• 대한치과의사협회지
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• 제49권9호
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• pp.527-534
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• 2011

Microvascular reconstruction of maxillary composite defect after oncologic resection has improved both esthetic and functional aspect of quality of life of the cancer patients. However, a lot of patients had prior surgery with radiation and/or chemotherapy as a part of comprehensive cancer treatment. Sometimes it is nearly impossible to find out adequate recipient vessel for maxillary reconstruction with microvascular anastomosis. Therefore long pedicle of the flap is needed to use distant neck vessels located far from the reconstruction site such as ipsilateral transverse cervical artery or a branch of contralateral external carotid artery. For this reason, although we know the treatment of the choice is osteocutaneous flap, it is difficult to use this flap when we need long pedicle with complex three dimensional osseous defect. Vascular option for these vessel-depleted neck patients can be managed by a soft tissue reconstruction with long vascular pedicle and additional free non-vascularized flap that is rigidly fixed to remaining skeletal structures. For this reason, maxillofacial reconstruction by vascularized soft tissue flap with or without the secondary restoration of maxillary bone with non-vascularized iliac bone can be regarded as one of options for reconstruction of profound maxillofacial composite defect resulted from previous oncological resection with chemo-radiotherapy.

• 대한정형외과학회지
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• 제54권6호
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• pp.557-561
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• 2019

대부분의 저에너지 외상에 의한 골반환 골절은 합병증 없이 보존적 치료만으로 호전이 되어 혈관손상 등의 합병증에 대한 초기평가를 간과하기 쉽다. 본 증례보고에서는 평소 aspirin을 복용하던 81세 여자환자가 낙상으로 비전위성 치골지 골절이 발생하면서 corona mortis가 손상되어 나타난 대량출혈을 보고하는 바이다. 고령의 골반환 골절 환자에서는 골절의 전위 여부와 관계없이 혈관 손상이 지연되어 발생할 수도 있기 때문에 면밀한 이학적 검사 및 감시가 필요하다.

• 센서학회지
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• 제22권1호
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• pp.76-83
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• 2013

A real-time wireless monitoring and analysis methods using the wearable PPG sensor to estimate cardiovascular condition is studied for ubiquitous healthcare service. A small size and low-power consuming wearable photoplethysmogram (PPG) sensor is designed as a wrist type device and connected with the IP node assigned its own IPv6 address. The measured PPG waveform in the IP node is collected and transferred to a central server PC through the IP-enabled wireless network for storage and analysis purposes. A monitoring and analysis program is designed to process the accelerated plethysmogram (APG) waveform by applying the second order derivatives to analyze systolic waves as well as heart rate variability analysis from the measured PPG waveform. From our results, the features of cardiovascular condition from individual's PPG waveform and estimation of vascular compliance by the comparison of APG-aging index (AI) and ratio of LF/HF are demonstrated.

• BMB Reports
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• 제47권6호
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• pp.311-317
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• 2014

microRNAs (miRNAs) are a class of small, non-coding RNAs that play critical posttranscriptional regulatory roles typically through targeting of the 3'-untranslated region of messenger RNA (mRNA). Mature miRNAs are known to be involved in global cellular processes, such as differentiation, proliferation, apoptosis, and organogenesis, due to their capacity to target multiple mRNAs. Thus, imbalances in the expression and/or activity of miRNAs are involved in the pathogenesis of numerous diseases, including pulmonary arterial hypertension (PAH). PAH is a progressive disease characterized by vascular remodeling due to excessive proliferation of pulmonary artery endothelial cells (PAECs) and pulmonary artery smooth muscle cells (PASMCs). Recently, studies have evaluated the roles of miRNAs involved in the pathogenesis of PAH in these pulmonary vascular cells. This review provides an overview of recent discoveries on the role of miRNAs in the pathogenesis of PAH and discusses the potential for miRNAs as therapeutic targets and biomarkers of PAH.

• BMB Reports
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• 제35권1호
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• pp.127-133
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• 2002

Nitrosative stress can prevent or induce apoptosis. It occurs via S-nitrosylation by the interaction of nitric oxide (NO) with the biological thiols of proteins. Cellular redox potential and non-heme iron content determine S-nitrosylation. Apoptotic cell death is inhibited by S-nitrosylation of the redox-sensitive thiol in the catalytic site of caspase family proteases, which play an essential role in the apoptotic signal cascade. Nitrosative stress can also promote apoptosis by the activation of mitochondrial apoptotic pathways, such as the release of cytochrome c, an apoptosis-inducing factor, and endonuclease G from mitochondria, as well as the suppression of NF-${\kappa}B$ activity. In this article we reviewed the mechanisms whereby S-nitrosylation and nitrosative stress regulate the apoptotic signal cascade.

• 한국의학물리학회지:의학물리
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• 제10권1호
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• pp.9-15
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• 1999

혈액에서의 산소 포화도는 Hb와 HbO$_2$의 광학 스펙트라에서 흡수계수의 차이에 의해서 측정할 수 있다. 본 연구는 하지 조직에서 발생하는 말초혈관계 질환진단을 위하여 파장이 660nm 와 940nm의 LED를 이용하여 산소포화도를 측정하는 장치를 개발하였다. 산소측정장치는 광 탐촉자와 광 신호처리부, LED 구동회로, 컴퓨터와 인터페이스로 구성하고, 데이터의 수집과 분석을 위한 프로그램 을 개발하였다. 구현된 산소측정장치에 대한 임상적인 평가를 위하여 하지조직에서 운동 부하에 따른 실험을 하여 생체조직내 생리적변화에 따른 산소량의 변화를 측정하고, 기기의 성능을 평가하였다. 실험결과 생체조직내의 산소포화도는 광원과 검출기의 간격에 따라 측정이 가능함을 보여 주었다.

• Applied Microscopy
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• 제21권1호
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• pp.86-107
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• 1991

An experimental study was performed to observe the early effects of monocrotaline on pulmonary vascular system by means of light microscopy and scanning electron microscopy, attempting to expore the mechanism behind the process of pulmonary hypertension. Experimental animal(Sprague-Dawley male rats ; 150-200g B. W.) were intra-peritoneal administered with 100mg/kg B. W. monocrotaline. Authors observed light microscopically various gradational increase of wall thickness in pulmonary muscular and non-muscular arteries in duration from 2 weeks to 5 weeks after monocrotaline administration and the changes were more sever in the latter than the former. The scanning electron microscopy shows severe and diffuse endothelical cell swelling, microvilli and microbleb formation since 1 hour after monocrotaline administration and during the course, after 5 hours the severity of endothelial cell damage was prominent with presence of fibrin, webs, platelet thrombi and white cell adherence. It was concluded that the monocrotaline primarily induced severe and diffuse endothelial cell damage of pulmonary arteries and laterly added the participation of platelets, which attributed to the pathogenesis of monocrotaline induced pulmonary vascular lesions in relation to pulmonary hypertension.

• 대한정형외과 초음파학회지
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• 제3권2호
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• pp.69-73
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• 2010

슬관절 주변부에 발생한 골연골종은 간혹 혈관 합병증을 동반하기도 한다. 혈관 합병증을 진단하기 위해 혈관 조영술이 보편적으로 사용되고 있으나 침습적 검사라는 단점이 있고 최근에는 비침습적 검사로 자기공명 혈관 조영술이 이용되기도 하나 고가의 검사라는 제한점이 있다. 저자들은 원위 대퇴골에 발생한 골연골종에 의해 슬와동맥이 압박되었던 20세 남자를 도플러 초음파를 사용하여 진단 및 치료결과를 평가하였기에 문헌고찰과 함께 도플러 초음파의 유용성을 보고하고자 한다.

• 대한한의진단학회지
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• 제17권3호
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• pp.241-252
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• 2013

Objectives The purpose of this study was to investigate the effects of walking exercise on diabetes mellitus indicator and vascular compliance of type 2 diabetes mellitus adults. Methods The subjects were 2 groups; exercise group(n=11, $age=57.36{\pm}8.74$), non-exercise group(n=10, $age=59.20{\pm}5.81$). Walking exercise five or more times a week, and more than 10,000 steps per day with writing the walking diary ordered to the exercise group. For date analysis, mean and standard deviation scores were calculated, and independent t-test was performed. Result After 45 days of walking exercise, weight (p <.01), abdominal obesity rate (p <.05), body fat mass (p <.05) showed significant difference between the groups. but diabetes indicators and vascular compliance tend to decreased in the exercise group, there was no significant difference between the groups. Conclusions Walking exercise is effective in improving body composition.

• Journal of Cerebrovascular and Endovascular Neurosurgery
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• 제26권1호
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• pp.79-84
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• 2024

Intracranial non-galenic pial arteriovenous fistula (PAVF) is an extremely rare vascular malformation, where one or more pial arteries feeds directly into a cortical vein without any intervening nidus. Though occasionally they can be asymptomatic, neurological symptoms such as headache, seizure, or focal neurological deficit are more common presenting features. Life threatening or fatal hemorrhage is not uncommon, hence needed to be treated more often than not. Spontaneous occlusion of PAVF is reported only four times before. We report a 49-year-old gentleman, who was diagnosed to have a PAVF, possibly secondary to trauma. He presented 5 months and 22 days from initial digital subtraction angiography (DSA) for treatment, and follow-up angiogram showed complete obliteration. He denied any significant event, medication or alternate treatment during this period. His clinical symptoms were stable as well. We postulate iodinated contrast medium induced vasculopathy as a possible cause, which has been described for other vascular pathologies, but never for PAVF.