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Regulation of Apoptosis by Nitrosative Stress

  • Kim, Ki-Mo (Vascular System Research Center, Kangwon National University) ;
  • Kim, Peter K.M. (Department of Surgery, School of Medicine, University of Pittsburgh) ;
  • Kwon, Young-Guen (Vascular System Research Center, Kangwon National University) ;
  • Bai, Se-Kyung (Department of Food and Nutrition, Division of Natural Sciences, Hallym University) ;
  • Nam, Woo-Dong (Department of Orthopaedic Surgery, School of Medicine, Kangwon National University) ;
  • Kim, Young-Myeong (Vascular System Research Center, Kangwon National University)
  • Published : 2002.01.31
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Abstract

Nitrosative stress can prevent or induce apoptosis. It occurs via S-nitrosylation by the interaction of nitric oxide (NO) with the biological thiols of proteins. Cellular redox potential and non-heme iron content determine S-nitrosylation. Apoptotic cell death is inhibited by S-nitrosylation of the redox-sensitive thiol in the catalytic site of caspase family proteases, which play an essential role in the apoptotic signal cascade. Nitrosative stress can also promote apoptosis by the activation of mitochondrial apoptotic pathways, such as the release of cytochrome c, an apoptosis-inducing factor, and endonuclease G from mitochondria, as well as the suppression of NF-${\kappa}B$ activity. In this article we reviewed the mechanisms whereby S-nitrosylation and nitrosative stress regulate the apoptotic signal cascade.

Keywords

References

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