• YAKHAK HOEJI
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• v.52 no.3
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• pp.188-194
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• 2008

Fexofenadine, ($\pm$)-4-1-hydroxy-4-{4-(hydroxydiphenylmethyl)-1-piperidinyl}-butyl-a,a-dimethyl benzeneacetic acid, is a selective histamine $H_1$ receptor antagonist, and is clinically effective in the treatment of seasonal allergic rhinitis and chronic idiopathic urticaria as a first-line therapeutic agent. The purpose of the present study was to evaluate the bioequivalence of two fexofenadine hydrochloride tablets, $Allegra^{(R)}$ (Handok Pharmaceuticals Co., Ltd.) and Alecort (Samchundang Pharmaceutical Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The release of fexofenadine from the two fexofenadine hydrochloride formulations in vitro was tested using KP VIII Apparatus II method with various dissolution media. Twenty six healthy male subjects, 25.62$\pm$3.35 years in age and 70.05$\pm$11.71 kg in body weight, were divided into two groups and a randomized 2$\times$2 cross-over study was employed. After a single tablet containing 120 mg as fexofenadine hydrochloride was orally administered, blood samples were taken at predetermined time intervals and the concentrations of fexofenadine in serum were determined using HPLC with fluorescence detector. The dissolution profiles of two formulations were similar in all tested dissolution media. The harmacokinetic parameters such as $AUC_t$, $C_{max}$ and $T_{max}$ were calculated, and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$, $C_{max}$ and untransformed $T_{max}$. The results showed that the differences between two formulations based on the reference drug, $Allegra^{(R)}$, were -1.37, 5.22 and 16.50% for $AUC_t$, $C_{max}$ and $T_{max}$, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., log 0.83$\sim$log 1.08 and log 0.81$\sim$log 1.03 for $AUC_t$ and $C_{max}$, respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating Alecort tablet was bioequivalent to $Allegra^{(R)}$ tablet.

• Korean Journal of Radiology
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• v.21 no.7
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• pp.812-828
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• 2020

Objective: To provide an evidence-based guide for the MRI interpretation of complete tumor response after neoadjuvant chemoradiation therapy (CRT) for rectal cancer using visual assessment on T2-weighted imaging (T2) and diffusion-weighted imaging (DWI). Materials and Methods: PubMed MEDLINE, EMBASE, and Cochrane Library were searched on November 28, 2019 to identify articles on the following issues: 1) sensitivity and specificity of T2 or DWI for diagnosing pathologic complete response (pCR) and the criteria for MRI diagnosis; 2) MRI alone vs. MRI combined with other test(s) in sensitivity and specificity for pCR; and 3) tests to select patients for the watch-and-wait management. Eligible articles were selected according to meticulous criteria and were synthesized. Results: Of 1615 article candidates, 55 eligible articles (for all three issues combined) were identified. Combined T2 and DWI performed better than T2 alone, with a meta-analytic summary sensitivity of 0.62 (95% confidence interval [CI], 0.43-0.77; I² = 80.60) and summary specificity of 0.89 (95% CI, 0.80-0.94; I² = 92.61) for diagnosing pCR. The criteria for the complete response on T2 in most studies had the commonality of remarkable tumor decrease to the absence of mass-like or nodular intermediate signal, although somewhat varied, as follows: (near) normalization of the wall; regular, thin, hypointense scar in the luminal side with (near) normal-appearance or homogeneous intermediate signal in the underlying wall; and hypointense thickening of the wall. The criteria on DWI were the absence of a hyperintense signal at high b-value (≥ 800 sec/mm²) in most studies. The specific algorithm to combine T2 and DWI was obscure in half of the studies. MRI combined with endoscopy was the most utilized means to select patients for the watch-and-wait management despite a lack of strong evidence to guide and support a multi-test approach. Conclusion: This systematic review and meta-analysis provide an evidence-based practical guide for MRI assessment of complete tumor response after CRT for rectal cancer.

• Journal of Elementary Mathematics Education in Korea
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• v.13 no.2
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• pp.211-229
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• 2009

The purpose of this study is analysis of to investigate relation proportion problem of mathematics textbooks of 7th curriculum to proportional reasoning(relative thinking, unitizing, partitioning, ratio sense, quantitative and change, rational number) of Lamon's proposal at sixth grade students. For this study, I develop two test papers; one is for proportion problem of mathematics textbooks test paper and the other is for proportional reasoning test paper which is devided in 6 by Lamon. I test it with 2 group of sixth graders who lived in different region. After that I analysis their correlation. The result of this study is following. At proportion problem of mathematics textbooks test, the mean score is 68.7 point and the score of this test is lower than that of another regular tests. The percentage of correct answers is high if the problem can be solved by proportional expression and the expression is in constant proportion. But the percentage of correct answers is low, if it is hard to student to know that the problem can be expressed with proportional expression and the expression is not in constant proportion. At proportion reasoning test, the highest percentage of correct answers is 73.7% at ratio sense province and the lowest percentage of that is 16.2% at quantitative and change province between 6 province. The Pearson correlation analysis shows that proportion problem of mathematics textbooks test and proportion reasoning test has correlation in 5% significance level between them. It means that if a student can solve more proportion problem of mathematics textbooks then he can solve more proportional reasoning problem, and he have same ability in reverse order. In detail, the problem solving ability level difference between students are small if they met similar problem in mathematics text book, and if they didn't met similar problem before then the differences are getting bigger.

• Korean Journal of Clinical Laboratory Science
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• v.51 no.1
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• pp.93-104
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• 2019

This study examined the relationship between the number of medical technologists and the medical test count. Data was obtained from 441 medical technologists in a hospital through a self-reported questionnaire. The Pearson correlation test, student's t-test, ANOVA or descriptive statistics were performed for data analysis. The distribution of medical technologist according to the size of hospitals was small 5.8, medium 14.9, large 25.8, and super 45.4. The analysis demonstrated a relationship between the number of medical technologists and the number of medical tests in the field, number of clinical tests per MT, and number of optimal medical test per MT according to the hospital size (P<0.001). The average time for quality control by the department at a higher hospital was less than two hours. In terms of the satisfaction of salary, work environment, test accomplishment, and welfare service, the dissatisfaction of medical technologists in small and medium hospitals was higher than those in large and super hospitals. Overall, a focus on intensifying systemic supplementation and improving the condition of medical technologists is needed to provide reliable data for medical examinations in medical areas.

• Journal of the Korean Society of Clothing and Textiles
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• v.30 no.3 s.151
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• pp.396-406
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• 2006

This research explored perfume consumption behaviors and fragrance sensibility attitude according to perfume involvement level. Data were collected by surveying 241 female college students who are recognized as a core consumer group for perfume products in Korea. The collected data were analyzed through descriptive analysis, factor analysis, and t-test. In results, 241 respondents were classified into 2 groups with respect to perfume involvement. Group difference was found in some of consumption behaviors and fragrance sensibility attitude. Specifically, the high involvement group used more often and spent more money on perfume, than did the low involvement group. Also, people highly involved with perfume shopped more often in perfume specialty stores, considering smelling test as the more important information source than did people in the low involvement group. Young females most liked delightful and young sensibility of perfume fragrance while they disliked stimulating and strong fragrance. People in the high involvement group preferred sophisticated and modem feelings of perfume fragrance more than did people in the low involvement group. Based on results, product development and marketing implications were generated.

• Journal of Korea Technology Innovation Society
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• v.16 no.3
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• pp.605-629
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• 2013

The aim of this study is analyzing the factors and performance related to the entry control mode when a SME advances into the global market. For this, the strategic factor of the SME was divided into the enterprise capabilities consisting of technology commercial capability, internal capability, and global capability of enterprise and information capabilities that are the capabilities on the global market and on the advanced technology. In the empirical study, a total of 27 variables that include the control variables and the financial and non-financial variables as a performance variable was used. The hypothesis was also established for analyzing the effect of the entry strategies on the entry control mode and the effect of the mode on performance. Logistic regression was conducted for verifying the hypothesis, and Multiple regression analysis and T-test were carried out on the additional analysis related to the performance.

• Journal of the Korea Society of Computer and Information
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• v.25 no.10
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• pp.143-150
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• 2020

The purpose of this study was to investigate the relationship between self-esteem, quality of life, and depression of nursing students, and to determine the effect on depression. The subjects of the study were 311 nursing students and collected data from November 20 to December 5, 2017. Data analysis was performed using the SPSS 21.0 program, t-test, ANOVA, Pearson correlation and multiple linear regression analysis. As a result, there were significant differences in college life satisfaction among general characteristics. Self-esteem was 3.37, quality of life was 3.54, and depression was 16.52. Depression was found to have a significant negative correlation with quality of life. The most significant influence on depression was quality of life, and the explanatory power was 48.2%. Based on the results of this study, it is necessary to develop and apply intervention programs to prevent depression of nursing students.

• Journal of Digital Convergence
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• v.18 no.6
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• pp.363-371
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• 2020

This study is a descriptive study to investigate the effects of grit and resilience on clinical practice adaptation of nursing students. The subjects of this study were 131 nursing students and data collection was from August 19 to September 30, 2019. Data was analyzed using the SPSS 20.0 program by descriptive statistics, t-test, correlation analysis, and multiple regression analysis. Grit and resilience were found to be factors affecting clinical practice adaptation of nursing students and 32.0% of clinical practice adaptation. Therefore, in order to increase the clinical practice adaptation of nursing students it is necessary to make efforts to improve grit and resilience and development of clinical practice curriculum.

• Journal of the Korea Society of Computer and Information
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• v.25 no.3
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• pp.199-206
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• 2020

The purpose of this study is to examine the relationship between intention to participation in sharing economy, digital cultural capital, and social connectedness and then analyze the variables affecting the intention to participate in sharing economy. This subjects were university students. Collected data were statistically processed by PASW 18.0 program using reliability, frequency analysis, T-test, one-way ANOVA, correlation and multiple regression analysis. The results were as follows. First, redistribution participation and cooperative lifestyle participation were relatively high. Second, intention to participate in sharing economy activities differs according to gender, age, monthly allowance, and SNS usage time. Third, intention to redistribution participation increases as the recognition of objectified digital culture capital, embodied digital culture capital, and social connectedness increases. And the intention to cooperative lifestyles participation and information sharing participation increased as digital culture capital increased. Forth, the most significant variable affecting the intention to participate in sharing economic activities was digital cultural capital.

• Journal of Digital Convergence
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• v.15 no.11
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• pp.339-349
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• 2017

The purpose of this study was to examine the influence of the meaning in life(ML) on the mental health(MH) of university students with relationship loss and to verify the mediating effects of posttraumatic growth(PTG). Data collected from 349 university students in Daejeon and Chugcheong region was analyzed by descriptive statistics, t-test, one-way ANOVA, correlation analysis, and hierarchical analysis using SPSS 18.0. As the results, 1. Both ML and PTG showed a significant influence on the MH. 2. ML, PTG and MH showed a positive correlation. 3. PTG had a mediating effects on the process where ML influenced MH. The implications and limitations of the study also was suggested for a healthy mental health formation of university students with relationship troubles.