• Transactions of the Korean Society of Mechanical Engineers A
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• v.21 no.2
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• pp.232-244
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• 1997

In this paper weight function theory is extended to the determination of the stress intensity factors for the mode I in elliptic crack. For the calculation of the fundamental fields Poisson's theorem and Ferrers's method were employed. Fundamental fields are constructed by single layer potentials with surface density of crack harmonic fundamental polynimials. Crack harmonic fundamental polynimials up to order four were given explicitly. As an example of the application of the weight function theory the stress intensity factors along crack tips in nearly penny-shaped elliptic crack are calculated.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2007.04a
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• pp.495-500
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• 2007

A Meshfree is a method used to establish algebraic equations of system for the whole problem domain without the use of a predefined mesh for the domain discretization. A point interpolation method is based on combining radial and polynomial basis functions. Involvement of radial basis functions overcomes possible singularity. Furthermore, the interpolation function passes through all scattered points in an influence domain and thus shape functions are of delta function property. This makes the implementation of essential boundary conditions much easier than the meshfree methods based on the moving least-squares approximation. This study aims to investigate a stress analysis of structural element between a meshfree method and the finite element method. Examples on cantilever type plate and stress concentration problems show that the accuracy and convergence rate of the meshfree methods are high.

• Science of Emotion and Sensibility
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• v.14 no.3
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• pp.425-434
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• 2011

In the present study was to examine the influence of cold stress conditions on memory function in relation with 5-hydroxytryptamine(serotonin, 5-HT), trptophanhydroxylase(TPH) expression and cell proliferation in the hippocampus. For this study, male Sprague-Dawley rats weighing $250{\pm}10g$ (7 weeks in age) were used. The rats were randomly divided into three groups(n = 10 in each group): the $22^{\circ}C$-control group, the $4^{\circ}C$-3 days group, the $4^{\circ}C$-5 weeks group. The environmental temperature at $22^{\circ}C$ set as the normal conditions, $4^{\circ}C$ was as the cold stress conditions. The present results showed that cold stress conditions shorten latency, representing cold stress disturbed memory function. 5-HT and TPH expressions in the dorsal raphe were increased cold stress. Neurogenesis in the dentate gyrus was increased under cold conditions. The present study revealed that cold stress exerted deteriorative memory function. However, through increasing of 5-HT, TPH and BrdU expression under cold stress conditions did not show memory enhancing effect.

• Journal of the Korea Safety Management & Science
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• v.2 no.2
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• pp.71-83
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• 2000

This paper presents accelerated life tests for Type I censoring data under probabilistic stresses. Probabilistic stress, $S_j$, is the random variable for stress influenced by test environments, test equipments, sampling devices and use conditions. The hazard rate, ,$theta_j$, is the random variable of environments and the function of probabilistic stress. Also it is assumed that the general stress distribution is uniform, the life distribution for the given hazard rate, $\theta$, is exponential and inverse power law model holds. In this paper, we obtained maximum likelihood estimators of model parameters and the mean life in use stress condition.

• Clinical and Experimental Pediatrics
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• v.50 no.3
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• pp.236-240
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• 2007

Majority of sick full term newborns have adequate adrenal cortical function in response to stress. Acutely ill neonates with a basal cortisol level less than $15{\mu}g/dL$ (414 nmol/L) suggest adrenal insufficiency and require function testing of adrenal function. In premature infant, immaturity of hypothalamic-pituitary adrenal axis (HPA axis), may limit the ability to increase cortisol production in response to stress. The response to low dose ACTH and CRH appears to be useful as an additional test of adrenal function. CRH stimulation has been used increasingly in neonates. The ACTH and CRH stimulated cortisol response of more than $17{\mu}g/dL$ (469 nmol/L) indicates a normal response.

• Structural Engineering and Mechanics
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• v.25 no.4
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• pp.423-444
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• 2007

By using the incremental form of the endochronic theory of plasticity, a model of material function is proposed in this paper to investigate plastic behavior. By comparing the stress-strain hysteresis loop, the theory is shown to agree well with the experimental results, especially in the evolution of peak stress values of SAE 4340 steel loaded by cyclic loading with various amplitudes. Depending on the choice of material parameters, the present model can substantially result in six categories of material function, each of which can behave differently with respect to an identical deformation history. In addition, the present model of material function is shown to be capable of describing the behavior of erasure of memory of materials, as experimentally observed by Lamba and Sidebottom (1978).

• Advances in concrete construction
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• v.9 no.1
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• pp.43-54
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• 2020

This paper presents an innovative stress-function variational approach in formulating the interfacial shear and normal stresses in an externally bonded concrete joint using carbon fiber-reinforced plastic (CFRP) plies. The joint is subjected to surface traction loadings applied at both ends of the concrete substrate layer. By introducing two interfacial shear and normal stress functions on the CFRP-concrete interface, based on Euler-Bernoulli beam idea and static stress equations of equilibrium, the entire stress fields of the joint were determined. The complementary strain energy was minimized in order to solve the governing equation of the joint. This yields an ordinary differential equation from which the interfacial normal and shear stresses were proposed explicitly, satisfying all the multiple traction boundary conditions. Lamination theory for composite materials was also employed to obtain the interfacial stresses. The proposed approach was validated by the analytic models in the literature as well as through a comprehensive computational code generated by the authors. Furthermore, a numerical verification was carried out via the finite element software ABAQUS. In the end, a scaling analysis was conducted to analyze the interfacial stress field dependence of the joint upon effective issues using the devised code.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.41 no.1
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• pp.7-11
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• 2017

In this study, we develop the exact field of mode I in an infinitely deep crack in a half-plane. Using this field, we obtain the exact stress intensity factor $K_{I}$. From the tractions on the crack faces induced by exact field, we calculate the stress intensity factor of this field. We compare the results with the stress intensity factor calculated using Bueckner's weight function formula and that calculated by using Tada's formula listed in "The Stress Analysis of Cracks Handbook" It was found that Bueckner's formula yields accurate results. However, the results obtained using Tada's formula exhibit inaccurate behavior.

• Transactions of the Korean Society of Automotive Engineers
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• v.8 no.3
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• pp.110-118
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• 2000

For reasonable fatigue design and estimation of fatigue durability considered fatigue strength and stiffness of the automotive body structure, many fatigue data must be insured according to the shapes, materials, and welding conditions of the spot welded lap joints. However, because it is actually difficult problem, there is need to establish a new method to be able to predict its fatigue life without any additional fatigue tests. Therefore, In order to improve such problems, in this study, the maximum stress function presenting the $\delta\sigma_{1max}―\delta P$ relation was defined form the relation between $\delta\sigma_{1max}-N_f$ and ${\delta}P-N_f$. By using the fatigue data on the IB type spot-welded lap joints previously obtained from the fatigue test results, fatigue life of the spot-welded lap joint previously obtained from the fatigue test results, fatigue life of the spot-welded lap joint having a certain dimension was tried to predict without any additional fatigue tests. And, its result was verified by ${\delta}P-$N_f$ curves. Obtained conclusion are as follows, 1) a maximum stress function considered the relation of the maximum principal stress, fatigue load, and the effects of geometrical factors of the IB type spot-welded lap joint was suggested. 2) the fatigue life predicted by the maximum principal stress function and the relation of $\delta\sigma_{1max}-N_f$ was well agreed with the fatigue life obtained through the actual fatigue test result. 3) the fatigue life of the IB type spot-welded lap joint having a certain dimension is able to be predicted without any additional fatigue tests from the fatigue life prediction method by the maximum principal stress function.

• Molecules and Cells
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• v.37 no.3
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• pp.234-240
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• 2014

Cisplatin is one of the most potent chemotherapy agents. However, its use is limited due to its toxicity in normal tissues, including the kidney and ear. In particular, nephrotoxicity induced by cisplatin is closely associated with oxidative stress and inflammation. Heme oxygenase-1(HO-1), the rate-limiting enzyme in the heme metabolism, has been implicated in a various cellular processes, such as inflammatory injury and anti-oxidant/oxidant homeostasis. Capsaicin is reported to have therapeutic potential in cisplatin-induced renal failures. However, the mechanisms underlying its protective effects on cisplatin-induced nephrotoxicity remain largely unknown. Herein, we demonstrated that administration of capsaicin ameliorates cisplatin-induced renal dysfunction by assessing the levels of serum creatinine and blood urea nitrogen (BUN) as well as tissue histology. In addition, capsaicin treatment attenuates the expression of inflammatory mediators and oxidative stress markers for renal damage. We also found that capsaicin induces HO-1 expression in kidney tissues and HK-2 cells. Notably, the protective effects of capsaicin were completely abrogated by treatment with either the HO inhibitor ZnPP IX or HO-1 knockdown in HK-2 cells. These results suggest that capsaicin has protective effects against cisplatin-induced renal dysfunction through induction of HO-1 as well as inhibition oxidative stress and inflammation.