A butterfly valve is a valve that adjusts flow rate by rotating a disc for about 90° with respect to the axis that is perpendicular to the flow path from the center of its body. This valve can be manufactured for low-temperature, high-temperature and high-pressure conditions because there are few restrictions on the used materials. However, the development of valves that can be used in a 600℃ environment is subject to many constraints. In this study, the butterfly valve's stability was evaluated by a fluid-structured interaction analysis, thermal-structure interaction analysis, and seismic analysis for the development of valves that can be used in high-temperature environments. When the reverse-pressure was applied to the valve in the structural analysis, the stress was low in the body and seat compared to the normal pressure. Compared with the allowable strength of the material for the parts of the valve system, the minimum safety factor was approximately 1.4, so the valve was stable. As a result of applying the design pressures of 0.5 MPa and 600℃ under the load conditions in the thermal-structural analysis, the safety factor in the valve body was about 3.4 when the normal pressure was applied and about 2.7 when the reverse pressure was applied. The stability of the fluid-structure interaction analysis was determined to be stable compared to the 600℃ yield strength of the material, and about 2.2 for the 40° open-angle disc for the valve body. In seismic analysis, the maximum value of the valve's stress value was about 9% to 11% when the seismic load was applied compared to the general structural analysis. Based on the results of this study, the structural stability and design feasibility of high-temperature valves that can be used in cogeneration plants and other power plants are presented.