Electrogastrography(EGG) is the technique by which gastric myoelectrical activity is recorded noninvasively, from electrodes on the abdominal skin. This gastric myoelectrical activity consists of two type signals : 1) slow wave, which is gastric basal rhyemic activity and is not closely related to gastric contraction 2) spike wave, which is generated only during contraction of the stomach. Despite many attempts made over the decades, analysis of surface EGG has not led to identification of the spike wave (gastric contraction) that would help the clinician to diagnose functional or organic diseases of the stomach. In this paper, we propose a feasible methods to detect gastric contraction by frequency-domain signal analysis of surface ECG signal. Synchronous measurement of gastric pressure by the antropyloric manometry with surface EGG established feasibility of this method.

In this paper, we attempted to analyze the contraction patterns of elbow flexor muscle during isometric, concentric and eccentric contraction. The analysis parameters are consisted of Sequency domain parameters (mean frequency, median frequency, skewness, kurtosis) and time domain parameters (zero crossing, positive maxima, integrated EMG). As a results, the analysis parameters have specific trends for muscles, muscle contraction patterns, muscle contraction angles. Especially, at the time domain analysis, IEMG is a dominant parameter for analysis of activation patterns, and the skewness, kurtosis are useful parameters for functional recognition.

We have developed the digital polysomnograph system to enhance the manual sleep study. This system is composed of host PC and target board. The host computer is IBM-PC Pentium 133 MHz and the target board is PC31 (processor type: TMS320C31). These two Processors communicate with each other by dualport RAM. Target board acquire 16 channel sleep signals from the Polysomnographic system (GRASS model 78, USA) and digitize them. We used high resolution monitor$(1600{\times}1280)$ to simulate the paper-recording quality of polysomnographic signal. We also implemented the GUI based polysomnographic staging program on the windows environment. Clinicians can score the sleep stage, and edit and mark the event efficiently. Finally it can support making patient database.

Evoked Potentials signals occur as a result of neuroelectric responses of the brain to sensory stimulation. In this paper, to analysis such signals we utilize a time-frequency analysis technique called wavelet transform. The wavelet analysis is performed based on a single prototype function,which can be thought of as a bandpass filter. Because the wavelet transform in a fine temporal analysis decomposes time-varying signals in EP into a dilated lowpass and a contracted highpass components, EP signal fetures can be obtained and analysed quantitatively at the levels of resolution. In the results, we analyze the VEP signal with the wavelet transform.

Even though there are several deterministic methods for the modeling of linear systems, there is no standard method for the modeling of nonlinear systems. For the modeling of nonlinear systems we have applied the genetic programming method to estimate nonlinear time sereis. We get the time series from the simple known nonlinear dynamics, and fed those to genetic programming. For the tested nonlinear systems, suggested method estimated the nonlinear dynamics correctly.

In this paper, we designed 4-channel electrolyte analyzer that can measure simultaneousely the 4 electrolytes - pH, $pNa^{+}$, $pCa^{2+}$, and $pK^{+}-$ using 2-point calibration and implemented it. Developed electrolyte analyzer consists of singal processing part, actuator part and control unit for sample flow system. To implement reliable instrument, design considerations are emphasized on flow system and sample chamber that requires small sample volume and prevent air contact with sample solution. In addition to the hardware design, we developed system software which controls full measuring process. After system developed, we verified the system performance by the test measurement for pH, $pNa^{+}$, $pCa^{2+}$, and $pK^{+}$ value.

PR interval variability has been proposed as a noninvasive tool for in-vestigating the autonomic nervous system as welt as heart rate variability. The goal of this paper is to determine whether PR interval variability is generated from deterministic nonlinear dynamics. The data used in this study is a 24-hour bolter ECGs of 20 healthy adults. We developed an automatic PR interval measurement algorithm, and tested it using MIT ECG Databases. The general discriminants of nonlinear dynamics, such as, correlation dimension and phase space reconstruction are used. Surrogate data is generated from simpler linear models to have similar statistical characteristics with the original data. Nonlinear discriminants are applied to both data, and compared for any significant results. It was concluded that PR interval variability shows non-linear characteristics.

This paper presents a real time algorithm for monitoring of the arrythmia of ECG signal. A real time monitoring, following by detecting a QRS complex, is the most important. Using 2-dimensional time-delay coordinates which are reconstructed by the phase portrait plotting special trajectory, we detect QRS complexes. In this study, arrythmias are detected by matching the past standard template with tile present pattern when changing abruptly In order to matching with each other, we propose modified chain coding algorithm which applies vetor table consisting of eight orthonormal code(=binary code) to the phase portraits. This algorithm using logical function increases the weight if exceeding to the threshold determinded by correlation value and the distance from a straight line(y=x). Evaluating the performance of the proposed algorithm, we use standard MIT/BIH database. The results are fellowing, 1) Improve the speed of matching template than that of cross-correlation ever has been used. 2) Because the proposed algorithm is robust to varing fiducial point, it is possible to monitor the ECG signal with irregular RR interval. 3) In spite of baseline wandering owing to the low frequency noise, monitoring performance is not reduced.

There are two prevailing techniques, mechanical and optical profilometers, to measure 3-dimensional configurations of the human skin furrows. The methods have some limitations such as, accuracies or resolutions of the acquired 3-dimensional data and consistencies according to the repeated experiments. We devised an optical profilometer that is called stereo image optical profilometer (SOP) based on stereo image processing techniques. A stereo image is a pair of images that obtained from two cameras which have different angles. From the digital stereo images, the clinical informations for skin can be obtained by some signal processing techniques. In this paper, we focused on the 3-dimensional graphical visualizations of the structures and state of the skin furrows by solving the corresponding problem from the left and right pairs of the stereo images.

There are studied for filmness methods due to disadvantage of conventional X-ray system. Have high DQE, high SNR, amorphous selenium was investigated with image plate. In this point, characteristics of all amorphous selenium image plate was investigated to understand the relationship between the amount of the X-ray exposure and the superficial charge potential in this study. Specially, changes in charge at the surface of the amorphous selenium plate with respect to change of X-ray energy(KeV) was investigated. It was found that the surface charge potential at the amorphous selenium inclosed with respect to the increse in X-ray exposure and that the changed surface potential was a semilinearity in 12.5KeV - 22.5KeV range. Therefore, which suggests that these results call be applied to the development of X-ray image plate.

In the case of $^{123}I$ from the $^{124}Te$ (p,2n)reaction, the radionuclidic impurity is the high-energy gamma-emitting $^{124}I$, which interferes greatly with nuclear medicine images. The choice of a collimator can affect the quality of clinical SPECT images of [I-123]MIBG or [I-123]TPT. The tradeoffs that two different collimators make among spatial resolution, sensitivity, and scatter were studied by imaging a line source at 5cm, 10cm, 15cm distance using a number of plexiglass sheets between source and collimator, petri dist two-dimensional Hoffman brain phantom, and Jaszczak phantom after filling with $^{123}I$ (FWHM, FWTM, Sensitivity) for low energy ultra high resolution parallel hole(LEUHRP) collimator and medium energy general purpose (MEGP) collimator were measured as (9.27mm, 61.27mm $129CPM/[\mu}$ Ci) and (10.53m 23.17mm $105CPM/{\mu}$ Ci), respectively. The image quality of two-dimensional Hoffman brain Phantom with LEUHRP looked better than the one with MEGP. However, the image quality of Jasgczak phantom with LEUHRP looked much worse than the one with MEGP, The results suggest that the MEGP is preferable to LEUHRP for SPECT studies of [I-123]MIBG or [I-123]IPT.

We have developed the prototype Multi-leaf Collimator(MLC) for Medical linear acclerator. In this study, we have examined the mechanical characteristics of newly developed multileaf collimator. The leaf movement in clinical situation and the modification of accessories is good. such as the block tray mount and the wedges, due to the new MLC installation are efficient. But it was that bolts and nuts for the leaf control should have better performance.

The spectra of whole blood EDTA samples from two people were generated using a CARY 5E (UV-VIS-NIR) spectrophotometer from 400 to 1000nm which contain visible and NIR region. Only the data between 400 and 800nm were used to analyze the components of blood. Using the same spectrophotometer, the spectra of Water, normal saline, plasma were generated These spectra were subtracted from each blood sample, and then the first derivative of each of the subtracted data was taken to minimize baseline variations and indicated the wavelength-shift of peak and valley. Normalization and division between two blood samples were used to correlate the quantity ratio of specific components with feature of spectra. Samples were controlled at $30^{\circ}C,\;37^{\circ}C$, ambient temperature.

The purpose of this study is to identify the cause of driver's drowsiness and to get information about driver's drowsiness from facial image using computer vision. We measured the driver's movements of a head and shoulders in the highway arid street. We also measured the eye blink duration and yawning duration of normal and drowsy drivers. from the results, we confirmed that the measurement of eye blink and yawning might be a way of drowsy detection.

This paper describes the development of portable arousal measurement and analysis system. Skin impedance change which responds the change of arousal level was detected by the three electrode constant current method and separated into two components (SIR, SIL). Relationship between Nz, IRI and arousal level was studied and Criteria of arousal level control was decided by the sleep study.

Neural networks are increasingly being used to enhance the classification and recognition powers of data collected from sensor array. This papers reports the effectiveness of multilayer perceptron network based on back-propagation algorithm combined with the outputs from "Electronic Nose" using electrically conducting polymers as sensor materials. Robust performance and classification results are produced with preprocessing method.

A new flow visualization image processing technique was studied. Our approach is based on texture fields and has higher performance than similar methods. We tested our method to flow visualization of Total Artificial Heart.

Computer simulation and magnetic resonance angiograms(MRAs) are used to understand for flow patterns in the carotid arterial bifurcation. Steady momentum equation is solved by the finite volume method. A Phantom of the carotid artery made of bioacrylic material is used for MRA observation. Flow Patterns are observed by using MRA for flow in the phantom of an automatic closed-type circulatory system filled with sugar 4 w% solution. For numerical analysis the idealized geometric shape of the carotid artery is constructed to portray the phantom. Results of numerical analysis are compared with those of MRA. The flow patterns of the phantom on MRA are almost identical to those of the computer simulation.

To emulate tri-phasic pulsatile flow of human circulatary system, we have selected control parameters and examined the changing effect of each parameter by using Doppler ultrasound. In this experiment, it was shown that the distal complaince and the break time were the major factors to form tri-phasic flow.

In this paper, we present a simplified model for complicance determination of the moving-actuator type totally implantable artificial heart (TAH). The modeling equations are derived from the mechanics and geometry of the TAH components. The interventricular pressure and volume are computed for determining the compliance of the interventricular space using this model. The model is capable of generating realistic hemodynamic variables such as the left atrial pressure and interventricular pressure and is proved to be acceptable. This model can be used as an initial step for analyzing characteristics of the moving-actuator type TAH.

We have been developed electrohydraulic left ventricular assist device and done various in vivo evaluation on the device. Through the in vivo experiment conducted from Jan. 23, 1996 to Feb. 8, we could have experience of long-term evaluation fur the first time. The sheep used in this experiment had survived for 16 days. We used new actuator with reduced size and linear motion guide replacing oil box and ball bearings. Also, we used improved blood chamber with reduced size, reduced weight facilitating fixing the chamber to animal's body, and polymer sac having improved folding pattern. Against suction problem, we used absolute pressure limiter only. Motor current for driving this new actuator was not much higher than older one. Effective stroke volume was about 48 cc. Thrombosis was found around top area and peripheral boundary of the sac and valves. There was no sign of damage from suction problem in the atrium observed at autopsy. Main cause of death was presumed to be progressive formation of thrombosis in the cannulae. In this paper, the results of this experiment are documented.

The right and left atrial pressures are important parameters in automatic control of a total artificial heart (TAH) within normal physiological ranges. Our TAH is composed of a moving actuator, right and left ventricles and the interventricular space enclosed by a semi-rigid housing. During operation of the TAH, the jnterventpicular space's volume is changed dynamically by the difference between the ejection volume of one ventricle and the inflow volume of the other. Therefore, the changes in pressure of the interventricular space is related to both atrial pressures. We measured the interventricular pressure (IVP) waveform using a pressure sensor and attempted to indirectly estimate the changes of atrial pressures. This method has an advantage that the sensor does not contact the blood directly. Furthermore, the IVP waveforms have its zero baseline in each pump cycle, thus the pressure measurements are free from the transducer drift problems by measuring the peak pressure from these baseline values. From the In vitro experiments, we found that the IVP waveform contained several useful parameters such as negative peak, dP/dT on the initial break, the area enclosed by the profile in each stroke, which are associated with atrial pressures and the filling conditions of the ventricles. The measured atrial pressures were linearly related to the negative peak of the interventricular pressure.

광반응을 이용하여 fibrinolytic 활성을 보이는 LK (lumbrokinase)를 생체재료인 PU (polyurethane) 표면에 고정화하는 방법에 관하여 연구하였다. 먼저 PU표면에 amino 작용기를 도입하기 위하여 side chain 작용기로 phenylazide 와 amino작용기를 갖는 AzPhPAL을 이용하였으며 광반응은 266nm 이상의 UV light을 약 1분간 조사시키는 방법을 이용하였다. LK를 amino작용기가 유도된 PU 표면에 공유결합시키기 위하여 amide결합 형성시 사용되는 수용성 carbodiimide인 EDC를 이용하였다. ESCA측정시, AzPhPAL으로 공유결합시킨 경우 반응하지 않은 PU표면에 비하여 N/C가 0.1717로, LK 고정시 S/C가 0.0043로 증가된것을 알 수 있었다. 이것으로부터 AzPhPAL과 LK가 PU표면에 공유결합된 것을 확인할 수 있었으며 static contact angle 측정으로 표면개질된 PU표면이 소수성에서 친수성으로 변화된 것을 확인 할 수 있었다. 또한 공유결합된 LK의 활성을 확인하기 위하여 fibrin plate test를 실시하였는데 그 결과 고정화된 후에도 LK의 활성이 존재함을 알 수 있었다.

Intracellular gradients of the free calcium concentration are thought to be critical for the localization of functional responses within a cell. The mechanism of mechanotransduction may be associated with the localized accumulation of calcium stores for shear stress-exposed endothelial cells. The distribution of the calcium stores and the formation of the stress fibers were investigated by the indirect double immunofluorescent staining method with the calreticulin antibody and rhodamine phalloidin under flow condition. The shear stress of steady flow reorganized the cytoskeleton structure including the bundling and translocation to focal contacts. The calcium stores translocated from the cytoplasm to the focal contacting area. Consequently. accumulation of the calcium stores may participate in the shear stress-induced cytoskeleton organization of endothelial cells.

In this paper, We propose an algorithm for reconstitution of chromosome images to extract its morphological feature parameters. It is reconstituted from 460 chromosome images using the 32 direction line algorithm. We extract three morphological feature parameters such as centromeric index, relative length ratio, and relative area ratio. The experiment results show that our method is batter than that of other researchers comparing with the error of feature parameters.

Open MRI is a new concept in clinical application of the MRI such as interventional study. Receiving RF coils used in the open MRI must have open structures to insure convenient manipulations fur the patient. In this paper, we presented experimental study fur open head coil suitable to 0.3 Tesla vertical field MRI system with its experimental results.

Mucociliary transport is one of the essential defensive functions of the airway mucosa. In this paper, the objective and quantitative method of measuring CBF(Ciliary Beat Frequency) was developed based on the image processing method. Microscopic ciliary images are acquired through image processing board inside PC, and data necessary for the FFT(Fast Fourier Transform) analysis are extracted. By means of FFT analysis, maximum peak frequencies are found in each divided block of a whole acquired image. Finally using these frequencies, we compose a frequency map showing the spatial distribution of CBF's.

The orientation effect of galactose ligand on hepatocyte attachment was investigated. Poly(N-p-vinyl benzyl-o-${\beta}$-D-galactopyranosyl-D-gluconamide) (PVLA), a ${\beta}$-galactose-carrying styrene homo-polymer, was used as a model ligand for the asialoglycoprotein receptors on hepatocytes. PYVA was transferred onto the poly(${\gamma}$-benzyl L-glutamate)(PBLG) or PBLG/ poly(ethylene glycol)(PEG)/PBLG Langmuir-Blodgett (LB) films as the monolayer level. The dichroic fluorescence values of confocal microscope indicated that the PVLA transferred onto the LB films was located with a preferential orientation of its molecular axes with regard to the direction of the a-helix of polypeptide. Hepatocyte recognized well-oriented galactose moieties of the surface of PVLA through asialoglycoprotein receptors.

Morphological changes of the heat treated dental procelain at toy have been investigated with SIM and TDX. The surface indium concentration of specimens increased as the heat treatment temperature and the oxygen partial pressure increased.

It is well known when porous calcium phosphate ceramics are used as a bone graft substitute, new tissues or blood vessels are grown into the porous implant due to their excellent biocompatibility. In this study, the ${\beta}$-crystalline form of calcium metaphosphate, $Ca(PO_{3})_{2}$ is prepared by the controlled thermolysis of monocalcium phosphate, $Ca(H_{2}PO_{4})_{2}$. The diameter of cylindrical pores formed during cooling was controlled by a holding time at the melting point of a monocalcium phosphate and by the change of a recrystallization temperature, to obtained the most appropriate size (about $200{\mu}m$) of pores. It was observed that the increasing holding time at the melting point of monocalcium phosphate results in the decreases of pore sizes.

We investigated how hydroxyapatite (HA) coating onto a porous super stainless steel (S.S.S, 22Cr-20Ni-6Mo-0.25N) affects bone ingrowth in a dog transcortical femoral model. Implants were histologically evaluated after 4 and 48 weeks of implantation, and the bone bonding strength at the bone/implant interface was examined by employing the pull-out test. The direct osseous tissue bonding onto the HA-coated S.S.S was observed, but the uncoated stainless steels had thin fibrous tissue layers. The mean interface strength of the HA-coated S.S.S was 1.5 and 2.5 times greater than those of the S.S.S and the 316L SS after one year of implantation, respectively. In preliminary studies, no toxic responce was observed from a cytotoxicity test of the S.S.S, having similar corrosion resistance to titanium. Our results suggest that early osteoconductive nature of HA coating may induce long term osteointegration for a bioinert substrate.

World Wide Web을 이용하여, 원격 제어 핵자기 공명 영상이 시도되었다. 이를 위하여, MRI시스템의 host computer에 HTTP server를 구축하였다. 원활한 원격 실험을 위하여 화상 및 음성통신기능도 추가하였다. 개발된 시스템으로 광운대학교의 신호처리연구실에서 대전 KAIST의 의학 영상 공학 센터에 있는 원격 MRI시스템을 이용하여 성공적으로 MRI 영상을 얻을 수 있었다.

An adaptive digital filtering of the electroencophalogram(EEG) is a successful way of suppressing mains interference, but it affects some of the frequency components of the signal, an artifact which not be acceptable in some cases of automatic EEG processing. The types of electrical artifact seen on EEG records is described. Those are the EOG and the PVC roller pump noise. And we study the method for cancelling these artifacts. The method does not need the reference channel, and are obtained by cascading the linear predictor and the noise canceller. The simulation results illustrate the performances of the presented method in terms of the capability of interferences suppression.

We are developing a teleconference system based on 3D medical image. The system consists in three sub-systems : conference operating system, medical image processing system and database management system. It makes it possible efficient computer-supported coorperative work among remote multi-located hospitals. In this paper, we present functions of each subsystem that have implemented until now.

The purpose of this paper is the development of Integrated Bio-signal Management System(IBMS) using the network. IBMS is the system to manage the medical signals that measured from the each independent medical measurement system module. Each has a LAN. We developed the file-server network using Novell Netware. Also, we developed the Graphic User Interface software for IBMS using Visual C++ at Windows 3.1.

We have developed the prototype Multi-leaf Collimator(MLC) for medical linear acclerator. In this study, we have examined the clinical effectiveness of our newly developed MLC by analysing treatment pattern of radiation therapy and studied the radiation safety by measuring the transmitted radiation and the leakage radiation. Over 81% patients can be treated with new MLC(20 pairs of leaves) and 98% with 30 pairs of leafed-MLC, while 95% with commercial MLC. New MLC showed superior properties of radiation leakage and transmission to commercially available MLC.

The correlation coefficients among hepatic extraction fraction(HEF), DISIDA-K, and ICG Rmax methods were found using two normal rabbits and four rabbits with damaged liver. The correlation coefficient between HEF and ICG R-max which is a standard technique in evaluating liver function was found to be 0.93. Therefore HEF is a valuable diagnostic method since it is not only accurate, but possible to estimate remaining liver function after surgical of cancerous hepatic tissue.

Human aorta has viscoelastic behavior. The test of tissues such as aorta, skin, muscle, and ok. is required to consider visco effect on deformation behavior. Creep and slow recovery are main aspects of viscoelasticity of tissue engineering. Volumatric strain plays a important role in determine slow recovery of human arota. This study is to suggest the method avoiding viscous effect in tissue experiment The results shows the time scale when the specimen can be fully recovered from slow deformation. Also, this study observes the qualitative creep-effect on elastic strain in 1 minute at the same loading.

Impact force and strains induced by impact between the occluder and the struts have been measured with force senfor and strain gages. The maximum reaction force was about 25N, and the calculated impact force on the root of the struts amount about $9{\sim}17N$. Impact force on the inlet strut is greater than that of the outlet strut, but the strain on the outlet strut is much higher than that of the inlet strut. These values might cause severe damage on the valve in the critical cases. The results of this study may be extended for the analysis of the endurance limit and optimal design of the struts and occluder.

The purpose of this thesis is the propose of various signal processing algorithm for the ECG(electrocardiogram) and the design of realtime automated ECG analyzer feasible with these algorithms. The algorithms are composed of (1)filtering procedure fer the estimation and removal of baseline drift, 60Hz power line interference, and muscle artifacts (2)detection procedure of QRS complex and P wave (3)typification procedure for the pattern classification according to the morphologies (4) selection of representative beat, significant point and wave boundary decision procedure and (5) parameter extraction and diagnosis procedure. All verifications are carried out between the algorithms proposed in this paper and other algorithms already proposed by many researchers, for the objective comparison in each procedure. The efficiency of proposed algorithms are demonstrated with the aid of internationally validated CSE database and the performances of filtering procedure are compared on artificial noise signal as well as actual ECG signals with appropriate noise components. for the comparison on the performance of designed automated ECG analyzer, the diagnosis results were compared with ECG analyzer manufactered by Fukuda denshi in Japan.

Most of the conventional electrocardiogaphies fail to detect signals other than P-QRS-T due to the limited SNR and bandwidth. High-resolution electrocardiography (HRECG) provides better SNR and wider bandwidth for the detection of micro-potentials with higher frequency components such as ventricual late potentials(LP). In this paper, we developed a HRECG using uncorrected XYZ lead. The overall gain of the amplifier is 4000 and the bandwidth is $0.5{\sim}300Hz$ without using 60Hz notch filter. Three 16-bit AH converters sample X, Y, and Z signals simultaneously with a sampling frequency of 2000Hz. Sampled data are transmitted to PC via a DMA-controlled serial communication channel using RS-485 and HDLC protocol. The noise level of the developed HRECG is less than $5{\mu}V_{rms,\;RTI}$. In order to further reduce the noise level, signal averaging technique is implemented utilizing template matching method. The SNR of the developed HRECG is high enough for the detection of LP.

We have been studying an implantable electrolarynx controlled by the EMG of the sternohyoid muscle(SH). Generally, the pitch control methods of the electrolarynx by SH EMG have two types. In the first pitch control method, the pitch of the electrolarynx increases according to the decrease in amplitude of the SH EMG, and vice versa. In the second pitch control method, the pitch of the electrolarynx decreases according to the decrease in amplitude of the SH EMG, and vice versa. We carried out four physiological experiments about two pitch control method. Also, we made two electrolarynges with two type pitch control, and tested those electrolarynges. From the result of the experiments, we found that the developed electrolarynx have a good property by the first pitch control method more than the second pitch control method.

This study is to find the distribution of the torso surface potential based on electrical cardiac dipole source. In order to find the torso surface potential, the governing equation was developed based on the Green's second theorem. The boundary element method(BEM) which has a good computing capability in case of homogeneous and isotropic medium was applied to solve the equation. To validate the BEM, we considered a homogeneous sphere model which has an electric dipole source inside. The results showed the good agreement between the analytic solution and the computed solution. In normal heart, the simulated torso surface isopotential maps are good agreement with that obtained from the ventricular excitation. The validity of the simulated results were verified by comparing with other results.

This paper is studid the flow analysis of cardio vascular assist device. The experimental study is carried out to measure velocity profiles, Shear stress distributions and Velocity Vector for the flowrare of 4l/min, the frequency of 0.5Hz, the stroke volume of 60ml, the inlet and outlet pressure of 100mmHg by the L.D.V and P.I.V system. These results are agreed with the numerical simulations.

Artificial hearts are intended for use in patients with severe forms of heart disease for which no surgical repair is possible. The moving-actuator pump was developed to decrease the overall volume size of the electromechanical total artificial heart (TAH) by eliminating the occupied space of the fixed-actuator in the conventional pusher-plate type pump. In our pump, the actuator moves back and forth for alternative ejections of left and right ventricles. The problem of fitting the TAH to atrial remnants and arterial vessels could also be improved by circular or penduluous mot ion of the actuator instead of linear mot ion of the pusher-plate in the conventional pumps. We have evaluated two types of moving- actuator pump; one is a rolling cylinder type, and the other a pendulum type pump. In the rolling cylinder pump, frictional energy loss exists between the pump housing's guide bars and the actuator's end caps, while the bottom rack under the cylindrical actuator increases the height of the pump, the pump is therefor not implantable inside the small chest of human-sized animals with a body weight of less than 70kg. The new human type pump has a penduluous mot ion actuator to correct the above problems while maintaining the advantage of the moving- actuator's small total volume. The totally implantable TAH is composed of a blood pump, a control system and pheriperal equipments. The blood pump, which is constructed by a moving actuator, a right and left blood sac, and four artificial valves, is implanted in the thoracic. In 1988, the first implantation of the rolling cylinder TAH was performed into a female calf weighing 100kg, and the cal f recovered to the degree of voluntary standing and eat ing and survived to 100 hrs. We then survived two female sheep weighing about 63kg with the new human type TAH for three days.

To understand the local fluid dynamics for different desists of Fontan operation, five models were made out of Pyrex glass to facilitate in-vitro study. Model I, II and III have same position of the center of the anastomosis of the IVC( inferior vena cava) with that of the SVC(superior vena cava), but Model IV and V have 10 mm offset between them. Also the anastomotic junction angles are different(Model I and $IV:90^{\circ}$, Model II and $V:70^{\circ}$, Model $III:45^{\circ}$). These models were then connected to a flow loop for flow visualization study. In Model I any dominant vortex was not seen in the central region of the juntion, but a large unstable vortex was created in the Model II and III. In Model IV and V a significant stagnation region was created in the middle of the offset region. It also showed that the flow direction from the IVC and SVC to the LPA(left pulmonary artery) and RPA(right pulmonary artery) highly depends on the offset of the junction rather than the anastomotic junction angle.

We developed pneumatic blood pump and its driving system as a pediatric ventricular assist device. The blood pump is diaphragm type system and its blood contacting area is coated with Bio-Span. The driving unit Is consists of dual pumps, valves for the reliable blood pumping and its controller uses 80C196(Intel) as a main processor. The acute animal experiment was performed with dogs and its body weight is about 20 kg. The maximum cardiac output is about 2.1 l/min and the pressure and flow curves showed reliable operation as assist device.

Experimental set-up for the characterization of Shape Memory Alloys springs which are applicacable to endoscope has been implemented. Fundamental properties of SMA springs were measured by iso-thermal test iso-metric test, iso-tonic test and the relationship between stress and strain, temperature and generated force, displacement and temperature could be characterized experimentally. The implemented experimental set-up and characterization method can be exploited for the design of SMA springs and evaluation of actuators used in endoscope.

In order to prepare the porous hydroxyapatite (HA) ceramics with different porosity, interconnectivity, mechanical properties, surface chemistry and tissue response, several methods have been developed. Of the different forms of Porous HA ceramics which were prepared by various methods, only the coralline HA has undergone major clinical applications in orthopaedic, maxillofacial and ophthalmic surgery. In this study, totally synthetic macroporous HA ceramics with various pore size distribution were prepared. It is shown that the new reticulate HA ceramics, comprised of interconnected voids surmunded by a web of ceramic, have a morphology which mimics that of human trabecular bone.

Poly (ethylene glycol) (PEG)macromers terminated with acrylate groups and interpenetrating polymer networks(IPN) composed of poly(hydroxyethyl methacrylate)(PHEMA) or poly(hydroxyethyl methacrylate-co-hydropropyl methacrylate-co-N-vinyl pyrrolidone) [P(HEMA-co-HPMA-co-NVP)] and PEG macromer were synthesized with the aim of obtaining protein adsorption resisatnt soft contact lens. Polymerization of PEG macromer resulted in the formation of cross-linked gels due to the multifunctionality of macromer. Crosslinked P(HEMA) or P(HEMA-co-HPMA-co-NVP) chains were interpenetrated into the cross-linked three-dimensional networks of PEG. It was found that albumin adsorption onto the contact lens prepared by P(HWMA)/PEG IPN decreases with a decrease of molecular weight of PEG whereas its adsorption onto the contact lens prepared by P(HEMA-co-HPMA-co-NVP)/PEG IPN decreases with an increase of molecular weight of PEG. Also, it was found that albumin adsorption onto the both contact lens decreases with an increase of concentration of PEG macromer in the IPN preparation. There are also more adequate in the bioinertness and bioadhesion for the contact lens by P(HEMA)/PEG IPN or P(HEMA-co-HPMA-co-NVP)/PEG IPN than that by P(HEMA) or P(HEMA-co-HPMA-co-NVP).

Recently Iontophoresis is tried to physical therapy field.. It is method for direct penetrate to skin with ionization pharmacon because it is decreased side effect of pharmacon treatment such as gastrophathy and aphylaris of disease-causing germs. We designed WIT-I that is trial manufacture for clinical experiment This system is has been elrectrical paramete with 0-140V out range, 1-7mA current 1-15mim time set. Invite experiment, WIT-I kept designed performance which is a constant current in variable load resistance such as skin and electrode contact. It is estimated to have a practical use for physical therapy by iontophcresis.

Cadiac output estimation scheme of LVAD using multi-dimensional interpolation technique was introduced in this paper. This paper also show appropriate input -output data for estimation. Experimental results show our approach is a good one for the estimation of nonlinear hemodynamics.

In recent years, the optical properties of multiple-scattering media like tissue have been studied for their potential applications in medicine. In this work the optical properties of multiple scattering media were investigated using the time-resolved reflectance measurement. The reflected light was measured by time-correlated single photon counting system. The transport scattering and absorption coefficient are related to the initial rapid decay and the subsequent decay in reflected light, respectively. Also the optical properties of the samples were measured by conventional method, ie., using continuous wave light. When the distance between the light source and the detector is over 8mm, the optical coefficient can be measured accurately using the suggested method.

In this paper, we proposed a method of a hearing aid suitable for the sensorineural hearing impaired. Generally as the sensorineural hearing impaired have narrow audible ranges between threshold and discomfortable level, the speech spectrum may easily go beyond their audible range. Therefore speech spectrum must be optimally amplified and compressed into the impaired's audible range. The level and frequency of input speech signal are varied continuously. So we have to make compensation input signal for frequency-gain loss of the impaired, specially in the frequency band which includes much information. The input sigaal is divided into short time block and spectrum within the block is calculated. The frequency-gain characteristic is determined using the calculated spectrum. The number of frequency band and the target gain which will be added input signal are estimated. The input signal within the block is processed by a single digital filter with the calculated frequency-gain characteristics. From the results of monosyllabic speech tests to evaluate the performance of the proposed algorithm, the scores of test were improved.

Electro-magnetic type implantable middle ear hearing aid has been empirically developed. But for further improvement of the system performance more quantitative approach is necessary. In this paper, we analyzed vibrating transducer which is most important to design the system, appropriate for given hearing level, and implemented it. Using this transducer, implantable hearing aid system are developed. To verify the design process, we experimented with driving metal strip by the developed system. From the experiment, frequency response of implemented device showed good characteristic at audio frequency and we confirmed that each part of the developed system operated well.

In this paper, we presented WT(wavelet transform) domain feedback canceller in hearing aids system. Most transform methods produce blocking effect and this effect degrades the performance of feedback canceller and overall hearing aids system. As a solution we proposed WT based feedback canceller. The performance of this new approach was compared with LOT (lapped orthogonal transform) based method in the frequency domain. As a result, WT based feedback canceller has not shown the blocking effect and improved convergence rate as compared with the LOT based feedback canceller.

We examined the effect of strip visual stimulation pattern on postural balance control. It was performed by using motor driven clothe panel as visual stimulation. We also investigated the usefulness of HMD in the postural balance rehabilitation training system from the view of reducing the scale of experimental system. Our result showed that strip visual pattern was effective on postural balance control. It also indicated that HMD might be applied to clinical use as a new postural balance training system.

In this paper, we proposed a new system for postural balance rehabilitation training. We used the cycle simulator using virtual reality technology as the sensory integration device. Our results showed that this system was effective postural balance rehabilitation training device and might be useful as the clinical equipment.

The purpose of this study was to implemented a general purpose programmable nerve stimulator system as a research tool for studying psychophysiological performance associated with various stimulation waveform. This system is composed of hardware and software, the former are the personal computer(180586) and control unit(one-chip microprocessor, D/A converter, digital output), the latter are programmed in VISUAL BASIC and ASSEMBLY Which are programmed for the programmable nerve stimuli pattern editor and communication interface, waveform preprocessing, and stimuli generator. The control unit which is entrolled by the personal computer is capable of delivering the programmable nerve stimuli waveform. This system has research potential for determining the effect of various neuromuscular blockade in alternated physiological stat is.

External linkage type spine motion analyzer was developed for measuring relative trunk motion respect to the pelvis. A special program for calculation of the relative angular motion and graphical display were also developed. The developed device assured its accuracy and conveniency after application to 15 normal volunteers and 18 patients after fixation and decompression surgery. Compare to the normal subjects, patients shows different angular motion especially in the angular acceleration.

Shell rendering technique, which is the combined technique of surface rendering and volume rendering, was realized on workstation. By applying it to colon data acquired by CT, its validity was shown. In addition perspective projection coordinate was used for rendering the internal surface of organ and its reality was shown to be improved. This result can be use as the essential technique of virtual endoscope which is the recent hot topic in three dimensional medical imaging.

Accuracy and reproducibility of coordinates, angles/areas and volume measurements are the mai goal of imaging-guided stereotactic systems. Errors in measurements are due to pitfalls in a present systems. Factors responsible for inaccuracy and variability on measurements are inappropriate display window settings, unequal spatial resolution, display/film distortion, inappropriate slice width, lack of isocentricity between gantry and frame, and nonparallelism between frame and scanning plan. The most important factor responsible for errors when using stereotactic frames is the nonparallel relationship to the plane of scanning. For the solution of above problem, author developed a computer program for the measurement of the coordinates of intracerebral target, which is operated using the personal computer. This program can calculate the actual spatial coordinates regardless of the inappropriate parallelism between frame and scanning plane and decrease the range of errors of measurements.

Sequential brain SPECT imaging has been used to assess the cerebral perfusion reserve(CPR) in cerebrovascular diseases(CVD). We have realized a parametric images of CPR using normalized difference ratio and deadtime correction. For the anatomical localization of CPR, the parametric images were registered to the contours of the cerebral regions using optimal threshold method. The parametric imags reflected the CPR more reliably and distinctively. We conclude that the qunatitative estimation of CPR using normalized difference ratio image could be useful for the diagnosis and assessment of postoperative prognosis in CVD.

This paper described the estimator and eliminator far three kinds of artifacts in electrocardiogram. The most efficient estimation of baseline drift could be obtain in the cubic spline interpolation method with the PQ and TP segment which are considered to be isoelectric, from the experimental results obtained from the applied 4 types of algorithms. The time loss and distortion could be avoided with the aid of detection criteria by checking if baseline drifts exist or not. The AIEF proposed in this paper was verified as having the best removal performance with less distortion in the QRS complex through the comparison of 5 proposed algorithms. furthermore, the AIEF are most suitable far the ECG analyzer which was only needed relatively short time data due to the fast conversion into the stable state. The proposed parabolic filter with 11 points width was identified as having the best performance for the elimination of muscle artifacts. Also we could obtain 99.7% detection accuracy of spike component and minimize the error identifying QRS complex as spike.

This paper describes far the detection of heart event that is, QRS complex and P wave which are result from heart activity. The proposed QRS detection method by using the spatial velocity was identified as having the 99.6% detection accuracy as well as fast processing time. Atrial flutter, coupled P wave, and noncoupled P wave as well as atrial fibrillation could be detected correctly by three different algorithms according to their origination farm. About 99.6% correction accuracy coupled P wave could be obtained and we could be found that most detection errors are caused by establishing wrong search interval.

For the representative beat calculation and efficient rhythm analysis new method, that is, QRS typification were proposed. A problem that were resulted from pattern classification based on binary logic could be solved out by the fuzzy clustering and classification nodes could be reduced by using the proposed new feature vector. The accurate representative beat could be obtained by excluding the ST-T segment that happened outlier through ST-T segment typification procedure.

The representative beat with high SNR could be obtained by the signal averaging, correct and fast detection of significant points and waveform boundary could be obtained by adoption of search interval. All experimental results of waveform boundary were compared with CSE database which had the 5 referees results and 11 ECG measurement programs. All results were within tolerance made by referees, especially the end point of T wave were more close to the referee's results than other 11 measurement programs. The diagnosis parameters that might be used in the Minnsota code criteria were extracted from the representative beat. The diagnostic classification were fulfilled using Minnsota code criteria. Through the comparison on the diagnosis results from designed automated ECG analyzer(YECGA) and the results ECG analyzer manufactured by Fukuda denshi(FCG-2201) in Japan, reliance of the performance on designed system(YECGA) could be validated.

The objective of this paper is to develop computer assisted learning system for the education of cardiac disease using multimedia. Total 20 cases of disease was selected and their asculation, X-Ray, ECG, Sanography, Angiogram and RI-Study results can be shown on the computer screen. The references about cardiology, surgical process can be also shown on the screen and the computer can test and score their records for the evaluation. This system will be widely applied for the education of medicine combined wi th the communication network.

The display of biological signals in monitors often involves a multirate sampling operation which consists of decimation and intenolation. All electroencephalographic (EEG) samples of 10 to 30 seconds must be displayed in the computer screen to keep the aspect ratio of the paper polygraph output. Since the current affordable display technology plots at most 2,000 pixels per row, some samples need to be discarded. This paper studies methods to perform this operation characterizing them from the signal processing viewpoint and compares the display quality among several decimations. Experimental results show that a nonlinear operation such as the peak detection could be preferable than the canonical linear filtering to reduce aliasing.

We have developed a prototype patient monitoring system including module-based bedside units, interbed network, and central stations. A bedside unit consists of a color monitor and a main CPU unit with peripherals including a module controller. It can also include up to 3 module cases and 21 different modules. In addition to the 3-channel recorder module, six different physiological parameters of ECG, respiration, invasive blood pressure, noninvasive blood pressure, body temperature, and arterial pulse oximetry with plethysmogaph are provided as parameter modules. Modules and a module controller communicate with up to 1Mbps data rate through an intrabed network based on RS-485 and HDLC protocol. Bedside units can display up to 12 channels of waveforms with any related numeric informations simultaneously. At the same time, it communicates with other bedside units and central stations through interbed network based on 10Mbps Ethernet and TCP/IP protocol. Software far bedside units and central stations fully utilizes gaphical user interface techniques and all functions are controlled by a rotate/push button on bedside unit and a mouse on central station. The entire system satisfies the requirements of AAMI and ANSI standards in terms of electrical safety and performances. In order to accommodate more advanced data management capabilities such as 24-hour full disclosure, we are developing a relational database server dedicated to the patient monitoring system. We are also developing a clinical workstation with which physicians can review and examine the data from patients through various kinds of computer networks far diagnosis and report generation. Portable bedside units with LCD display and wired or wireless data communication capability will be developed in the near future. New parameter modules including cardiac output, capnograph, and other gas analysis functions will be added.

Digital fetal monitoring system based on the personal computer combined with the digital signal processing board was implemented. The DSP board acquires and digitally processes ultrasound fetal Doppler signal for digital rectification, FIR filtering, autocorrelation function calculation, its peak detection and MEDIAN filtering. The personal computer interfaced with the DSP board is in charge of graphic display, hardcopy, data transmission and on-line analysis of fetal heart rate change including and variability. I used a recursive technique for autocorrelation function computation method and MEDIAN filter which can greatly reduce the amount of calculation and accuracy. I also implemented analysis algorithm of fetal heart rate change based on normal fetal sample data in order to exact diagnosis.

We investigated the possibility of preventing a passenger's whiplash injury by rear-end collision. We sought to prevent the whiplash injury by appling an active headrest system to a passenger A main factor in whiplash injury is the backward, rapid, passive, and negative acceleration of the head. Our results showed that the active headrest system does reduce the backward, rapid, passive, and negative acceleration of the head. As a conclusion, Our active headrest system is a useful equipment to prevent whiplash injury.

The present study was performed to investigate gait characteristics of 30-39 year-old normal adults and 9-10 year-old children. The results focused on joint motions in the sagittal plane and ground reaction forces. The results will play an important role as a valuable data to determine normal and abnormal gait patterns as well as gait characteristics of Korean people.

We attempted to reconstruct basement membrane (BM) in between the epidermal compartment and dermal compartment in the artificial skin preparation and examine its effect on the skin architecture as well as on the epidermal differentiation. Laminin, one of the component of BM, stimulate the migration of the basal cells but type IV collagen which is a major component of the mechanical network of BM did not stimulate epidermal migration. However laminin in the presence of type IV collagen at a 1:1 molar ratio did not stimulate epidermal migration but provide nice demarcation between epidermis and dermis. This mixture of laminin and type IV collagen enhanced epidermal differentiation in the artificial skin based on the morphological observation as well as biochemical criteria. The epidermal acquirement of migratory ability on the laminin-rich substrate suggest that this type of unbalance in the expression of the components of BM may prevail in the area of healing tissue and the invasive transition of the tumor. The result in this study provide the technical improvement in the artificial skin preparation and further application of this technique for the reconstruction of other bio-artificial organ.

Vertical ground reaction forces on a treadmill were measured at different walking speeds using two tandem force plates. Comparing vertical ground reaction forces in treadmill walking with those in ground free walking, treadmill walking overestimated the first and second peak forces. With the increase of the walking speed, this phenomenon becomes more significant. In treadmill running, the first peak force reached 210-280% of the body weight. However, the instrumented treadmill showed a great potential to investigate the kinetics for multiple foot-strike measurements.