The operating tasks of overhead crane have caused undue stress to the operators from physical, mental, and environmental workload. Existing workload assessment models for musculoskeletal disorders such as OWAS, RULA, and QEC have limited applicability to the crane operating tasks because they focus mainly on physical factors and do not consider the relative importance of each factor. The present study was to develop a workload assessment model customized to overhead crane operation, following a systematic process: (1) analyzing task characteristics, (2) selecting workload factors, (3) developing assessment methods, (4) establishing action levels, and (5) computerizing the assessment model. Based on literature review, worksite survey, and focus group interview, 4 physical factors (awkward posture, static posture, repetitive motion, and excessive force), 6 mental factors (visual demand, auditory demand, task complexity and difficulty, time urgency, work schedule related stress, and safety related stress), and 4 environmental factors (noise, vibration, dust, and temperature) were selected and their rating scales and relative weights were determined. Then, based on the workload assessment results of 8 overhead cranes operated at different workplaces, the action levels of each factor category were established. Finally, the crane operation assessment model was computerized for effective analysis and report preparation. The present approach is applicable to develop a customized workload assessment model for an operating task under consideration.