national railways and subways. The strength of EMFs on the platforms of national railways was stronger than that of subway's platforms. EMF measured on the platform during railway carriage's arriving and leaving was stronger than that without carriages. The strength of the magnetic fields in the carriages of national railways was measured stronger than that of subway's carriage while national railway is run by AC while subway is run by DC. Also The strength of the subway line 8 were measured stronger two to three times than others.
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In this paper, we analyzed the spectroscopic properties of strip to analyzer urine qualitatively & quantitatively and make urine analyzer system stable by spectroscopy, and research the property of preamplifier unit. The analysis of spectroscopic properties of 10 pads in the strip is used for determine the wave length of light source of optic detector unit and used for basic materials which are necessary that we develop the algorithm analyzing the density grade of pad accurately. We make preamplifier unit by using the current to frequency method to measure the distribution of pad color. We implemented urine analyzer system. This system's hardware is composed of measuring unit for detect of distribution density of strip pad, main processing unit, communication unit, interface device, thermal printer, and indicator. The software consists of the program which manage the argument of test, proportion initial value of urine analyzer and calibrate analyzed result.
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Meridian collteral and meridian points have been he base of acupunurre therapy. Also the theory have composed the main portion of oriental medicine. But the mechanism and scientific backgroud has not been completely eastablished, and the research on the objectification of diagonosis of meridian collateral and meridian points, and acupuncture therapy has been necessary nowday. A new understanding of value of oriental medicine has been increasing, the scientific understanding of meridian collateral and meridian points should have been examined. In this paper, we observed meridian point on the morphology for objectification and meridian visulalization we try to meridian point to use methylene blue and optical equipment of high power magnifications. The result of this study suggest that we can observe ruggedness part on body surface to be estimated meridian point. It is observed to have similarity each time of different meridian points. Also, we can observe part alteration of meridian points each time which observed to use method of electronic resistance of unsimilarity on the morphology.
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We developed a new analysis technique for the assessment of irregular vibratory movement of vocal folds. Successive frames of pre-recorded video images from videostroboscopy were transferred to computer memory and a vibratory tract of one selected point was described as a waveform by displaying the same lines of all frames along the y-direction. By applying this technique, irregular vibratory patterns of multiple regions, such as asynchronized registration of glottal cycles, could be easily visualized. It would be possible to monitor and analyze the pathologic changes of vocal fold movement by means of this newly developed system.
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For successful endodontic therapy, complete and accurate biochemical and chemical preparations will allow accurate root canal. Hence the accurate determination of root length is very important for the highest rates of success in endodontic therapy. Among the apex locators, frequency dependent type has higher accuracy and more advantages than others. In this paper, we proposed better frequencies for the method of measuring root canal length by the ratio of two different impedances. It was found that 500Hz and 10kHz is better selection than other frequencies used in the commercial products.
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In this study, we propose a non-invasive method to detect the drowsiness of a driver. The computer vision technology was used to extract an eye, track eyelids and measure the parameters related to the blink. We examined the blink patterns of a driver in drowsy state. For the evaluation of our image processing algorithm, the blink patterns were compared with the measured EOG signals. The result showed that our algorithm might be available in detection of drowsiness.
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This paper describes a new ECG monitor that has a TFT LCD panel as its display unit. The monitor is thinner, smaller and lighter than most commonly used CRT-based monitors. In addition to portability, the system can be expanded to measure blood pressure and oxygen saturation through its flexible design.
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In this paper, we designed a low power and small-sized, light weighted intelligent ambulatory monitoring system using a flash memory card. The system's hardware specifications are as follows: 2 channels, 8bit/250Hz sampling rate, 20M byte storage capacity, a single-chip microcontroller (68HC11E9). To easily interface with PC based system, FFS(Flash File System) was used. We obtained the QRS detection rate of 99.14 through the evaluation with MIT/BIH database.
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Von Mises stress and compliance distribution was evaluated using a finite element analysis on the end-to-side anastomosis of an artery with length of
$20\sim24mm$ , inner diameter of 4mm, thickness of 0.5mm and a PTFE graft with length of 10mm, inner diameter of 2mm, thickness of 0.2mm when the anastomotic angle was taken from$30^{\circ}\sim90^{\circ}$ in every$10^{\circ}$ and the diameter ratio from$0.1\sim1$ in every 0.1. The inner pressure of$1330dyne/mm^2$ was applied inside the 2 conduits. It was found that the compliance whose magnitude is larger on the acute angle anastomotic side than on the acute angle side became larger as the anastomotic angle became smaller and the diameter ratio larger and that the equivalent stress on the acute angle anastomotic side was larger than that on the abtuse angle side and became larger as the anastomotic angle and the diameter ratio became larger. -
The current consumption and the heat produced in the printhead of thermal printer are mainly governed by total printing dots and printing time for each line. Simple algorithm is proposed to optimize the performance of a thermal printhead, which use variable division according to bit-mapped data of its 1 line. And, for protecting the thermal printhead from exceeding heat, I control the heat energy of each microheater(dots) on the thermal printhead through changes in the applied pulse width.
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Owing to technical advances in very large-scale integrated circuits (VLSI), high-speed digital signal processing (DSP) chips become fast enough to allow for real-time implementation of hearing aid algorithms in units small enough to be wearable. In this paper, we present a digital hearing aid processor (DHAP) chip built around a general-purpose 16-bit DSP core. The designed DHAP performs a nonlinear loudness correction of 8 octave frequency bands based on audiometric measurements. By employing a programmable DSP, the DHAP provides all the flexibility needed to implement audiological algorithms. In addition, the has a low power feature and
$5.410\times5.720mm^2$ dimensions that fit for wearable devices. -
Endoscope image is the shape that a doctor sees inside of patient through endoscope. The characteristics of these images are much effected by the light source of endoscope, specially areas in short distance from a light have much light source and look clear, but areas in long distance from a light look dark relatively because of little light quantity. So we developed a new level adaptive image enhancer for the dark area in a endoscope image. The algorithm we made consists of three parts ; 1) Classification of histogram in segmented area 2) Smoothing and Adaptive Histogram Equalization 3) Adaptive Histogram Modification.
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The EEG amplifier satisfies high gain, high common mode rejection ratio(CMRR), high input impedance, low thermal drift, low noise and good d.c. performance. The Bipolar amplifier of this paper safisfies above categories and aim at minimization of the ESU(electric surgical unit) interference.
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We have developed a prototype of a module-based patient monitor. In this paper, we describe the design methodology and specifications of the developed module-based patient monitors. The monitor consists of a main unit and module cases with various parameter modules. The main unit includes a 12.1" TFT color LCD, a main CPU board, and peripherals such as a module controller, Ethernet LAN card, video card, rotate/push button controller, etc. The main unit can connect at maximum three module cases, each of which can accommodate up to 7 parameter modules. They include the modules for electrocardiograph, respiration, invasive blood pressure, noninvasive blood pressure, temperature, and
$SpO_2$ with plethysmograph. -
This paper describes a multichannel epileptic seizure detection algorithm based on wavelet transform(WT), artificial neural network(ANN) and expert system. First, through the WT, a small number of wavelet coefficients is used to represent the single channel epileptic spike. Next, 3-layer feed-forward network employing the error back propagation algorithm is trained and tested using parameters obtained above. Finally, 16 channel expert system which is based on clinical experience is introduced as a artifact rejection and reliable detection. The suggested algorithm was implemented on personal computer(PC). Two main events i.e., epileptiform and normal activities, were selected from 32 person's EEGs(normal: 20, seizure disorder: 12) in consensus among experts. The result was that WT reduced data input size and ANN detected 97 of the 100 EEGs containing definite spike - sensitivity of 97%. Expert rule system was capable of rejecting a wide variety of artifacts commonly found in EEG recordings. It also reduced false positive detections of ANN.
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To visualize electrical activities in the cerebral cortex, we develop the 3D topographic mapping system based on PC. For this work, we utilize OpenGL tool and an optimized interpolation method known as 3D barycentric algotithm, which has a little computational complexity. OpenGL processes the 3D coordinates, and 3D barycentric algotithm interpolates to get overall EEGs with EEGs measured from finite electrodes on 3D. To prove validity of this algorithm on the PC-based system, we developped Windows-based 3D topographic mapping program using the Barycentric algorithm. The result showed that the performance of this system is comparable to that of workstation in terms of speed and precision. Also, the result of clinical test was the same as that of a EEG technician's analysis.
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In this study, we measured upper right, lower right, upper left region to find the optimal region which represent liver function. We found that the upper right region is optimal because of high accuracy and low standard deviation. For normal subjects all the calculated HEFs were greater than 100% and all those of abnormal ones were less than 80%. Thus HEF can be assumed to discriminate abnormal livers from normal ones. It was found that the patients with surgical operation would survive if both the pre-and the post-operative HEFs are greater than 50%. Therefore HEF method can be a good estimator for surgeon to determine the surgical operation and to evaluate remaining hepatic function after surgery as well as it is reliable and simple.
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We are exposed to the various external stimuli input from the environment, which cause emotional changes based on the characteristics of the stimuli. Unfortunately there are no quantitative results on relationship between human sensibility and the characteristics of physiological signals. The objective of this study was to quantify EEG signals evoked by auditory stimulation based on the assumption that the analysis of the variability on the characteristics of the EEG waveform may provide the significant information regarding changes in psychological states of the subject. The experiment was devised with seven experimental conditions, which are control and six different types of auditory stimulation. Six subjects were used to obtain EEGs while introducing auditory stimulation. Wavelet transformation was employed to analyze the EEG signals. The results showed that the reconstructed signals at the decomposition level revealed the different energy value on the EEG signal. Also, general patterns of EEG signals in rest state compare with negative and positive stimulus were found. This study could be extended to establish an algorithm which distinguishes psychophysiological states of the subjects exposed to the auditory stimulation.
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Operative procedures such as core drilling with and without fibular bone grafting have been recognized as the treatment methods for osteonecrosis of femoral head(ONFH) by delaying or preventing the collapse of the femoral head. In addition, core drilling with cementation using polymethylmethacrylate (PMMA) has been proposed recently as another surgical method. However, no definite treatment modality has been found yet while operative procedures remain controversial to many clinicians In this study, a finite element method(FEM) was employed to analyze and compare various surgical procedures of ONFH to provide a biomechanical insight. This study was based upon biomechanical findings which suggest stress concentration within the femoral head may facilitate the progression of the necrosis and eventual collapse. For this purpose, five anatomically relevant hip models were constructed in three dimensions : they were (1) intact(Type I), (2) necrotic(Type II), (3) core drilled only(Type III), (4) core drilled with fibular bone graft(Type IV), and (5) core drilled with cementation(Type V). Physiologically relevant loading were simulated. Resulting stresses were calculated. Our results showed that the volumetric percentage subjected to high stress in the necrotic cancellous region was greatest in the core drilled only model(Type III), followed by the necrotic(Type II), the bone graft (Type IV), and the cemented(Type V) models. Von Mises stresses at the tip of the graft(Type IV) was found to be twice more than those of cemented core(Type V) indicating the likelihood of the implant failure. In addition, stresses within the cemented core(Type V) were more evenly distributed and relatively lower than within the fibular bone graft(Type IV). In conclusion, our biomechanical analyses have demonstrated that the bone graft method(Type IV) and the cementation method(Type V) are both superior to the core decompression method(Type III) by reducing the high stress regions within the necrotic cancellous bone. Also it was found that the core region filled with PMMA(Type V) provides far smoother transfer of physiological load without causing the concentration of malignant stresses which may lead to the failure than with the fibular bone graft(Type IV). Therefore, considering the above results along with the degree of difficulties and risk of infection involved with preparation of the fibular bone graft, the cementation method appears to be a promising surgical treatment for the early stage of osteonecrosis of the femoral head.
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A method for measuring optical properties of biological medium was investigated by using the frequency domain spectroscopy. When amplitude-modulated light with the frequency of several tens up to several hundred MHz propagates through a scattering medium, the phase lag and the amplitude reduction occur. The phase lag depends on the average of optical path lengths. The amplitude reduction with respect to the radial distance is influenced by the penetration depth. The mean of optical path length and penetration depth are related to optical coefficients. The phase lag and the amplitude reduction were measured based on the heterodyne detection method. The experimental data were fitted with the theoretical curves derived from diffusion theory and the absorption and scattering coefficients were calculated.
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In the EMG evaluation, the neuropathy may be diagnosed by a detection of denervation potentials in the group of muscles. These abnomal potentials might be confused with normal endplate spikes. In this paper we present the software algorithm in C, which automatically detects spontaneous activity such as denervation potentials and endplate potentials and distingushes between those potentials. Parameters with statistically significant differences were used for this automated algorithm. It was concluded that the algorithm established in this study will improve accuracy in EMG diagnosis.
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Electrogastrography(EGG), the cutaneous recording of the myoelectrical activity of the stomach using surface electrodes, is attractive due to its non-invasiveness. We propose feasible methods to detect tile gastric contraction by vector analysis of the surface EGG signals obtained from three paired electrodes. The amplitude and direction of the calculated EGG vector were analyzed and compared with the gastric contraction signals such as the strain gauge signal from the gastric serosa in dog. From the vector analysis of the EGG signal, we found a typical change of the amplitude and direction of the EGG vector, which can indicate occurrences of the gastric contraction.
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In this paper, we considered newly the use of wavelet transform in order to improve the troubles of the established methods for the analysis of ultrasound echo signals. We made the phantoms of 13.2g, 19.8g, 26.4g, 33.0g, 39.8g by ourselves, and extracted the only pulse-echo signals that reflected through the mediums using windowing technique. For determining the characterized value, the signals were wavelet transformed, absoluted, and integral calculated. As the result, we acquired characterized value of each signals, and acknowledged the differences among them except of some datas. But this will be improved by advanced work as sellecting a proper mother wavelet, a method of making phantoms, correcting the various errors, etc. We expect that wavelet transform is powerful for analysis of ultrasound signals.
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We have applied the neural network method for the neural networkmethod for the automatic scoring of the sleep stage. 17 features are extracted from the recorded EEG, EOG and EMG signals. These features are inputed to tile multilayer perceptron model. Neural network was trained with error-back propagation method. Results are compared with manual scoring of the experts, and show the possibility of application of automatic method in sleep stage scoring.
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The EMG signal of spinal cord injured patient is very feeble because that the information from central nervous system is not sufficiently transmitted to molter neuron or muscle fiber. Therefore the observer can not observe contraction and relaxation movement of muscle from the raw EMG signal. In this paper, we propose the muscle contraction and relaxation pattern analysis method of spinal cord injured patient whose EMG signal is composed of the sum of motor unit action potential train with additive white Gaussian noise and impulsive noise. From the EMG model, we denoise impulsive noise using median filter which is a kind of nonlinear filter and the output of median filter is transformed to wavelet transform domain for denoising additive white Gaussian noise using threshold level removal technique. As a result, we can obtain the clear contraction and relaxation pattern.
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The analysis of heart sounds is a noninvasive diagnostic method useful to diagnose heart valve function. In this paper we compared the ability of spectral analysis method for prosthetic heart valve sounds. Phonocardiograms of prosthetic heart valve were analyzed in order to derive frequency domain feature suitable for the classification of the valve state. The FFT-based methods did not provide sufficient frequency resolution to completely characterize the spectrum of prosthetic heart valve sounds. A high resolution parametric methods were shown to give superior frequency resolution. In parametric methods, all methods provide a 1st & 2nd & 3rd frequency component. But Shank method provided a most dominant frequency peak.
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In this paper, the power spectral analysis and fractral dimension analysis of heart rate variability(HRV) were performed to evaluate effects of orthostatic stress with head-up tilt on autonomic nervous system(ANS) for 24 young and healthy subjects(age:
$24{\pm}5yr$ .). The ECG and respiration signals were recorded at the tilt angle of$0^{\circ},\;15^{\circ},\;30^{\circ},\;45^{\circ},\;70^{\circ}$ and$90^{\circ}$ successively for 5 minutes per each stage under the condition of frequency controlled respiration (0.25Hz). Heart rate(HR) gradually increased as the angle increased. Similarly, according to the increment of angle, normalized low frequency(LF) component(0.05-0.15Hz) gradually increased, whereas normalized high frequency(HF) component (0.20-0.30Hz) was reduced. From these results it is speculated that orthostatic stress, head-up tilt, results in the prevalence of sympathetic tone in autonomic balance with the increment of sympathetic tone and the decrement of parasympathetic tone, which seems to mean that autonomic nervous system plays a major role in compensating for disturbances of cardiovascular system due to it. -
The most important wave set in ECG is the QRS complex. Automatic classification of the QRS complex is very useful in the diagnosis of cardiac dysfunction. Also, diagnosis is influenced by selection of dominant beat. In this paper, we propose simple algorithm for QRS detection. And we determine correlation between significan attributes of QRS complexs. We evaluated the efficiency of proposed method with the CSE database.
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This paper presents vessel contour for extracting features and segmentating narrow blood vessels down to a diameter of two pixels in digital subtraction angiographic image. We present a new tracking algorithm for contour, mainly blood vessels in DSA image, and extracting properties such as their intensities, diameters, and center lines by exploiting spatial continuity. The proposed algorithm comes to detect blood vessel's boundary using difference edge detector one of homogeneity operator and find a next centerline position by direction vector of edge information. This algorithm enhanced variation of vessel's diameter compared to Sun's tracking algorithm and lessoned to compute as direction vector decide adaptively entire vessel's direction field. The processed images are intended to support radiologists in diagnosis, radiation therapy planning, and surgical planning. The algorithm should be useful for automating angiographic analyses of blood vessels.
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We examined the effect of the auditory stimulus on postural control. The auditory stimulus control system composed of 8 speakers ,the audio amplifier, the PPI interface and the sound controller. We measured the sway of head position and COP. Our result showed that the auditory stimulus was effective on postural control. It also indicated that the auditory stimulus system might be applied to clinical use as a new postural control training system.
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The purpose of this study is to estimate human sensibility quantitatively under color stimulation. We measured biological signals such as EEG, ECG, skin conductance and the number of respiration and eye blinking that were compared with color sensibilities mutually. Our result showed that red, yellow and violet color provoked active and exciting senses dominatively and blue, cyan, pink, and black color were involved in tranquil and resting emotions deeply. Our quantitative estimations of color sensibilites are useful in the design of manufactured goods and color therapy.
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This paper describes the relationship among physiological, behavioral signal, and subjective evaluation depending on arousal level. Nz and reaction time hall similar pattern with KSS level, but eyeblink rate was different from these two parameters. Eyeblink rate increased slowly from KSS level 1 to 5, and had high increasing rate at KSS 7. But it showed steep descent at KSS level 9. From the result of reaction time test, since human performance was decreased rapidly above the KSS level 5, it is desirable to give a subject some stimulus such as sound or aroma to rise arousal level above the KSS level 3.
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We present the preliminary algorithms for automatic sleep scoring. According to the Rechtschaffen & Kales[3]'s critera, we developed six events detectors and eight parameters which contain the background information of signals, such as EEG, EMG, EOG. With the calculated parameters, we scored each epoch by IF-THEN rules, ANFIS for REM preiods, and finally Neural Network for unobvious epochs. The typical point of this algorithm is that the epoch which had good data sets were calculated in the first stage, and unobvious epochs were postponed until the final stage. After staging the good epochs, we classified unobvious epochs by the dominant stage of previous and posterior epochs.
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For the treatment of arteriovenous malformations (AVM), we developed a new liquid embolic material and named it Embol. The material was pre-tested in an in vitro AVM model and tested in rete mirabile of pigs that is similar in structure with the AVM in human. We report on the construction of the in vitro AVM model, the pre-test results of Embol in the AVM model, and the animal test result in pig rete mirabile.
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A new technique for the preparation of porous vascular prostheses was investigated. Polyurethane solution (10 to 14wt%) was injected into a mold. After freezing at low temperature
$(0^{\circ}C\sim-40^{\circ}C)$ , solvent was dissolved out with water at$0^{\circ}C$ to form porous tubes. The average pore size$( < 10{\mu}m)$ and pore occupation (10% to 51%) were easily changed by changing polyurethane concentration, freezing temperature, and freezing methods. This technique can give a proper pore size$(30\sim60{\mu}m)$ for tissue ingrowth, and suitable compliances for matching with arteries and veins. This method might give a desired compliant graft for artificial implantation with the presently valid medical polymers. -
In this paper, we present the developement of Biofeedback system. Biofeedback is a method for learned control of physiological response of the body. It can be used to control certain biological response that cause health problems. Over the past 2 decades, biofeedback has received much attention from medicine as a cure-all for a variety of disease. It has been heralded as a technique that can provide normalization of disturbed physiology without the need for drugs or surgery and their attendant negative side effects. Biofeedback system has been implemented by using PIC microprocessor. We have displayed 5-channel value on PC and managed patient information by using Delphi.
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The photoconductive gain mechanism in various types of hydrogenated amorphous silicon devices, such as p-i-n, n-i-n and n-i-p-i-n structures was investigated in connection with applications to radiation detection. We measured the photoconductive gain in two time scales: one for short pulses of visible light
$( < 1{\mu}sec)$ which simulate the transit of energetic charged particles, and the other for rather long pulses of light$(\sim1msec)$ which simulate x-ray exposure in medical imaging. We used two definitions of photoconductive gain: current gain and charge gain which is an integration of the current gain. We found typical charge gains of$3\sim9$ for short pulses and a few hundred for long pulses at a dark current density level of$10mA/cm^2$ . -
The ECG monitoring system had play a significant roll in ICU, CCU and operating room. By alarming the change of ECG wave form and heart rate, staff can control emergency state. The improve of recent digital technology is able to develope low cost and high quality ECG monitoring system. In this paper, we develope new monitoring system with low price microprocessor and control system.
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A Study on Computer Assisted Diagnosis (CAD) system extract ing lung cancer part from Digital X-ray Computerized Tomography(CT) image is discussed in this paper. It is very crucial to segment the image of lung into the three organ area such as inside, outside and the hilum so that the variant image processing algorithm can be applied an each area respectively. In this paper, the efficient algorithm extracting lung cancer part is proposed with characterizing lung hilum part and its associated vessel patterns.
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Several selective excitation pulses are used in MRI. Because of the nonlinearity of the Block equation, the pulse problem is nonlinear generally. Recently, Shinnar & Le Roux have proposed a direct solution of this problem. In this paper, we introduce the SLR algorithm and design pulses using SLR algorithm. This SLR pulse produces a specified slice profile. For example, we demonstrate the sinc function pulse with piece wise constant duration
${\Delta}t$ . Further, we will design$\pi/2$ pulse and slice profile. -
A new open structure of the bird-cage RF coil is proposed. By applying in-phase or out-of-phase voltage to the two terminals of the open bird-cage RF coil, desirable level of RF field uniformity has been achieved. Theoretical resonance frequencies of the RF coil has been obtained and compared with experimental ones. The quality factor of the open bird-cage RF coil has been found to be comparable to the one of the conventional RF coil.
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Design and Implementation of PC-based hospital-integrated PACS in Seoul National University HospitalThe SNUH has started a PACS project with three main goals : to develop a fully hospital-integrated PACS, to develop a cost effective PACS using open systems architecture, and to extend PACS' role to the advanced application such as image guided surgery, multi-media assisted education and research. In order to achieve these goals, we have designed a PACS architecture which takes advantages of client-server computing, high speed communication network, computing power of up-to-date high-end PC, and advanced image compression method. We have installed ATM based communication network in radiology department and in-patient wards, and implemented DICOM compliant acquisition modules, image storage and management servers, and high resolution display workstations based on high-end PC and Microsoft Windows 95 and Windows NT operating systems. The SNUH PACS is in partial scale operation now, and will be expanded to full scale by the end of 1998.
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In this Paper, We use Maximum-Intensity Projection(MIP) algorithms. Maximum-Intensity Projection algorithms currently used for construction of magnetic resonance angiograms. The blood flow in a volume of interest is represented by bright intensities in the MR data volume. The flow within the vasculature shows up in the projections plane. By relating the intensities of the pixel to their location in the slice, the total number of pixels considered for the projection plane was reduced, thus saving calculation time. The algorithm was written in visual C++.