Purpose: This study investigated the correlations among resilience, the awareness of patient safety management, proactive behavior, and the performance of standard precautions among nurses working in the emergency department. Additionally, it aimed to identify the factors influencing the performance of standard precautions. Methods: Data were collected through a descriptive survey conducted between June 10 and July 9, 2023. The participants included 208 nurses working in the emergency department in Korea. The collected data were analyzed using SPSS/WINdows software version 29.0, based on the frequency, percentage, mean, standard deviation, t-test, one-way analysis of variance, Scheffé test, Pearson's correlation coefficients, and multiple regression. Results: The analysis based on the participants' general characteristics showed that performance of standard precautions varied significantly according to age (t=2.10, p=.036), size of the emergency department (F=7.46, p<.001), average number of patients treated per day while working in the past month (t=-3.88, p<.001) and standard precautions training experience (t=2.16, p=.032). The main factors influencing the performance of standard precautions among nurses working in the emergency department are awareness of patient safety management (β=.62, p<.001), resilience (β=.18, p=.042), and age (β=-.15, p=.007), with a total explanatory power of approximately 46.0%. Conclusion: It is necessary to establish programs and an effective education system to increase resilience and awareness in patient safety management to improve the performance of standard precautions among nurses working in the emergency department.