• 한국콘텐츠학회논문지
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• 제14권9호
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• pp.85-92
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• 2014

본 논문은 <도가니>가 어떠한 재현전략으로 대중성을 확보하는지에 관하여 짚어낸다. <도가니>의 '집단적 기억의 환기', '고전적인 내러티브', '영화의 자기반영성'은 관객을 분노하게 하여 사이버 공론장으로 모이게 했으며, 더 나아가 '참여적인 관객성'을 가능하게 했던 중요한 요인들이다. 그런데 관객의 분노를 극대화시킬 수 있었던 이 영화의 장치들은 윤리적 논란을 불러일으킨다. 본 논문은 <도가니>가 다양한 재현전략을 통해 '참여적인 관객성'을 이끌어 낼 수 있었던 원인분석을 목표로 한다.

• 복식문화연구
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• 제23권1호
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• pp.11-23
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• 2015

The purpose of this study was to investigate the differences in female college students' sociocultural attitude toward appearance and pursuit of clothing benefits according to their narcissism. Data collection was conducted through survey for female college students, and a total 221 questionnaires were used for data analyses. For analysis of data, frequency analysis, factor analysis, reliability analysis, and one-way ANOVA were applied. The results were summarized as follows. First, the factor analysis on narcissism resulted in two dimensional structures: self-initiated and other-dependent narcissism. The respondents were categorized into four narcissism groups, such as compositive, self-initiated, other-dependent, and withdrawn narcissism groups. Second, the factor analysis on sociocultural attitude toward appearance resulted in two dimensional structures: internalization and awareness. Five dimensions of pursuit of clothing benefits were identified: individuality, self-expression, fashion, comfort, and social recognition pursuit. Third, there were significant differences among the categorized narcissism groups in sociocultural attitude toward appearance and pursuit of clothing benefits. The results confirm that narcissism has an impact on sociocultural attitude toward appearance and pursuit of clothing benefits. It is expected that this study provides insight for apparel makers or retailers to develop their marketing strategies.

• Molecules and Cells
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• 제41권5호
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• pp.381-389
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• 2018

ARF is a tumor suppressor protein that has a pivotal role in the prevention of cancer development through regulating cell proliferation, senescence, and apoptosis. As a factor that induces senescence, the role of ARF as a tumor suppressor is closely linked to the p53-MDM2 axis, which is a key process that restrains tumor formation. Thus, many cancer cells either lack a functional ARF or p53, which enables them to evade cell oncogenic stress-mediated cycle arrest, senescence, or apoptosis. In particular, the ARF gene is a frequent target of genetic and epigenetic alterations including promoter hyper-methylation or gene deletion. However, as many cancer cells still express ARF, pathways that negatively modulate transcriptional or post-translational regulation of ARF could be potentially important means for cancer cells to induce cellular proliferation. These recent findings of regulators affecting ARF protein stability along with its low levels in numerous human cancers indicate the significance of an ARF post-translational mechanism in cancers. Novel findings of regulators stimulating or suppressing ARF function would provide new therapeutic targets to manage cancer- and senescence-related diseases. In this review, we present the current knowledge on the regulation and alterations of ARF expression in human cancers, and indicate the importance of regulators of ARF as a prognostic marker and in potential therapeutic strategies.

• 한국의류학회지
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• 제21권4호
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• pp.699-709
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• 1997

The purpose of this study is to investigate consumer shopping orientation toward foreign brands in the context of clothing involvement, ethnocentrism, country-of-origin effects and demograpic variables. Prior to this paper, shopping orientation was studied in connection with ethnocentrism and country-of-origin effects. The questionnaire was distributed to 300 female consumers over twenty years old living in Pusan area and finally 213 data serfs were used for statistical analysis. By factor analysis, 6 clothing involvement factors were identified; fashion interest, symbolism, pleasure interest, inclination to harmony, aesthetic expression and perceived risk. A result of canonical correlation analysis about shopping orientation factors and clothing involvement factors is as follows. Two shopping orientation factors (follow to foreign brands and country-of-orion consciousness) positively correlate with three clothing involvement factors (fashion interest, symbolism and pleasure interest) , and two shopping orientation factors (preference to domestics and country-of-orion consciousness) positively correlate with author clohting involvement factor (percived risk). Anocova procedure revealed that five shopping orientation factors were related to clothing involvement factors, groups according to ethnocentric disposition, country-of-origin effects and demograpics respectively, even though there are some differences. Based on the conclusions, marketing strategies were developed.

• 한국의류학회지
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• 제31권7호
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• pp.1075-1084
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• 2007

The purpose of this study is to find out the important factors and efficient strategies concerning internet marketing. This study tries to examine satisfaction of the on-line consumers on internet shopping mall via fashion products. To fulfill this objectives, a survey was conducted from May 15 to May 30 in 2006, and an subject of study is men and women aged from 10s to 40s in purchase experience of the fashion merchandise to internet shopping malls. Data collected over the internet, and analyzed the 205 subjects. The statistical analysis methods was frequency analysis, reliability analysis, factor analysis, multiple regression analysis. The empirical studies were summarized as follows. First, internet shopping mall's fashion goods attributes(goods characteristics, aesthetic expression, variety of goods) significantly affect consumer's utilitarian shopping value. Second, internet shopping mall good's price attributes(economical efficiency of price, price reasonableness, price value, price information, price discount) significantly affect consumer's shopping utilitarian shopping value and hedonic shopping value. Third, consumer's utilitarian shopping value and hedonic shopping value are positively related to the internet consumer's shopping satisfaction.

• 정보관리학회지
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• 제16권3호
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• pp.65-82
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• 1999

부적절한 검색어의 선정 및 검색식의 작성은 인터넷 정보검색 수행 시 검색 효율 저하의 주요 원인으로 작용하게 된다. 또한 정보검색 수행 시 발생하는 어휘의미중의성(Word Sense Ambiguation) 역시 검색 효율 저하의 주요 원인으로 작용하는데, 어휘의미중의성에 의한 효율 저하 정도를 실험을 통해 확인하였다. 어휘의미중의성에 의한 검색 효율 저하란 검색어로 입력한 어휘가 문서에서 서로 다른 의미로 사용됨에 따라 의도하지 않은 다른 문서가 검색될 수 있음을 의미한다. 본 논문에서는 새로운 정보검색 환경인 인터넷기반정보검색에 있어 어휘의미중의성이 검색 정확률에 미치는 영향을 살펴보고, 기존의 정보검색에 있어 어휘의미중의성에 관한 연구가 인터넷기반 정보검색에 있어서도 제대로 적용되는지를 조사 분석하였다.

• 한국동물생명공학회지
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• 제35권1호
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• pp.12-20
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• 2020

Cell adhesion plays an important role in the differentiation of the morphogenesis and the trophectoderm epithelium of the blastocyst. In the porcine embryo, CDH1 mediated adhesion initiates at compaction before blastocyst formation, regulated post-translationally via protein kinase C and other signaling molecules. Here we focus on muscle RAS oncogene homolog (M-RAS), which is the closest relative to the RAS related proteins and shares most regulatory and effector interactions. To characterize the effects of M-RAS on embryo compaction, we used gain- and loss-of-function strategies in porcine embryos, in which M-RAS gene structure and protein sequence are conserved. We showed that knockdown of M-RAS in zygotes reduced embryo development abilities and CDH1 expression. Moreover, the phosphorylation of ERK was also decreased in M-RAS KD embryos. Overexpression of M-RAS allows M-RAS KD embryos to rescue the embryo compaction and blastocyst formation. Collectively, these results highlight novel conserved and multiple effects of M-RAS during porcine embryo development.

• 한국어교육
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• 제25권1호
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• pp.115-144
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• 2014

The purpose of this paper is to compare the two different instruction methods for Korean learners of academic purposes in learning request expression. Participants were divided into two groups, explicit and implicit group. Both groups viewed several scenes from the drama that involved native speakers interacting in different situations. The instructional treatment for the explicit group included metapragmatic information while the treatment for the implicit group did not. On the other hand, the treatment for the implicit group followed implicit techniques, which were repetition of the video presentation and a script reading activity. This study was made up of a pre-test, a post-test, and a delayed-test. The pre-test was conducted prior to the instructional treatment. The post-test was administered a day after the last instruction and the delayed-test was conducted five weeks after the treatments. Two types of tests, speaking and writing, were used in this study to examine subjects' knowledge of Korean request. The result of this research reveals that implicit treatment was more effective than explicit treatment in Korean learners' request acquisition. This results might have been due to the operationalization of the implicit condition in this study. Implicit instruction may help language learners make rules by themselves through tasks.

• 기본간호학회지
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• 제26권2호
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• pp.107-116
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• 2019

Purpose: The purpose of this study was to identify factors with nursing students's confidence in performing fundamental nursing skills. The focus was on professionalism and self-efficacy. Method: For the sample 258 fourth graders of nursing students were recruited in two universities located in Gyeongnam or Ulsan. Data were analyzed using t-test, Pearson's correlation coefficients, and hierarchical multiple regression. Results: The mean score for confidence in performing fundamental nursing skills was $3.71{\pm}0.58$. Nursing professionalism and self-efficacy were positively correlated with confidence in performing fundamental nursing skills. Analysis using multiple regression showed that 27% of factors predicting confidence in performance of fundamentals of nursing practice (F=16.43, p<.001) included nursing professionalism (${\beta}=.37$, p<.001), self-expression (${\beta}=.15$, p=.009), and self-efficacy (${\beta}=.14$, p=.029). Conclusion: Findings show that nursing professionalism is one of the major factors influencing confidence in performing fundamental nursing skills. In order to improve the confidence in performing fundamental nursing skills, it is necessary to establish effective educational strategies that firmly enhance nursing professionalism and improve self-efficacy in nursing students.

• Molecules and Cells
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• 제44권3호
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• pp.127-135
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• 2021

Since the introduction of RNA sequencing (RNA-seq) as a high-throughput mRNA expression analysis tool, this procedure has been increasingly implemented to identify cell-level transcriptome changes in a myriad of model systems. However, early methods processed cell samples in bulk, and therefore the unique transcriptomic patterns of individual cells would be lost due to data averaging. Nonetheless, the recent and continuous development of new single-cell RNA sequencing (scRNA-seq) toolkits has enabled researchers to compare transcriptomes at a single-cell resolution, thus facilitating the analysis of individual cellular features and a deeper understanding of cellular functions. Nonetheless, the rapid evolution of high throughput single-cell "omics" tools has created the need for effective hypothesis verification strategies. Particularly, this issue could be addressed by coupling cell engineering techniques with single-cell sequencing. This approach has been successfully employed to gain further insights into disease pathogenesis and the dynamics of differentiation trajectories. Therefore, this review will discuss the current status of cell engineering toolkits and their contributions to single-cell and genome-wide data collection and analyses.