• 약학회지
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• 제52권4호
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• pp.279-282
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• 2008

Plasmids were isolated from 15 tetracycline (Tc) resistant S. aureus. Two small tetracycline resistance plasmids, pKH16 and pKH17, have been isolated from Staphylococcus aureus JY10 and Staphylococcus aureus JY22, respectively and the complete nucleotide sequences of those plasmids have been determined. pKH16 consisted of 4,442 bp and showed high identity to pKH6 (99% matching percentage) isolated in 1989 from S. aureus SA2. pKH17 consisted of 4,441 bp and showed less identity to pKH6 (95% matching percentage) than pKH16. PCR analysis showed that tetK and tetM did not exist in ten large plasmids isolated from ten Tc resistant S. aureus. Twelve Tc resistant S. aureus showed reistance both to Tc and Mn and we might analogize that twelve Tc resistant S. aureus had tetM in their chromosome.

• Journal of applied mathematics & informatics
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• 제12권1_2호
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• pp.31-37
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• 2003

In this Paper, we investigate local stability, oscillation and bounde-ness character of positive solutions of the difference equation $X_{N+l}$ = $\alpha$ + ( $X_{N-1}$$^{P/)}$( $X_{N}$$^{P}$), n = 0, 1, … under specified conditions.s.tions.s.

• Journal of Dental Anesthesia and Pain Medicine
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• 제23권6호
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• pp.327-335
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• 2023

Background: Pain control is a crucial aspect of pediatric dentistry for patient management. Thermo-mechanical devices (Buzzy^TM Pain Care Labs, USA) work on the concept of vibration and cooling and have shown promising results in pain control during local anesthesia in pediatric dentistry. On the other hand, audio distraction has also been used for pain management. The amount of pain endured is determined by the patient's perception and attentiveness. Thus, if audio function is added to the thermomechanical device it might increase its efficiency. Hence, the present study aimed to compare pain on injection using a thermo-mechanical device with and without audio during inferior alveolar nerve block (IANB) injection in children aged 5-10 years old. Methods: Twenty-eight children aged between 5 and 10 indicated for IANB were included in this randomized study. Children who were undergoing the dental procedure were divided into 2 groups, with 14 children in each group. The study group was the thermo-mechanical device with audio distraction; the control group was the thermo-mechanical device without audio distraction. IANB was administered. Subjective pain evaluation was performed using the Wong-Baker Faces Pain Rating Scale (WBFPR) and objective pain evaluation was done using the Faces, Leg, Activity, Consolability, Cry (FLACC) scale. Results: The outcome depicted a significant reduction in pain on injection for both objective and subjective evaluations in the thermo-mechanical device with an audio distraction group. Conclusions: Less pain on injection was observed, when a thermo-mechanical device was used with audio distraction for IANB procedures.

• 대한수학회지
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• 제49권6호
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• pp.1139-1161
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• 2012

Let $p$ be an odd prime number and let F be a finite field with $p^m$ elements. We study representations and strict representations of polynomials $M{\in}F$[T] by sums of ($p^r$ + 1)-th powers. A representation $$M=M_1^k+{\cdots}+M_s^k$$ of $M{\in}F$[T] as a sum of $k$-th powers of polynomials is strict if $k$ deg $M_i<k$ + degM.

• 한국식품과학회지
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• 제25권5호
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• pp.565-570
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• 1993

가공 과정 중 갈변에 관여하는 돼지감자의 peroxidase가 ammonium sulfate, DEAE-cellulose column, Sephacryl S-200 column chromatography에 의하여 36.65배로 정제되었다. 이 효소는 p-phenylenediamine을 기질로 사용하였을 때 pH5.0가 활성 최적 pH이었으며 pH $5.0{\sim}6.0$의 범위에서 비교적 안정하였다. 열 불활성화 곡선은 1차 곡선에서 벗어났고 60, 70, $80^{\circ}C$에서의 D값은 각각 86, 45, 33초이었으며 활성화에너지는 4,111 J/mole이었다. 이 효소의 기질특이성은 amine류 중에서 p-phenylenediamine과 가장 친화력이 좋았고 potassium cyanate, sodium diethyldithiocarbamate, L-ascorbic acid, sodium hydrosulfite, L-cysteine에 의해 활성이 완전히 억제되었으며 $Ca^{2+},\;Cu^{2+}$에 의해서는 활성이 촉진되었다.

• Biomolecules & Therapeutics
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• 제27권6호
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• pp.577-583
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• 2019

Human cytochrome P450 2C9 is a highly polymorphic enzyme that is required for drug and xenobiotic metabolism. Here, we studied eleven P450 2C9 genetic variants-including three novel variants F69S, L310V, and Q324X-that were clinically identified in Korean patients. P450 2C9 variant enzymes were expressed in Escherichia coli and their bicistronic membrane fractions were prepared The CO-binding spectra were obtained for nine enzyme variants, indicating P450 holoenzymes, but not for the M02 (L90P) variant. The M11 (Q324X) variant could not be expressed due to an early nonsense mutation. LC-MS/MS analysis was performed to measure the catalytic activities of the P450 2C9 variants, using diclofenac as a substrate. Steady-state kinetic analysis revealed that the catalytic efficiency of all nine P450 2C9 variants was lower than that of the wild type P450 2C9 enzyme. The M05 (R150L) and M06 (P279T) variants showed high $k_{cat}$ values; however, their $K_m$ values were also high. As the M01 (F69S), M03 (R124Q), M04 (R125H), M08 (I359L), M09 (I359T), and M10 (A477T) variants exhibited higher $K_m$ and lower $k_{cat}$ values than that of the wild type enzyme, their catalytic efficiency decreased by approximately 50-fold compared to the wild type enzyme. Furthermore, the novel variant M07 (L310V) showed lower $k_{cat}$ and $K_m$ values than the wild type enzyme, which resulted in its decreased (80%) catalytic efficiency. The X-ray crystal structure of P450 2C9 revealed the presence of mutations in the residues surrounding the substrate-binding cavity. Functional characterization of these genetic variants can help understand the pharmacogenetic outcomes.

• Parasites, Hosts and Diseases
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• 제30권2호
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• pp.141-146
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• 1992

Kato후층도말변법 (M.C.T.S.)과 Stoll 회석충란계산법(D.E.C.T)으로 회충, 괸충, 간흡 충란 양성자 197명에 대하여 충란 정량검사를 실시하고 그 결과를 비교하여 상관함수식을 도출하였다. M.C.T.S.법에 소요된 검경시간은 표본 1매당 평균 12.6분으로 D.E.C.T.법의 14.6분보다 짧았으며, 층계부하가 낮은 감염자에 있어서도 위음성이 적었다. 각 윤충류 충란에 있어서 M.C.T.S.으로 얻은 결과를 대변 1 g당 충란수(E.P.G.)로 바꾸어 주는 전환함수식은 회충의 경우 E.P.G.=47.86×100.87 logM.C.T.S., 편충은 E.P.G.=41.69×100.83 logM.C.T.S., 간흡충은 E.P.G=63.10×100.55 logM.C.T.S.이었다. 장내 윤충류 감염에 대한 정량적 대변검사법으로 Kato후층도말변법이 Stoll희석충란계산 법보다 더 유용하다고 생각되었다.

• Journal of Applied and Pure Mathematics
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• 제4권3_4호
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• pp.85-97
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• 2022

Let a graph G = (V, E) be a (p, q) graph. Define $${\rho}\;=\;\{\array{{\frac{p}{2}}&p\text{ is even}\\{\frac{p-1}{2}}\;&p\text{ is odd,}}$$ and M = {±1, ±2, ⋯ ± 𝜌} called the set of labels. Consider a mapping λ : V → M by assigning different labels in M to the different elements of V when p is even and different labels in M to p - 1 elements of V and repeating a label for the remaining one vertex when p is odd. The labeling as defined above is said to be a pair mean cordial labeling if for each edge uv of G, there exists a labeling $\frac{{\lambda}(u)+{\lambda}(v)}{2}$ if λ(u) + λ(v) is even and $\frac{{\lambda}(u)+{\lambda}(v)+1}{2}$ if λ(u) + λ(v) is odd such that ${\mid}\bar{\mathbb{S}}_{{\lambda}_1}-\bar{\mathbb{S}}_{{\lambda}^c_1}{\mid}{\leq}1$ where $\bar{\mathbb{S}}_{{\lambda}_1}$ and $\bar{\mathbb{S}}_{{\lambda}^c_1}$ respectively denote the number of edges labeled with 1 and the number of edges not labeled with 1. A graph G for which there exists a pair mean cordial labeling is called a pair mean cordial graph. In this paper, we investigate the pair mean cordial labeling of graphs which are obtained from path and cycle.

• Journal of Applied and Pure Mathematics
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• 제5권3_4호
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• pp.237-253
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• 2023

Let a graph G = (V, E) be a (p, q) graph. Define $${\rho}=\{\array{{\frac{p}{2}} & \;\;p\text{ is even} \\ {\frac{p-1}{2}} & \;\;p\text{ is odd,}$$ and M = {±1, ±2, … ± ρ} called the set of labels. Consider a mapping λ : V → M by assigning different labels in M to the different elements of V when p is even and different labels in M to p - 1 elements of V and repeating a label for the remaining one vertex when p is odd. The labeling as defined above is said to be a pair mean cordial labeling if for each edge uv of G, there exists a labeling ${\frac{{\lambda}(u)+{\lambda}(v)}{2}}$ if λ(u) + λ(v) is even and ${\frac{{\lambda}(u)+{\lambda}(v)+1}{2}}$ if λ(u) + λ(v) is odd such that ${\mid}{\bar{{\mathbb{S}}}}_{\lambda}{_1}-{\bar{{\mathbb{S}}}}_{{\lambda}^c_1}{\mid}{\leq}1$ where ${\bar{{\mathbb{S}}}}_{\lambda}{_1}$ and ${\bar{{\mathbb{S}}}}_{{\lambda}^c_1}$ respectively denote the number of edges labeled with 1 and the number of edges not labeled with 1. A graph G for which there exists a pair mean cordial labeling is called a pair mean cordial graph. In this paper, we investigate the pair mean cordial labeling behavior of few graphs including the closed helm graph, web graph, jewel graph, sunflower graph, flower graph, tadpole graph, dumbbell graph, umbrella graph, butterfly graph, jelly fish, triangular book graph, quadrilateral book graph.

• Journal of Applied and Pure Mathematics
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• 제6권1_2호
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• pp.55-69
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• 2024

Let a graph G = (V, E) be a (p, q) graph. Define $${\rho}=\{\array{{\frac{p}{2}} && p\;\text{is even} \\ {\frac{p-1}{2}} && p\;\text{is odd,}}$$ and M = {±1, ±2, … ± 𝜌} called the set of labels. Consider a mapping λ : V → M by assigning different labels in M to the different elements of V when p is even and different labels in M to p - 1 elements of V and repeating a label for the remaining one vertex when p is odd. The labeling as defined above is said to be a pair mean cordial labeling if for each edge uv of G, there exists a labeling $\frac{{\lambda}(u)+{\lambda}(v)}{2}$ if λ(u) + λ(v) is even and $\frac{{\lambda}(u)+{\lambda}(v)+1}{2}$ if λ(u) + λ(v) is odd such that ${\mid}\bar{\mathbb{s}}_{{\lambda}_1}-\bar{\mathbb{s}}_{{\lambda}^c_1}{\mid}\,{\leq}\,1$ where $\bar{\mathbb{s}}_{{\lambda}_1}$ and $\bar{\mathbb{s}}_{{\lambda}^c_1}$ respectively denote the number of edges labeled with 1 and the number of edges not labeled with 1. A graph G with a pair mean cordial labeling is called a pair mean cordial graph. In this paper, we investigate the pair mean cordial labeling behavior of some union of graphs.