• Journal of Periodontal and Implant Science
• /
• v.45 no.4
• /
• pp.145-151
• /
• 2015

Purpose: The aim of this study was to investigate the therapeutic effects of a herbal formula, PerioH-035, containing Angelica sinensis, steamed Rehmannia glutinosa, Angelica dahurica, Cimicifuga heracleifolia, and Zanthoxylum piperitum on the periodontal breakdown in a well-established ligature-induced periodontitis model in rats. Methods: Sprague-Dawley rats were randomly assigned to 1 of 4 groups: NL (non-ligatured), L (ligatured), P1 (ligatured and treated with 1 mg/mL PerioH-035), P100 (ligatured and treated with 100 mg/mL PerioH-035). Periodontitis was induced by placing a ligature around the mandibular first molars. PerioH-035 was topically applied to both sides of the first molar for 2 weeks. The right side of the mandibles was retrieved for micro-computed tomography (CT) and methylene blue staining to analyze alveolar bone loss. The left side of the mandibles was histologically analyzed by TRAP and H&E staining. The MMP-9 mRNA level in gingival tissue was investigated by RT-PCR. Results: Alveolar bone resorption was significantly reduced in the PerioH-035-treated groups. The number of dense multi-nucleated cells found to be TRAP-positive by staining in the ligatured rats was markedly decreased by PerioH-035 application. In addition, periodontal tissue destruction, especially cementum demineralization, was ameliorated in the P1 and P100 groups. Moreover, gingival tissue from the PerioH-035-treated group showed a decrease in the MMP-9 mRNA level, resulting in recovery of collagen degradation. Conclusions: These results suggest that PerioH-035 has therapeutic effects on periodontitis, and thus, PerioH-035 shows promise as a treatment for periodontitis.

• Asian-Australasian Journal of Animal Sciences
• /
• v.33 no.10
• /
• pp.1590-1598
• /
• 2020

Objective: The objective of this study was to evaluate the effects of lysophospholipids (LPL) supplementation on rumen fermentation, degradability, and microbial diversity in forage with high oil diet in an in vitro system. Methods: Four experimental treatments were used: i) annual ryegrass (CON), ii) 93% annual ryegrass +7% corn oil on a dry matter (DM) basis (OiL), iii) OiL with a low level (0.08% of dietary DM) of LPL (LLPL), and iv) OiL with a high level (0.16% of dietary DM) of LPL (HLPL). An in vitro fermentation experiment was performed using strained rumen fluid for 48 h incubations. In vitro DM degradability (IVDMD), in vitro neutral detergent fiber degradability, pH, ammonia nitrogen (NH₃-N), volatile fatty acid (VFA), and microbial diversity were estimated. Results: There was no significant change in IVDMD, pH, NH₃-N, and total VFA production among treatments. The LPL supplementation significantly increased the proportion of butyrate and valerate (Linear effect [Lin], p = 0.004 and <0.001, respectively). The LPL supplementation tended to increase the total bacteria in a linear manner (p = 0.089). There were significant decreases in the relative proportions of cellulolytic (Fibrobacter succinogenes and Ruminococcus albus) and lipolytic (Anaerovibrio lipolytica and Butyrivibrio proteoclasticus) bacteria with increasing levels of LPL supplementation (Lin, p = 0.028, 0.006, 0.003, and 0.003, respectively). Conclusion: The LPL supplementation had antimicrobial effects on several cellulolytic and lipolytic bacteria, with no significant difference in nutrient degradability (DM and neutral detergent fiber) and general bacterial counts, suggesting that LPL supplementation might increase the enzymatic activity of rumen bacteria. Therefore, LPL supplementation may be more effective as an antimicrobial agent rather than as an emulsifier in the rumen.

• Journal of Preventive Medicine and Public Health
• /
• v.55 no.3
• /
• pp.234-242
• /
• 2022

Objectives: This study assessed the validity and reliability of the Health-related Quality of Life Instrument with 8 Items (HINT-8) in patients with diabetes. HINT-8 is a newly-developed, generic health-related quality of life (HRQoL) instrument. Methods: Three HRQoL instruments-HINT-8, EuroQoL 5-Dimension 5-Level (EQ-5D-5L), and Short Form Health Survey version 2.0 (SF-36v2)-were provided to 300 patients with diabetes visiting a tertiary hospital for follow-up visits in Korea. The HRQoL scores obtained using the HINT-8 were evaluated for subgroups with known differences based on demographics and diabetes-related characteristics (known-group validity). The mean scores of the instruments were compared between groups segmented by their responses to the HINT-8 (discriminatory ability). Correlation coefficients of the HINT-8 with other instruments were calculated (convergent and divergent validity). The Cohen kappa and intra-class correlation coefficient (ICC) were also evaluated (test-retest reliability). Results: The average HINT-8 indexes were lower among women, older, and less-educated subjects. Subjects who did not list any problems on the HINT-8 had significantly higher HRQoL scores than those who did. The correlation coefficients of the HINT-8 with the EQ-5D-5L index and EuroQoL visual analogue scale were 0.715 (p<0.001) and 0.517 (p<0.001), respectively. The correlation coefficients between the HINT-8 index and the scores of 8 domains of the SF-36v2 ranged from 0.478 (p<0.001) to 0.669 (p<0.001). The Cohen kappa values for the HINT-8 ranged from 0.268 to 0.601, and the ICC of the HINT-8 index was 0.800 (95% confidence interval [CI], 0.720 to 0.860). Conclusions: This study showed that the HINT-8 is a valid and reliable HRQoL instrument for patients with diabetes.

• Korean Journal of Applied Biomechanics
• /
• v.29 no.4
• /
• pp.205-211
• /
• 2019

Objective: The purpose of this study was to analyze the effects of skill and distance factors on CoP (Center of pressure) and CoM (Center of mass) during golf putting. Method: 38 golfers were participated in this study. 8 motion capture cameras (250 Hz) and 2 force plates (1,000 Hz) were used to collect CoP and CoM during 2 m and 3 m of distance golf putting. To identify main effect and interaction effect, it was performed Two-Way ANOVA at a significant level of a .05. Results: In the novice group, CoP distance was significantly difference in the A/P direction and main effect between skill level and distance. Both groups indicated that CoP distance was significantly different and main effect between skill level and distance in the M/L direction. Finally, both groups showed that CoM was significantly different and main effect between skill level and distance in the M/L direction. Conclusion: Therefore, novice golfers are expected to be able to perform more accurate and proper putting exercise through the practice of minimizing the center of mass(CoM) and center of pressure (CoP) in the M/L direction, which is the pendulum movement of the putter head.

• Journal of IKEEE
• /
• v.25 no.2
• /
• pp.322-329
• /
• 2021

In this study, a method for improving the light extraction efficiency of organic light emitting diodes was presented using the polymer Poly(vinylidenefluoride-co-trifluoroethylene) [P(VDF-TrFE)] having an island surface structure after annealing. Polydimethylsiloxane (PDMS) imprinted on the island-structured P(VDF-TrFE) surface has a spike structure, which improves the external light extraction efficiency aroud 20%. It was confirmed that the produced film showed a low haze characteristic of 8.2, and the Current and external quantum efficiency could be improved without pixel blur due to the excellent transmittance of 93.4%.

• ALGAE
• /
• v.31 no.4
• /
• pp.391-401
• /
• 2016

To develop an easy and rapid method of quantifying lipid contents of marine dinoflagellates, we quantified lipid contents of common dinoflagellate species using a colorimetric method based on the sulpho-phospho-vanillin reaction. In this method, the optical density measured using a spectrophotometer was significantly positively correlated with the known lipid content of a standard oil (Canola oil). When using this method, the lipid content of each of the dinoflagellates Alexandrium minutum, Prorocentrum micans, P. minimum, and Lingulodinium polyedrum was also significantly positively correlated with the optical density and equivalent intensity of color. Thus, when comparing the color intensity or the optical density of a sample of a microalgal species with known color intensities or optical density, the lipid content of the target species could be rapidly quantified. Furthermore, the results of the sensitivity tests showed that only $1-3{\times}10^5cells$ of P. minimum and A. minutum, $10^4cells$ of P. micans, and $10^3cells$ of L. polyedrum (approximately 1-5 mL of dense cultures) were needed to determine the lipid content per cell. When the lipid content per cell of 9 dinoflagellates, a diatom, and a chlorophyte was analyzed using this method, the lipid content per cell of these microalgae, with the exception of the diatom, were significantly positively correlated with cell size, however, volume specific lipid content per cell was negatively correlated with cell size. Thus, this sulpho-phospho-vanillin method is an easy and rapid method of quantifying the lipid content of autotrophic, mixotrophic, and heterotrophic dinoflagellate species.

• Journal of the Korea Convergence Society
• /
• v.9 no.11
• /
• pp.443-454
• /
• 2018

The purpose of this convergence study was to evaluate and to identify predictors of health-related quality of life(HRQoL) of families with cancer survivor(FCS) focusing on the comparison of families with cancer patient(FCP) receiving treatments. The research was conducted with the data for 153 FCS and 115 FCP taken from the 6th wave of the Korea National Health and Nutrition Examination Survey. The independent variables included socio-demographic, health related, psychological and social factors. The data were analyzed by hierarchical multiple regression analysis using SPSS/WIN 18.0. The results showed different patterns of predictors on the HRQoL of FCS and FCP. In FCS, the statistically significant factors were stress(${\beta}=-.192$, p<.05) and exclusion from economic activities(${\beta}=-.191$, p<.05). Therefore, families of cancer patients also need appropriate interventions for each stage of the disease.

• Korean Journal of Mathematics
• /
• v.24 no.3
• /
• pp.545-565
• /
• 2016

In this paper, we present some general results on the pointwise convergence of the non-convolution type nonlinear singular integral operators in the following form: $$T_{\lambda}(f;x)={\large\int_{\Omega}}K_{\lambda}(t,x,f(t))dt,\;x{\in}{\Psi},\;{\lambda}{\in}{\Lambda}$$, where ${\Psi}$ = and ${\Omega}$ = stand for arbitrary closed, semi-closed or open bounded intervals in ${\mathbb{R}}$ or these set notations denote $\mathbb{R}$, and ${\Lambda}$ is a set of non-negative numbers, to the function $f{\in}L_{p,{\omega}}({\Omega})$, where $L_{p,{\omega}}({\Omega})$ denotes the space of all measurable functions f for which $\|{\frac{f}{\omega}}\|^p$ (1 ${\leq}$ p < ${\infty}$) is integrable on ${\Omega}$, and ${\omega}:{\mathbb{R}}{\rightarrow}\mathbb{R}^+$ is a weight function satisfying some conditions.

• Journal of the Korea Convergence Society
• /
• v.12 no.10
• /
• pp.105-112
• /
• 2021

The effect of buckwheat dietary fiber (BDF) as hypolipidemic and antioxidant agent were determined in C57BL/6 mice fed a high fat diet (HFD) with different doses of 500 (low, BDF-L) or 1,000 (high, BDF-H) mg/kg of body weight, compared with the HFD-diet control group (HFD). The negative control group (ND) was fed the basal diet. Body weights in the BDF-L and BDF-H groups were significantly decreased as compared to those in the HFD group (p<0.05). BDF also improved the lipid profile in a dose-dependent manner; serum lipid profiles and levels of insulin, glucose, and free fatty acid were significantly decreased in the BDF-L and BDF-H groups, whereas HDL-C and adiponectin significantly increased as compared to the HFD group (p<0.05). Meanwhile, BDF lowered serum malondialdehyde (MDA) in comparison with the HFD group (p<0.05). The results demonstrate that the intake of BDF might prevent obesity and its related metabolic disorders by inducing dyslipidemia and oxidative stress.

• Honam Mathematical Journal
• /
• v.32 no.3
• /
• pp.399-412
• /
• 2010

In this paper, we consider a preconditioned accelerated overrelaxation (PAOR) method to solve systems of linear equations. We show the convergence of the PAOR method. We also give com-parison results when the coefficient matrix is an L- or H-matrix. Finally, we provide some numerical experiments to show efficiency of PAOR method.