• Korean Journal of Pharmacognosy
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• v.49 no.4
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• pp.298-304
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• 2018

Malus sieboldii is a dicotyledonous plant that grows widely in Jeju Island and Ganghwa Island in Korea. Malus sieboldii has been known as a detoxifying and antioxidant plant, but study on allergic diseases is not known. In this study, we investigated the effect of Malus sieboldii extract (MSE) on the activation of mast cells, which is well known to be a critical causative cell to induce allergic diseases. As a result of our experiments, MSE inhibited the degranulation and inflammatory cytokine secretion from mast cells by antigen stimulation. As the mechanism of MSE in mast cells, it inhibited the activation of Syk kinase, a essential signaling protein activated by antigen, and further inhibited activation of $PLC{\gamma}$ and MAP kinase(P38, ERK1/2, and JNK). Furthermore, in vivo animal studies showed that MSE significantly inhibited IgE-mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis in a dose-dependent manner. Taken together, the results of this study showed for the first time that MSE inhibited IgE-mediated allergic responses by suppressing Syk kinase in mast cells. Therefore, it could be considered that MSE is worth developing as an anti-allergic material.

• Journal of Food Hygiene and Safety
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• v.29 no.4
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• pp.356-362
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• 2014

Allergic diseases have increased rapidly over the past decades, affecting an estimated 20~30% of the population in developed countries. In this study, we investigated whether or not a typical costal sand dune plant Carex pumila (CPE) suppresses the activation of mast cells and IgE-mediated allergic response in vitro and in vivo. As the results, the extract of Carex pumila inhibited antigen-stimulated degranulation in RBL-2H3 cells and Bone marrow-derived mast cells (BMMCs), and IgE-mediated passive cutaneous anaphylaxis (PCA) in mice. CPE also suppressed the production of pro-inflammatory cytokines, TNF-${\alpha}$ and IL-4, in antigen-stimulated mast cells. As its mechanism of action, CPE inhibited the activation of Syk in $Fc{\varepsilon}RI$-mediated signalling pathway, and that of LAT, a downstream adaptor molecule of Syk, in a dose-dependent manner. CPE also suppressed the activation of mitogen-activated protein (MAP) kinases, p38, ERK1/2, JNK, and Akt. Altogether, CPE inhibited mast cell activation and IgE-mediated allergic response by antigen through suppressing the activation of Syk. These results suggest that CPE may be useful for the treatment of allergic diseases.

• Journal of the Korean Chemical Society
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• v.59 no.2
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• pp.164-178
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• 2015

The purpose of this study was to design a teaching and learning method conductive to the development of creative thinking skills and investigate its effects. It has been developed integrated mind map with feature of visualizing the divergent thinking to the aspects of Science (S), Technology (T) & Engineering (E), Arts (A), Mathematics (M). Integrated mind map can be divided into four types of STEAM type, STEA type, STEM type, STE type depending on the category of key words in the first branch. And Integrated mind map can be divided into three levels of guided, intermediate, open depending on the teacher's guide degree. And also integrated mind map activities were carried out in the form of group, class share as well as individual. This study was implemented during a semester and students in experiment group experienced individual-integrated mind map activity 10 times, group-integrated mind map activity 10 times, class share-integrated mind map activity 3 times. The results indicated that the experimental group presented statistically meaningful improvement in creative thinking skills (p<.05). And there was a statistically meaningful improvement in fluency, flexibility, originality as a sub-category of creative thinking skills(p <.05). Also creative thinking skills are not affected by the level of cognitive, academic performance, gender (p<.05). In conclusion, it was found that 'integrated mind map activity' improved student's creative thinking skills. There was no interaction effect about creative thinking skills between the teaching strategy and cognitive level, achivement, gender of those students.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.11 no.7
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• pp.1305-1310
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• 2007

ePosition is a technology that can provide the spacial position of the earth to the information of ePosition ID through the Internet. It is serving the information of land location based on the Internet using the ePosition technology now, but it needs the service technique which can supply the marine data and the information of maritime position. Moreover, to support the information service of marine position, it needs the ENC linked technique based on S-57 that is an IHO transfer standard for digital hydrographic data. In this paper, therefore, it develops a linkage method for applying and utilizing the ePosition technology to ENC data, and supplements the base technology for applying it to marine related fields. As study method, firstly, this paper analyses ENC data model and structure, and converses for processing ENC file to ePosition data. Lastly, it derives the interconnection method with ePosition database and shows the ePosition service application based on the linked data and its validity.

• Korean Journal of Pharmacognosy
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• v.44 no.2
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• pp.118-124
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• 2013

Mast cells is the key effector cells for IgE-mediated allergic responses. In this study, we investigated whether Rhus trichocarpa extract (RT) inhibited IgE-mediated allergic responses in mast cells and an allergic animal model. We further tried to find its mechanism of action in mast cells. We found that RT suppressed antigen-stimulated degranulation and production of TNF-${\alpha}$ and IL-4 in rat basophilic leukemia (RBL)-2H3 mast cells and bone marrow-derived mast cells (BMMC), as well as IgE-mediated passive cutaneous anaphylaxis (PCA) in mice. As the mechanism of action of RT, it inhibited the activation of spleen tyrosine kinase (Syk), a pivotal signaling molecule for activation of mast cells and that of LAT, a downstream adaptor molecule of Syk in $Fc{\varepsilon}RI$-mediated signal pathways. RT also suppressed the activation of mitogen-activated protein (MAP) kinases and Akt. The current results demonstrated for the first time that RT has the anti-allergic effect through inhibiting degranulation and secretion of cytokines by suppression of Syk in antigen-stimulated mast cells. Therefore, RT might be useful for allergic diseases.

• Proceedings of the Korean Society for Quality Management Conference
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• 2004.04a
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• pp.148-151
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• 2004

This study presents a new intelligent yield management methodology which can forecast the yield level of a production unit based on features' behaviors. In this proposed methodology, we identify the existing features using C5.0 that are combination of nodes (i.e., variables) in the decision tree generated by C5.0, use SOM(Self-Organizing Map) neural networks in oder to extract the feature's patterns and classify, and then make features' control rules using C5.0.

• Journal of Korean Society for Geospatial Information Science
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• v.13 no.3 s.33
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• pp.53-57
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• 2005

The moors ecosystem is sensitive environment change and weak in artificial interference. These nature property are very important to people. It is necessary to preservation and protection the moors with a countermeasure. We really need to Environment-GIS(E-GIS) using Geographical Information System(GIS) and digital map including range, correct position and attribute data of moors. In this study, we take priority of making a database of moors management. Taking effect an environment assesment, we concentrate on a standard method of digital map production and a preservation of moors in our research using GIS. Especially, we have to preserve our important national heritage using GIS when Environment Assesment is conducting under construction. We suggest to pre-estimated model of hidden moors as analysing terrain, geological feature, a geographical distribution of plants and animals using GIS.

• Journal of Biomedical Engineering Research
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• v.44 no.6
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• pp.392-403
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• 2023

This study presents a new hybrid fNIRS-EEG system to meet the demand for a lightweight and low-cost sleep pattern monitoring device. For multiple-channel configuration, a six-channel electroencephalogram (EEG) and a functional near-infrared spectroscopy (fNIRS) system with eight photodiodes (PD) and four dual-wavelength LEDs are designed. To enhance the convenience of signal measurement, the device is miniaturized into a patch-like form, enabling simultaneous measurement on the forehead. Due to its fully integrated functionality, the developed system is advantageous for performing sleep stage classification with high-temporal and spatial resolution data. This can be realized by utilizing a two-dimensional (2D) brain activation map based on the concentration changes in oxyhemoglobin and deoxyhemoglobin during sleep stage transitions. For the system verification, the phantom model with known optical properties was tested at first, and then the sleep experiment for a human subject was conducted. The experimental results show that the developed system qualifies as a portable hybrid fNIRS-EEG sleep pattern monitoring device.

• Journal of environmental and Sanitary engineering
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• v.18 no.4
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• pp.15-23
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• 2003

The purpose of this study is to construct e-Nonsan, a user friendly river quality management information system for Nonsan-si basin using GIS (geographical information system) technology. GIS was ideally suited featuring a geographical characteristics(e.g., industries, cattle sheds) and very effectively used in mapping and symbolization for the distribution of the spatial/periodic status(e.g., pie or column chart) of the point/non-point pollutant source loads which can be effectively applied to a information system on the web-site. And a user interface, GUI(graphic user interface) was designed very diversely and simply enabled the and non environmental experts connect with the system and obtain a useful information of river quality. e-Nonsan, a visual mapping system for river quality was developed by reframing the monitoring data as graphic symbols and it was ideally suited to exploring area-wide river quality at a user-friendly manner due to extensibility and scalability along the various survey points. Eventually the final step of this study was to construct e-Nonsan based on Web-GIS could be assessed anywhere if internet service is available and offer a very useful information services of the river quality to the publics.

• Journal of Digital Contents Society
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• v.11 no.4
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• pp.545-552
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• 2010

To a developing country, the advancement of economic status through informatization is an important element contributing to the local society, nation, and to the global world. This research paper is a study on application of Korea's local informatization successful model to Indonesia. Through activated interaction between enterprises and policy makers from Korea and Indonesia, the research paper seeks to create research based network and provide opportunities of information access and business matching to local informatized and e-business enterprises. In research adopted regions, Indonesia's pekalongan region where infra is settled to certain extent by city development project is selected. Therefore, investigating on pekalongan's current geographical, humanistic status quo, and infra, the paper suggest a road map to customized pekalongan's local informatization based on Korean local informatizing successful model.