Objectives: The purpose of this study was to investigate the characteristics and usage patterns of traditional Korean herbal medicine users, as well as the factors related to traditional Korean herbal medicine usage, using data from the 2020 Korean Medical Panel. Methods: Characteristics between traditional Korean herbal medicine users and non-users were compared using the chi-squared test. Additionally, binomial logistic regression analysis was employed to analyze the factors influencing traditional Korean herbal medicine usage. Andersen's healthcare utilization model was used to examine factors that potentially influenced the usage of traditional Korean herbal medicine. Results: Analysis using Andersen's healthcare utilization model revealed significant differences in factors influencing traditional Korean herbal medicine usage. Predisposing factors such as age and region; enabling factors such as annual household income; and need factors such as the presence of chronic diseases and the number of chronic disease episodes were all significant. Conclusions: Further research on the various factors influencing the use of traditional Korean herbal medicine could extend beyond short-term policy challenges to explore individual health issues and the direction of health care policy from a broader, macro perspective.

Objectives: Research on the general prescription patterns of insured herbal preparations in Korea has been limited. This study aimed to analyze prescription patterns of insured herbal preparations, utilizing the National Health Insurance Service (NHIS) sample cohort 2.0 data from 2010 to 2019. Methods: NHIS sample cohort 2.0 database, which represents a sample of 2.2% of the Korean population, was analyzed. We analyzed data related to prescriptions recognized as insured herbal preparations. Variables included patient demographics, diagnosis codes, prescription details, and healthcare institution characteristics. We examined trends over the decade, focusing on herbal formulae and single herb extracts. Results: During the study period, 275,358 patients visited Korean traditional medicine clinics and received at least one prescription of herbal preparations, representing 27.5% of the total sample. The number of prescriptions increased by 209%, from 34,621 in 2010 to 72,553 in 2019. Females accounted for 67% of these prescriptions, and 77% were for patients aged 70 and older. The top ten herbal formulae (TTHF), including Ojeok-san and Gungha-tang, constituted 76% of all prescriptions. Herbal formulae were used more frequently than single herb extracts, with certain prescriptions being commonly utilized. There was a notable focus on musculoskeletal disorders, with low back pain being the most common diagnosis. Conclusion: The study demonstrates a significant increase in the use of insured herbal preparations, primarily in small clinics and among the elderly. Prescription patterns showed a preference for specific single herb extracts and herbal formulae, with consistent trends over time. These findings provide valuable insights for future clinical research and policy development, particularly as herbal medicine's role in the national healthcare system continues to expand.

Background: In the Republic of Korea, the implementation of the Life-Sustaining Treatment Decision System has facilitated end-of-life care planning through advanced directives. Despite the availability of this system, there are few studies about advance directives itself and Korean medicine clinics(KMC) have been underrepresented as registration institutions, with limited data on their involvement. Objective: The study delved into the landscape of advance directives within KMC, shedding light on the characteristics of the subject and the correlation between sociodemographic factors with the intention to use hospice and the allowance of pre-access. Results: Data from a specific KMC's advance directives registry were analyzed, with 89 cases meeting the criteria for investigation. Results revealed a predominant female presence among registrants, with an average age of 70.28 ± 9.47 years. While no statistically significant relationship was found between gender/age/distance and the intention to use hospice or pre-access allowance, those expressing a desire for hospice care were more inclined to permit pre-access. In addition, the closer the distance, the older the subject. These findings underscore the evolving dynamics of end-of-life care planning in Korea, urging greater participation of KMC in hospice palliative care initiatives. The study's limitations include its single-institution focus and potential impact from the COVID-19 pandemic. Conclusion: The study found a strong link between hospice intention and pre-access allowance and highlighted the association between distance and age. These findings emphasized the evolving role of KMC in end-of-life care planning and call for further research to explore their increasing involvement in hospice palliative care initiatives.

Objectives: This study aimed to investigate whether Ligigeopoong-san induces acute toxicity and genotoxicity Methods: Ligigeopoong-san contains the rhizome of Cnidium officinale MAKINO, an herb with potential teratogenicity. Teratogenicity is closely associated with genotoxicity. We analyzed whether Ligigeopoong-san induces acute toxicity and genotoxicity using various experimental models in accordance with Korean non-clinical test standards for pharmaceuticals and OECD test guidelines. Results : When Ligigeopoong-san was administered as a single dose to male and female rats, no toxic reactions, including organ damage, were observed at doses up to 2,500 mg/kg. In the bacterial reverse mutation test, no DNA mutations were detected at concentrations up to 5,000 ㎍/plate. In cell models, Ligigeopoong-san did not induce structural or numerical chromosomal aberrations at concentrations up to 2,000 ㎍/mL. Additionally, in animal studies, it did not cause bone marrow toxicity or form micronuclei in erythrocytes at doses up to 2,000 mg/kg. Conclusions : The experiments using various models demonstrated that Ligigeopoong-san did not induce acute toxicity or genotoxicity.

Objectives: Tonifying herbal medicines are used to nourish and balance the body's qi, blood, yin, and yang, targeting deficiencies. They are the second most frequently used category by consumers visiting Korean medicine clinics, following prescriptions for back pain. This study aimed to analyze the adverse events associated with herbal medicine products classified as tonics through a national pharmacovigilance database. Methods: We investigated 11 types of tonifying herbal medicine products (466 product codes) in the Korea Adverse Event Reporting System (KAERS) database from 2012 to 2021. Extracted adverse event reports were analyzed based on information of reports, patient demographics, classification of adverse events, reported herbal medicine products, and causality assessment results. Results: A total of 31 individual case safety reports were identified, covering 33 adverse events. The annual number of reports has increased over the study period. Most reports were filed by physicians and pharmacists, with the majority of patients being adults or elderly. Gastrointestinal disorders were the most frequently reported adverse events, accounting for 48.5% of cases. Of the 33 adverse events, 93.9% were classified as non-serious, while 6.1% were classified as serious. The most frequently reported herbal medicine products were Bojungikgi-tang, Yukmijihwang-tang, and Palmijihwang-tang. Conclusions: Although the study found that adverse events associated with tonifying herbal medicine products are generally not serious, it highlights the importance of systematic monitoring and reporting. The findings underscore the need for improved adverse event reporting systems within traditional Korean medicine to ensure patient safety and guide future research.

Objectives: This study aims to develop a revised classification system of the Korean Medicine (KM) industry that is practically feasible, ultimately laying the groundwork for the KM industry's development. Methods: The draft of classification structure and categories were established through review of literature on existing classification systems related to KM or industry. The experts who affiliated to representative organizations on KM industry were invited to conduct reviews for enhancing the draft's practical validity and usability. The review process was iterated until consensus was achieved among the experts, ensuring the revised classification was comprehensive and robust. Results: Three drafts were created in total, and the final revised classification system consisted of the 'KM industry' and the 'KM-related industry' (indirectly related or supportive of the KM industry). The 'KM industry' includes KM medicaments, KM medical instruments and appliances, and KM healthcare service. The 'KM-related industry' includes KM research, KM administration, KM education, and KM organization. Two key points emerged from the open feedback: the necessity of establishing new sectors within the KM industry and the need for further research on methods to link these new sectors with existing statistical data. Conclusions: The revised classification system of the KM industry developed in this study can serve as an important foundational resource for policymakers, researchers, and industry practitioners in the relevant field, supporting their research and policy development.

Objectives: The purpose of this study is to summarize the etiology, diagnosis and treatment of pelvic congestion syndrome(PCS) in traditional East-Asian medicine(TEM) and Western medicine(WM) from the point of blood stasis. Methods: We followed the methodology of 5 steps of scoping review by Arksey and O'Malley and Levac et al. Studies from 2010 to October 19, 2023 were searched through seven search engines. Two reviewers independently searched and screened the studies. When there was a disagreement, a third reviewer decided its eligibility. Results: A total of 78 studies were selected, and 40 were TEM studies and 38 were WM. The average age of the study subjects was in their 30s and most had more than one child. Most of TEM were intervention studies and WM were mostly observational studies. In the WM, the etiology of PCS was considered pelvic venous insufficiency, and in the TEM, pathological conditions caused blood stasis in the pelvis. In TEM, the diagnosis was made according to previous studies' criteria; in WM, it was made through imaging. To treat PCS, WM seeks to block extended veins with embolization, and TEM to improve the environment in which stagnant blood is created through various treatments such as herbal medicine, enema therapy, etc. Total efficient rate (TER) in TEM and imaging findings in WM were most often used as outcome measures. Conclusions: This study summarized and analyzed overall concepts of PCS in TEM and WM.

Objectives: Recent trends in traditional Korean medicine (TKM) lung cancer treatment involve the administration of a few ready-made herbal formulas in batches. However, utilizing a TKM pathology-based formulation of herbs can fill in the gaps in holistic treatment that are often missed in a one-size-fits-all approach. The author aimed to analyze treatment trends between a traditional Chinese medicine (TCM) cancer treatment specialty book and a series of Korean lung cancer TKM treatment case reports. Methods: The frequently used pattern identification types, herbal formulas, and herbs in the lung cancer chapter of a TCM cancer treatment specialty book and case reports of TKM treatment of lung cancer were analyzed in a comparative manner. Results: Twenty-four pattern identification types for lung cancer were derived from the TCM book, and they were Phlegm-blood stasis, lung heat, and deficiency type. Six types of pattern identification types were derived from the 20 cases reports of TKM treatment, and they were blood stasis due to qi stagnation and deficiency type. Twelve cases were treated with ready-made anti-tumor herbal preparations without performing a pattern identification, accounting for two-thirds of the cases. Conclusions: The treatment of lung cancer in TCM is characterized by the use of pattern identification to formulate herbal formulas with simultaneous administration of anti-tumor herbs within the same formula. The treatment of lung cancer in TKM is relatively infrequent in its use of pattern identification. In addition, herbal formulas derived through the process of pattern identification and derived for anti-tumor purposes were often administered separately.

Objectives: The purpose of this study was to suggest the another Method of Treatment of Seunggi-Tang by reviewing ShanHanZaBingLun GuiLinGuBon Methods: The book of ShanHanZaBingLun GuiLinGuBon published by the Eui-Seong-Dang in 2004 was used. All Seunggi-tang was researched and classified into Method of Treatment. Results: Seunggi-tang included Doinseunggi-tang, Soseunggi-tang, Jowiseunggi-tang, and Daeseunggi-tang. There were two methods of using Seunggi-tang: the Ha treatment with usual volume and the Hwa treatment, with reduced volume. Seunggi-tang especially Soseunggi and Jowiseunggi-tang, were used not only as the Ha treatment but also as the Hwa treatment for several diseases such as gastrointestinal diseases with Bokman or Chogyeonghudang. Conclusions: This study reveals that Seunggi-Tang could be used Ha or Hwa treatment and Hwa treatment could be utilized in various clinical situation. Further study is needed.

Objectives : : The purpose of this study is to analyze the evaluation results and score deviation between interraters after performing ankle sprain CPX. Methods : Ankle sprain CPX was performed on fourth-year students in the Department of Korean Medicine. A student standardized patient(SSP) filled out the 50-point PPI questionnaire. Results : Ankle sprain CPX final score was 28.20 ± 1.40. Evaluation items showed low scores in the following order: performance time, physical examination, and past and social history check. The "physical examination" accounted for the largest proportion of the score deviation between interraters. In PPI, the lowest score was "effective questioning", and the highest scores were "listening" and "empathy". Conclusions : We hope that follow-up research will be conducted to develop objective and reliable CPX evaluation standards and scoring checklists in the future.

Objectives: This study aimed to analyze trend of names of clinic-level medical institutions and pharmacy in Korea to understand interaction between health care provider and consumer. Methods: This study analyzes 60,101 medical clinic names, 27,609 dental clinic names, 25,506 Korean medicine clinic names, and 68,032 pharmacy names. Official records from Korea Local Information Research & Development Institute, data from 1946 to June 2024. Researcher uses text-mining technique including tokenizer of Soynlp and wordcloud to visualize trends. Results: In pharmacy business names, franchise name 'Onnuri' is dominant. In case of dental clinic and Korean medicine clinic, university names like 'Seoul', 'Yeonsei', 'Kyunghee' are dominant. Similarly, medical clinic names include university names but also teaching hospital names like 'Samsung' or 'Seongmo(St. Mary)'. Commonly used word in clinic-level medical institution and pharmacy is 'Uri' and latest trend words are 'Bareun' and '365'. Conclusions: Methods presented in this study for analyzing business names can directly applied to the study of business names in other industries. The results of this study would develop marketing strategies of medical industry. Furthermore, since business name provide concentrated data on market perception and the interaction between consumers and providers, they can be useful for sociology and medical humanities researchers.

Background: The Republic of Korea has maintained a stable number of convalescent hospitals; however, the presence of Korean Medicine(KM) doctors in such establishments has increased. Despite this trend, it is hard to find the recent researches on KM within convalescent hospitals. Objective: This study aimed to investigate the current status of convalescent hospitals, particularly focused on patient characteristics and the provision of KM. Method: Data were obtained from the Health Insurance Review&Assessment Service, relying on the Korea Institute Healthcare Accreditation, spanning from January to March 2024. Analysis was conducted through the categorization of in-patients and the provision of KM, utilizing R software. Results: Among the 143 convalescent hospitals, the majority(83.9%) provided KM, with 43.4% of them located near Seoul. Convalescent hospitals offering KM were characterized by a higher number of doctors(p=0.003) and a greater total bed number(p<0.001). The hospitals with KM specializing in dementia care located near Seoul and exhibited a higher proportion of doctors, total beds(p=0.010), uninsured beds, grade of certification evaluation(Gr) and supported activities of daily living(ADL)(p<0.001, respectively). However, the hospitals with KM specializing in cancer care had higher rate of doctors(p=0.036), total beds, uninsured beds, Gr, and average daily out-of-pocket per person and lower levels of self ADL(p<0.001, respectively). In addition, the hospitals with specialists in KM belonging to dementia care only located near Seoul(p=0.042) and exhibited a higher rate of total beds(p=0.007). Conclusion: These findings indicate significant differences among convalescent hospitals based on patient characteristics and the provision of KM. Consequently, such distinctions merit consideration in future studies.

Objectives: Puriton^® is the electrolyte enriched water consisting of 31 essential minerals from biotite, kaolinite, montmorillonite, serpentine, and clinochlore, and vermiculite. It has been reported to be bactericidal and virucidal. However, the protective effect of Puriton^® against acute pancreatitis (AP) has not yet been studied. Therefore, we aimed to evaluate the protective effect of Puriton^® against cerulein-induced AP. Methods: AP was induced by intraperitoneal injections of cerulein (50 ㎍/kg) hourly for 6 times. Puriton^® (100, 300, 500, or 700 μL) was administered orally 1 hour before the first cerulein injection. Mice were sacrificed 6 hours after the last cerulein injection. Pancreas, lung, and serum samples were quickly collected for further analysis. Results: Administration of Puriton^® did not reduce the ratio of pancreas weight to body weight. However, the increased serum amylase and lipase were decreased in the Puriton^® administration group, and histological damage to pancreas and lung tissue was suppressed in the Puriton^® 100 and 300 μL administration groups, but not in the Puriton^® 500 and 700 μL administration groups. Additionally, among pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α, the mRNA level of only IL-6 was decreased by Puriton^® administration. Conclusion: In summary, we showed that the administration of Puriton^® improved the severity of cerulein-induced AP, suggesting the possibility of being an effective drug for AP.

Objectives: This study was performed to investigate the effects of Rhus verniciflua Stokes (RVS) on apoptosis and autophagy in the human leukemic cell line, MOLT-4. Methods: Cell viability was measured by MTS/PMS assay, and cell cycle distribution was analyzed by flow cytometry. The expression levels of mRNA implicated in apoptosis and ER-stress were investigated with RT-qPCR. Lastly, apoptosis- and autophagy-related protein expressions were measured by Western blot analysis. Results: RVS inhibited proliferation of MOLT-4 in a dose-dependent manner over 24, 48 and 72 hours. RVS treatment also induced an increase in subG1 phase. Exposure to RVS increased the expression of the mRNAs encoding Bax and caspase-3, while decreasing the expression of Bcl-2 mRNA, suggesting that RVS induced apoptosis in MOLT-4 cells. Additionally, RVS extract up-regulated ER-stress related mRNAs such as IRE1α, CHOP, PERK and ATF6. Changes in RVS extract-induced apoptosis and autophagy proteins on MOLT-4 cells were also investigated. The level of Bcl-2 was decreased, whereas the levels of Bax, caspase-3, AMPK, Beclin-1, Atg5, p62, and LC3II were increased. Conclusion: These results suggest that RVS would be beneficial in the treatment of Acute Lymphoblastic Leukemia.

Objectives: This study aims to understand the current state of regional healthcare services and explore the role of public health doctors of Korean medicine (PHDKMs) in addressing healthcare disparities. Methods: An online survey was conducted among 951 PHDKMs registered with the Korean Public Health Korean Medicine Doctors Association from July 15 to July 19, 2024. A total of 266 responses were collected, and after removing 2 insincere responses, 264 responses were used for analysis. The survey included questions on the provision of healthcare services and the role of PHDKMs in local healthcare crisis. Results: Out of 264 responses, 85 community health centers and branches (32.2%) lacked public health doctors (PHDs). The traveling clinics were the most common alternative in these cases. Centers without PHDs received 46 complaints (54.1%) about healthcare gaps, while centers with PHDs received 70 complaints (39.1%), showing statistically significant differences. The most common complaints involved consultation and management of chronic elderly diseases. PHDKMs reported being capable of providing musculoskeletal and internal medicine treatments, but identified a need for improvement in emergency response, basic and inflammatory treatments, consultation and management of chronic elderly diseases, administration of medications, and vaccinations. They expressed a high willingness and perceived capability to perform minor medical tasks. Conclusion: The decline in PHDs is adversely affecting regional healthcare. PHDKMs can help address these gaps through expanded roles and additional training. Policymakers should consider better integrating PHDKMs into the public healthcare system to ensure continuous and comprehensive healthcare services in underserved areas.

Objectives: This study aimed to identify the effects in competency enhancement of students participating in medical volunteer activities and to investigate the current conditions and needs for developing guidelines. Methods: A self-reporting online survey was conducted with Korean medicine students who participated in the medical volunteer activities. The first survey, sent to 147 participants on July 6, 2024, consisted of questions on clinical guidelines for medical volunteer activities and professional competency evaluation before the volunteer activities. The second survey, sent to 53 participants on July 12, 2024, used the same competency evaluation items to assess changes after the volunteer activities. Results: Due to the lack of current clinical guidelines, most students are experiencing difficulties. There is a demand for comprehensive guidelines and specific items for immediate application in medical volunteer activities. Medical volunteer activities have enhanced the professional competencies of Korean medicine students in all aspects. Conclusions: Through these results, Research on medical volunteer activities and the development of guidelines is essential for its advancement.

Objectives: We analyzed Sasang constitution case reports using text mining to derive network analysis results and designed a classification algorithm using machine learning to select a model suitable for classifying Sasang constitution based on text data. Methods: Case reports on Sasang constitution published from January 1, 2000, to December 31, 2022, were searched. As a result, 343 papers were selected, yielding 454 cases. Extracted texts were pretreated and tokenized with the Python-based KoNLPy package. Each morpheme was vectorized using TF-IDF values. Word cloud visualization and centrality analysis identified keywords mainly used for classifying Sasang constitution in clinical practice. To select the most suitable classification model for diagnosing Sasang constitution, the performance of five models-XGBoost, LightGBM, SVC, Logistic Regression, and Random Forest Classifier-was evaluated using accuracy and F1-Score. Results: Through word cloud visualization and centrality analysis, specific keywords for each constitution were identified. Logistic regression showed the highest accuracy (0.839416), while random forest classifier showed the lowest (0.773723). Based on F1-Score, XGBoost scored the highest (0.739811), and random forest classifier scored the lowest (0.643421). Conclusions: This is the first study to analyze constitution classification by applying text mining and machine learning to case reports, providing a concrete research model for follow-up research. The keywords selected through text mining were confirmed to effectively reflect the characteristics of each Sasang constitution type. Based on text data from case reports, the most suitable machine learning models for diagnosing Sasang constitution are logistic regression and XGBoost.

Background: This case study aimed to report the efficacy of scalp acupuncture in a patient with diplopia or lateropulsion and lateral medullary infarction. Case report: A 41-year-old woman with lateral medullary infarctions presented with symptoms of left-sided diplopia, left lateropulsion, headache, dizziness, and right-sided dysesthesia for 8 months. She received daily Korean medicine treatments, including scalp acupuncture. During the treatment period, various assessments were conducted, including the symptom score, visual analog scale (VAS), diplopia questionnaire (DQ), eyeball movement, dizziness handicap inventory (DHI), Korean version of the berg balance scale (K-BBS), activities-specific balance confidence scale (ABC), vestibular disorders activities of daily living scale (VADL), and the EuroQol five-dimension index (EQ-5D index). The patient's symptom score, VAS, DQ, DHI, and VADL scores decreased, while K-BBS, ABC, and EQ-5D scores increased. Additionally, eyeball movements improved after Korean medicine treatment including scalp acupuncture. Conclusions: The observed improvements suggest that Korean medicine treatment including scalp acupuncture can effectively alleviate diplopia and lateropulsion in patients with lateral medullary infarction.

Objectives: The objective of this study is to report three successful cases of tinnitus treatment using thread-embedding therapy. Methods: Thread-embedding therapy was performed on GV20 (百會), CV12 (中脘), and both sides of GB2 (聽會), TE17 (翳風), ST25 (天樞), and ST36 (足三里) for a duration ranging from 2 to 13 sessions. The severity of tinnitus was assessed using the Korean Tinnitus Handicap Inventory (K-THI) and the Verbal Numerical Rating Scale (VNRS). Results: In Case 1, the patient's THI score decreased from 92 to 8, and the VNRS score decreased from 10 to 0. In Case 2, the patient's THI score decreased from 62 to 2, and the VNRS score decreased from 7 to 0. In Case 3, the patient's THI score decreased from 88 to 42, and the VNRS score decreased from 8 to 4. Conclusions: Thread-embedding therapy demonstrated a positive clinical effect in the treatment of tinnitus.

Objectives: In order to select proper acupoints, it is important to understand the principle of major acupoints composition among 361 acupoints. Methods: We investigated the composition of major acupoints from Four Command points to Star Twelve points based on the classical medical texts. We reviewed the common principle of major acupoints composition. Results: First, major acupoints are chosen to treat the targeted diseases associated with the corresponding meridian channels and these acupoints are located in distal part of the body below the knee and the elbow. Second, main acupoints are supposed to be the representative points among acupoints with similar indications. Main acupoints can be selectively to treat a specific disease or condition, rather than be used for general effect simultaneously. Conclusions: We demonstrated the major acupoints from classical medical texts and revealed the common principles of major acupoints composition. These findings can help Korean medical doctors to choose more appropriate acupoints by understanding the principle of major acupoints composition.

Objectives: This study analyzed the factors related to outpatient service to Western medicine (WM) and Korean medicine (KM) of Korean adults with depressed mood using data from the 2019 Korea Health Panel Study. Methods: The general characteristics according to group of 827 individuals, and the factors influencing the use of integrative medicine (IM) medical service were identified using the Chi-square test and binary logistic regression results. The factors were classified based on the Andersen healthcare utilization model. The results of regression analysis were presented as odds ratio (OR) and 95% confidence interval (CI). Results: Among the individuals of the study, 658 (79.6%) were in the WM group and 169 (20.4%) were in the IM group. In the WM group and the IM group, the presence of suicidal ideation was common at 37.7% and 43.2%, respectively. As a result of regression analysis, the living in Busan/Daegu/Ulsan/Gyeongsang compared to living in Seoul/Gyeonggi/Incheon [OR = 0.522 (95% CI = 0.328 to 0.830)], and presence of musculoskeletal [OR = 1.686 (95% CI = 1.071 to 2.653)] and mood disorders [OR = 1.737 (95% CI = 1.106 to 2.726)] were the most influential factors on the use of IM medical service. Conclusions: This study is the first in Korea to analyze the patterns of medical institution use and factors used in KM treatment among adults with depressed mood. The results of this study provide preliminary evidence for the contribution of KM to national mental health in the context of depression.

Objectives: The purpose of this study is to investigate the effect of music therapy combined with hand manipulation on depression and cognition in elderly women with mild depression. Methods: In order to investigate the effects of a music therapy program through hand, 20 elderly women with a GDS-K score of 14-18 were selected among women aged 65 to 84 living in Busan. The 10 subjects in the experimental group were given the music therapy program 3 times a week for 4 weeks, 12 sessions, and the 10 subjects in the control group were not given it. GDS-K and K-MoCA were performed before and after the experiment, and data analysis was performed through Wilcoxon's test using the SPSS 24.0 statistical package program. Results: The music therapy program through hand manipulation is effective in reducing depression in elderly women with mild depression, and there was a significant decrease. The sub-domains of depression, such as tension and depressive emotions, life dissatisfaction, lethargy, cognitive difficulties, low energy, and loss of motivation, were significantly reduced. In addition, it has an effect on cognition, and it significantly increased in attention, delayed recall ability, which are sub-domains of cognition. There is a significant difference in depression between the experimental group and the control group, and there is a significant difference in cognition between the two groups. Conclusions: The music therapy program with hand manipulation has a positive effect on depression and cognition in elderly women with mild depression