Korean journal of food and cookery science (한국식품조리과학회지)

Korean Society of Food and Cookery Science (한국식품조리과학회)
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Beneficial effects of body fat and obesity through the inhibition of the digestion of carbohydrate and lipid in gastrointestinal tract

장내의 탄수화물과 지방 흡수 억제를 통한 체지방 및 비만 개선 효과에 관한 연구

  • 정은희 (㈜바이오랩 기술연구소) ;
  • 윤승원 (㈜바이오랩 기술연구소) ;
  • 이홍석 (㈜바이오랩 기술연구소) ;
  • 윤유식 (한국 한의학 연구소) ;
  • 유경미 (서울대학교 생활과학대학 식품영양학과) ;
  • 황인경 (서울대학교 생활과학대학 식품영양학과)
  • Published : 2003.02.01
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Abstract

In a previous study, a dietary supplement was developed in our lab using natural herbal extracts against digest enzyme activity in GI tract for weight control. This natural herbal extracts could regulate absorption of glucose and lipid by the inhibition of digest enzyme activity. In this study, we screened the natural herbs that inhibit glucoamylase activity and developed an water extract of cinnamon. The cinnamon extract delayed and decreased the increment of carbohydrate degradation through the inhibition of glucoamylase activity in vitro. Fifty volunteers were subjected to the intake of the herbal extracts by taking twice a day for 60 days. As a result, the treated subjects lost 3 kg of body weight and 3.5 kg of body fat mass after the treatment. Furthermore, the body mass index and waist size were significantly decreased during the experimental period. Above results suggested that the administration of the dietary additives composed of cinnamon and natural herbal extract improves the obesity by the decrement of body weight and body fat mass.

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References

  1. Colditz, GA : Economic costs of obesity. Am. J. Clin. Nutr., 55:503, 1992
  2. Higgins, M and D'Agostino, R : Obesity and cardiovascular disease, In Oomura Y.ed. Progress in Obese Research. John Libbey & Comp. Ltd., London, P.381, 1990
  3. DeFronzo, RA and Ferrannini, E : Insulin resistance. Amultifaceted syndrome responsible for NIDDM, obestiy. hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14:173, 1991 https://doi.org/10.2337/diacare.14.3.173
  4. Daly, PA and Landsberg, L : Hypertension in obesity and non-insulin-dependent diabetes mellitus. Role of insulin and sympathetic nervous system. Diabetes Care 14:240, 1991 https://doi.org/10.2337/diacare.14.3.240
  5. Sjostrom, LV : Morbidity of severly obese subjects. Am. J. Clin. Nutr., 55:508, 1992
  6. Ljung, T, Ahlberg, AC, Holm, G, Friberg, P, Anderson, B, Eriksson, E and Bjorntorp, P : Treatment of abdominally obese men with a serotonin reuptake inhibitoria pilot study. J. Intern. Med., 250(3):219, 2001 https://doi.org/10.1046/j.1365-2796.2001.00881.x
  7. Beermann, B, Melander, H, Sawe, J, Ulleryd, C and Dahlqvist, R ; Incorrect use and limited weight reduction of orlistat (Xenical) in clinical practice. A cohort study. Eur, J. Clin. Pharmacol., 57(4):309, 2001 https://doi.org/10.1007/s002280100316
  8. Trichopoulou, A, Gnardellis, C, Benetou, V, Lagiou, P, Bamia, C and Trichopoulos, D : Lipid, Protein and carbohydrate intake in relation to body mass index., Eur. J. Clin. Nutr., 56(1):37, 2002 https://doi.org/10.1038/sj.ejcn.1601286
  9. Hong, SG, Kim, DW, Kim, JW and Lee, HS : Inhibition of carbohydrate digestion using egg yolk antibody, Korean J. Soc. Food Cookery Sci., 18(1):94, 2002
  10. Hatta, H, Kim, M and Yamamoto, T : A novel isolation method for hen egg yolk antibody, 'IgY', Agric. Biol. Chem., 54, 2531-5, 1990 https://doi.org/10.1271/bbb1961.54.2531
  11. Yoon, YS, Choi, SM, Hong, SB, Hong, JM, Kim, JW, Lee, HS and Hong, SG : Development of an anti-obesity dietary supplement inhibiting the digestion of carbohydrate and lipid, Korean J. Soc. Food Cookery Sci., 18(3):319, 2002
  12. Kim, KS, Ezaki, O, Ikemoto, S and Itakura, H : Effects of Platycodon grandiflorum feeding on serum and liver lipid concentrations in rats with diet-induced hyperlipidemia. J. Nutr. Sci. Vitaminol., 41(4):485, 1995 https://doi.org/10.3177/jnsv.41.485
  13. Kritchevsky, D, Tepper, SA and Story, JA : Influence of an eggplant (Solanum melongena) preparation on cholesterol metabolism in rats., Exp. Pathol., 10(3-4):180, 1975
  14. Jorge, PA, Neyra, LC, Osaki, RM, Almeida, E and Bragagnolo, N : Effect of eggplant on plasma lipid levels, lipidic peroxidation and reversion of endothelial dysfunction in experimental hypercholesterolemia. Arq. Bras. Cardiol., 70(2):87, 1998 https://doi.org/10.1590/S0066-782X1998000200004