• 한국산업보건학회지
• /
• 제11권2호
• /
• pp.111-117
• /
• 2001

A cross-sectional study was performed to evaluate associations between lead biomarkers, lead-related symptoms, and ${\delta}$-aminolevulinic acid dehydratase (ALAD) genotype among 598 lead workers and 144 control office workers in storage battery industries, secondary smelting and litharge making industries. Lead inhibits the second enzymes, ALAD, in the heme synthesis pathway. ALAD gene, which codes for one of three isozymic proteins (termed ALAD1-1, ALAD1-2, and ALAD2-2), seems to modify the toxicokinetics of lead. The result as follows; The percents of total workers whose genotype of ALAD1-1 and ALAD1-2 were 88.4% and 11.6%, respectively. The zinc protoporphyrin in blood (ZPP) and ${\delta}$-aminolevulinic acid in urine (ALAU) of lead workers with ALAD1-2 were significantly lower than those of lead workers with ALAD1-1, but there were no significant difference between two genotype for blood lead, age, and work duration. The proportion of ALAD1-2 genotype in control office workers was 13.2%. The proportions of ALAD1-2 genotype of lead workers were 14.0%(their mean air lead level below $0.024mg/m^3$), 10.4%($0.025-0.049mg/m^3$), 11.8%($0.050-0.099mg/m^3$), and 9.4%(above $0.100mg/m^3$), respectively. In the logistic analysis of 15 lead related symptoms, 'arthralgia'(S7) symptom of ALAD1-2 was significantly lower (OR=0.481; 95% CI=0.248-0.932) than that of ALAD1-1, but 'feeling of irritation'(S11) of ALAD1-2 was significantly higher(OR=1.636; 95% CI=1.035-2.586) than that of ALAD1-1 after controlling possible confounder (blood lead, work duration, smoking and drinking habit).

• 생명과학회지
• /
• 제22권4호
• /
• pp.545-551
• /
• 2012

중년 비만여성들을 대상으로 다리 근육의 정맥 혈류를 제한한 가압 걷기 트레이닝 그룹 15명으로 연구대상자를 선정하여 3주간의 가압 걷기 트레이닝을 실시한 결과 다음과 같은 결론을 얻었다. 첫째, 가압 걷기 트레이닝을 통해 LBM에서 트레이닝 전보다 후에 1.2 kg이 증가, FM과 %fat에서는 각각 2.8 kg, 3.3% 감소하였으며, 통계적으로도 유의한 차이를 나타냈다($p$<0.05). 둘째, 가압 걷기 트레이닝을 통해 $VO_2max$와 VEmax에서 트레이닝 전보다 후에 각각 3.6 ml/kg/min, 6.0 l/min 증가하였고, HRmax에서는 7 beat/min으로 감소하였으며 통계적으로도 유의한 차이를 나타냈다($p$<0.05). 셋째, 가압 걷기 트레이닝을 통해 심혈관 반응에서 트레이닝 전보다 후에서 운동 강도가 증가함에 따라 CO과 TVC가 증가하는 것으로 나타났으며, 통계적으로도 유의한 차이를 나타냈다($p$<0.05). 이상의 결과로부터 가압 걷기 트레이닝을 통해서 호흡 순환계 및 심혈관 기능의 증가와 근육량 증가에 따른 체성분의 변화를 유발할 수 있다는 것을 제시하였다. 본 연구의 결과를 토대로 향후 연구에서는 연구대상자의 범위를 넓혀 노년층까지 효과를 검증하는 연구와 3주 이상의 운동을 적용시키면 보다 높은 임상학적 효과가 나타날 것으로 판단된다.

• 대한예방한의학회지
• /
• 제17권3호
• /
• pp.155-164
• /
• 2013

Purpose : This study was conducted to assess whether Korean medicine doctors' attire influences patients' preference (confidence, comfortability, neatness) in a university hospital. Materials and Methods : Employing a cross-sectional design, outpatients answered a questionnaire in a university hospital of Korean Medicine. Respondents were asked for completing the questionnaire to estimate their preference of doctor's attire for confidence, comfortability and neatness after watching 4 types of attire in both male and female Korean medicine doctors, including white coat, traditional attire, formal suit and casual clothes. Whether Korean medicine doctors' attire on a patients' preference is important was also asked for the respondents using a 5-point Likert scale. Results : All 175 patients were enrolled, of whom 38.9% were male respondents, 46.3% graduated from a university at least and mean age of responders was 47.1. Most had a tendency for preferring white coat followed by traditional attire and only a small portion of respondents preferred for formal suit and casual clothes. When comparing preferences in confidence between white coat and traditional attire only, male patients preferred white coat more than female patients did with statistical significance. In addition, 85.4% of respondents answered that Korean medicine doctors' attire is important to a clinical situation with higher ratio of female respondents (87.9%) than male respondents (80.9%). Conclusion : Patients preferred white coat and traditional attire mostly for the Korean Medicine doctor's attire with only small preference for formal suit and casual clothes. Also, Patients recognized that Korean medicine doctors' attire is important in the clinical situation.

• 한국산학기술학회논문지
• /
• 제15권1호
• /
• pp.367-376
• /
• 2014

이 연구의 목적은 건강한 남자 14명을 대상자로 단기간의 지구성 훈련과 지구성 운동에 웨이트 운동을 병행한 복합훈련이 골격근 섬유의 형태 및 골격근 내 산화적 효소의 활성도에 미치는 영향을 구명하고자 하였다. 지구성 트레이닝 집단은 최대심박수의 70~80% 에서 40분간 자유형으로 수영을 6주간 실시하였으며 복합 트레이닝 집단은 동일한 수영을 실시한 후 웨이트 트레이닝을 추가로 실시하였다. 근섬유 횡단면적에 있어 복합훈련 집단과 지구성 훈련 집단 간에 차이가 나타나지 않았으며 훈련기간에 따라 복합훈련 집단에서 지구성 훈련 집단보다 증가한 것으로 나타났다. 모세혈관 수에 있어서도 집단 간 차이는 나타나지 않았으며 훈련기간에 따라 복합훈련 집단에서 지구성 훈련 집단보다 증가한 것으로 나타났다. 유산소성 대사 효소 중 CS, ${\beta}$-HAD 그리고 CPT의 활성도는 훈련형태에 따른 차이는 통계적으로 나타나지 않았으나 복합훈련 집단에서 지구성 훈련 집단에서 보다 더 큰 증가의 폭을 나타냈다. 이와 같은 결과를 종합해 볼 때 유산소성 훈련만을 실시할 때 보다 유 무산소 운동이 복합적으로 구성되어 있는 훈련의 수행이 근섬유의 에너지 대사 관련 효소들의 활성도 증가와 근 세포 모세혈관의 발달에 보다 효과적이라는 결론을 도출할 수 있었다.

• 대한지역사회영양학회지
• /
• 제17권5호
• /
• pp.664-675
• /
• 2012

This study was conducted to investigate the cross-sectional associations between dietary factors and the risk of metabolic syndrome (MetS) in 12,755 subjects (males 5,146, females 7,609) aged 19 years or above using data from the 4th (2007-2009) Korea National Health and Nutrition Examination Survey (KNHANES). The prevalence of MetS in Korean adults was 23.6% (males 26.1%, females 20.9%) with the criteria for modified National Cholesterol Education Program Adult Treatment Panel III. While males had a higher prevalence of abdominal obesity, hyperglycemia, hypertriglyceridemia, and high blood pressure than females, the prevalence of low HDL-cholesterol level was higher in females than in males. Among dietary guidelines, the response of 'yes' for asking practice of 'avoiding salty foods', and 'eating moderately and increasing physical activity for healthy weight' were significantly associated with the decreased risk of MetS in both males and in females. Especially, the risk of MetS was significantly lower in the subjects that responded the practice of all items of Korean Dietary Guidelines. Significantly negative associations with MetS were also found in the responding for practice of 'limiting consumption of alcoholic beverages' in males, and taking dietary supplements in females. Skipping breakfast was positively associated with the risk of MetS. In conclusion, dietary behaviors such as having breakfast, practice of dietary guidelines, and food consumption in moderation could modify the prevalence of MetS, and our findings could be useful for establishing guidelines for preventing MetS.

• 디지털융복합연구
• /
• 제13권8호
• /
• pp.357-368
• /
• 2015

대한방사선사협회에 등록이 되었고 현재 근무를 하는 방사선사 213명을 대상으로 방사선사의 직무만족도를 높이기 위한 융복합요인과 직무스트레스를 낮추기 위한 기초자료로 제공하고자 하였다. 일반적특성, 직무특성, 직무스트레스, 직무만족도를 포함한 총 105문항의 설문지를 통하여 자료를 수집하였다. 직무만족도는 심리적요인, 환경적요인, 구조적요인으로 구분하였으며, 직무스트레스는 물리환경, 직무요구, 직무자율성 결여, 관계갈등, 직무불안정, 조직체계, 보상부적절, 직장문화로 구분하였다. 심리적요인은 학력이 높을수록, 근무처가 서울에 있는 경우, 사명감을 많이 느끼는 경우, 이직의도가 없는 경우 직무불안정의 스트레스가 낮을수록 직무만족도가 높았다. 환경적요인은 급여가 낮은 그룹이 직무만족도가 높았다. 구조적요인은 사명감이 높을수록, 이직의도가 없는 경우, 조직체계 및 보상 부적절, 직장문화에 대한 스트레스가 낮을수록 직무만족도가 높았다. 전체 만족도는 사명감이 높을수록, 이직의도가 없는 사람, 보상부적절, 직장문화에 대한 스트레스가 높을수록 직무만족도가 낮았다. 방사선사의 안정적인 일자리 제공과 적절한 보상 및 조직문화에 관련된 제도가 필요하다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권19호
• /
• pp.8063-8067
• /
• 2014

Background: Cervical cancer is a major public health problem in Bangladesh. Persistence of high risk human papillomavirus (HRHPV) influences the progression of the disease, with an important role in followup for cervical intraepithelial neoplasia (CIN). Objective: To establish application of high risk HPV DNA test in the follow-up of women after treatment of CIN. Materials and Methods: This cross-sectional and hospital based study was carried out among 145 CIN treated women during the previous six months to three years at the colposcopy clinic of Bangabandhu Sheikh Mujib Medical University, Dhaka, between January 2011 and June 2012. Pap smear and HPV samples were collected and colposcopy was performed to find out the persistence of the disease. Cervical samples obtained were tested for HPV DNA using the Hybrid Capture II (HC-II) test. A cervical biopsy was collected whenever necessary. The results were compared to assess the efficacy of different methods during follow up such as Pap smear, HPV test and colposcopy. Results: Mean age of the recruited women (n=145) was 33.6 (${\pm}7.6$), mean age of marriage was 16.8 (${\pm}2.9$) and mean age of 1st delivery was 18.8 (${\pm}3.5$) years. More than half had high grade CIN before treatment and 115 (79.3%) women were managed by LEEP and 20.7% were managed by cold coagulation. Among the 145 treated women, 139 were negative for HPV DNA and six of them (4.1%) were HPV positive. Sensitivity of Pap smear (40.0) and HPV DNA test (40.0) was poor, but specificity was quite satisfactory (>93.0) for all the tests. Conclusions: The high risk HPV DNA test can be an effective method of identifying residual disease. It can be added to colposcopy and this should be applied to all treated women attending for their first or second post-treatment follow-up visit at 6 months to one year, irrespective of the grade of treated CIN.

• 한국환경보건학회지
• /
• 제42권4호
• /
• pp.235-245
• /
• 2016

Objectives: This study estimated the adult Korean daily intake of acrylamide (AA) and investigated its relationship with demographic, lifestyle and dietary habits by using urinary concentrations of N-acetyl-S-(2-carbamoylethyl)-cysteine (AAMA). Methods: Human data (n=1870) was collected in a nationwide cross-sectional biomonitoring program representing the population (18-69 years) residing in South Korea. Urinary AAMA was analyzed with a LC-MS/MS system. Daily intakes of AA were estimated using mass daily AAMA, which was calculated through urinary AAMA concentration and daily creatinine excretion. Statistical analysis was performed with SAS procedures for calculating geometric means, confidence intervals and the exponentiated beta coefficient of multiple linear regressions. Results: Daily intake of AA was estimated at $0.475{\mu}g/kg$ body weight (BW) per day (95% confidence interval (CI): 0.447-0.503). In the case of current smokers, AA intake was $0.957{\mu}g/kg$ BW per day (95% CI: 0.847-1.067), which was significantly higher than that of former smokers and never smoked (p<0.0001). The strong affecting factors were age (95% CI: 0.68-1.14; p=0.0180), education level (95% CI: 1.05-1.42; p=0.0163), body mass index (BMI) (95% CI: 1.00-1.82; p<0.0001), and smoking status (95% CI: 0.97-3.05; p<0.0001). Korean dietary habits increasing AA intake were coffee (p=0.0005), cup noodles (p=0.0010) and canned foods (p=0.0005). Meanwhile, foods decreasing AA intake were fresh fruit (p=0.0076), cooked beef (p=0.0335) and cooked pork (p=0.0147). Conclusion: The Korean daily intake of AA in adults was estimated to be similar with those found in developed countries. The factors increasing daily AA intake were coffee, cup noodles and canned foods, and decreasing factors were fresh fruit, cooked beef and cooked pork.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권5호
• /
• pp.2565-2571
• /
• 2016

A cross-sectional survey was conducted among 730 participants from 4 rural districts of Nakhon Ratchasima province, Thailand, with a reported high incidence of liver fluke infection. This study was aimed to examine and evaluate the nutritional status in relation to Opisthorchis viverrini infection. Participants were purposive selected from Chum Phuang, Mueang Yang, Bua Yai, and Kaeng Sanam Nang districts. Stool samples were prepared by Kato Katz technique and then assessed by microscopy. Anthropometry was evaluated according to the body mass index from weight and height. Descriptive statistics and Spearman rank correlation coefficients were used to evaluate the association between the nutritional status and O. viverrini infection. Of 1.64% infected with O. viverrini the highest proportions were found in age groups ${\geq}61$ and 41-50 years old, Mueang Yang district. The majorities of participants had normal weight (32.2%), followed by class II obesity (28.1 %), class I obesity (21.8%), underweight (10.3%), and class III obesity (8.63%). Nutritional status with class II obesity (rS=0.639, p<0.01) and class I obesity (rS=0.582, p<0.05), had moderately statistical significant correlations with O. viverrini infection. Meanwhile, normal weight (rS=0.437, p<0.05) and class III obesity (rS=0.384, p<0.05) demonstrated lower statistical significance. These findings raise the possibility that infection with O. viverrini may contribute to fat deposition and thereby have long-term consequences on human health. Further studies are needed to better understand whether O. viverrini contributes directly to fat deposition and possible mechanisms.

• 한국전통조경학회지
• /
• 제33권4호
• /
• pp.129-139
• /
• 2015

본 연구는 중국 북경시의 대표적인 성곽역사공원인 황성근성곽역사공원(皇城根城墻遺址公園), 명성곽역사공원(明城墻遺址公園), 원대도성곽역사공원(元大都城墻遺址公園)을 중심으로 성곽 역사공원의 조성방식을 분석하여 문제점과 시사점을 찾는데 목적이 있다. 이를 위해 문헌과 현장조사를 통해 성곽 역사공원의 일반적 개념을 정의하고 북경성의 변천과정을 규명하여 북경시 성곽역사공원의 조성방식을 분석하였다. 그리고 각 공원의 구체적인 정책, 조성과정, 공간계획, 경관구 테마설정, 식재 등을 분석한 결과 성곽역사공원의 조성에 있어 입지 환경을 적절히 활용하지 못하였으며 테마경관구 역시 성곽유적의 역사성과 적합하게 조성되지 못하는 등 문제점이 도출되었다. 연구 결과 성곽역사공원의 조성은 성곽 유적을 대상으로 하는 유적에 관한 보호 및 관리계획, 역사공원에 관한 활용 및 운영계획 등 전문적이고 다차원적인 제도가 필요하며 성곽의 특성상 타 문화재에 비해 조성 면적이 넓기 때문에 공원조성을 위한 토지매입비용 등 사업비가 많이 드는 특징을 갖고 있어서 정부의 적극적인 재정 지원이 필요하다. 또한, 성곽역사공원의 계획을 수립하기 전에 대상지의 자연환경 및 시설현황을 면밀히 분석하여 최대한 활용하고 공간간의 원활한 연결을 통한 공간이용의 효율성을 제고하여야 한다. 아울러 타 시설과의 조화 및 시설물 상호간의 연계성을 가지도록 하여야 하며 형태 및 색채, 재료 등을 고려하여 계획하여야 한다. 그리고 성곽역사공원 조성 계획 수립 후 향후 개발여건 변화에 능동적인 대처가 가능하도록 고려되어야 한다.