• 제목/요약/키워드: Blood flow area

검색결과 189건 처리시간 0.022초

p53 Protein Expression Area as a Molecular Penumbra of Focal Cerebral Infarction in Rats

  • Hong, Hyun-Jong;Park, Seung-Won;Kim, Young-Baeg;Min, Byung-Kook;Hwang, Sung-Nam;Suk, Jong-Sik
    • Journal of Korean Neurosurgical Society
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    • 제38권4호
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    • pp.293-298
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    • 2005
  • Objective : The authors investigate the spatial characteristics of apoptotic genes expressed around the focal cerebral infarction, and attempted to explain the penumbra with them. Methods : A delayed focal cerebral infarction was created in twelve adult Sprague-Dawley rats. We performed the immunohistochemical staining for the apoptosis, bcl-2 and p53 proteins and measured the local cerebral blood flow [CBF] at the infarction core area and peri-infarct area pre- and intra-operatively. The peri-infarct area was divided into six sectors by distance from the infarction border. Results : The size [$mm^2$] of apoptosis, bcl-2, and p53 areas were $3.1{\pm}1.2$, $4.7{\pm}2.1$, and $6.8{\pm}2.4$, respectively. Apoptosis, bcl-2 or p53 positive cells were concentrated at the peri-infarct area adjacent to the infarction core. Their numbers reduced peripherally, which was inversely proportional to the local CBF. The p53 area seems to overlap with and larger than the ischemic penumbra. Conclusion : The p53 positive area provides a substitutive method defining the penumbra under the molecular base of knowledge.

헬스케어증진을 위한 하지혈류제한운동이 20대 여대생의 순발력과 균형에 미치는 영향 (Effects of Blood Flow Restriction Exercise on the Alacrity and Balanced Capacity of Female University Students in Their 20s for Health-Care Increase)

  • 서태화;김은호;정연우
    • 한국엔터테인먼트산업학회논문지
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    • 제14권4호
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    • pp.333-340
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    • 2020
  • 본 연구는 하지혈류제한벨트를 한 그룹과 하지 않은 그룹의 균형과 순발력의 변화를 알아보기 위해 광주 지역에 소재한 K대학교 학생 40명을 선정하여 실험군 20명과 대조군 20명을 무작위 배치하여 2019년 9월 16일부터 10월 11일까지 4주간 스쿼트 운동을 실시하였다. 스쿼트 운동 시 혈류제한은 BFR band를 착용하였고 편안하게 선 상태에서 120 mmHg 압력을 넣어 하지혈류제한을 하였다. 실험 결과 앞·중간·뒷부위 발바닥 압력의 시간에 따른 변화에서 두 그룹 모두 통계학적으로 유의한 차이가 나타나지 않았고(p>.05), 실험군과 대조군 간 상호작용 차이도 없었다(p>.05). Height, Maximum Concentric Power, Take Off Speed에서 시간에 따른 유의한 차이를 확인할 수 있었다(p<.05). 이와 같은 결과로 보아 낮은 강도 운동을 통해서도 하지혈류제한을 통해 큰 효과를 얻을 수 있을 것으로 사료된다. 본 논문은 혈류제한운동이 순발력과 균형에 미치는 영향을 알아보고자 하였으며 향후 하지혈류제한 운동을 통해 낮은 강도의 운동으로도 큰 운동 효과를 얻을 수 있는 것의 기초자료로 활용될 수 있을 것이다.

경피신경전기자극기를 이용한 비지각적 감각자극 강도가 뇌혈류에 미치는 영향 (Effect of Non-perceptual Sensory Stimulation Intensity Using Transcutaneous Electrical Nerve Stimulation on Cerebral Blood Flow)

  • 정주연;강창기
    • 감성과학
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    • 제27권2호
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    • pp.81-90
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    • 2024
  • 본 연구에서는 경피신경전기자극(TENS)을 이용하여 다양한 자극 강도에 따른 뇌혈관에 미치는 영향을 확인하고자 한다. 특히 비지각적 감각의 전기자극을 통해 총경동맥(CCA)에서의 혈류 변화 및 혈관의 구조적인 변화를 확인해 보고자 한다. 본 연구에는 20대의 건강한 성인 24명이 참여하였다. 자극 강도는 감각 역치 미만, 감각 역치, 그리고 감각 역치 초과 세 가지를 각각 랜덤 순서로 적용하였다. 측정위치는 CCA 분기점의 1cm 하단에서 측정하였고, 혈류속도는 C-mode 도플러, 혈관의 구조는 B-mode 영상을 통해 측정하였다. 측정은 각각의 자극별로 중재 전, 중재 중, 그리고 중재 후에 수행하였고 각 세션마다 혈압의 변화를 측정하였다. 그 결과 최고 수축기 속도(PSV)는 역치미만의 비지각적 감각자극에서 중재 후 유의하게 감소함이 확인되었다(p = .008). 역치 미만의 자극 후 PSV는 자극 전보다 평균 3.04% 유의하게 감소한 것으로 나타났다(p = .011). 반면 CCA의 혈관 직경의 변화는 모든 강도에서 자극 전후 유의한 변화가 나타나지 않았다. 본 연구에서 적용한 단시간의 비지각적 전기자극이 혈관의 직경이나 혈압의 유의한 변화를 주지 않으면서 즉각적인 혈류속도 감소에 효과가 있음을 발견했다. 따라서 본 연구는 경동맥 부위에 환자의 불편함과 부작용이 없는 전기자극을 통해 뇌혈류의 조절이 가능하다는 것을 보여주는 중요한 시도로 평가될 수 있다.

영역기반 윤곽선 기법과 표면 분할 유동모델에 기반한 근위 등속 표면적 기법을 이용한 혈류량 추정 (Blood Flow Rate Estimation using Proximal Isovelocity Surface Area Technique Based on Region-Based Contour Scheme and Surface Subdivision Flow Model)

  • 진경찬;조진호
    • 전자공학회논문지SC
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    • 제38권1호
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    • pp.45-52
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    • 2001
  • PISA 방법은 주로 승모판에서 역류하는 혈류량을 측정하기 위해 사용되고 있다. 이 방법은 PISA isotach의 기하학적 모양에 대한 모델링에 관한 것이다. PISA의 일반적인 유동모델은 isotach의 표면이 수식적으로 반구이거나 비반구임을 가정하여 계산된 것이지만, 본 논문에서는 영역기반방법으로 isotach를 추정한 후, 타원체의 높이에 기초한 실제적인 표면분할 유동모델을 이용하여 유체량을 추정하였다. 제안한 밥법을 평가하기 위해, $30cm^3/sec-60\;cm^3/sec$의 실제 유량을 가지는 동적인 180개의 유동영상에 대해서 기존 방법들과 비교하였다. 실험한 결과, 반구 유동모델의 유체량 평균이 $29\;cm^3/sec$로 실제 유체량 평균보다 35%정도 적게 추정을 하였고, 제안한 방법의 평균은 $45\;cm^3/sec$으로 비반구 유동모델의 평균과 같았고, 유체량 변화파형도 유사한 결과를 가짐을 알 수 있었다.

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가잠 가수분해물에 의한 학습력 개선 및 두뇌의 혈류변화와 글루코스 사용정도의 긍정적 변화 (Association between Cerebral Blood Flow and Cognitive Improvement Effect by B. mori Extracted Component)

  • 이상형;김용식;김성수;강용구;이무열;이광길;여주홍;이원복;김대경
    • 한국잠사곤충학회지
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    • 제46권2호
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    • pp.77-79
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    • 2004
  • 최근 잠상산물 추출물인 BF-7이 기억력과 학습력 개선에 크게 유용하다는 연구결과들이 보고되고 있다. 이를 바탕으로 본 연구는 과연 이 BF-7이 일반적인 학생들의 학습력 및 인지력 개선을 유도하는지 여부를 재확인하고자 하였다. 본 연구결과 3주 동안의 BF-7 복용(매일 400mg)으로, 평균 IQ 10 이상의 증가를 보였다. 이의 의학적 검증을 위하여, SPECT를 이용하여 두뇌의 인지기능과 학습력 등을 담당하는 부위의 혈류량 개선을 살펴봄으로써 이런 개선효과를 확인하고자 하였다. 그 결과 parahippocampal gyrus 와 medial temporal area부위 즉 학습 관련한 두뇌부위의 혈류량과 글루코오스 사용량이 증가하는 것으로 나타났다. 따라서 BF-7의 복용은 효과적으로 두뇌의 활성을 유도하여, 인지기능과 기억력, 학습력 증진 효과를 갖는 것으로 나타났다.

Laminar Flow Inhibits ER Stress-Induced Endothelial Apoptosis through PI3K/Akt-Dependent Signaling Pathway

  • Kim, Suji;Woo, Chang-Hoon
    • Molecules and Cells
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    • 제41권11호
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    • pp.964-970
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    • 2018
  • Atherosclerosis preferentially involves in prone area of low and disturbed blood flow while steady and high levels of laminar blood flow are relatively protected from atherosclerosis. Disturbed flow induces endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). ER stress is caused under stress that disturbs the processing and folding of proteins resulting in the accumulation of misfolded proteins in the ER and activation of the UPR. Prolonged or severe UPR leads to activate apoptotic signaling. Recent studies have indicated that disturbed flow significantly up-regulated $p-ATF6{\alpha}$, $p-IRE1{\alpha}$, and its target spliced XBP-1. However, the role of laminar flow in ER stress-mediated endothelial apoptosis has not been reported yet. The present study thus investigated the role of laminar flow in ER stress-dependent endothelial cell death. The results demonstrated that laminar flow protects ER stress-induced cleavage forms of PARP-1 and caspase-3. Also, laminar flow inhibits ER stress-induced $p-eIF2{\alpha}$, ATF4, CHOP, spliced XBP-1, ATF6 and JNK pathway; these effects are abrogated by pharmacological inhibition of PI3K with wortmannin. Finally, nitric oxide affects thapsigargin-induced cell death in response to laminar flow but not UPR. Taken together, these findings indicate that laminar flow inhibits UPR and ER stress-induced endothelial cell death via PI3K/Akt pathway.

스키니 진 착용이 인체생리반응과 주관적 압박감에 미치는 영향 (The Effect of the Skinny Pants on the Physiological Responses and Subjective Pressure)

  • 권수애
    • 한국생활과학회지
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    • 제21권3호
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    • pp.567-576
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    • 2012
  • The purpose of this study was to analyze and determine the relationship between physiological responses including blood flow rate and garment pressure, and the feeling of restrictive tightness associated with the wearing skinny pants as a popular clothing style. Evaluation was based on material type, posture and activity type, and body part location. Five female college students took part in this research. Five kinds of experimental clothes with waist measurements of 66cm were chosen. An analysis of the selected skinny pants demonstrated the degree of the whole looseness was higher in this order: clothing type A>B>D>C, and E with E being knitted cloth. Garment pressure was the highest in the front knee portions and was lowest in the outside thigh region. Garment pressure was highest in this sequence : clothing type C>=D>A>=B>E. In terms of posture and activity types, garment pressure was the highest when research participants were crouching, and was the lowest when standing. The blood flow rate was highest in this order: clothing type E>D>B>A>C. Type C skinny pants impeded blood flow and demonstrated the tightest and most restrictive relationship. Blood flow rate varied depending on the type of movement and was highest in this order: getting up, rowing, kicking, jumping and O-shaped leg posture. The results of subjective pressure evaluation demonstrated that pressure was highest in this order: E>=C>B>A>D. These results suggests the need to improve on the patterns and the material design in the area of the front knees. The degree of the looseness when wearing skinny pants did not always correspond to garment pressure or subjective sensation.

약물에 노출되지 않은 공황장애 환자들에서 인지행동치료 후 뇌혈류 변화에 대한 예비연구 (Preliminary Study for Changes in Brain Perfusion in the Drug-Naive Patients with Panic Disorder with SPECT Following Cognitive-Behavioral Therapy)

  • 김정범;신영아;채정호;장은진;류설영;원경숙;전석길;정용안
    • 대한불안의학회지
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    • 제4권2호
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    • pp.148-156
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    • 2008
  • Objective : Although cognitive-behavior therapy (CBT) is effective in patients with panic disorder, its the-rapeutic mechanism of action in the brain remains unclear. This study was performed to investigate regional blood flow changes associated with successful completion of CBT in drug-naive patients with panic disorder. Method : The regional blood flow in 4 patients with panic disorder was compared to that in 11 healthy controls before and after a 12-week group CBT using $^{99m}Tc$-ECD SPECT imaging. Psychopathology was assessed using Panic Disorder Severity Scale. Data were analyzed using software for statistical parametric mapping (SPM2). Results : Before CBT, significantly decreased blood flow was found in the parietal and occipital area in panic patients than normal volunteers. In all the patients who showed remission after CBT, increased blood flow was detected in the right cingulate gyrus, left lingual gyrus, and left superior parietal lobule, whereas decreased blood flow was seen in the left inferior temporal gyrus. Conclusion : These results suggested that CBT is effective for panic disorder and change the activity of cingulate gyrus and left temporal gyrus, a part of the brain areas associated with fear in panic disorder.

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하지 혈류제한 운동이 근육크기와 근력에 미치는 영향 (The Effects of Leg Blood Flow Restriction Exercise on Muscle Size and Muscle Strength)

  • 권해연;안소윤
    • PNF and Movement
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    • 제10권1호
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    • pp.61-70
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    • 2012
  • Purpose : The purpose of this study was to investigate thigh muscle-bone CSA and leg strength during low-intensity exercise program with leg blood flow restriction by external compression to reduce muscle outflow. Methods : Eighteen health students gave informed written consent to participate in this investigation. An occlusion cuff was attached to the proximal end of the leg so that blood flow was reduced during the training. The training was conducted one times a day, three times a week, for 8 weeks using one sets of 30 minutes. The training program performed to squat with standing, lunge with standing and heel raise with one leg standing. Measurements of thigh muscle-bone CSA(cross-sectional area) and leg strength were evaluated pre and post-training. Statistical evaluation of these data was accomplished utilizing a paired t-test by SPSS 12.0 program for windows. Significance level was set at p <.05. Results : All data are reported as means and standard deviations(SD) for all variables. The result of the study is followed; After the training, muscle-bone CSA, gluteus maximus m, quadriceps m, hamstring m of both legs were significantly improved but not calf muscle(p<.05). There was no significant difference of change quantity between muscle-bone CSA and leg strength in Lt. and Rt. side. But the variation in leg muscle strength of Rt. leg(dominant) was much more increased than Lt. leg(non-dominant) after 8 weeks training. Conclusion : Low-intensity training with leg blood flow restriction offers a potentially useful method for improving leg muscle strength.

전교통동맥류 내부 유동 전산해석을 통한 낮은 벽면 전단 응력 영역 발달 분석 (Evolution of Low Wall-Shear Stress Area in Anterior Communicating Artery Aneurysm)

  • 국윤혁;권태호;문성득;김동민;황진율;배영오
    • 한국가시화정보학회지
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    • 제20권2호
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    • pp.45-54
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    • 2022
  • We analyzed the low wall-shear stress area in the intracranial aneurysm that occurred at an anterior communicating artery with a special emphasis on vortical structures close to the wall. We reconstructed the aneurysm model from patient CTA data. We assumed blood as an incompressible Newtonian fluid and treated the blood vessel as a solid wall. The pulsatile boundary condition was applied at the inlet of the anterior cerebral artery. From the instantaneous flow field, we computed the histogram of the wall-shear stress over the aneurysm wall and found the low wall-shear stress event (< 0.4 Pa). This extreme event was due to the low wall-shear stress area that occurred at the daughter sac. We found that the merging of two vortices induced the low wall-shear stress area; one arises from the morphological characteristics of the daughter sac, and the other is formed by a jet flow into the aneurysm sac. The latter approaches the daughter sac, which ultimately leads to the strong ejection event near the daughter sac.