• East Asian mathematical journal
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• 제36권1호
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• pp.81-90
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• 2020

Many compartment models assume a kinetically homogeneous amount of materials that have well-stirred compartments. However, based on observations from such processes, they have been heuristically fitted by exponential or gamma distributions even though biological media are inhomogeneous in real environments. Fractional differential equations using a specific kernel in Pharmacokinetic/Pharmacodynamic (PKPD) model are recently introduced to account for abnormal drug disposition. We discuss a tumor growth inhibition (TGI) model using fractional-order derivative from it. This represents a tumor growth delay by cytotoxic agents and additionally show variations in the equilibrium points by the change of fractional order. The result indicates that the equilibrium depends on the tumor size as well as a change of the fractional order. We find that the smaller the fractional order, the smaller the equilibrium value. However, a difference of them is the number of concavities and this indicates that TGI over time profile for fitting or prediction should be determined properly either fractional order or tumor sizes according to the number of concavities shown in experimental data.

• Earthquakes and Structures
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• 제13권5호
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• pp.465-471
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• 2017

This work derives a generalized time fractional differential equation governing wave propagation in a radially vibrating non-classical cylindrical medium. The cylinder is made of a transversely isotropic hyperelastic John's material which obeys frequency-dependent power law attenuation. Employing the definition of the conformable fractional derivative, the solution of the obtained generalized time fractional wave equation is expressed in terms of product of Bessel functions in spatial and temporal variables; and the resulting wave is characterized by the presence of peakons, the appearance of which fade in density as the order of fractional derivative approaches 2. It is obtained that the transversely isotropic structure of the material of the cylinder increases the wave speed and introduces an additional term in the wave equation. Further, it is observed that the law relating the non-zero components of the Cauchy stress tensor in the cylinder under consideration generalizes the hypothesis of plane strain in classical elasticity theory. This study reinforces the view that fractional derivative is suitable for modeling anomalous wave propagation in media.

• 대한수학회보
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• 제47권1호
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• pp.81-87
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• 2010

In this paper, we consider the existence of nontrivial solutions for the nonlinear fractional differential equation boundary-value problem(BVP) $-D_0^{\alpha}+u(t)=\lambda[f(t, u(t))+q(t)]$, 0 < t < 1 u(0) = u(1) = 0, where $\lambda$ > 0 is a parameter, 1 < $\alpha$ $\leq$ 2, $D_{0+}^{\alpha}$ is the standard Riemann-Liouville differentiation, f : [0, 1] ${\times}{\mathbb{R}}{\rightarrow}{\mathbb{R}}$ is continuous, and q(t) : (0, 1) $\rightarrow$ [0, $+\infty$] is Lebesgue integrable. We obtain serval sufficient conditions of the existence and uniqueness of nontrivial solution of BVP when $\lambda$ in some interval. Our approach is based on Leray-Schauder nonlinear alternative. Particularly, we do not use the nonnegative assumption and monotonicity which was essential for the technique used in almost all existed literature on f.

• Nonlinear Functional Analysis and Applications
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• 제27권3호
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• pp.679-689
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• 2022

In this paper, we establish sufficient conditions for the existence and uniqueness of solution for a class of initial boundary value problems with Dirichlet condition in regard to a category of fractional-order partial differential equations. The results are established by a method based on the theorem of Lax Milligram.

• 호남수학학술지
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• 제45권1호
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• pp.1-24
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• 2023

In the present paper, we prove common fixed point theorems for a pair of weakly compatible mappings under implicit contractive relation in quasi-partial S_b-metric spaces. We also provide an illustrative example to support our results. Furthermore, we will use the results obtained for application to two boundary value problems for the second-order differential equation. Also, we prove a common solution for the nonlinear fractional differential equation.

• Nonlinear Functional Analysis and Applications
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• 제26권1호
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• pp.197-223
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• 2021

In this paper, we investigate existence, uniqueness and four different types of Ulam's stability, that is, Ulam-Hyers stability, generalized Ulam-Hyers stability, Ulam-Hyers-Rassias stability and generalized Ulam-Hyers-Rassias stability of the solution for a class of nonlinear fractional Pantograph differential equation in term of a proportional Caputo fractional derivative with mixed nonlocal conditions. We construct sufficient conditions for the existence and uniqueness of solutions by utilizing well-known classical fixed point theorems such as Banach contraction principle, Leray-Schauder nonlinear alternative and $Krasnosel^{\prime}ski{\breve{i}}{^{\prime}}s$ fixed point theorem. Finally, two examples are also given to point out the applicability of our main results.

• Korean Journal of Mathematics
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• 제27권1호
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• pp.119-129
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• 2019

Balance function is one of the joint factors to determine fall in risk theory. It helps to moderate the progression and riskiness of falls for detecting balance and fall risk factors. Nevertheless, the objective measures for balance function require expensive equipment with the assessment of any expertise. We establish the existence and uniqueness of a multi-order fractional differential equations based on ${\psi}$-Hilfer operator on time scales with balance function. This class describes the dynamic of time scales derivative. Our tool is based on the Schauder fixed point theorem. Here, sufficient conditions for Ulam-stability are given.

• 호남수학학술지
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• 제37권4호
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• pp.411-421
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• 2015

This paper investigates the issue of analytic travelling wave solutions for some important coupled models of fractional order. Analytic travelling wave solutions of the considered model are found by means of the Q-function method. The results give us that the Q-function method is very simple, reliable and effective for searching analytic exact solutions of complex nonlinear partial differential equations.

• Kyungpook Mathematical Journal
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• 제62권3호
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• pp.583-593
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• 2022

Lienard's equations are important nonlinear differential equations with application in many areas of applied mathematics. In the present article, a new approach known as the modified fractional Taylor series method (MFTSM) is proposed to solve the nonlinear fractional Lienard equations with Caputo fractional derivatives, and the convergence of this method is established. Numerical examples are given to verify our theoretical results and to illustrate the accuracy and effectiveness of the method. The results obtained show the reliability and efficiency of the MFTSM, suggesting that it can be used to solve other types of nonlinear fractional differential equations that arise in modeling different physical problems.

• East Asian mathematical journal
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• 제30권5호
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• pp.631-637
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• 2014

In this paper, we construct some results on the existence and regularity for solutions of neutral functional differential equations with unbounded principal operators in Hilbert spaces. In order to establish the existence and regularity for solutions of the neutral system by using fractional power of operators and the local Lipschtiz continuity of nonlinear term without using many of the strong restrictions considering in the previous literature.