Journal of Food Hygiene and Safety (한국식품위생안전성학회지)

The Korean Society of Food Hygiene and Safety (한국식품위생안전성학회)
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Carex pumila Extract Supresses Mast Cell Activation and IgE-Mediated Allergic Response in Mice

좀보리사초의 IgE 매개성 알레르기 반응 억제 효과 및 기전

  • Lim, Hannah (College of Pharmacy, Duksung Women's University) ;
  • Kim, Young Mi (College of Pharmacy, Duksung Women's University)
  • 임한나 (덕성여자대학교 약학대학) ;
  • 김영미 (덕성여자대학교 약학대학)
  • Received : 2014.11.04
  • Accepted : 2014.11.10
  • Published : 2014.12.31
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Abstract

Allergic diseases have increased rapidly over the past decades, affecting an estimated 20~30% of the population in developed countries. In this study, we investigated whether or not a typical costal sand dune plant Carex pumila (CPE) suppresses the activation of mast cells and IgE-mediated allergic response in vitro and in vivo. As the results, the extract of Carex pumila inhibited antigen-stimulated degranulation in RBL-2H3 cells and Bone marrow-derived mast cells (BMMCs), and IgE-mediated passive cutaneous anaphylaxis (PCA) in mice. CPE also suppressed the production of pro-inflammatory cytokines, TNF-${\alpha}$ and IL-4, in antigen-stimulated mast cells. As its mechanism of action, CPE inhibited the activation of Syk in $Fc{\varepsilon}RI$-mediated signalling pathway, and that of LAT, a downstream adaptor molecule of Syk, in a dose-dependent manner. CPE also suppressed the activation of mitogen-activated protein (MAP) kinases, p38, ERK1/2, JNK, and Akt. Altogether, CPE inhibited mast cell activation and IgE-mediated allergic response by antigen through suppressing the activation of Syk. These results suggest that CPE may be useful for the treatment of allergic diseases.

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References

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