Objectives : Lateral epicondylitis on elbow is one of the most common causes of elbow pain. Lateral epicondylitis can be managed with acupuncture, but the evidence for its effectiveness is uncertain. The purpose of this review is to investigate the trends of acupuncture treatments on lateral epicondylitis. Methods : We investigated the studies about acupuncture treatments for lateral epicondylitis via searching 5 Korean web databases(KTKP, RISS, OASIS, KCI, Kisti) The key search terms were 'Lateral epicondylitis', 'Tennis elbow', 'External epicondylitis'. 12 research papers(10 case reports, 1 RCT, 1NRCT) were found to be analyzed according to their published year, the titles of journals, published institution, the types of study, the number of cases, the types of treatments, the instruments for assessment and ethical approvals. The effectiveness of acupuncture treatment was classified. Results : 12 papers were published since 2003. The studies on acupuncture treatments about lateral epicondylitis were mainly published in The journal of pharmacopuncture. 10 case reports, 1 non-randomized controlled trials, 1 randomized controlled trials had been under research. In most of the research, the number of the cases were not enough. In 9 cases of the studies, various korean medicine treatments including acupuncture were used to treat the symptoms. In 3 cases of the studies single method was used to treat the symptoms. Visual analogue scale(VAS) and range of motion(ROM), grip strength were used as primary assessments. Among 12 clinical studies, 1 of them were accepted by institutional review board(IRB). Conclusions : In this study, we analyzed the trends of acupuncture treatments on lateral epicondylitis. Reviewing the domestic trends of studies on acupuncture treatments for lateral epicondylitis and examining the strong and weak points of those treatments are essential for the future studies.

Objectives : The aim of this study was to report the cases of knee injury that are treated with both CPM and Korean medicine. Methods : We treated 3 patients who had knee joint pain and gait disturbance by knee injuries with Korean medicine and CPM treatment. We evaluated the outcomes by checking NRS, ROM, Lysholm knee score, walking state and other symptoms. Results : The NRS, ROM, Lysholm knee score, and other symptoms of 3 patients were improved before they. These results show possibilities of simultaneous treatment of Korean medicine and CPM. But there is a limit that the number of cases is not sufficient, and there was no long-term follow-up after discharge. Conclusions : Simultaneous treatment of Korean medicine and CPM has an effect on knee joint rehabilitation. Further studies are needed to prove the effectiveness of Korean medicine combined with CPM.

Objectives : The purpose of this report is to prove the effect of The Daoyin exercise program combined with Korean medicine treatment on supraspinatus tendon tear. Methods : Two patients, diagnosed with Supraspinatus tendon tear by shoulder MRI, were treated with The Daoyin exercise program and Korean medicine treatment. VAS(Visual analog scale), ROM(Range of motion) and Physical examination were used to evaluate patients. Results of application : The Daoyin exercise program combined with Korean medicine treatment reduced shoulder pain and improved shoulder ROM of the two patients significantly. Conclusions : The Daoyin exercise program combined with Korean medicine treatment is proved to be effective treatment for reducing pain and improving shoulder ROM of supraspinatus tendon tear patients.

Objectives : This study was designed to investigate the effect of Gamishinchubogun-tang (JiaweiShenzhuibujian-tang; GSB) on regeneration of PC12 cells. Methods : PC12 cells have been used extensively as a model for studying the cellular and molecular effects of neuronal cells. In order to check the effect of GSB on the regeneration of PC12 cells, the morphological change of PC12 cells were observed comparatively in GSB group and control group. Results : The significant changes in neurite length of PC12 cells have been observed on GSB group. In proportion to the concentration of GSB it was observed an increase in neurite outgrowth. Conclusions : This study confirmed that GSB made a significant influence on regeneration of PC12 cells.

Objectives : The purpose of this study is to report the clinical effects of Hominis Placenta Pharmacopunture(HPP) on Vertigo. Methods : A 82-year-old female patient whose chief complaint was Vertigo was treated with Placenta Pharmacopunture at CV6 and GB21, twelves times for a month. Acupuncture and herbal medicine were added depending on the symptoms. Laboratory test was taken and Korean Version of Dizziness Handicap Inventory was examined before and after each treatment. Results : After the treatments, the symptoms were improved. Conclusions : Hominis Placenta Pharmacopuncture may be an efficacious therapy for Iron Deficiency Anemia.

Objectives : The purpose of this study was to report a case of a patient efficacy of electromagnetic acupuncture using Whata 153 in facial nerve palsy in Herpes zoster oticus. Methods : We treated the patient with magnetic acupuncture combined with electro-acupuncture. Acupuncture points were at the face (BL2, GB14, TE23, ST4, ST6, ST3). All the acupuncture points were stimulated with magnetic field and 4 of them were combined with electro-acupuncture. Results & Conclusions : The improvement of facial movement and symptom was evaluated by Yanagihara grading system(Y-system), House-Brackmann scale(HB scale) and Sunnybrook facial grading system(SFGS). After treatment, all of the scales(Y-system, HB scale and SFGS) and symptom of the patient were improved. From the above results, we suggest that magnetic acupuncture and electro-acupuncture might be effective on facial nerve palsy in Herpes zoster oticus.

이 임상례는 근육 경직으로 인한 견비통에 태충혈이 유효함을 제시하고 있다. 환자의 주관적인 만족도를 평가하기 위해 점수식 평점 척도(Numerical rating scale;NRs)를 측정하였고 어깨 경직의 객관적인 호전 정도를 평가하기 위하여 양측 견정혈의 통증 통각 역치(Pressure pain threshold;PPT)와 어깨 외전력, 어깨관절의 외전시 가동범위(Range of motion;ROM)을 측정하였다. 양측 태충혈에 15분간 유침 후 NRS는 5에서 2로 감소하였다. 치료 전 왼쪽 견정혈의 PPT는 19N이었고 오른쪽은 22N이었다. 치료 후 왼쪽 견정혈의 PPT는 22N이었고 오른쪽은 27N이었다. 치료 전 견관절의 외전력은 왼쪽에서 29N, 오른쪽에서 22N으로 측정되었다. 치료후 견관절의 외전력은 왼쪽에서 33N, 오른쪽에서 22N으로 측정되었다. 견관절 ROM은 치료 전과 후 동일하게 왼쪽 관절 170도, 오른쪽 관절 165도로 나타났다. 결론적으로, 태충혈 자극은 어깨의 경직을 해소하고 어깨 근력을 강화하는 것으로 나타났다. 또한 그것은 상부 승모근의 압통을 감소시킬 수 있다. 이러한 측면에서, 태충혈의 효과에 대해서 보다 추가적인 연구가 필요할 것으로 보인다.

Objective : Hongyi (Formica yessensis) is the dried insect of fomicidae. In previous studies, it appeared possibilities on anti-thrombosis, preventing atherosclerosis, treating rheumatoid disease, and inhibiting hela cell. In this study, we investigated anti-inflammatory effects and mechanism of Hongyi. Methods : Hongyi A was extracted by water and made dried powder. Hongyi B was extracted by ethanol and made dried powder. We measured Nitric Oxide (NO) production on the mouse macrophages (RAW 264.7), mouse vascular endothelial cell (MOVAS) and human vascular endothelial cell (HUVEC) for anti-inflammatory effect. In addition, we conducted reverse transcription reaction (RT-PCR) for investigating the mechanism. Results : In RAW 264.7 macrophages stimulated by LPS, Hongyi A ($100{\mu}g/m{\ell}$) decreased NO production compared with LPS $2{\mu}g/ml$ control group with statistical significance (p<0.05). Hongyi A (50, $100{\mu}g/m{\ell}$) also decreased NO production compared with LPS $4{\mu}g/ml$ control group with statistical significance (p<0.01). Hongyi B (50, $100{\mu}g/m{\ell}$) decreased NO production compared with LPS $2{\mu}g/ml$ control group with statistical significance (p<0.01). Hongyi B (10, 50, $100{\mu}g/m{\ell}$) also decreased NO production compared with LPS $4{\mu}g/ml$ control group with statistical significance (p<0.01, p<0.001, p<0.001). In the MOVAS, Hongyi A and B increased NO production compared with control group. In the HUVEC, Hongyi B increased NO production compared with control group. The expression of NF-${\kappa}B$ in 12-hours MOVAS culture was decreased by Hongyi A and B (10, $50{\mu}g/ml$) compared with control group, but expression of $I{\kappa}B$ was increased. In the 24-hours MOVAS culture, expression of $I{\kappa}B$ was significantly increased. The expression of NF-${\kappa}B$ in 12-hours HUVEC culture was decreased by Hongyi A and B compared with control group, but expression of $I{\kappa}B$ was increased. Hongyi B also increased eNOS mRNA gene expression. Conclusions : Hongyi A and B showed anti-inflammatory effect in mouse macrophages with the activation of vascular endothelial cell through NO production in MOVAS and HUVEC repectively. Honyi B showed superior effect than Hongyi A, but additonal mechanism study should be conducted.

Objectives : The purpose of this study was to present the clinical guidelines for Korean medical treatment of Irritable Bowel Syndrome. Methods : Reports for Korean medical treatment of Irritable Bowel Syndrome were collected, analyzed and summarized from the Electronic journal search since 2000. Results : In Korean medicine treatment of irritable bowel syndrome used herbs, acupuncture, moxibustion, herbal acupuncture, and auricular acupuncture. Herb medicines were administered according to the patient's case by a prescription of considering physical condition and symptoms. Acupuncture and moxibustion therapies stimulate the median points of LR(足厥陰肝經), ST(足陽明胃經), LI(手陽明大腸經), SI(手太陽小腸經). The assessment items for Korean medical treatment of Irritable Bowel Syndrome were abdominal symptoms, defecation, autonomic nervous system changes, stress, Live blood condition and mental health. Conclusions : Through continued research need to develop better treatment strategies for Korean treatment of Irritable Bowel Syndrome.

While axons in the peripheral nerve can regenerate and lead to functional recovery to a certain extent after injury, its efficacy varies depending on the severity and duration of the injury. Here, we investigated the effects of Boyanghwano-tang (BYHOT) treatment on the regenerative responses in the sciatic nerves after prolonged transection and coaptation surgery. In mice given crush injury, axonal regeneration was completed when analyzed 1 week later and did not show any difference in regenerative reponses in the distal portion of the nerve between saline- and BYHOT-treated groups. In animal models with transection and reconnection, axonal regeneration was markedly retarded compared to animals with crush injury. Regenerating axons were extended into the reconnected distal portion of the nerve more actively in animals treated with BYHOT than saline controls. Cdc2 protein was similarly induced in nerves with crush injury and with transection and recollection, and its level was lower in BYHOT-treated animal than saline control when measured 2 weeks after nerve reconnection. These results suggest that BYHOT may be useful to promote axonal regeneration in the peripheral nerve after severe injury.

"Regulatory Function of Lung(肺主治節)" is one of the major function of lung, but its meaning is still controversial. The word "治節(Regulatory Function)" was first discovered in "黃帝內經(Huangdineijing)". In Chinese medicine text of modern China, physiological meaning of "治節" can be roughly divided into two; one is respiratory function, and another is to help cardiovascular function of the heart. In addition to this, "治節" has been construed in various ways, but all of them is not realistic. There has been several viewpoints that '節' in '治節' means 24 seasonal divisions and they can be representatively found in "東醫寶鑑(Donguibogam)". Based on all of these views, modern western medical physiology is requirement for further study about physiology of internal organs.

Objectives : The aim of this study is to investigate the effect of natural carbonated hot spring water (NCHW) on DNCB-induced NC/Nga mice, an atopic dermatitis (AD) model. Methods :At first, NC/Nga mice were prepared and induced to have atopic lesion on their back skin by dinitrochlorobenzene (DNCB). They swam for 20 minutes everyday in tanks where the one is filled with $28^{\circ}C$ NCHW, the other is with $25^{\circ}C$ carbonated hot spring water and another is with artificial carbonated hot spring water (ACHW). After 3 weeks, We assessed the skin clinical score and macroscopic appearance, total IgE, IgG1 levels, WBC differential counting, IFN-${\gamma}$, IL-4, IL-13, TNF-${\alpha}$ production levels and histological changes. Results : There are meaningful results of improving atopic lesion-state by relieving the count of total IgE, IgG1 levels, WBC differential counting, IFN-${\gamma}$, IL-4, IL-13, TNF-${\alpha}$ production levels and recovering skin clinical score in the group with $28^{\circ}C$ NCHW in comparison with the other groups. Conclusions : The NCHW may have potential as an effective treatment for atopic dermatitis.

Objectives : This study was aimed to investigate the effect of ACLL extract (Artemisia capillaris Thunb, Curcuma longa L, Lycium chinense, Ligustrum lucidum Aiton complex extract) in a dyslipidemia animal model induced by a high-fat diet. Methods : ACLL extracts was administered at 200 mg/kg, and 400 mg/kg to Apoe mice, where arthritis was induced by high cholesterol diet. After mice were treated with GO for 4 weeks, we measured AST, ALT, BUN and lipid levels (total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride), atherogenic index(AI) and cardiac risk factor(CRF). Results : Serum AST, ALT, creatinine, BUN levels were not changed by ACLL extract do not show any toxic effects. Also, ACLL extract groups were found to have atherogenic Index and cardiac risk factor as well as lipid metabolism improvement (total cholesterol, LDL cholesterol and triglyceride decrease). Conclusions : We suggest that ACLL extract may have the control effects of Dyslipidemia by improving lipid metabolism.

Objectives : The purpose of this study is to evaluate the wound healing potential of Glycyrrhiza uralensis extract. Methods : Free radical scavenging activity tests for DPPH, peroxynitrite (ONOO) and hydroxyl radical (${\cdot}OH$) and total phenolic contents of Glycyrrhiza uralensis extract were conducted. Tube formation assay was performed using human umbilical vein endothelial cells (HUVECs). Results : The results showed that Glycyrrhiza uralensis extract exerted inhibitory effects on ONOO and ${\cdot}OH$. Tube formation in HUVEC was increase in a dose dependent manner. Conclusions : These results show the potential to promote the wound healing process by Glycyrrhiza uralensis extract.

Objectives : Since the Korean pronunciation of the Mantidis Oothea is not unified, it is necessary to unify pronunciation of this particular herb. According to ancient herbal literature, genuine Mantidis Oothea has been regarded as the product which is attached to mulberry tree. However, all forms of Mantidis Oothea need to be used as a medicinal ingredient. Methods : The current study explores pronunciations of the herbal medicinal names, Collection, and the herbal processes of the Mantidis Oothea. There are approximately about 30 herbal manuals dealing with the Mantidis Oothea after Shen Nong's herbal manual(神農本草經) was published. Results & Conclusions : 1. Sangbicho, Sangpyeojo, Sangpyeocho, and other names have been used as a name of medicinal ingredient for the Mantidis Oothea. 2. The Other names of medicinal ingredient for the Mantidis Oothea were Sik woo, Danglangja(螳螂子), Danglanglan(螳螂卵), Danglangso(螳螂巢), Danglangwa(螳螂窩), Danglanggag(螳螂殼), etc.. 3. The name of medicinal ingredient for the Mantidis Oothea should not be pronounced as Sangpyoso but Sangpyocho. 4. The name of medicinal ingredient for the Mantidis Oothea was originated from a type of the egg case, eating habit, therapy of the Mantidis Oothea and so on. 5. Collecting real thing of The Mantidis Oothea does not really matter whether it is attached to the mulberry tree or not. 6. The herbal processes of the Mantidis Oothea is to kill the eggs, so typical methods were to steam, roast, boil with vinegar and so on. In addition, the main effect seemed to be protection from the diarrhea.

Objectives : The objective of this study is to report a treated case with elderly gravida who suffered from two-times of traffic accidents during pregnancy. Methods : The patient, 39-year-old, was hospitalized to care pain and symptoms caused by traffic accidents during pregnancy. The patient was treated with herbal medicine, acupuncture, moxibustion, cupping therapy and physical treatment during the admission period. We investigated the clinical management of Korean obstetrics and gynecology in an elderly gravida during pregnancy. Results & Conclusions : Despite of hard conditions such as elderly gravida and two-times of traffic accidents, pregnancy was well maintained through medical treatment. It is suggested that medical treatment of Korean medicine is effective to manage pregnancy of symptoms after accident.