Purpose: The purpose of this study was to identify factors influencing the quality of working life of cancer survivors (QWL-CS) after return to the workplace. Methods: Data were collected from 154 cancer survivors from May 16 to June 23, 2018. Participants were selected as candidates from two different hospitals in the metropolitan area and snowball sampling was used in parallel. The data were analyzed by SPSS 21.0 using descriptive statistics, t-test, ANOVA, Pearson's correlation coefficient, and stepwise multiple linear regression. Results: Mean score of QWL-CS was $4.39{\pm}0.59$. QWL-CS was negatively correlated with fatigue, and job stress: however, it was positively correlated with workplace spirituality. The factor that had the greatest influence on the QWL-CS was job stress (${\beta}=-.36$, p<.001), followed by fatigue (${\beta}=-.35$, p<.001), workplace spirituality (${\beta}=.35$, p<.001), number of currently cancer treatment (${\beta}=-.15$, p=.009), and number of children (${\beta}=.12$, p=.031). The explanatory power of models was 54%. Conclusion: Effective and practical intervention programs for increasing the quality of working life are required to be provided to cancer survivors after return to the workplace in accordance with job stress, fatigue, workplace spirituality, and general characteristics of cancer survivors such as number of currently cancer treatments and number of children.