• Title/Summary/Keyword: select

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Network pharmacoligical analysis for selection between Saposhnikoviae Radix and Glehniae Radix focusing on ischemic stroke (방풍(防風)과 해방풍(海防風) 중 뇌경색 연구에 더욱 적합한 약재 선정을 위한 네트워크 약리학적 분석)

  • Jin Yejin;Lim Sehyun;Cho Suin
    • Herbal Formula Science
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    • v.31 no.3
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    • pp.171-182
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    • 2023
  • Objectives : Saposhnikoviae Radix (SR) and Glehniae Radix (GR) have been frequently used in traditional medicine to treat diseases related to 'wind' syndrome, but there have been cases where it has been mixed in a state where the plant of origin is not clear. In this study, to select materials for conducting preclinical cerebral infarction research, the network pharmacology analysis method was used to select suitable medicinal materials for the study. Methods : In this study, a Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) based network pharmacology analysis method was used, and oral bioavailability (OB), drug likeness (DL), Caco-2 and BBB permeability were utilized to select compounds with potential activity. For the values of each variable used in this study, OB ≥ 20%, DL ≥ 0.18, Caco-2 ≥ 0, and BBB ≥ -0.3 were applied, then networks of bioactive compounds, target proteins, and target diseases was constructed. STRING database was used to construct a protein-protein interaction network. Results : It was confirmed that SR rather than GR has various target proteins and target diseases based on network pharmacological analysis using TCMSP database. And it was analyzed that the bioactive compounds only in SR act more on neurovascular diseases, and both drugs are expected to be effectively used for cardiovascular diseases. Conclusions : In our future study, SR will be used in an ischemic stroke mouse model, and the mechanism of action will be explored focusing on apoptosis and cell proliferation.

A Study on the Indicator Development for the Target Technology Selection of Technology Assessment (기술영향평가 대상기술 선정 지표 개발에 관한 연구)

  • Han, Min-Kyu;Kang, Ji-Min
    • Journal of Technology Innovation
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    • v.19 no.1
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    • pp.55-78
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    • 2011
  • The social impact of science and technology is increasing, the meaning of technology assessment is not small in modern society, Specially, the technology assesment(TA) has been institutionalized and performed by Korean administration and its official results has reflected directly in the S&T policy. Therefore, the technology assesment is a device that prepare the negative effects of S&T and the social controversy in advance. To select the target technology of technology assessment will be done carefully in various perspective and concerned with the characteristics of technology assessment emphasizing social assessment, the institutional system of selecting one technology in each year and the contents and methods of evaluation that are determined in accordance with technology characteristics. However, the method of selecting target technology in TA is mostly peformed by qualitative discussion and vote rather than by reflecting various opinion and understanding TA until now. In this paper, we developed the indicator has to be considered to select target technology for TA by using factor analysis. Developed indicator is consist of five factor, such as the need for social consensus and the size of social/cultural impact etc., and we weight each factor by using Analytic Hierarchy Process(AHP). Futhermore, we show the example how to applicate directly these indicator and weights to select target technology and suggest institutional application in TA. Though using developed indicator in this paper, we expect to select appropriate technology for institutional TA and the application of TA results in society and public policy can be strengthened.

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Gwang-Ju Citizens' Attitudes towards Tree Burials and Intentions to Select Tree Burials (도시민의 수목장에 대한 태도 및 수목장 선택의도 - 광주시민을 대상으로 -)

  • Kim, Sang-Mi;Kim, Sang-Oh
    • Korean Journal of Environment and Ecology
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    • v.26 no.1
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    • pp.100-112
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    • 2012
  • Governments and related agencies have made efforts to introduce tree burials (TB) as an alternative to solve the problems involved in the traditional funeral manners. Citizens' TB selection rates are, however, still very low. It is important to understand citizens' perceptions and attitudes towards TB to make people more actively participate in TB. This study examined citizens' knowledge, behavioral belief, attitudes towards selecting TB, intentions to select TB, and their relationship with citizens' socio-demographic characteristics. A total of 320 citizens in Gwang-ju, Korea, completed the survey during May, 2011. Results showed that 65.3% of respondents were aware of TB, and many of them (47.6%) obtained information from TV/Radio. Age, education level, marital status and birth order were related with knowledge about TB. Respondents with higher age or higher education level tended to have higher knowledge rates. The married or the non-eldest sons also had higher knowledge rates. Respondents with higher age or higher education level, and the married tended to have more positive attitudes towards selecting TB and to rate 'unconventional funeral customs' high. Respondents with higher age, education level or married respondents tended to have higher intention to select TB. The knowledge level about TB was positively related with attitudes about TB selection and intention to select TB. The results were discussed and some ways to promote TB were suggested.

The Study to Derive Empirical Formula of Rainfall Intencity in Korea (한국에 있어서 강우강도의 효과에 관한 연구)

  • 박성우
    • Magazine of the Korean Society of Agricultural Engineers
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    • v.11 no.2
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    • pp.1644-1650
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    • 1969
  • In the design of general hydrological structures, it is well know that the design flood is of importance in the design of those structures. As the design flood is estimated using the design storm, the design storm is defined by the rainfall intensity itself. Though I had studied and reported many times the reports about the rainfall-intensity in my country, poorly I did not study the long-period variation of the intensity through each section in my country before. But now, in the basin area of the Han river and the Keum river, the self-recorded rainfall charts of the single storms, which are mostly above rainfall amount of 30mm and data of about 4500 with the 150 stationyear, were analyzed, And then, the intensity formula of the hourly unit is estimated using the period from 10 minutes to 5 days. The method to analyze and estimate them, and the final results will be summarized as mentioned below: (i) At first I intended to select out the homogeneous watersheds of three, one in the Han river and two in the Keum river. But I would select the northern and the sourthern river basins, and westward from Koan station, in the basins of the Han river. Also I would select the upstream area, and the downstream area including the watershed of Chungioo, Kongjoo, Chupungryung, and the Mt. Sock, in the basins of the Keum river. Finally, I could find that there couldn't in the Keum river basin. So, I decided out and analyze only river basins of the Han river with limitation mentioned above. (ii) The statistical method to select out the homogenous watersheds is the test of homogeneous variance, and it is estimated from the following equation: $$X_{k1}^2=[{\Sigma}(n_i-1)log\bar{S^2}-\Sigma(n_i-1)log\bar{S^2}]{\times}loge$$ (iii) Actually, each homogeneous watershed has individually its own intensity formula, But I would express them as the actual amount, because the equation of intensity variance is experiential and theoretical equation of the variance. Therefore the caluating equation is actually more convenient in the actual uses. (iv) This report is one of the series for me to give the basis to the actual designs. The cost for this study is provided by the Ministry of Construction. And the designs of the hydrological structures in the watersheds with limitation mentioned above may be concerned with and based upon this report.

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GEO-KOMPSAT-2A AMI Best Detector Select Map Evaluation and Update (천리안위성2A호 기상탑재체 Best Detector Select 맵 평가 및 업데이트)

  • Jin, Kyoungwook;Lee, Sang-Cherl;Lee, Jung-Hyun
    • Korean Journal of Remote Sensing
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    • v.37 no.2
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    • pp.359-365
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    • 2021
  • GEO-KOMPSAT-2A (GK2A) AMI (Advanced Meteorological Imager) Best Detector Select (BDS) map is pre-determined and uploaded before the satellite launch. After the launch, there is some possibility of a detector performance change driven by an abrupt temperature variation and thus the status of BDS map needs to be evaluated and updated if necessary. To investigate performance of entire elements of the detectors, AMI BDS analyses were conducted based on a technical note provided from the AMI vendor (L3HARRIS). The concept of the BDS analysis is to investigate the stability of signals from detectors while they are staring at targets (deep space and internal calibration target). For this purpose, Long Time Series (LTS) and Output Voltage vs. Bias Voltage (V-V) methods are used. The LTS for 30 secs and the V-V for two secs are spanned respectively for looking at the targets to compute noise components of detectors. To get the necessary data sets, these activities were conducted during the In-Orbit Test (IOT) period since a normal operation of AMI is stopped and special mission plans are commanded. With collected data sets during the GK2A IOT, AMI BDS map was intensively examined. It was found that about 1% of entire detector elements, which were evaluated at the ground test, showed characteristic changes and those degraded elements are replaced by alternative best ones. The stripping effects on AMI raw images due to the BDS problem were clearly removed when the new BDS map was applied.

An Object Selection Method through Adaptive Casting in Immersive Virtual Reality (몰입 가상현실 환경에서 적응형 캐스팅을 통한 객체 선택 방법)

  • Lee, JunSong;Lee, Jun
    • The Journal of the Korea Contents Association
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    • v.19 no.9
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    • pp.666-673
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    • 2019
  • In the immersive virtual reality environment, we can select and manipulate various virtual objects. in order to select a virtual object, we generally use Ray-casting method that fires a virtual line in user's view and selects an object when the line and the object match, or Cone-casting method that is widely used to select multiple objects at the same time. However, since the virtual objects used in CAD are composed of small and complex objects in detail, when selecting an object in the user's view by existing methods, there occurs a ambiguity problem that needs additional realignment operation even though an object is selected as a group. in this paper, even if a virtual object is composed of several small virtual objects, it calculates the spatial and logical relationship among objects and expands or shrinks desired objects, so that the user can quickly and accurately select a desired object. in order to evaluate the proposed method, performance comparison were performed using Our and Ray-Casting and Cone-Casting methods. Experimental results show that the proposed method has the fastest speed and the highest accuracy when selecting the desired objects.

CSR Ad Strategy Based on Corporate Social Responsibility Theme, Model and Message Appeal (사회적 책임 활동 주제와 광고모델 및 메시지 소구방식에 따른 CSR광고 제작전략)

  • Yu, Seung-Yeob
    • Journal of Digital Convergence
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    • v.17 no.1
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    • pp.159-168
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    • 2019
  • The purpose of this study is to propose a strategy for creating an advertisement for Corporate Social Responsibility(CSR) based on the strategy of selecting an advertisement model in order to efficiently execute the advertisement of CSR. Data were analyzed by regression analysis. The results of this study are as follows: First, it is found that the value-relevance factors of the model are important regardless of the theme of CSR. In the economic field, the reliability of the model is important. But, the attractiveness of the model was more important in the environmental field. Second, it is effective to select a model with high value-relevance when selecting CSR advertising model. But, in the case of an expert, it is effective to select not only value addition, but also attractive and reliable models. Third, when producing CSR ads using emotional messages, it is important to consider the value and reliability of the advertising model. But, it is important to select the model considering the importance of the value and attractiveness of the advertisement model when producing the CSR advertisement using the informational message. It was found that it is very important to select a model that has a high relevance to the image of the social responsibility subject and the advertisement model when producing the social responsibility advertisement.

Design of 4Kb Poly-Fuse OTP IP for 90nm Process (90nm 공정용 4Kb Poly-Fuse OTP IP 설계)

  • Hyelin Kang;Longhua Li;Dohoon Kim;Soonwoo Kwon;Bushra Mahnoor;Panbong Ha;Younghee Kim
    • The Journal of Korea Institute of Information, Electronics, and Communication Technology
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    • v.16 no.6
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    • pp.509-518
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    • 2023
  • In this paper, we designed a 4Kb poly-fuse OTP IP (Intellectual Property) required for analog circuit trimming and calibration. In order to reduce the BL resistance of the poly-fuse OTP cell, which consists of an NMOS select transistor and a poly-fuse link, the BL stacked metal 2 and metal 3. In order to reduce BL routing resistance, the 4Kb cells are divided into two sub-block cell arrays of 64 rows × 32 rows, with the BL drive circuit located between the two 2Kb sub-block cell arrays, which are split into top and bottom. On the other hand, in this paper, we propose a core circuit for an OTP cell that uses one poly-fuse link to one select transistor. In addition, in the early stages of OTP IP development, we proposed a data sensing circuit that considers the case where the resistance of the unprogrammed poly-fuse can be up to 5kΩ. It also reduces the current flowing through an unprogrammed poly-fuse link in read mode to 138㎂ or less. The poly-fuse OTP cell size designed with DB HiTek 90nm CMOS process is 11.43㎛ × 2.88㎛ (=32.9184㎛2), and the 4Kb poly-fuse OTP IP size is 432.442㎛ × 524.6㎛ (=0.227mm2).

Regression Estimators with Unequal Selection Probabilities on Two Successive Occasions

  • Kim, Kyu-Seong
    • Journal of the Korean Statistical Society
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    • v.25 no.1
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    • pp.25-37
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    • 1996
  • In this paper, we propose regression estimators based on a partial replacement sampling scheme over two successive occasions and derive the minimum variances of them. PPSWR, RHC, $\pi$PS and PPSWOR schemes are considered to select unequal probability samples on two occasions. Simulation results over four populations are given for comparison of composite estimators and regression estimators.

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