Purpose: This study was a descriptive research design to identify nursing professionalism, communication competence, and working environment factors of dedicated COVID-19 hospital nurses and investigate factors affecting person-centered care. Methods: Participants were 211 nurses working in one tertiary hospital, two general hospitals, and one dedicated COVID-19 hospital in a metropolitan area. Collected data were analyzed using descriptive analysis, an independent t-test, one-way ANOVA, Scheffé test, Pearson correlation coefficient, and multiple regression analysis. Analysis was performed using SPSS 26.0 software. Results: Person-centered care was statistically significant. It positively correlated with nursing professionalism (r=.57, p<.001), communication competence (r=.56, p<.001), and nursing work environment (r=.60, p<.001). As a result, communication competence (𝛽=0.33, p<.001), hospital type (𝛽=0.25, p<.001), nursing professionalism (𝛽=0.23, p=.002), nursing work environment (𝛽=0.18, p=.006) and clinical career (𝛽=-0.11, p=.045) in that order. The regression model was statistically significant (F=30.467, p<.001) and showed an explanatory power of 49.6%. Conclusion: It is necessary for individuals and hospitals to provide opportunities for nurses to participate in various education and programs to improve person-centered care. This may enable them to enhance their nursing professionalism and communication competence.