• 한국산업정보학회논문지
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• 제14권4호
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• pp.143-152
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• 2009

본 논문은 철강산업의 R&D 역량강화를 위해 IT 부문이 지원할 수 있는 정책을 모색하고 이에 대한 타당성을 검증한 사례연구이다. 기술추격형에서 기술선도형으로의 전환기에 놓여있는 국내 철강산업이 R&D 역량을 강화하기 위해서는 개별 철강사뿐만 아니라 대학, 연구소 등 외부와 개방형 R&D 연계체제를 적극 추진해야 한다. 이러한 상황 하에서 IT가 R&D 역량 강화를 효과적으로 지원하는 역할을 수행해야 한다. 본 연구에서는 이러한 목적을 갖는 IT 분야의 지원정책들을 개발하고 우선순위분석 등을 통해 제안된 정책들의 타당성을 검토하며, Triple Helix관점에서 정부, 기업, 학계의 역할을 논의한다.

• BMB Reports
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• 제56권7호
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• pp.374-384
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• 2023

Fibrosis is a pathological condition that is characterized by an abnormal buildup of extracellular matrix (ECM) components, such as collagen, in tissues. This condition affects various organs of the body, including the liver and kidney. Early diagnosis and treatment of fibrosis are crucial, as it is a progressive and irreversible process in both organs. While there are certain similarities in the fibrosis process between the liver and kidney, there are also significant differences that must be identified to determine molecular diagnostic markers and potential therapeutic targets. Long non-coding RNAs (lncRNAs), a class of RNA molecules that do not code for proteins, are increasingly recognized as playing significant roles in gene expression regulation. Emerging evidence suggests that specific lncRNAs are involved in fibrosis development and progression by modulating signaling pathways, such as the TGF-β/Smad pathway and the β-catenin pathway. Thus, identifying the precise lncRNAs involved in fibrosis could lead to novel therapeutic approaches for fibrotic diseases. In this review, we summarize lncRNAs related to fibrosis in the liver and kidney, and propose their potential as therapeutic targets based on their functions.

• Structural Engineering and Mechanics
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• 제89권1호
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• pp.23-31
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• 2024

Ratcheting is the cyclic buildup of inelastic strain on a structure resulting from a combination of primary and secondary cyclic stress. It can lead to excessive plastic deformation, incremental collapse, or fatigue. Ratcheting has been numerically investigated on a cantilever beam, considering the current study's primary and secondary bending loads. In addition, the effect of input frequency on the onset of ratcheting has been investigated. The non-linear dynamic elastic-plastic approach has been utilized. Analogous to Yamashita's bending-bending ratchet diagram, a non-dimensional ratchet diagram with a frequency effect is proposed. The result presents that the secondary stress values fall sequentially with the increase of primary stress values. Moreover, a displacement amplification factor graph is also established to explain the effect of frequency on ratchet occurrence conditions. In terms of frequency effect, it has been observed that the lower frequency (0.25 times the natural frequency) was more detrimental for ratchet occurrence conditions than the higher frequency (2 times the natural frequency) due to the effect of dynamic displacement. Finally, the effect of material modeling of ratcheting behavior on a beam is shown using different hardening coefficients of kinematic hardening material modeling.

• 한국의학물리학회지:의학물리
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• 제25권2호
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• pp.65-71
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• 2014

A Varian Portal Dosimetry system was compared to an isocentrically mounted MapCHECK 2 diode array for volumetric modulated arc therapy (VMAT) QA. A Varian TrueBeam STx with an aS-1000 digital imaging panel was used to acquire VMAT QA images for 13 plans using four photon energies (6, 8, 10 and 15 MV). The EPID-based QA images were compared to the Portal Dose Image Prediction calculated in the Varian Eclipse treatment planning system (TPS). An isocentrically mounted Sun Nuclear MapCHECK 2 diode array with 5 cm water-equivalent buildup was also used for the VMAT QAs and the measurements were compared to a composite dose plane from the Eclipse TPS. A ${\gamma}$ test was implemented in the Sun Nuclear Patient software with 10% threshold and absolute comparison at 1%/1 mm (dose difference/distance-to-agreement), 2%/2 mm, and 3%/3 mm criteria for both QA methods. The two-tailed paired Student's t-test was employed to analyze the statistical significance at 95% confidence level. The average ${\gamma}$ passing rates were greater than 95% at 3%/3 mm using both methods for all four energies. The differences in the average passing rates between the two methods were within 1.7% and 1.6% of each other when analyzed at 2%/2 mm and 3%/3 mm, respectively. The EPID passing rates were somewhat better than the MapCHECK 2 when analyzed at 1%/1 mm; the difference was lower for 8 MV and 10 MV. However, the differences were not statistically significant for all criteria and energies (p-values >0.05). The EPID-based QA showed large off-axis over-response and dependence of ${\gamma}$ passing rate on energy, while the MapCHECK 2 was susceptible to the MLC tongue-and-groove effect. The two fluence-based QA techniques can be an alternative tool of VMAT QA to each other, if the limitations of each QA method (mechanical sag, detector response, and detector alignment) are carefully considered.

• 해양환경안전학회지
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• 제24권3호
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• pp.352-359
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• 2018

As a fuel for ship propulsion, liquefied natural gas (LNG) is currently considered a proven and reasonable solution for meeting the IMO emission regulations, with gas engines for the LNG-fueled ship covering a broad range of power outputs. For an LNG-fueled ship, the LNG bunkering process is different from the HFO bunkering process, in the sense that the cryogenic liquid transfer generates a considerable amount of boil-off gas (BOG). This study investigated the effect of the temperature difference on boil-off gas (BOG) production during ship-to-ship (STS) LNG bunkering to the receiving tank of the LNG-fueled ship. A concept design was resumed for the cargo/fuel tanks in the LNG bunkering vessel and the receiving vessel, as well as for LNG handling systems. Subsequently, the storage tank capacities of the LNG were $4,500m^3$ for the bunkering vessel and $700m^3$ for the receiving vessel. Process dynamic simulations by Aspen HYSYS were performed under several bunkering scenarios, which demonstrated that the boil-off gas and resulting pressure buildup in the receiving vessel were mainly determined by the temperature difference between bunkering and the receiving tank, pressure of the receiving tank, and amount of remaining LNG.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 1999년도 가을 학술발표회 논문집
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• pp.271-278
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• 1999

Soil filters are commonly used to protect the soil structures from eroding and piping. When filters are clogged by fine particles which are progressively accumulated, these may lead to buildup of excessive pore pressures also leading to instability in subsurface infrastructure. A filter in the backfill of a retaining wall, a filter adjacent to the lining of a tunnel, or a filter in the bottom of an earth dam can be clogged by transported fine particles. This causes reduction in the permeability, which in turn may lead to intolerable decreases in their drainage capacity. In this thesis, the extent of this reduction is addressed using results from both experimental and theoretical investigations. In the experimental phase, the permeability reduction of a filter is monitored when an influent of constant concentration flows into the filter (uncoupled test), and when the water flow through the soil-filter system to simulate an in-situ condition (coupled test), respectively. The results of coupled and uncoupled test are compared with among others. In the theoretical phase of the investigation, a representative elemental volume of the soil filter was modeled as an ensemble of capillary tubes and the permeability reduction due to physical clogging was simulated using basic principles of flow in cylindrical tubes. In general, it was found that the permeability was reduced by at least one order of magnitude, and that the results from the uncoupled test and theoretical investigations were in good agreement. It is observed that the amount of deposited particles of the coupled test matches fairly well with that of the uncoupled test, which indicates that the prediction of permeability reduction is possible by preforming the uncoupled test instead of the coupled test, and/or by utilizing the theoretical model.

• 한국지구과학회지
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• 제28권3호
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• pp.343-356
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• 2007

새롭게 개발한 대기-해양 접합모형(CGCM)에서 모사한 열대 태평양 해수면 온도(SST)의 경년 변동성의 특징을 조사하였다. 모형은 SST의 경년변동과 평균분포, 계절변동, 강수량, 그리고 해양 내부 구조를 관측과 유사하게 모사하였다. 모델은 서태평양 경계 부근에서 관측에 비해 큰 SST 경년변동을 보였는데 이 원인으로 적도 태평양의 SST 동서 변화율을 제시하였다. 즉 관측에 비해 강한 SST 경도는 zonal advection feedback을 강화시켜 SST 아노말리의 서진(westward propagation)과 서태평양의 경년 변동성 증가를 가져왔다. 간단한 two-strip 모델을 이용한 민감도 실험 결과는 이를 뒷받침하였다. 동서 평균한 수온약층의 깊이와 NINO3 SST 인덱스의 분석 결과는 모델의 경년 변동이 충전-방전 진동자에 의한 것임을 나타냈다. 그리고 지연 회귀분석 결과를 이용하여 엘니뇨가 발달하기 전에 barrier layer thickness(BLT) 증가에 의한 열 축적 과정이 서태평양에서 먼저 일어난다는 것을 제시하였다.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2009년도 춘계학술대회 논문집
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• pp.711-711
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• 2009

Global warming has been widely recognized as a serious problem threatening the future of human beings. It is caused by the buildup in the atmosphere of greenhouse gases, such as carbon dioxide, methane, hydrofluorocarbons (HFCs), and sulfur hexafluoride (SF6). Particularly, SF6 has extremely high global warming potential compare to those of other global warming gases. One option for mitigating this greenhouse gas is the development of an effective process for capturing and separating these gases from anthropogenic sources. In general, gas hydrates can be formed under high pressure and low temperature. However, SF6 gas is known to form hydrate under relatively milder conditions. Therefore, technological and economical effects could be expected for the separation of SF6 gas from waste gas mixtures. In this study, we carried out morphological study for the SF6 hydrate crystals to understand its formation and growth mechanisms. The observations were made in high-pressure optical cell charged with liquid water and SF6 gas at constant pressure and temperature. Initially SF6 hydrate formed at the surface between gas and liquid regions, and then subsequent dendrite crystals grew at the wall above the gas/water interface. The visual observations of crystal nucleation, migration, growth and interference were reported. The detailed growth characteristics of SF6 hydrate crystals were discussed in this study.

• 대한환경공학회지
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• 제28권6호
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• pp.654-660
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• 2006

본 연구에서는 대전천에 위치한 오정천지역의 소유역을 대상으로 CSOs 배출특성에 관한 모델링을 실시하였다. SWMM을 이용하여 대상유역에서 $2001{\sim}2004$년까지의 연간 유량, 수질, 및 부하량 변화에 대하여 모의를 실시하였다. 모의결과에 의하면, 강우에 의해 발생된 SS 유출부하량은 강우가 집중되는 $7{\sim}8$월에 가장 높게 나타났으나, 이때 강우의 증가에 비하여 부하량의 증가는 크지 않았는데 이는 강우가 잦은 $7{\sim}8$월에는 짧은 건기일수로 인하여 유출수의 SS농도가 낮아졌기 때문이다. $2001{\sim}2004$년 동안의 유량과 수질을 기초로 유출부하량을 산정한 결과 SS가 연간 하천에 미치는 부하량은 건기에 9.3%, 우기에 90.7%로 우기시에 미치는 영향이 매우 큰 것으로 나타났다. 우기시에 우수토실에서 월류를 통해 유출되는 CSOs는 38.4%, 차집관거로 차집 되어 하수처리장 방류구를 통해 방류되는 부분은 61.6%로 산정되었다.

• 한국농공학회논문집
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• 제48권7호
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• pp.73-86
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• 2006

Concentrated poultry production in the State of Alabama, U.S.A. results in excessive poultry litter. Application of poultry litter to pastures and row crops serves as a cheap alternative to commercial fertilizer. However, over the years, poultry litter application to perennial forage crops in the Appalachian Plateau region of North Alabama has resulted in phosphorus (P) buildup in soils. Phosphorus index (P-index) and comprehensive nutrient management plans (CNMP) are often used as a best management practice (BMP) for proper land application of litter. Because nutrient management planning is often not done for small animal feeding operations (AFOs), and also because, in case of excess litter, litter transportation infrastructure has not been developed, over application of poultry litter to near by area is a common practice. To alleviate this problem, optimal poultry litter management and transportation infrastructure needs to be developed. This paper presents a methodology to optimize poultry litter application and transportation through efficient nutrient management planning and transportation network analysis. The goal was accomplished through implementation of three important modules, a P-Index module, a CNMP module, and a transportation network analysis module within ArcGIS, a Geographic Information System (GIS). The CNMP and P-Index modules assist with land application of poultry litter at a rate that is protective of water quality, while the transportation network analysis module helps transport excess litter to areas requiring litter in the Appalachian Plateau and Black Belt (a nutrient-deficient area) regions. Once fully developed and implemented, such a system will help alleviate water quality problems in the Appalachian Plateau region and poor soil fertility problems in the Black Belt region by optimizing land application and transportation. The utility of the methodology is illustrated through a hypothetical case study.