• Toxicological Research
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• 제22권2호
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• pp.87-93
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• 2006

The KFDA (Korea Food & Drug Administration) has performed a collaborative toxico-genomics project since 2003. Its aim is to construct a toxicologenomic database of 12 hepatotoxic compounds from mice livers. Phenylbutazone which is non-steroidal anti-inflammatory drug was assigned. It was administered at low (0.0238 mg/kg) and at high (0.238 mg/kg) dose (5 mice per group) orally to the postnatal 6 weeks ICR mice, then the serum and liver were collected at the indicated time (6, 24 and 72 h) after administration. Serum biochemical markers for liver toxicity were measured and histopathologic studies also were carried out. The gene expression profiling was carried out by using Applied Biosystems 1700 Full Genome Expression Mouse. The 2-way ANOVA was used to find genes that reflected phenylbutazone-induced acute toxicity or dose-dependant changes. By self-organization maps (SOM), we identified groups with unique gene expression patterns, some of them are supposed to be related to phenylbutazone induced toxicity, including lipid metabolism abnormality, oxidative stress, cell death and cytoskeleton destruction.

• 간호행정학회지
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• 제15권4호
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• pp.539-549
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• 2009

Purpose: The purpose of this study was to identify the relationships among trait anger, anger expression, job satisfaction, job commitment, and organizational performance, and especially to verify the effect of anger experience on organizational performance. Method: A descriptive study was conducted using a convenient sample. Data were collected by a self-report questionnaire from 671 clinical nurses in three university hospitals and analyzed by using SPSS 14.0 Win program with descriptive statistics, t-test, ANOVA, pearson correlation coefficient, and stepwise multiple regression. Result: Organizational performance was significantly correlated with trait anger, anger expression-in, anger expression-out, anger control, job satisfaction, and job commitment. Multiple regression analysis showed that organizational performance was significantly predicted by job commitment, job satisfaction, educational level (university graduation), anger control, and working place (operative room), and 34.7% was explained by these variables. Conclusions: Out of anger expression, anger control significantly affected on organizational performance together with job commitment and job satisfaction. From this result, it could be concluded that nursing intervention for anger control have a positive effect on improving organizational performance. Further studies are needed to develop and test the effect of nursing intervention programs for anger control.

• 복식문화연구
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• 제10권3호
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• pp.213-235
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• 2002

The purpose of this study was to recognize the meanings of plastic language by analyzing the sign of the Graffiti depicted in western modern costumes. And the scope of this study was focused on analysing the costumes from 1980's when the Graffiti was recognized as one of the plastic arts. Graffiti was an unprofessional and covert desire of self-expression, having a close relation with our lives. It was used in diverse ways with repeating creation, development, and extinction, from expressing liveliness in Old Stone Age through describing symbolic meaning in the modern art. Graffiti means rude, humorous, or political writing and pictures on the walls of buildings. It's different from the delicate letters or pictures to inscript on the tree or rocks. Being introduced as part of Post-modernism in the 1970s, Graffiti was acknowledged as a new artistic action with the culture of hip-hop. In addition the Graffiti, the expression of sign was reflected artist's internal consciousness with boundless sign. The sign is something to transmit message from the nonverbal point of view, the oldest sign was the sign for petition or the expression of something as a primitive form. Sign can be defined as a framework of life inherited as a practice from the primitive age long past. Graffiti was cited as a concrete example of sign, theme of this paper, and general understanding on sign expression was pursued through free work which all artists present with essential and positive ways using signs, their own languages, and life style. The result of this study was summarized as follows: Since the end of the 20th century, a lot of fashion designers have represented symbolic images, such as letter and signs, as purely personal ways of expression through the western costumes. It was found that fashion designers of the Graffiti whose free work style from inherent inner consciousness might provide a basic framework to search for complex signs of modem costumes naturally understood life itself as plastic art, and sublimated human inherent desire and their inner world through their works.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제26권4호
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• pp.288-294
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• 2015

Objectives : The purpose of this study was to assess anger of middle school adolescents in an urban community using State-Trait Anger Expression Inventory (STAXI)-Korean and Korean Child Behavior Checklist (K-CBCL), and to determine whether specific anger expression of adolescents is associated with certain psychopathology including depression. Methods : Data were collected from 395 middle school students and their parents in Incheon city. The students completed the STAXI, Children's Depression Inventory, Korean version of Mood disorder Questionnaire, and Conners-Wells' Adolescent Self-Report Scale (Short Form), and their parents completed the K-CBCL. Results : No significant correlation was observed between aggression subscale K-CBCL and each scale of the STAXI, except anger out (r=0.704). The scores for STAXI total and respective scales were significantly higher for female students than male students. A stepwise logistic regression model was used to explore the possible predictors for depression in adolescents and lower anger control and higher anger suppression were found to be predictors for depression in adolescence. Conclusion : There is a possibility of a large discrepancy between anger that the adolescents actually feel and parents' judgment of their children's anger. It must be considered in assessment of adolescent anger and use of further structured interviews is necessary. In addition, it may be useful to consider the anger expression style in adolescents who report depressive symptoms.

• 한국발생생물학회지:발생과생식
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• 제17권1호
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• pp.9-16
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• 2013

Coactivator-associated arginine methyltransferase 1 (CARM1) is included in the protein arginine methyltransferase (PRMT) family, which methylates histone arginine residues through posttranslational modification. It has been proposed that CARM1 may up-regulate the expression of pluripotency-related genes through the alteration of the chromatin structure. Mouse embryonic stem cells (mESCs) are pluripotent and have the ability to self-renew. The cells are mainly used to study the genetic function of novel genes, because the cells facilitate the transmission of the manipulated genes into target mice. Since the up-regulated methylation levels of histone arginine residue lead to the maintenance of pluripotency in embryos and stem cells, it may be suggested that CARM1 overexpressing mESCs elevate the expression of pluripotency-related genes in reconstituted embryos for transgenic mice and may resist the differentiation into trophectoderm (TE). We constructed a fusion protein by connecting CARM1 and 7X-arginine (R7). As a cell-penetrating peptide (CPP), can translocate CARM1 protein into mESCs. CPP-CARM1 protein was detected in the nuclei of the mESCs after a treatment of 24 hours. Accordingly, the expression of pluripotency-related genes was up-regulated in CPP-CARM1-treated mESCs. In addition, CPP-CARM1-treated mESC-derived embryoid bodies (EBs) showed an elevated expression of pluripotency-related genes and delayed spontaneous differentiation. This result suggests that the treatment of recombinant CPP-CARM1 protein elevates the expression of pluripotency-related genes of mESCs by epigenetic modification, and this protein-delivery system could be used to modify embryonic fate in reconstituted embryos with mESCs.

• 한국실내디자인학회논문집
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• 제19권1호
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• pp.85-93
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• 2010

This study aimed to show the possibility of approaching Steven Holl's Stretto House as a vital space identical to the flow of our consciousness through Bergson's philosophy of life by understanding the expression of Bergsonian duration in the house. For the Purpose of this study, Bergson's concept of aesthetic duration was considered and duration in the Stretto House design process was analyzed, Based on the study's findings, duration according to Bergson's expression of reality in the Stretto House was further analyzed. The results of the analysis of duration in the Stretto House design process showed that duration is expressed as phenomenological time through the continuity and movement of the perceptual phenomena of space, sound, light and material that reflected Merleau-Ponty's anchoring and Bartok's Music for Strings, Percussion and Celesta. The results of the analysis of duration as an expression of reality in the Stretto House showed that duration is expressed as real time, as reality's continuous and diverse movement of vital duration, through the image and rhythm based on the intuitive recollection of the real self, sound, light and pond. Consequently, it was shown that the Stretto House could be understood as a vital space in which a vital movement of duration identical with the flow of our consciousness is expressed through the expression of reality in Bergson's philosophy of life. This study is meaningful as a foundational study of the experiential space of phenomena through Bergson's philosophy of life.

• 경영과정보연구
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• 제31권2호
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• pp.21-39
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• 2012

본 연구는 이용-충족이론의 관점에서 SNS 이용동기에 관해 진행된 연구를 토대로 이용동기에 대한 검토를 실시하고, 이용과정을 통해 형성된 관여도가 만족으로 형성되는 구조를 살펴보고자 한다. 또한 남성과 여성간의 이용동기, 감정적/인지적 관여, 만족의 형성구조를 비교하여 성별 차이에 따른 전략적 시사점을 도출하고자 한다. 이를 위해 구조방적식모형을 설정하고 SNS 이용경험이 있는 306명의 데이터를 Lisrel로 분석하였다. 정보추구동기와 자아표현동기가 감정적 관여에 영향을 미치지 않는 것으로 나타났고, 이를 제외한 나머지 가설은 채택되었다. 이에 추가적으로 성별에 따라 비교해 보기위해 남성집단과 여성집단의 경로분석을 실시하였다. 그 결과, 남성의 경우는 정보추구동기, 오락적동기, 자아표현동기가 높은 경우에 감정적 관여가 높아지며, 오락적동기가 높은 경우만 인지적 관여가 높아지는 것으로 나타났다. 여성의 경우에는 사회적동기와 오락적동기가 감정적 관여와 인지적 관여를 높이는 것으로 나타나 만족으로 이어졌고, 정보추구동기와 자아표현동기는 감정형성에 영향을 미치지 않았다.

• 한국가정과교육학회지
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• 제25권1호
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• pp.67-77
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• 2013

본 연구는 중학교 기술 가정 수업에서 상황학습이론이 학습자들의 의생활 영역에 관련한 의식과 태도 및 수업에 대한 만족도에 미치는 영향을 검토하였다. 이를 목표로 가정교과의 중학교 1학년 '옷차림과 자기 표현' 단원에 상황학습 이론을 적용하여 총 3차시의 교수-학습 과정안을 개발하였다. 이렇게 개발한 교수-학습 과정안으로 서울시 B중학교 1학년 중에서 실헙집단 2학급에는 상황학습 이론을 적용한 수업을 진행하였고, 비교집단 2학급에는 전통적 강의 수업을 진행하였다. 상황학습 이론을 적용한 수업의 교육적 효과를 검증하기 위해 의생활 영역에 관련한 의식과 태도와 수업만족도 검사를 실시하고 SPSS 12.0을 이용해 신뢰도분석, 독립표본 t-검정을 실시하였다. 연구결과를 요약하면 다음과 같다. 첫째, 의생활 영역에 관련한 의식과 태도는 사전검사에서 두 집단 모두 유의한 차이가 없었다. 사후검사에서는 상황학습에 따른 수업을 받은 실험집단이 전통적 강의 수업을 받은 비교집단보다 긍정적인 영향을 받은 것으로 나타났다. 둘째, 수업에 대한 만족도는 상황학습을 적용한 실험집단이 대체로 모든 항목에서 높은 점수를 나타낸 것으로 보아 수업에 대한 만족도가 전반적으로 높았다고 할 수 있다.

• 산경연구논집
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• 제9권1호
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• pp.99-110
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• 2018

Purpose - The purpose of this study is to investigate the relationship among narcissism, usage motives, usage behaviors, satisfaction with and continuance intention to use fashion social media. Research design, data, methodology - A questionnaire survey was used to collect data after conducting a pilot test. Based on the reliability test of the preliminary questionnaire used for the pilot test, the questionnaire was revised. The final questionnaires were administered to 238 fashion social media users and 216 were used for the data analysis. To assess the validity of these measures, exploratory factor analysis and the confirmatory factor analysis were performed. Structural equation modeling analysis were employed for data analysis. Results - Five factors of the usage motivation of fashion social media were extracted: information-seeking, relationship-seeking, practicality-seeking, enjoyment-seeking and self-expression motives. The statistical analysis confirmed the influence of the narcissism tendency on all of the usage motives of fashion social media, three of the fashion social media usage motives influencing information diffusion behavior, and the influence of the information diffusion behavior on users' satisfaction and continuance intention to use fashion social media. Narcissism exerted the highest influences on self-expression motive followed by information-seeking, enjoyment-seeking, relationship-seeking and practicality-seeking motives in order. Factors affecting fashion information diffusion behaviors are practicality-seeking motive, self-expression motive, and relationship-seeking motive. The greater the diffusion of information, the higher the satisfaction with using fashion social media. The consumers with higher satisfaction intended to use fashion social media and share information more frequently. Conclusions - The results indicate that narcissism is an important factor in fashion social media usage motivation. The main motives for narcissistic people to spread information is for the practical purpose at the most, and then to express their personality and style, and to build relationship with others. The satisfaction through active information sharing behaviors seems to play a key role to lead high continuance intention of fashion social media. These implies that marketing strategies to satisfy consumers' narcissism and motives to use social media, and to stimulate the information diffusion behaviors can be used to meet their needs for higher satisfaction with fashion social media.

• 한국심리학회지 : 코칭
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• 제7권1호
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• pp.91-116
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• 2023

본 연구의 목적은 마음챙김과 자비심 수준 조합에 따른 직무소진, 정서노동 수행방식, 정서강도, 정서명료성에서의 차이를 밝히는 것이다. 이를 위해 137명의 심리 전문가가 참여하였고, 마음챙김과 자비심 수준에 대한 군집분석을 통해 네 집단으로 분류한 후 집단 간 차이를 비교하였다. 경력을 통제한 다변량공분산분석 또는 다변량분산분석을 실시하여 분석한 결과, 마음챙김과 자비심이 모두 높은 집단은 긍정 정서강도, 자기와 타인의 정서명료성, 진심표현이 가장 높았고, 부정 정서강도, 표면행동, 직무소진이 가장 낮았다. 마음챙김과 자비심 중 어느 하나의 요인이 상대적으로 높거나 낮은 집단은 마음챙김과 자비심이 모두 높은 집단과 비교해서 긍정 및 부정 정서강도를 모두 높은 수준으로 경험하거나 모두 낮은 수준으로 경험하고, 자기 및 타인의 정서에 대한 명료성과 진심표현은 상대적으로 더 낮았으며, 표면행동과 직무소진은 상대적으로 더 높게 나타났다. 마음챙김과 자비심이 모두 낮은 집단은 긍정 정서강도는 낮게, 부정정서강도는 높게 경험하고, 자기 및 타인 정서명료성, 진심표현이 가장 낮았으며, 표면행동과 직무소진은 가장 높게 나타났다. 이러한 결과를 바탕으로 심리 전문가를 비롯한 휴먼서비스 전문가의 직무소진을 예방하기 위해 마음챙김과 자비심의 균형 있는 계발을 논의하고, 연구의 의미와 제한점, 후속 연구의 방향성을 제시하였다.