Purpose: We examined the effects of cognitive flexibility, resilience, and professional quality of life on the job embeddedness of nurses. Methods: The participants were 120 nurses in three general hospitals. Data collection was conducted using self-report questionnaires from May 17 to June 2, 2022. Data were analyzed using descriptive statistics, independent t-test, one-way ANOVA, Pearson correlation coefficients, and multiple regression analysis. Results: There were significant differences in job embeddedness by experience of turnover (t=-3.15, p=.002). The factors influencing the job embeddedness of the nurses were compassion satisfaction (β=.44, p<.001), resilience (β=.24, p=.035), experience of turnover (β=.23, p=.002), and cognitive flexibility (β=.21, p=.027). It was found that 39% could explain job embeddedness. Conclusion: It is necessary for nurses' support programs to be related to the experience of turnover to enhance job embeddedness. The results indicate a need to develop a program for cultivating compassion satisfaction, resilience, and cognitive flexibility to improve job embeddedness.