• Journal of Korean Critical Care Nursing
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• v.15 no.1
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• pp.35-46
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• 2022

Purpose : This study aimed to identify the factors affecting coronavirus disease 2019 (COVID-19) infection control practices of nurses in negative pressure isolation rooms. Methods : The participants were 150 nurses working in three hospitals with negative pressure isolation rooms. Data were collected using structured questionnaires and analyzed using an independent t-test, one-way ANOVA, Scheffé test, Pearson correlation coefficients, and multiple regression analysis using the SPSS/WIN 26.0 program. Results : Factors significantly influencing the subject's COVID-19 infection control practice include Being married (𝛽=.18, p =.016), working in a ward with negative pressure isolation rooms (𝛽=.44, p <.001), working in an ICU with negative pressure isolation rooms (𝛽=.27, p =.010), COVID-19 infection control attitude (𝛽=.28, p =.001), anxiety for COVID-19 (𝛽=.30, p <.001). The explanatory power of these variables for COVID-19 infection control practice was 24.6% (F=8.67, p <.001). Conclusion : It is expected that strategies that utilize positive attitudes which believe that COVID-19 disease may be overcome by COVID-19 infection control practice will help improve emerging infectious diseases infection control practice.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.8
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• pp.240-249
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• 2019

This study was conducted to examine the effects of awareness of infection control, career decision making self efficacy and critical thinking disposition on the performance of infection control among nursing students. The study subjects were 404 third and fourth year nursing students at 4 colleges in D and K cities. The data were collected from November 5 to December 21, 2018 by using a structured questionnaire. The data were analyzed by using the SPSS WIN 17.0 program to conduct descriptive statistics, independent t-test, one-way ANOVA, post-hoc Duncan's test, Pearson's correlation coefficients, and multiple regression. The average score of awareness of infection control was 4.75 points, career decision making self efficacy was 3.02 points, critical thinking disposition was 4.73 points and performance of infection control was 4.46 points. Performance of infection control was positively influenced by age, awareness of infection control and career decision making self efficacy. The explanatory power of the model was 38.6%. Therefore, these results imply the need to develop an education program to improve the awareness of infection control and career decision making self efficacy, which will enhance the performance of infection control of nursing students.

• Journal of Korean society of Dental Hygiene
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• v.14 no.4
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• pp.463-470
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• 2014

Objectives : The purpose of this study was to investigate the association factors of infection control practice based on health belief model in the dental hygienists in dental clinics. Methods : A self-reported questionnaire was filled out by 278 dental hygienists in 160 dental clinics in Gwangju by a proportional stratified sampling method from September 13 to October 7, 2013. Data were analyzed by t-test, ANOVA, correlation analysis, and multiple regression analysis using SPSS version 12.0. Results : In multiple regression analysis, practice scores were significantly higher in aged dental hygienists and those who took infectious disease history from the patients before treatment. With regard to health belief model, perceived barrier was negatively associated with the practice(${\beta}$=-.16, p<.001), importance of infection control in hand hygiene(${\beta}$=.14, p=.026), and use of personal protective equipment(${\beta}$=.17, p=.043). The intention of action was positively associated with the practice(${\beta}$=.13, p=.002). Conclusions : This study will provide the basic evidence for the quality improvement of infection control and prevention. So the dental hygienists will be able to put into practice in infection control management.

• Journal of Advanced Technology Convergence
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• v.2 no.3
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• pp.25-32
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• 2023

This study was conducted to find out the relationship between knowledge and attitudes about COVID-19 and infection control performance among college students in paramedicine. The subjects of the study were 154 university students attending a 3-4 year paramedicine located in Gwangju Metropolitan City, Jeollabuk-do Province, and the collected data were frequency, percentage, sum, average and It was analyzed by standard deviation, t-test, ANOVA(Scheffe), Pearson's Correlation Coefficient, and Multiple Linear Regression. The order of attitude and knowledge about COVID-19 affected the infection control performance of college students in the paramedicine. Therefore, it is necessary to develop and apply regular or non-regular curriculum and multidisciplinary curriculum that can improve knowledge and attitudes about COVID-19 in order to improve the infection control performance of paramedic students.

• Journal of the Korean Applied Science and Technology
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• v.41 no.1
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• pp.119-127
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• 2024

The purpose of this study is a descriptive research study to identify the factors affecting the performance of infection control by general hospital nurses' empowerment and job burnout. The subjects collected data from September 15 to October 31, 2023 from a total of 210 nurses at a general hospital located in D city. The collected data were analyzed using descriptive statistics, t-test, ANOVA, Sheffe, Pearson's correlation, and multiple regression using the SPSS/WIN 25.0 program. As a result of the study, empowerment and infection control performance showed a positive correlation, and empowerment was analyzed as the most influential factor in infection control performance with 14.8% of explanatory power. Therefore, it is necessary to reflect programs and policies to efficiently perform infection control that can improve the empowerment of nurses.

• IMMUNE NETWORK
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• v.11 no.5
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• pp.245-252
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• 2011

Antimicrobial peptides/proteins are ancient and naturally-occurring antibiotics in innate immune responses in a variety of organisms. Additionally, these peptides have been recognized as important signaling molecules in regulation of both innate and adaptive immunity. During mycobacterial infection, antimicrobial peptides including cathelicidin, defensin, and hepcidin have antimicrobial activities against mycobacteria, making them promising candidates for future drug development. Additionally, antimicrobial peptides act as immunomodulators in infectious and inflammatory conditions. Multiple crucial functions of cathelicidins in antimycobacterial immune defense have been characterized not only in terms of direct killing of mycobacteria but also as innate immune regulators, i.e., in secretion of cytokines and chemokines, and mediating autophagy activation. Defensin families are also important during mycobacterial infection and contribute to antimycobacterial defense and inhibition of mycobacterial growth both in vitro and in vivo. Hepcidin, although its role in mycobacterial infection has not yet been characterized, exerts antimycobacterial effects in activated macrophages. The present review focuses on recent efforts to elucidate the roles of host defense peptides in innate immunity to mycobacteria.

• IMMUNE NETWORK
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• v.13 no.5
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• pp.168-176
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• 2013

In the last few years major progress has been made in better understanding the role of natural killer (NK) cells in hepatitis C virus (HCV) infection. This includes multiple pathways by which HCV impairs or limits NK cells activation. Based on current genetic and functional data, a picture is emerging where only a rapid and strong NK cell response early on during infection which results in strong T cell responses and possible subsequent clearance, whereas chronic HCV infection is associated with dysfunctional or biased NK cells phenotypes. The hallmark of this NK cell dysfunction is persistent activation promoting ongoing hepatitis and hepatocyte damage, while being unable to clear HCV due to impaired IFN-${\gamma}$ responses. Furthermore, some data suggests certain chronically activated subsets that are $NKp46^{high}$ may be particularly active against hepatic stellate cells, a key player in hepatic fibrogenesis. Finally, the role of NK cells during HCV therapy, HCV recurrence after liver transplant and hepatocellular carcinoma are discussed.

• Pediatric Infection and Vaccine
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• v.23 no.2
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• pp.137-142
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• 2016

Severe cytomegalovirus (CMV) infection involving multiorgan is very rare except in very low-birth weight infants, or in immunocompromised pediatric patients. We report an unusual case of severe CMV infection involving multiple organs including the central nervous system, liver, lung, and gastrointestinal tract in a late-preterm infant at 2 months of age.

• IMMUNE NETWORK
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• v.23 no.5
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• pp.41.1-41.21
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• 2023

CD4 and CD8 T cells are key players in the immune response against both pathogenic infections and cancer. CD4 T cells provide help to CD8 T cells via multiple mechanisms, including licensing dendritic cells (DCs), co-stimulation, and cytokine production. During acute infection and vaccination, CD4 T cell help is important for the development of CD8 T cell memory. However, during chronic viral infection and cancer, CD4 helper T cells are critical for the sustained effector CD8 T cell response, through a variety of mechanisms. In this review, we focus on T cell responses in conditions of chronic Ag stimulation, such as chronic viral infection and cancer. In particular, we address the significant role of CD4 T cell help in promoting effector CD8 T cell responses, emerging techniques that can be utilized to further our understanding of how these interactions may take place in the context of tertiary lymphoid structures, and how this key information can be harnessed for therapeutic utility against cancer.

• Urogenital Tract Infection
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• v.13 no.3
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• pp.58-65
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• 2018

Purpose: This study aimed to investigate the relationship between uropathogens of infants with febrile urinary tract infection (UTI) and vesicoureteral reflux (VUR). Materials and Methods: We analyzed 308 infants hospitalized for febrile UTI between January 2010 and December 2015, and assessed the voiding cystourethrography (VCUG). The medical records, including clinical symptoms, laboratory findings, urinalysis, urine culture tests, ultrasound (US), dimercaptosuccinic acid scan, and VCUG, were retrospectively obtained. The incidences of VUR and high-grade VURs (III, IV, and V) were analyzed in 4 groups categorized by uropathogens and renal US findings. Results: The mean age of 308 infants was $3.29{\pm}2.18months$. The male-to-female ratio was 3.46:1. In urine culture tests, 267 infants (86.69%) showed single bacterial uropathogen; Escherichia coli in 241 infants (78.25%) and non-E. coli uropathogens in 26 infants (8.44%). Multiple distinctive microorganisms were identified as causative uropathogens in 41 infants (13.31%). Abnormal findings of US and VCUG were identified in 216 and 64 patients, respectively. In 308 infants, the incidences of VUR and high-grade VUR were not different among the 4 groups. In 239 male infants, the incidences of high-grade VUR were higher in patients with non-E. coli single or multiple uropathogen and with abnormal US findings (p=0.042). Conclusions: In male infants with non-E. coli uropathogen or multiple uropathogens and with abnormal US findings at febrile UTI, there was an increased chance of finding high-grade VURs on subsequent VCUG tests.