• Proceedings of the PSK Conference
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• 2003.04a
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• pp.257.1-257.1
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• 2003

The bioassay-guided fractionation of preventive agents against lethality due to septic shock from the fruits of Illicium verum lead to the isolation of two known racemic mixtures of phenylpropanoids (1 and 2), along with two known phenylpropanoid glucosides (3 and 5) and two new phenylpropanoid glucosides (4 and 6). Their chemical structures were elucidated on the basis of spectroscopic studies. (omitted)

• Journal of Information Processing Systems
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• v.18 no.5
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• pp.701-710
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• 2022

With the development of artificial intelligence technology, various methods have been developed for recognizing objects in images using machine learning. Image segmentation is the most effective among these methods for recognizing objects within an image. Conventionally, image datasets of various classes are trained simultaneously. In situations where several classes require segmentation, all datasets have to be trained thoroughly. Such repeated training results in low training efficiency because most of the classes have already been trained. In addition, the number of classes that appear in the datasets affects training. Some classes appear in datasets in remarkably smaller numbers than others, and hence, the training errors will not be properly reflected when all the classes are trained simultaneously. Therefore, a new method that separates some classes from the dataset is proposed to improve efficiency during training. In addition, the accuracies of the conventional and proposed methods are compared.

• Biomolecules & Therapeutics
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• v.30 no.5
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• pp.399-408
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• 2022

Diabetic cardiomyopathy (DCM) is described as abnormalities of myocardial structure and function in diabetic patients without other well-established cardiovascular factors. Although multiple pathological mechanisms involving in this unique myocardial disorder, mitochondrial dysfunction may play an important role in its development of DCM. Recently, considerable progresses have suggested that mitochondrial biogenesis is a tightly controlled process initiating mitochondrial generation and maintaining mitochondrial function, appears to be associated with DCM. Nonetheless, an outlook on the mechanisms and clinical relevance of dysfunction in mitochondrial biogenesis among patients with DCM is not completely understood. In this review, hence, we will summarize the role of mitochondrial biogenesis dysfunction in the development of DCM, especially the molecular underlying mechanism concerning the signaling pathways beyond the stimulation and inhibition of mitochondrial biogenesis. Additionally, the evaluations and potential therapeutic strategies regarding mitochondrial biogenesis dysfunction in DCM is also presented.

• Journal of the Korean Mathematical Society
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• v.59 no.5
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• pp.927-944
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• 2022

Let $\vec{p}{\in}(0,\;1]^n$ be an n-dimensional vector and A a dilation. Let $H^{\vec{p}}_A(\mathbb{R}^n)$ denote the anisotropic mixed-norm Hardy space defined via the radial maximal function. Using the known atomic characterization of $H^{\vec{p}}_A(\mathbb{R}^n)$ and establishing a uniform estimate for corresponding atoms, the authors prove that the Fourier transform of $f{\in}H^{\vec{p}}_A(\mathbb{R}^n)$ coincides with a continuous function F on ℝⁿ in the sense of tempered distributions. Moreover, the function F can be controlled pointwisely by the product of the Hardy space norm of f and a step function with respect to the transpose matrix of A. As applications, the authors obtain a higher order of convergence for the function F at the origin, and an analogue of Hardy-Littlewood inequalities in the present setting of $H^{\vec{p}}_A(\mathbb{R}^n)$.

• Bulletin of the Korean Mathematical Society
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• v.60 no.5
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• pp.1365-1374
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• 2023

Let F be a periodic singular fiber of genus g with dual fiber F^*, and let T (resp. T^*) be the set of the components of F (resp. F^*) by removing one component with multiplicity one. We give a formula to compute the determinant | det T | of the intersect form of T. As a consequence, we prove that | det T | = | det T^*|. As an application, we compute the Mordell-Weil group of a fibration f : S → ℙ¹ of genus 2 with two singular fibers.

• Biomolecules & Therapeutics
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• v.31 no.5
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• pp.496-514
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• 2023

Cold atmospheric plasma (CAP), a redox modulation tool, is capable of inhibiting a wide spectrum of cancers and has thus been proposed as an emerging onco-therapy. However, with incremental successes consecutively reported on the anticancer efficacy of CAP, no consensus has been made on the types of tumours sensitive to CAP due to the different intrinsic characteristics of the cells and the heterogeneous design of CAP devices and their parameter configurations. These factors have substantially hindered the clinical use of CAP as an oncotherapy. It is thus imperative to clarify the tumour types responsive to CAP, the experimental models available for CAP-associated investigations, CAP administration strategies and the mechanisms by which CAP exerts its anticancer effects with the aim of identifying important yet less studied areas to accelerate the process of translating CAP into clinical use and fostering the field of plasma oncology.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2013.05a
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• pp.27-28
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• 2013

This study investigates the effect of a protective layer on the level of carbonation resistance of concrete. For the protective layer, a PE film, bubble sheets, double layered bubble sheets and styroform were placed in a mold before placing the concrete. In addition, PE film was retrofitted by attaching on the surface of the substrate concrete with a glue. Results showed that the carbonation depths of the control concrete were 4.6 mm and 5.2 mm at one week and two weeks exposure in an accelerated carbonation chamber, whereas the concrete with all types of protective layer except PE flim did not allow the ingress of carbon dioxide during the same period.

• Journal of Microbiology and Biotechnology
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• v.31 no.1
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• pp.154-162
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• 2021

L-5-methyltetrahydrofolate (5-MTHF) is one of the biological active forms of folate, which is widely used as a nutraceutical. However, low yield and serious pollution associated with the chemical synthesis of 5-MTHF hampers its sustainable supply. In this study, 5-MTHF production was improved by engineering the 5-MTHF biosynthesis pathway and NADPH supply in Lactococcus lactis for developing a green and sustainable biosynthesis approach. Specifically, overexpressing the key rate-limiting enzyme methylenetetrahydrofolate reductase led to intracellular 5-MTHF accumulation, reaching 18 ㎍/l. Next, 5-MTHF synthesis was further enhanced by combinatorial overexpression of 5-MTHF synthesis pathway enzymes with methylenetetrahydrofolate reductase, resulting in 1.7-fold enhancement. The folate supply pathway was strengthened by expressing folE encoding GTP cyclohydrolase I, which increased 5-MTHF production 2.4-fold to 72 ㎍/l. Furthermore, glucose-6-phosphate dehydrogenase was overexpressed to improve the redox cofactor NADPH supply for 5-MTHF biosynthesis, which led to a 60% increase in intracellular NADPH and a 35% increase in 5-MTHF production (97 ㎍/l). To reduce formation of the by-product 5-formyltetrahydrofolate, overexpression of 5-formyltetrahydrofolate cyclo-ligase converted 5-formyltetrahydrofolate to 5,10-methyltetrahydrofolate, which enhanced the 5-MTHF titer to 132 ㎍/l. Finally, combinatorial addition of folate precursors to the fermentation medium boosted 5-MTHF production, reaching 300 ㎍/l. To the best of our knowledge, this titer is the highest achieved by L. lactis. This study lays the foundation for further engineering of L. lactis for efficient 5-MTHF biosynthesis.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.16
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• pp.7295-7302
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• 2015

Background: Lung cancer has been a major health problem in developed countries for several decades, and has emerged recently as the leading cause of cancer death in many developing countries. The incidence of lung cancer appears to be increasing more rapidly in rural than in urban areas of China. This paper presents the trends of lung cancer incidence and survival derived from a 40-year population-based cancer monitoring program in a rural area, Qidong, China. Materials and Methods: The Qidong cancer registration data of 1972-2011 were used to calculate the crude rate, age-standardized rate by Chinese population (CASR) and by world population (WASR), birth cohort rates, and other descriptive features. Active and passive methods were used to construct the data set, with a deadline of the latest follow-up of April 30, 2012. Results: The total number of lung cancer cases was 15,340, accounting for 16.5% of all sites combined. The crude incidence rate, CASR and WASR of this cancer were 34.1, 15.7 and 25.4 per 100,000, respectively. Males had higher crude rates than females (49.7 vs 19.0). Rapidly increasing trends were found in annual percent change resulting in lung cancer being a number one cancer site after year 2010 in Qidong. Birth cohort analysis showed incidence rates have increased for all age groups over 24 years old. The 5 year observed survival rates were 3.55% in 1973-1977, 3.92 in 1983-1987, 3.69% in 1993-1997, and 6.32% in 2003-2007. Males experienced poorer survival than did females. Conclusions: Lung cancer has become a major cancer-related health problem in this rural area. The rapid increases in incidence likely result from an increased cigarette smoking rate and evolving environmental risk factors. Lung cancer survival, while showing some improvement in prognosis, still remains well below that observed in the developed areas of the world.

• Korean Journal of Acupuncture
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• v.29 no.2
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• pp.300-314
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• 2012

Objectives : This study is to observe the changes in the expression of neurotransmitters, such as NO, nNOS, and NE, upon the needle insertion to the sea points, which is one of the five transport points. Methods : Needles were inserted into rats, on both left and right sides of all sea points, including the LU5, PC3, HT3, LI11, TE10, SI8, SP9, LR8, KI10, ST36, GB34, and BL40, which are the sea points of five transport points for 12 meridian vessels. After insertion, needles were retained for five minutes. After the retention, blood was drawn via cardiac puncture, and tissues of each point near meridian vessels were extracted to examine the changes in the expression of NO, nNOS and NE. Results : In terms of the effect in NO production, there was a significant decrease only in the LU5 point, whereas there was a significant increase in the TE10 point alone. In terms of the expression of nNOS within tissues, none of the experimental groups showed significant changes based on the results of immunohistochemistry and western blotting. Regarding the formation of norepinephrine within tissues, the HT3, SP9, and KI10 point showed a significant decrease, while the PC3 and LR8 point showed a significant increase. Production of plasma norepinephrine was significantly increased at the TE10, SP9, LR8, GB34, and BL40 point. Conclusions : The effect of needles applied at the sea points of five transport points of 12 meridian vessels on the functions of NO, nNOS, and NE could be observed, and it is considered that the effect of needle stimulation on nervous system disorders could be studied through additional researches based on this one.