Purpose: This study was conducted to examine psychological empowerment and awareness and performance of Healthcare-Associated Infections(HAIs) control among Intensive Care Unit (ICU) nurses. Method: The data for this study were collected using structured questionnaires from 178 nurses working in the ICUs of four hospitals with more than 500 beds. Results: The subjects'psychological empowerment, awareness and performance of HAIs control were mean over. The subjects'psychological empowerment showed statistically significant differences depending on age, marital status, academic background, clinical career, ICU career, and position and experience in infection control among their general characteristics. Awareness of HAIs control showed statistically significant differences depending on age, gender, marital status, clinical career, and ICU career. Performance showed statistically significant differences depending on age, gender, marital status, and, ICU career. Regarding the subjects' performance of HAIs control, there was a statistically significant positive correlation between psychological empowerment and awareness. Conclusion: It was found that it is necessary to strengthen differential customized training according to the subjects'characteristics for effective HAIs control, and to strengthen the nurses'awareness of HAIs control through systematic evaluation, monitoring, and feedback, as well as continuous education and training.