• Journal of the Society of Disaster Information
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• v.19 no.4
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• pp.958-967
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• 2023

Purpose: This study aims to analyze the fire resistance performance applied to plant facilities with high fire risk in Korea, secure suitable fire resistance performance, and ensure the fire safety of plant facilities. Method: Using the finite element analysis program Ansys, thermal transfer analysis and structural analysis were performed with fire load and fireproof coating as variables, and the fire resistance performance of plant facilities was analyzed based on the analysis results. Result: The fireproof coating applied to domestic plant facilities failed to secure fire resistance performance when the fire load of hydrocarbon fire presented in UL 1709 was applied, and it was confirmed that the deformation of steel after the fire was also significant. Conclusion: The current fire resistance performance applied to plant facilities in Korea cannot secure fire resistance performance in sudden fire growth and large fire loads like petrochemical plants, and it is necessary to secure fire safety by evaluating suitable fire resistance performance through performance evaluation of plant facilities.

• Structural Monitoring and Maintenance
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• v.10 no.3
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• pp.207-220
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• 2023

The safety of bridges are critical in our transportation infrastructure. Bridge design and analysis require complex structural analysis procedures to ensure their safety and stability. One common method is to calculate the maximum moment in the girders to determine the appropriate bridge section. Girder distribution factors (GDFs) provide a simpler approach for performing this analysis. A GDF is a ratio between the response of a single girder and the total response of all girders in the bridge. This paper explores the significance of GDFs in bridge analysis and design, including their importance in the evaluation of existing bridges. We utilized Bridge Weigh-in-motion (B-WIM) measurements of five simple supported girder bridge in Indonesia to develop a simple GDF provisions for the Indonesia's bridge design code. The B-WIM measurements enable us to know each girder strain as a response due to vehicle loading as the vehicle passes the bridge. The calculated GDF obtained from the B-WIM measurements were compared with the code-specified GDF and the American Association of State Highway and Transportation Officials (AASHTO) Load and Resistance Factor Design (LRFD) bridge design specification. Our study found that the code specified GDF was adequate or conservative compared to the GDF obtained from the B-WIM measurements. The proposed GDF equation correlates well with the AASHTO LRFD bridge design specification. Developing appropriate provisions for GDFs in Indonesian bridge design codes can provides a practical solution for designing girder bridges in Indonesia, ensuring safety while allowing for easier calculations and assessments based on B-WIM measurements.

• Journal of the Korea institute for structural maintenance and inspection
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• v.27 no.5
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• pp.1-8
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• 2023

Marine and hydraulic structures are subject to durability damage not only due to the penetration of sea water but also due to the attachment of marine organisms. Therefore, in this study, we tried to develop an antifouling coating agent with self-cleaning function for marine concrete. It was confirmed that the antifouling coating agent mixed with AKD, cellulose nanofibers and BADGE had sufficient antifouling performance at a well hydrophobicity of around 140° in contact angle and an inclination angle of 15°. In the abrasion resistance test of the surface, only a maximum loss of 0.015 g occurred. In the durability test, as a result of the chloride ion permeation test, almost no chloride ion permeation occurred in the variable where the coating agent was applied, and carbonation and freeze-thaw damage also rarely occurred, so it was analyzed that it was effective in securing durability of concrete.

• Analytical Science and Technology
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• v.37 no.2
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• pp.98-113
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• 2024

The current investigation entails the characterization of five degradation products (DPs) formed under different stress conditions of loteprednol using liquid chromatography-tandem mass spectrometry (LC-MS/MS). In addition, this study developed a stable high-performance liquid chromatography (HPLC) method for evaluating loteprednol along with impurities. The method conditions were meticulously fine-tuned which involved the exploration of the appropriate solvent, pH, flow of the mobile phase, columns, and wavelength. The method conditions were carefully chosen to successfully resolve the impurities of loteprednol and were employed in subsequent validation procedures. The stability profile of loteprednol was exposed to stress degradation experiments conducted under five conditions, and DPs were structurally characterized by employing LC-MS/MS. The chromatographic resolution of loteprednol and its impurities along with DPs was effectively achieved using a Phenomenex Luna 250 mm C18 column using 0.1 % phosphoric acid, methanol, and acetonitrile in 45:25:30 (v/v) pumped isocratically at 0.8 mL/min with 243 nm wavelength. The method produces an accurate fit calibration curve in 50-300 ㎍/mL for loteprednol and LOQ (0.05 ㎍/mL) - 0.30 ㎍/mL for its impurities with acceptable precision, accuracy, and recovery. The stress-induced degradation study revealed the degradation of loteprednol under basic, acidic, and photolytic conditions, resulting in the formation of seven distinct DPs. The efficacy of this method was validated through LC-MS/MS, which allowed for the verification of the chemical structures of the newly generated DPs of loteprednol. This method was appropriate for assessing the impurities of loteprednol and can also be appropriate for structural and quantitative assessment of its degradation products.

• Advances in concrete construction
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• v.16 no.3
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• pp.155-167
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• 2023

The penetrated chloride in concrete has different behavior with mix proportions and local exposure conditions, even in the same environments, so that it is very important to quantify surface chloride contents for durability design. As well known, the surface chloride content which is a key parameter like external loading in structural safety design increases with exposure period. In this study, concrete samples containing OPC (Ordinary Portland Cement), GGBFS (Ground Granulated Blast Furnace Slag), and FA (Fly Ash) had been exposed to submerged, tidal, and splash area for 5 years, then the surface chloride contents changing with exposure period were evaluated. The surface chloride contents were obtained from the chloride profile based on the Fick's 2nd Law, and the regression analysis for them was performed with exponential and square root function. After exposure period of 5 years in submerged and tidal area conditions, the surface chloride content of OPC concrete increased to 6.4 kg/m³ - 7.3 kg/m³, and the surface chloride content of GGBFS concrete was evaluated as 7.3 kg/m³ - 11.5 kg/m³. In the higher replacement ratio of GGBFS, the higher surface chloride contents were evaluated. The surface chloride content in FA concrete showed a range of 6.7 kg/m³ to 9.9 kg/m³, which was the intermediate level of OPC and GGBFS concrete. In the case of splash area, the surface chloride contents in all specimens were from 0.59 kg/m³ to 0.75 kg/m³, which was the lowest of all exposure conditions. Experimental constants available for durability design of chloride ingress were derived through regression analysis over exposure period. In the concrete with GGBFS replacement ratio of 50%, the increase rate of surface chloride contents decreased rapidly as the water to binder ratio increased.

• Biomolecules & Therapeutics
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• v.32 no.4
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• pp.442-450
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• 2024

The type-1 cannabinoid receptor (CB₁R) is a potential therapeutic target in several pathological conditions, including neuropsychological disorders and neurodegenerative diseases. Owing to their structural diversity, it is not easy to derive general structure-activity relationships (SARs) for CB₁R ligands. In this study, CB₁R ligands were classified into six structural families, and the corresponding SAR was determined for their affinities for CB₁R. In addition, we determined their functional activities for the activation of extracellular signal-regulated kinases (ERKs). Among derivatives of indol-3-yl-methanone, the highest ligand affinity was observed when a pentyl and a naphthalenyl group were attached to the N1 position of the indole ring and the carbon site of the methanone moiety, respectively. In the case of adamantane indazole-3-carboxamide derivatives, the presence of fluorine in the pentyl group, the substituent at the N1 position of the indazole ring, strongly increased the affinity for CB₁R. For (naphthalen-1-yl) methanone derivatives, the presence of 4-alkoxynaphthalene in the methanone moiety was more beneficial for the affinity to CB₁R than that of a heterocyclic ring. The functional activities of the tested compounds, evaluated through ERK assay, were correlated with their affinity for CB₁R, suggesting their agonistic nature. In conclusion, this study provides valuable insight for designing novel ligands for CB₁R, which can be used to control psychiatric disorders and drug abuse.

• Tribology and Lubricants
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• v.40 no.3
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• pp.97-102
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• 2024

The next-generation Molten Salt Reactor is known for its high safety because it uses nuclear fuel dissolved in high-temperature molten salt, unlike traditional solid atomic fuel methods. However, the high-temperature molten salt causes severe corrosion in internal structural materials, threatening the reactor's safety. Therefore, it is crucial to investigate the high-temperature corrosion resistance and wear performance of materials used in reactors to ensure safety. In this study, the high-temperature corrosion resistances and wear performances of corrosion samples in a NaCl-MgCl2-KCl (20-40-40 [wt%]) molten salt are investigated to evaluate the applicability of economically viable stainless steels, 316SS and 304SS. Hastelloy C276 and a new alloy containing a small amount of Nb are used as reference samples for comparative analysis. The mass loss, mass loss rate per unit volume, and surface roughness of each sample are measured to understand the corrosion mechanisms. Scanning electron microscopy and energy-dispersive spectroscopy analyses are employed to analyze the corrosion mechanisms. Wear tests on the corroded samples are also conducted to assess the extent of corrosion. Based on the experimental results, we predict the lifespans of the materials and evaluate their suitability as candidate materials for molten salt reactors. The data obtained from the experiments provide a valuable database for structural materials that can enhance the stability of molten salt reactors and recommend high-temperature corrosion-resistant materials suitable for next-generation reactors.

• Journal of the Earthquake Engineering Society of Korea
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• v.28 no.4
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• pp.193-203
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• 2024

Existing reinforced concrete (RC) building frames constructed before the seismic design was applied have seismically deficient structural details, and buildings with such structural details show brittle behavior that is destroyed early due to low shear performance. Various reinforcement systems, such as fiber-reinforced polymer (FRP) jacketing systems, are being studied to reinforce the seismically deficient RC frames. Due to the step-by-step modeling and interpretation process, existing seismic performance assessment and reinforcement design of buildings consume an enormous amount of workforce and time. Various machine learning (ML) models were developed using input and output datasets for seismic loads and reinforcement details built through the finite element (FE) model developed in previous studies to overcome these shortcomings. To assess the performance of the seismic performance prediction models developed in this study, the mean squared error (MSE), R-square (R²), and residual of each model were compared. Overall, the applied ML was found to rapidly and effectively predict the seismic performance of buildings according to changes in load and reinforcement details without overfitting. In addition, the best-fit model for each seismic performance class was selected by analyzing the performance by class of the ML models.

• Journal of the Korea institute for structural maintenance and inspection
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• v.10 no.6
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• pp.163-176
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• 2006

The paper proposes rating equations for main components such as girders, towers and cables in cable-stayed bridges. Load rating equations for girders and towers are proposed using stress and stability equations and load rating equation for cables is presented. A moving load analysis is performed and distribution types of live loads are determined for the cases of a maximum axial tensile force, a maximum axial compressive force, a maximum positive and a negative moment for each component. The Dolsan Grand bridge is used to verify a validity of proposed equations, The conventional rating equation overestimates rating factors of girders and towers in the Dolsan Grand bridge, whereas proposed rating equations properly reflect the axial-flexural interaction behavior of girders and towers in cable-stayed bridges.

• Journal of the Korea institute for structural maintenance and inspection
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• v.11 no.2
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• pp.109-116
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• 2007

The purpose of this paper is to evaluate the fire resistant performances of load-bearing wall using both composite and steel stud panel infilled with light-weight formed mortar under axial loading according to KS F 2257(1999). The minimum requirement of 2 hours fire resistant rating is needed for the residential and commercial buildings under the fire regulation of Korea. From test results, it is found that two types of specimen composed of the hybrid stud and steel stud panel filled with light-weight formed mortar fited in with the requirement of 2 hours fire resisting rate for the load-bearing wall. In the conclusions, the specimen with hybrid stud shows predominating fire-resistant performance on the adiabatic effects rather than that of the steel stud specimen.