Science of Emotion and Sensibility (감성과학)

Korean Society for Emotion and Sensibility (한국감성과학회)
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Effect of Non-perceptual Sensory Stimulation Intensity Using Transcutaneous Electrical Nerve Stimulation on Cerebral Blood Flow

경피신경전기자극기를 이용한 비지각적 감각자극 강도가 뇌혈류에 미치는 영향

  • Ju-Yeon Jung ;
  • Chang-Ki Kang
  • 정주연 (가천대학교 휴먼보건과학융합연구소) ;
  • 강창기 (가천대학교 의과학대학 방사선학과)
  • Received : 2024.04.19
  • Accepted : 2024.05.22
  • Published : 2024.06.30
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Abstract

In this study, we aimed to determine the effect on cerebral blood vessels of various stimulus intensities using transcutaneous electrical nerve stimulation (TENS). In particular, we wanted to monitor changes in blood flow and structural changes in the blood vessels in the common carotid artery (CCA) through low-intensity electrical stimulation that can cause non-perceptual sensory stimulation. Twenty-four healthy adults in their 20s participated in this study. Three stimulus intensities (below the sensory threshold, at the sensory threshold, and above the sensory threshold) were applied in random order. Changes in blood flow velocity according to the intensity of TENS stimulus were measured by placing the Doppler ultrasound transducer 1 cm below the CCA bifurcation, and the vascular structure was measured using B-mode imaging. C-mode Doppler and B-mode images were acquired before, during, and after the intervention for each stimulus, and changes in blood pressure were measured in each session. As a result, it was confirmed that peak systolic velocity (PSV) decreased significantly after the intervention in non-perceived sensory stimulation below the threshold, compared to other thresholds (p = .008). In particular, the PSV decreased by 3.04% on average compared to before stimulation (p = .011). However, there was no significant change in the CCA diameters before and after stimulation at all intensities. It was found that short-term, non-perceptual sensory stimulation was effective in reducing the blood flow rate without causing significant changes in either the blood vessel diameter or blood pressure. This change appears to be caused by a decrease in blood flow due to the effect of subtle vasodilation at non-perceptual sensory stimulation, and at stimulation intensity higher than that, the sympathetic nerves in the blood vessels are stimulated excessively and the blood vessels constrict. Therefore, this study can be rated as an important attempt to control blood flow through stimulation without such a psychological burden and sensory discomfort in the carotid area.

본 연구에서는 경피신경전기자극(TENS)을 이용하여 다양한 자극 강도에 따른 뇌혈관에 미치는 영향을 확인하고자 한다. 특히 비지각적 감각의 전기자극을 통해 총경동맥(CCA)에서의 혈류 변화 및 혈관의 구조적인 변화를 확인해 보고자 한다. 본 연구에는 20대의 건강한 성인 24명이 참여하였다. 자극 강도는 감각 역치 미만, 감각 역치, 그리고 감각 역치 초과 세 가지를 각각 랜덤 순서로 적용하였다. 측정위치는 CCA 분기점의 1cm 하단에서 측정하였고, 혈류속도는 C-mode 도플러, 혈관의 구조는 B-mode 영상을 통해 측정하였다. 측정은 각각의 자극별로 중재 전, 중재 중, 그리고 중재 후에 수행하였고 각 세션마다 혈압의 변화를 측정하였다. 그 결과 최고 수축기 속도(PSV)는 역치미만의 비지각적 감각자극에서 중재 후 유의하게 감소함이 확인되었다(p = .008). 역치 미만의 자극 후 PSV는 자극 전보다 평균 3.04% 유의하게 감소한 것으로 나타났다(p = .011). 반면 CCA의 혈관 직경의 변화는 모든 강도에서 자극 전후 유의한 변화가 나타나지 않았다. 본 연구에서 적용한 단시간의 비지각적 전기자극이 혈관의 직경이나 혈압의 유의한 변화를 주지 않으면서 즉각적인 혈류속도 감소에 효과가 있음을 발견했다. 따라서 본 연구는 경동맥 부위에 환자의 불편함과 부작용이 없는 전기자극을 통해 뇌혈류의 조절이 가능하다는 것을 보여주는 중요한 시도로 평가될 수 있다.

Keywords

Acknowledgement

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2020R1A2C1004355).

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