• 대한치과기공학회지
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• 제39권2호
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• pp.111-118
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• 2017

Purpose: The study aims to evaluate satisfaction of toothpaste adding natural materials extracted from Zanthoxylum schinifolium and various herbs (Pine, Lemongrass, Spearmint). Methods: We performed the first survey to collect basic data for the development of natural herbal toothpaste. Participants were the general public in Jeonju and Iksan of Jeollabuk-do, and a total of 273 questionnaires were analyzed for the study. By adding anthoxylum schinifolium and herbal extracts (Pine, Lemongrass, Spearmint) to the toothpaste, four kinds of natural herbal toothpaste prototypes were manufactured. The second survey was conducted to assess the satisfaction one week after using the natural herbal toothpaste prototypes. Results: Satisfaction with current toothpaste was 3.52. The most important criterion of toothpaste was the prevention of tooth caries. 55.3% participants obtained toothpaste information through advertising. The survey indicated the most worrisome ingredient of toothpaste was surfactant, showing 55.3%. The overall satisfaction of natural herbal toothpaste was 3.99; among the four natural herbal toothpaste, toothpaste 2 (Zanthoxylum schinifolium, Lemongrass) showed the highest satisfaction as 3.99; and toothpaste 3 (Zanthoxylum schinifolium, Spearmint) showed the lowest satisfaction as 3.56. Conclusion: Four kinds of natural herbal toothpaste showed higher satisfaction as 3.99. In particular, the toothpaste adding Zanthoxylum schinifolium and Lemongrass extracts.

• 동의신경정신과학회지
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• 제34권3호
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• pp.247-257
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• 2023

Objectives: To analyze the trend of Korean patents of natural product extracts for depression. This study also aimed to enhance the development and application of natural product extracts for depression in Korean herbal medicine. Methods: We searched the Korea Intellectual Property Rights Information Service and Science ON to collect Korean patent data of natural product extracts for depression. Two authors independently screened and assessed full texts of screened patents for eligibility. Included patents were analyzed both quantitatively and qualitatively. Results: A total of 62 patents from 2002 to December 2021 were included for analysis. The number of patents has constantly increased since 2002. Glycyrrhiza uralensis Fischer, Perilla frutescens Britton var. acuta Kudo, Zizyphus jujuba Miller var. inermis Rehder were frequently used among 62 patents. Alcohol extraction was mostly used, followed by water extraction and ethyl extraction regarding extract methods. Eight patents were herbal medicine used for treating depression in Korean Medicine. Conclusions: Various Korean herbal medicine and minerals were used as natural-products for treating depression. These results provide fundamental data that can be used for inventing new patents using Korean herbal medicine, developing new natural product extracts for depression, and extending the range of application of these products in clinical setting.

• 생약학회지
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• 제26권4호
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• pp.355-359
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• 1995

To find serotonin(5-hydroxytryptamine, 5-HT)-antagonizing activities in traditional herbal drugs, crude extracts from 66 kinds of traditional herbal drugs were randomly screened for inhibitory effects on 5-hydroxytryptophan(HTP)-induced diarrhea in mice. Intraperitoneal injection of 5-HTP(2.5 mg/kg) induced diarrhea in 92% of mice, when observed from 10 to 15 min after injection. Crude extracts(2 g/kg) from 66 kinds of traditional herbal drugs were orally pretreated for 1 h before 5-HTP injection. Of the 66 herbal drugs screened, Ephedrae Herba(麻黃), Cimicifugae Rhizoma(升麻), Anisi stellati Fructus(八角茴香), Aurantii Fructus(枳實), Polygalae Radix(遠志) showed the most potent inhibiting activities against 5-HTP(2.5 mg/kg)-induced diarrhea in mice. There are at least 3 possible mechanisms that would be responsible for the inhibitory effect of crude extracts on 5-HTP-induced diarrhea; 1) crude extract-induced inhibition of the activity of aromatic aminoacid decarboxylase catalyzing the conversion of 5-HTP to 5-HT, 2) crude extract-induced blockade of 5-HT receptor(s) in the gastrointestinal tract responsible for 5-HTP-induced diarrhea, 3) crude extract-induced inhibition of gastrointestinal activity, irrespective of 5-HT system. The exact mechanisms and molecules, responsible for the inhibitory effect of crude extracts on 5-HTP-induced diarrhea remain to be clarified.

• 한국동물학회:학술대회논문집
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• 한국동물학회 2000년도 한국생물과학협회 학술발표대회
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• pp.235.2-235
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• 2000

• 대한본초학회지
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• 제24권3호
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• pp.51-58
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• 2009

Objectives : This study was conducted to evaluate the antioxidative and anticancer activity of the water and ethanol extracts from pickled soybean products by manufacturing stage. Methods : Yakkong (YK) was pickled for 15 days to prepare Chokong (CK) and Chokong pills (CKP) were mixed Chokong (CK) powder with vinegar. Herbal Chokong pills (HCKP) were made by addition five kinds of medicinal herbs to Chokong. Pickled soybean products by each manufacturing process were extracted with distilled water and 70% ethanol, and the extracts were tested for their antioxidative and anticancer activities. Results : The highest electron donating abilities (EDA) of the water and ethanol extracts were from HCKP among pickled soybean products and those were 81.2% and 91.5% at 1,000 $\mu$g/mL, respectively. The ethanol extracts of pickled soybean products had higher activities of EDA and superoxide dismutase (SOD) than water extracts. The highest anticancer activity was the water extracts of HCKP against both of MDA and A549 cells. Conclusions : These results suggest that herbal Chokong pills (HCKP) can be used as natural antioxidant to prevent oxidative damage in normal cells probably because of their antioxidative characteristics.

• 한국식품조리과학회지
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• 제19권1호
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• pp.107-113
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• 2003

In a previous study, a dietary supplement was developed in our lab using natural herbal extracts against digest enzyme activity in GI tract for weight control. This natural herbal extracts could regulate absorption of glucose and lipid by the inhibition of digest enzyme activity. In this study, we screened the natural herbs that inhibit glucoamylase activity and developed an water extract of cinnamon. The cinnamon extract delayed and decreased the increment of carbohydrate degradation through the inhibition of glucoamylase activity in vitro. Fifty volunteers were subjected to the intake of the herbal extracts by taking twice a day for 60 days. As a result, the treated subjects lost 3 kg of body weight and 3.5 kg of body fat mass after the treatment. Furthermore, the body mass index and waist size were significantly decreased during the experimental period. Above results suggested that the administration of the dietary additives composed of cinnamon and natural herbal extract improves the obesity by the decrement of body weight and body fat mass.

• 생약학회지
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• 제44권2호
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• pp.176-181
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• 2013

In order to search for protein tyrosine phosphatase 1B (PTP1B) inhibitors as therapy of type 2 diabetes and obesity from Korean traditional prescriptions, we selected 58 traditional prescriptions based on a review of the Korean traditional medicine books. The hot water extracts of Korean traditional prescriptions were screened for the inhibitory activity against PTP1B. Among the tested extracts, water extracts of Jakgamhwangsinbu-tang, Seonbanghwalmyung-eum, and Takreeonjoong-tang showed relatively good inhibitory activity against PTP1B at the concentration of $30{\mu}g/ml$. Additionally, we evaluated PTP1B inhibitory effect for each herbal ingredient and composition in Jakgamhwangsinbu-tang (芍甘黃辛附湯). Of the tested ingredients from this herbal medicine, water extracts of Paeoniae Radix rubra and Rhei Rhizoma, and ethanol extracts of Paeoniae Radix alba, Rhei Rhizoma, Asiasari Radix, and Aconiti Tuber showed good PTP1B inhibitory effect. Herbal compositions composed of these active herbal ingredients exhibited significant activity for PTP1B inhibition over 70% at $7.5{\mu}g/ml$.

• 치위생과학회지
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• 제15권3호
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• pp.308-317
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• 2015

본 연구는 천연한방 식물 추출물의 치아우식 예방제제로서 가능성을 평가하고자 구강 양치용액과 함께 S. mutans에 대한 항균활성을 측정하고, 정상인 치은섬유모세포에 대한 독성 유무를 평가하여 다음과 같은 결과를 얻었다. 용매별 천연한방 추출물의 S. mutans에 대한 최소성장억제농도는 증류수보다 에탄올 추출물에서 우수한 성장억제 효과를 보였다. S. mutans에 대한 최소성장억제농도를 비교한 결과, 천연한방 에탄올 추출물은 보골지가, 구강양치액은 헥사메딘이 가장 낮은 농도에서 성장억제 효과를 보였다. S. mutans에 대한 최소살균농도를 비교한 결과, 천연한방 에탄올 추출물은 보골지가, 구강양치액은 헥사메딘과 가그린이 낮은 농도에서 사멸효과를 나타냈다. 정상인의 치은섬유모세포에 천연한방 에탄올 추출물을 최소성장억제농인 10, 39, $78{\mu}g/ml$로 처리하여 독성 유무를 측정한 결과 세포독성이 없었다. 그러나 최소살균농도 값을 토대로 각 추출물별 농도를 달리하여 처리한 결과, 보골지를 제외하고는 다른 추출물은 농도가 높아짐에 따라 세포독성이 있는 것으로 나타났다. 이상의 결과를 종합하면, 4종의 천연한방 추출물은 합성 화학물질인 구강양치액과 비교 시 유사한 항균효과가 있었다. 따라서 천연한방 추출물은 적정 농도를 첨가함으로써 치아우식 대체 예방제제로 실용화할 수 있을 것으로 생각된다.

• 생약학회지
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• 제30권2호
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• pp.105-110
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• 1999

In our continuing search for new antineoplastic agents from natural products, one hundred and thirty-five herbal drugs were extracted with petroleum ether/ether (1:1), ethyl acetate and methyl alcohol, successively and their cytotoxicities were evaluated against A549 (human lung carcinoma) and SK-OV-3(human ovary adenocarcinoma) cell lines. Among them, fifteen kinds of ether extracts, eighteen kinds of ethyl acetate extracts and seven kinds of methanol extracts showed significant cytotoxic activities (above 70% inhibition) against A549 cell lines at a concentration of $40\;{\mu}g/ml,$ while ten kinds of ether extracts, thirteen kinds of ethyl acetate extracts and six kinds of methanol extracts demonstrated significant cytotoxic activities against SK-OV-3 cell lines at the above same concentration.

• Biomolecules & Therapeutics
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• 제32권1호
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• pp.25-37
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• 2024

Atopic dermatitis (AD) is an allergic disorder characterized by skin inflammation. It is well known that the activation of various inflammatory cells and the generation of inflammatory molecules are closely linked to the development of AD. There is accumulating evidence demonstrating the beneficial effects of herbal extracts (HEs) on the regulation of inflammatory response in both in vitro and in vivo studies of AD. This review summarizes the anti-atopic effects of HEs and its associated underlying mechanisms, with a brief introduction of in vitro and in vivo experiment models of AD based on previous and recent studies. Thus, this review confirms the utility of HEs for AD therapy.