The objective of this research works is to investigate into characteristics of bending stiffness and failure for the ISB ultra-lightweight panel with internally structured material. The expanded metal with a crimped pyramid shape and woven metal are employed as an internally structured material. Through three-points bending test, the force-displacement curve and failure shape are obtained to examine the deformation pattern, characteristic data, such as maximum load, displacement at maximum load, etc, and failure pattern of the ISB panel. In addition, the influence of design parameters fur ISB panel on the specific stiffness, the specific stiffness per unit width, failure mode and failure map has been found. Finally, it has been shown that ISB containing expand metal with the crimped pyramidal shape is prefer to that containing woven metal from the view point of optimal design for ISB panel.