Journal of Sericultural and Entomological Science (한국잠사곤충학회지)

Korean Society of Sericultural Science (한국잠사학회)
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Association between Cerebral Blood Flow and Cognitive Improvement Effect by B. mori Extracted Component

가잠 가수분해물에 의한 학습력 개선 및 두뇌의 혈류변화와 글루코스 사용정도의 긍정적 변화

  • Lee, Sang-Hyung (Department of Neurosurgery, College of Medicine, Seoul National University) ;
  • Kim, Yong-Sik (Department of Pharmacology, College of Medicine, Seoul National University) ;
  • Kim, Sung-Su (Department of Anatomy, Chung-Ang University) ;
  • Kang, Yong-Koo (Department of Anatomy, College of Medicine, Chung-Ang University) ;
  • Lee, Moo-Yeol (Department of Physiology, College of Medicine, Chung-Ang University) ;
  • Lee, Kwang-Gill (Sericulture and Apiculture Division, National Institute of Agricultural Science and Technology) ;
  • Yeo, Joo-Hong (Sericulture and Apiculture Division, National Institute of Agricultural Science and Technology) ;
  • Lee, Won-Bok (Department of Anatomy, Chung-Ang University) ;
  • Kim, Dae-Kyong (Department of Phamacy, College of Phamacy, Chung-Ang University)
  • 이상형 (서울대학교 의과대학 신경외과학교실) ;
  • 김용식 (서울대학교 의과대학 약리학교실) ;
  • 김성수 (중앙대학교 의과대학 해부학교실) ;
  • 강용구 (중앙대학교 의과대학 해부학교실) ;
  • 이무열 (중앙대학교 의과대학 생리학교실) ;
  • 이광길 (농업과학기술원 농업생물부) ;
  • 여주홍 (농업과학기술원 농업생물부) ;
  • 이원복 (중앙대학교 의과대학 해부학교실) ;
  • 김대경 (중앙대학교 약학대학 약학과)
  • Published : 2004.12.01
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Abstract

To investigate whether BF-7, extracted from Bombyx mori, improved learning and memory of ordinary people, K-WAIS (Korean version of Wechsler adult intelligence scale) was performed in 4 normal students. Treatment with 400 mg of BF-7 increased mean IQ from 103 to 114. To know how BF-7 plays such a positive role, we measured the blood flow to brain, especially for the area concerned with learning and memory, with Single Photon Emission Computed Tomography(SPECT). Our result showed that the blood flow to parahippocampal gyrus and medial temporal area was increased. Also, our results showed the image representing the increase of blood supply in this area. So, our results suggest that BF-7 effectively help to use brain concerning with learning and memory.

최근 잠상산물 추출물인 BF-7이 기억력과 학습력 개선에 크게 유용하다는 연구결과들이 보고되고 있다. 이를 바탕으로 본 연구는 과연 이 BF-7이 일반적인 학생들의 학습력 및 인지력 개선을 유도하는지 여부를 재확인하고자 하였다. 본 연구결과 3주 동안의 BF-7 복용(매일 400mg)으로, 평균 IQ 10 이상의 증가를 보였다. 이의 의학적 검증을 위하여, SPECT를 이용하여 두뇌의 인지기능과 학습력 등을 담당하는 부위의 혈류량 개선을 살펴봄으로써 이런 개선효과를 확인하고자 하였다. 그 결과 parahippocampal gyrus 와 medial temporal area부위 즉 학습 관련한 두뇌부위의 혈류량과 글루코오스 사용량이 증가하는 것으로 나타났다. 따라서 BF-7의 복용은 효과적으로 두뇌의 활성을 유도하여, 인지기능과 기억력, 학습력 증진 효과를 갖는 것으로 나타났다.

Keywords

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