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Development of Dissolution Test Method for Buflomedil Hydrochloride Tablets and Ticlopidine Hydrochloride Tablets (염산부플로메딜 정과 염산티클로피딘 정의 용출시험법 개발)

  • Lee, Ryun-Kyung;Jeong, Gyeong-Rok;Oh, Hyun-Sook;Shim, Jee-Youn;Suh, Sang-Chul;Lee, Hyo-Jung;Kim, Min-A;Park, Seong-Min;Lee, Kyu-Ha;Sohn, Kyung-Hee;Kim, In-Kyu;Sah, Hong-Kee;Choi, Hoo-Kyun;Cho, Tae-Yong;Hong, Choong-Man
    • YAKHAK HOEJI
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    • v.56 no.4
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    • pp.211-216
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    • 2012
  • Drug dissolution test has been used for the purpose of both quality control of solid oral dosage forms and predicting in vivo drug release profiles. In this study, the dissolution profiles of buflomedil hydrochloride tablets and ticlopidine hydrochloride tablets were investigated according to the "Guidelines on Specifications of Dissolution tests for Oral dosage forms" of Korean Pharmacopoeia (KP). The analytical method using HPLC was validated. The validation was performed in terms of specificity, linearity, accuracy, precision and limit of quantitation.

Monitoring of Pesticide Residues in Special Products (지역특산품 중 잔류농약 실태조사)

  • Kim, Mi-Ra;Na, Mi-Ae;Jung, Woo-Young;Kim, Chang-Soo;Sun, Nam-Kyu;Seo, Eun-Chae;Lee, Eun-Mi;Park, You-Gyoung;Byun, Jung-Ah;Eom, Joon-Ho;Jung, Rae-Seok;Lee, Jin-Ha
    • The Korean Journal of Pesticide Science
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    • v.12 no.4
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    • pp.323-334
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    • 2008
  • This experiment was carried out to analyze for pesticide residues in 17 different types of the special of geographical indication. We purchased 3 cereal grains, nuts and seeds, 3 fruits, 8 vegetables, mushrooms and other plants (Korean medicines) mainly at the agricultural cooperative's joints markets. Total 209 pesticides including multi-analysed pesticides (204) and single-analysed pesticides (5 ; acephate, methamidophos, monocrotophos, omethoate, vamidothion) were analysed with a GC/MS/MS, an HPLC/UVD (PDA) and a GC/FPD. No. 83 method and single-analysed method (Screening of multi-pesticide residue in the special products of geographical indication) of Korea Food Code was selected for validation in recovery and interferences of matrice. The results were as follows: among the selected 17 the special products, the residual pesticides were detected in 8 types of the special products (40 in 302 samples, detection ratio; 13.2%). All of the samples were not detected over MRLs, but tebuconazole, procymidone and isoprothioran were detected with considerable high frequency. These results could be used as KFDA official methods for the analysis of pesticide residues in foods and reference data will be provided to the related institutions.

Growth and Maturation of Laminaria japonica Transplanted for Seaforest Construction on Barren Ground (갯녹음 해역에 해중림 조성을 한 다시마의 생장과 성숙)

  • Kim, Young-Dae;Hong, Jung-Pyo;Song, Hong-In;Jeon, Chang-Yeong;Kim, Su-Kyoung;Son, Yong-Soo;Han, Hyoung-Kyun;Kim, Dong-Sam;Kim, Jin-Hee;Kim, Myoung-Rae;Gong, Yong-Gun;Kim, Dae-Kweon
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.40 no.5
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    • pp.323-331
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    • 2007
  • Barren ground is an abnormal phenomenon in coastal ecosystems where seaweeds are destroyed and largely replaced by coralline algae containing calcium carbonate components. To restore the seaweed forest, we attempted reconstruction in an area of Samcheok, Korea, where barrenness is extensive. We developed two methods of seaforest construction underwater longline and seed transplantation for the brown seaweed Laminaria japonica, a fast-growing edible seaweed. The blade length of L. japonica attached to an underwater long line was $93.9{\pm}38.2cm$ and blade weight $7.6{\pm}2.1g$ in February 2004. Seaweed size declined after August 2004. A Similar pattern was observed using the transplantation method with maxima of $179.3{\pm}40.3cm\;and\;14.9{\pm}3.2g$ for blade length and weight, respectively in July 2004. The transplanted seaweeds matured in October as did a wild population. These results indicate that transplanted seaweed acclimate to new environments.

Monitoring of Veterinary Drug Residues in Foods Produced in Korea (국내 유통 식품의 잔류동물용의약품 모니터링)

  • Kim, Hee-Yun;Chung, So-Young;Choi, Sun-Hee;Lee, Jin-Sook;Choi, In-Sun;Cho, Min-Ja;Shin, Min-Su;Song, Jae-Sang;Choi, Jae-Chun;Park, Hee-Ok;Ha, Sang-Chul;Shin, Il-Shik;Seo, Eun-Chae
    • Korean Journal of Food Science and Technology
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    • v.42 no.6
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    • pp.653-663
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    • 2010
  • This study was conducted to monitor residues of 10 veterinary drugs in food products. Various veterinary drugs were examined including enrofloxacin, ciprofloxacin, norfloxacin, oxolinic acid, amoxicillin, ampicillin, oxytetracycline, tetracycline, chlortetracycline, and doxycycline in beef, pork, egg, chicken, eel, flatfish, and rockfish obtained from 6 different regions (Seoul, Incheon, Daejeon, Gwangju, Daegu, Busan). Residues were detected in 21 (6.5%) samples out of 321 samples. In particular, 2 (1.0%) livestock samples had detected residues among 203 products, and 19 (16.1%) aquaculture samples had residues detected among 118 products. The most frequently detected drug residues in aquaculture products were oxytetracycline and amoxicillin, but the levels were mostly below the MRL (Maximum Residue Limit). In only one flatfish sample, amoxicillin was found at a level higher than the MRL (0.05 mg/kg). In livestock products, residues of most veterinary drugs were not detected. But enrofloxacin was detected in 2 chicken (Korean name: Ogolgae) samples at a higher level than the MRL (0.1 mg/kg as the sum of ciprofloxacin).

Growth and Maturation of the Brown Seaweed Costaria costata Transplanted for the Wildstock Enhancement (해조장 조성을 위하여 이식한 갈조류 쇠미역(Costaria costata)의 생장과 성숙)

  • Kim, Young-Dae;Song, Hong-In;Hong, Jung-Pyo;Jeon, Chang-Yeong;Kim, Su-Kyoung;Han, Hyoung-Kyun;Kim, Dong-Sam;Bang, Jong-Deuk
    • Journal of Life Science
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    • v.16 no.6
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    • pp.1044-1051
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    • 2006
  • The barren ground is an abnormal phenomenon of coastal ecosystem in which seaweeds, are destroyed and mostly replaced by the coralline algae containing the calcium carbonate components. To restore the seaweed forest, We have exerted an effort in the local areas, Samchuck, Korea, where barren phenomena are profound. Two methods of seaweed forest construction developed in the present study are underwater longline and seed transplantation for the brown seaweed Costaria costata, a fast growing edible seaweed. The sizes of C. costata attached on the underwater longline were $96.7{\pm}2.2mm$ of blade length and $83.6{\pm}7.7g$ of blade weight in April. Thereafter the sizes declined from May. Similar pattern was obtained from in the transplantation method with maxima of $90.4{\pm}15.8mm$ and $70.1{\pm}31.7g$ for blade length and weight, respectively in April. It appeared totality maturation from two methods in May. This maturation time is the same like that of wild C. costata.

Detection and Monitoring of Benzylpenicillin Residues in Livestock and Marine Products (유통 축·수산물 중 잔류벤질페니실린의 검출 및 모니터링)

  • Lee, Hyo Jeong;Kang, Young Won;Lee, Soo Min;An, Kyung A;Lee, Ryun Kyung;Seo, Sang Cheol;Lee, Ju Hee;Im, Moo Hyeog;Lee, Jeong Rim;Hong, Choong Man;Chang, Moon Ik;Cho, Yoon Jae
    • Korean Journal of Food Science and Technology
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    • v.46 no.3
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    • pp.288-294
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    • 2014
  • Penicillin and its salts, including the benzatine, procaine, and sodium salts, have been widely used in human and veterinary medicine. Owing to their low toxicity, they currently form the most important group of antibiotics. However, overdose and abuse of these antibiotics may lead to potential risk in human health. Therefore, this study was conducted to validate the analysis method established by the Korea Food Code in 2012 and to monitor the levels of benzylpenicillin residues in products with reference to the maximum residue level (MRL). Of the 232 product samples tested, benzylpenicillin was detected in 11 livestock products and 2 marine products. Benzylpenicillin concentrations were found to be lower than the MRL in 12 products; however, the concentration of benzylpenicillin was found to be greater than the MRL in 1 pork product. The limit of quantification (LOQ) for benzylpenicillin was found to be 0.001-0.002 mg/kg, with an average recovery of 90.4-115.3%. Calibrations showed good linearity of 0.995 over a range of 0.002-0.05 mg/kg.

Characteristics Analysis of Small AFPM Generator with Variation of Coil Winding Method (권선 방법에 따른 소형 축방향 자속 발전기 특성 해석)

  • Lee, Keon-Su;Lee, Kyu-Seok;Park, Jung-Hyung;Yang, Hee-Jung;Lee, Sung-Ho;Park, Sung-Jun
    • Proceedings of the KIEE Conference
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    • 2011.07a
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    • pp.1015-1016
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    • 2011
  • 본 논문에서는 권선 방법에 따라 코일 U, V, W를 같은 층에 원주방향으로 배치한 집중권 권선 모델, 코일 U, V, W를 각각 한 층씩 원주 방향으로 배치한 분포권 권선 #1 모델, 코일에 경사각을 적용하여 코일 U, V, W를 한 층에 배치하는 분포권 #2 모델로 총 3가지 사양의 3상 코어리스 축방향 자속 발전기를 설계하였다. 3차원 유한요소 해석을 활용하여, 무부하 상태에서의 역기전력, 쇄교 자속 밀도와 외부 정류 회로를 구성한 부하 상태에서의 정류 전압, 정류 전류와 같은 전자기 특성에 대한 해석 및 특성 비교를 수행하였다.

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Tobacco Related Habits among First Degree Relatives of Patients Undergoing Surgery for Advanced Head and Neck Malignancies in India

  • Balagopal, P.G.;George, N.A.;Venugopal, A.;Mathew, A.;Ahamed, M. Iqbal;Sebastian, P.
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.1
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    • pp.217-220
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    • 2012
  • This prospective study records the tobacco related habits among the relatives of patients with advanced head and neck cancers who underwent both surgery and chemotherapy as part of their treatment from September 2009 to March 2010. A total of 200 relatives were interviewed (148 males and 52 females). 198 (99%) were aware of the fact that tobacco use can lead to cancer and 168 (84%) had any one of the habits. Smoking alone was reported in 36 (18%) individuals, pan chewing alone in 66 (33%) and multiple habits in 64 (32%). Alcohol and tobacco chewing alone was reported in one case each. There were change in habits following diagnosis of head and neck cancers among the relatives, 33 (16.5%) stopped their habits and smoking was reduced by 25% in 72 (36%)and by 50% in 63 (31.2%) individuals. However, 135 continued the habit even after the diagnosis of cancer in their relatives. Of note, 15 out of the 33 who quit the habit did it because of health advice given to them during the hospital visit.