• Preventive Nutrition and Food Science
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• v.12 no.3
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• pp.141-147
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• 2007

Cordycepin (3'-deoxyadenosine), which comes from Cordyceps militaris, the Chinese medicinal fungal genus Cordyceps, is used in the treatment of various diseases such as cancer and chronic inflammation. We recently reported that cordycepin has a novel antiplatelet effect through the down regulation of $[Ca^{2+}]_{i}$ and the elevation of cGMP/cAMP production. In this study, we further investigated the effect of cordycepin on collagen-induced platelet aggregation in the presence of cGMP-dependent protein kinase (PKG)- or cAMP-dependent protein kinase (PKA)-inhibitor. PKG inhibitor Rp-8-pCPT-cGMPS potentiated the collagen-induced platelet aggregation, but PKA inhibitor Rp-8-Br-cAMPS did not. However, both Rp-8-pCPT-cGMPS and Rp-8-Br-cAMPS reduced inhibition by cordycepin of collagen-induced platelet aggregation. Moreover, cordycepin inhibited $Ca^{2+}-dependent$ phosphorylation of both 47 kDa- and 20 kDa-protein in the presence of both PKG inhibitor and PKA inhibitor. Taken altogether, these results suggest that the inhibitory effect of cordycepin on collagen-induced platelet aggregation is associated with cGMP/PKG- and cAMP/PKA-pathways, and thus cordycepin may be an efficacious intervention against platelet aggregation-mediated thrombotic disease.

• Journal of the Korean Regional Science Association
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• v.11 no.1
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• pp.79-91
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• 1995

As an exit to solve the economic depression of the development countries in the early twentieth century, the 'old international division of labor' developed. The economic crisis(i.e., under-consumption crisis) was due to the absence of the mode of regulation compatible with the extensive regime of accumulation(i.e., "Fordist" regime). The crisis was solved by the state intervention through the creation on institutions in order to increase the level of consumption. Until the late 1960s when "high Fordism" reached(i.e., a harmonious relation between the monopoly mode of regulation and the intensive accumulation of capital), the developed core countries enjoyed a remarkable economic growth. The external market was not a necessity for the economic growth because there were increases in labor productivity and proportional increases in real wages and thus increases in consumption level. In the 1970s, however, the core faced with economic crisis again. Due to the breakdown of the postwar "Fordist" regime of capital accumulation and the post 1973 world depression, the core needed the Third World as a solution for their internal and international economic crisis. Thus the 'new international division of labor'(NIDL) arose. The "Fordist" method of production(i.e., the divisions of production process) led to the territorial division of labor and to the detailed division of labor. The aim of the NIDL is to exploit reserve armies of labor on a world scale and thus to reduce production costs. According to the NIDL model, the Third World countries have been developing by the core countries' investment on mainly labor-intensive industries and thus have been playing an important role in the global economy. And the NIDL theorists argue that multinational corporations have increasingly invested in the Third World nations and contributed to the economic growth in those regions. Tables presented in the paper show that the global trend since the 1970s does not follow the argument exactly as the NIDL theorists predicted. On the contrary, the core countries focus on developing technology, adopting the automation of production process, and trading within the core countries rather than on investing in the periopheral countries. The continuing investment of multinational corporations into the periphery is not because of cheap labor force but because of the market potentials in the regions. Majority of corporations of the core tries to reduce production costs by investing in technological development more intensively and also by changing regional strategies (i.E., investment from metropolitan areas to medium - or small - size cities, focusing on agglomeration economy, boosting regional diversification, etc.) within their own countries. The main purpose of the paper is to review and to criticize the NIDL theory based on some empirical data.IDL theory based on some empirical data.

• The Journal of Fisheries Business Administration
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• v.41 no.3
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• pp.103-127
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• 2010

The FAO reports that IUU fishing activities have widespread economic, social, and management consequences, including depriving legitimate fishers of harvest opportunities. It affects all fisheries from small scale to industrial. It also affects the ability of governments to support sustainable livelihoods for fishers and, more broadly, to achieve food security. The complexity of IUU requires various measures to combat IUU fishing such as adoption of IUU vessel lists; stronger port State controls; improved monitoring, control and surveillance (MCS); implementation of market-related measures to help ensure compliance; and capacity-building assistance. Trade and market measures reduce opportunities for IUU fishing activities by precluding or impeding access to markets for IUU product in a manner consistent with international law. ICCAT, CCAMLR, and IATTC, have put in place trade tracking programs or catch documentation schemes, and WCPFC is considering such a program. Vessel lists assist enforcement authorities in determining which vessels are or are not authorized to be fishing or conducting fishing support activities in specified areas. A number of RFMOs maintain records of IUU vessels: CCAMLR, IATTC, ICCAT, NAFO, NASCO, NPAFC, WCPFC. Section 608 of the US MSRA calling on the Secretary of Commerce, in consultation with the Secretary of State, and in cooperation with relevant regional fishery management councils and any relevant advisory committees, to take actions to improve the effectiveness of international fishery management organizations in conserving and managing stocks under their jurisdiction. EU IUU Regulation entered into force on 1 January 2010, was intended to regulate the highly complex multi-channel fisheries supply system of the European Community (EC) in an effort to improve global fisheries sustainability.

• Journal of the Korean Institute of Educational Facilities
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• v.21 no.3
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• pp.29-36
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• 2014

Properties of school foundation are divided into fundamental property for education and fundamental property for profit. As school sites and teachers used for educational and study activities of students, fundamental property for education includes practice sites, farms and support research attached facilities in addition to school facilities. According to the Clause 1 of Article 4 of the University Foundation and Management Regulation and the Attached Table 2 of the Same Regulation, dormitory is classified as property for education(non-profit). In other words, there is no need to create profit for dormitory management. It is supposed that there are little regional differences in construction cost of dormitory with general specifications. In this case, boarding fees of university dormitories should make no difference. This study analyzed boarding fees, depending on regional factors(Seoul, Gyeonggi-do, metropolitan cities and provinces), and depending on foundation subjects(national public university and private university), classes(four-year university and college) and principal schools-branch schools. The result of One-Way ANOVA showed that Seoul showed the highest average boarding fee and it was followed by Gyeonggi-do, metropolitan cities and provinces. Also, the average boarding fees of private universities and four-year universities were higher than national public universities and than colleges, respectively. In addition, branch school's boarding fee was higher than principal school's. Additionally, this study extracted a model using the hedonic model to see how various characteristics such as region, foundation subject and class influence the boarding fee. This study would serve as fundamental research on the boarding fee. Thus far, there have been difficulties in obtaining accurate data and analyzing boarding fees, since there is no open data about dormitories and it isn't mandatory to open it, but it is anticipated that this would be used as fundamental research for estimating and analyzing boarding fees of many universities in the future.

• Journal of the Economic Geographical Society of Korea
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• v.16 no.2
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• pp.167-181
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• 2013

The cross-border flow of workers in EU having the freedom of labor mobility and residence plays a role in the border labor markets as a structural factor of regulation. The regulation role of the cross-border flow of workers on the Grand R$\acute{e}$gion, which is the border among the France-Belgium-Luxemburg-Germany, is as follows. First, the cross-border flow of workers regulates the regional surplus and lack of labor in quantity and quality. Second, the border labor markets are regulated by the regionally segmented supply and demand of labor and are modulated by the flexible employment like a part-time and temporary employment. Third, the residence of the cross-border workers concentrates on the adjacent regions to the border. And the atypical cross-border workers, who have their residence in the neighboring country but works in the existing country, are rising rapidly.

• Molecules and Cells
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• v.28 no.6
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• pp.565-573
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• 2009

The pig could be a useful model to characterize molecular aspects determining several delicate phenotypes because they have been bred for those characteristics. The Korean native pig (KNP) is a regional breed in Korea that was characterized by relatively high intramuscular fat content and reddish meat color compared to other western breeds such as Yorkshire (YS). YS grew faster and contained more lean muscle than KNP. We compared the KNP to Yorksire to find molecular clues determining muscle characteristics. The comparison of skeletal gene expression profiles between these two breeds showed molecular differences in muscle. We found 82 differentially expressed genes (DEGs) defined by fold change (more than 1.5 fold difference) and statistical significance (within 5% of false discovery rate). Functional analyses of these DEGs indicated up-regulation of most genes involved in cell cycle arrest, down-regulation of most genes involved in cellular differentiation and its inhibition, down-regulation of most genes encoding component of muscular-structural system, and up-regulation of most genes involved in diverse metabolism in KNP. Especially, DEGs in above-mentioned categories included a large number of genes encoding proteins directly or indirectly involved in p53 pathway. Our results indicated a possible role of p53 to determine muscle characteristics between these two breeds.

• Journal of the Korean Geographical Society
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• v.42 no.1 s.118
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• pp.41-62
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• 2007

This paper aims to interpret the changes of the regional inequality between Seoul Metropolitan Area(SMA) and Non-SMA after 1981 on the regulationist approaches that examine institution changes and power dynamics that motivate regional disparities in South Korea. Despite the restrict laws and aims that alms to reduce the concentration into SMA before 1988, the acts were not executed effectively due to the structural selectivity of the bureaucratic authoritarian state of those years. Thus, the regional concentration phenomena of SMA was intensified in the 1980s. However, the democratization in 1987 invoked Non-SMA regions to claim their regional development and it also forced the state to mediate the conflicting interests between the regional agents protesting the SMA concentration and the Capital agents supporting the SMA deregulation. From the early 1990s. the state launched a series of national strategies and policies to diminish regional inequality. They included execution of the existing acts mitigating SMA concentration and construction of industrial complexes in the underdeveloped areas of Non-SMA. Thus, the equalizing polities led the reduction of the concentration of SMA from 1989 to 1997. However, the financial crisis of Korea in 1997 intensified the claims of the Capital agents to deregulate the SMA control. The circumstance also forced the state towards the Capital side that request the deregulation of SMA control. As the result, the regional disparity between SMA and Non-SMA has been enlarged again since 1998.

• Microbiology and Biotechnology Letters
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• v.43 no.3
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• pp.280-285
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• 2015

Anti-oxidative and anti-inflammatory activities of Cotoneaster horizontalis Decne ethanol extract (CHEE) were evaluated. CHEE possessed a potent scavenging activity against 1,1-diphenyl-2-picryl hydrazyl, which was similar to the activity of ascorbic acid which was used as a positive control. CHEE also effectively suppressed hydrogen peroxide-induced reactive oxygen species on RAW 264.7 cells. Furthermore, CHEE induced the expression of the anti-oxidative enzyme heme oxygenase 1, and its upstream transcription factor, nuclear factor-E2-related factor 2. CHEE inhibited LPS induced nitric oxide (NO) formation as a consequence of inducible NO synthase (iNOS) down regulation. Taken together, these results provide us with an important new insight; that C. horizontalis possesses anti-oxidative and anti-inflammatory activities. Therefore, C. horizontalis may be utilized as a promising material in the field of nutraceuticals.

• Journal of Forest and Environmental Science
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• v.30 no.1
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• pp.50-55
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• 2014

DMZ has a lot of natural resources. Also there is very important position as a ecological and geographical. Meanwhile, development schemes and plans were established but that was development to only simple plan such as a tourism and income without communication with local residents. This study was tried to exhibit increasing income of residents in DMZ area using FGI (Focus Group Interview) and SWOT analysis. First of all, analyzed the status of forest resources and carried out a Focus Group Interview targeting residents who live in around DMZ, and then suggest an alternative to increasing income and regional development in Yanggu-gun by SWOT strategies. As a result, realistic plan for achieving regional development is deregulation of the laws related to forest land use conversion for the forest product in DMZ area. Military experts and forest experts have to inspect the area for considering the practical application of the regulation in protected areas directly. National or local government has to effort pursuing future business for regional development through the communication with residents in DMZ area.

• Environmental and Resource Economics Review
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• v.20 no.2
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• pp.199-228
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• 2011

In this study, the effect on the economy-energy-environment gap among regions of reducing GHGs is analyzed under various scenarios, using a multiregional dynamic CGE model. Regions in Korea are classified as six metropolitan areas. Scenarios are set in three cases such as self-regulatory measures, carbon tax and emissions trading scheme. The reduction target under each scenario is again classified according to volume basis and intensity basis. In results, self-regulation is shown to deepen the economic divide mostly, followed by a carbon tax, emissions trading scheme in order. This result could be interpreted such that a system based on market incentives gives less effect on the gap among regions. However, market incentives based system is expected to take time to build. Thus in implementing policies to increase short-term effects of the reduction targets, complementary policies are needed to reduce the regional devide.