This study aimed to investigate the actual smoking status, knowledge of oral health related to smoking, and attitude toward smoking cessation in 161 health students of the University in Jeonnam. This was done to examine the role of smoking cessation guidance as health care professionals after graduation. The collected data were analyzed using SPSS version 18.0. The significance level was α=0.05. Of those surveyed, 33.3% had previously smoked, and 30.4% were current smokers. The high school period had the highest smoking rate, at 59.2%. A daily smoking rate of 20 or more cigarettes was the highest at 30.4%. Of the respondents, 68.3% had received smoking cessation, while 10.6% said that they were encouraged by others to quit, such as friends. As a result of a correlation analysis between major satisfaction, smoking-related oral health knowledge, and attitudes toward smoking cessation, major satisfaction showed a negative correlation(r=-.394, -.337*) with smoking-related oral health knowledge and attitude towards smoking cessation. Smoking-related oral health knowledge showed a positive correlation(r=.546**) with attitude towards smoking cessation. As a result of a regression analysis, the knowledge of oral health related to smoking was the primary variable that affected the attitude towards smoking cessation(t=6.799, p<0.001). Based on these results, it is suggested that education on smoking cessation and the risk of smoking is delivered so that health care workers can be better prepared and educated for their future roles.