Purpose: This study was conducted at small-to-medium-sized manufacture enterprises less than 300 employees. Method: For 167 workers in 12 small-to-medium-sized manufacture, we examined the self-recording questionnaires about general characteristics, health characteristics, occupational characteristics and subjective musculoskeletal symptoms designed by NIOSH. Result: Related factors of upper limb musculoskeletal symptoms were found in using of the PC except work, the speed control at working and inappropriate positions for neck, and that using of the PC except work, the degree of intensity at working and the speed control at working for shoulder, and that the degree of intensity at working, the speed control at working, inappropriate positions and excessive workforce for arm/elbow, and that the degree of intensity at working, the speed control at working, inappropriate positions, excessive strong and vibration for hand/wrist/fingers. Conclusion: As a result of multiple logistic regression analysis, musculoskeletal symptoms of neck were influenced by use of the PC except work, household work, and the speed control at working, symptoms of shoulder by using of the PC of except work and the degree of intensity at working, symptoms of arm/elbow by the speed control at working, and symptoms of hand/wrist/fingers by the degree of intensity at work and excessive workforce.