Purpose: The purpose was to investigate the relations among job stress, depression, social support, and coping strategies of nurses. Method: The data were collected from 362 nurses. A self-administered questionnaire was used to assess general characteristics, job stress, depression, social support and coping strategies. Results: The prevalence of depression was 41.7%. Scores of job demand and insecurity, and organizational climate were very high. Logistic regressions showed that nurses, who were single, their 20s, had less than a career year, or working in private hospitals, associated with an increased risk of depression. The sub-scales of job stress except interpersonal conflict and lack of autonomy contributed to an increased risk of depression (lower group; OR=0.248, 95% CI:0.14-0.43). Also individual and organizational support and control coping strategies were associated with depression(lower group: OR=2.993, 95% CI: 2.11-6.30; OR=2.993, 95% CI: 1.51-5.65; OR=2.372, 95% CI=1.43-3.93). Conclusion: These findings indicated that the job stress, especially organizational climate, insecurity of job, lack of reward, individual and organizational support, and control coping strategies contributed to a risk of depression. In order to prevent the depression, the organizational support and strategies will be needed. The depression in specific context and organizational climate should be considered in future studies.