• Journal of Pharmaceutical Investigation
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• v.24 no.3
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• pp.155-165
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• 1994

Some mucoadhesive polymers such as hydroxypropylcelluose (HPC) and carbopol-934 (CP) have been employed for the preparation of mucoadhesive polymeric systems, and their physical properties including mucoadhesion, swelling, and drug release were evaluated. A new simple experimental technique that can quantitatively measure the bioadhesive properties of various polymeric systems has been developed by the methods of detachment force test. As the polymeric systems, the discs of freeze-dried HPC/CP solid dispersions were prepared. The mucosa used in these tests were upper, middle, and lower parts of small intestine of male rats weighing $300{\sim}350\;g$. Detachment forces were increased as the mole fraction of CP increased in discs of HPC/CP solid dispersions. In the points of intestinal site dependence of mucoadhesion, the solid dispersions revealed non-specific mucoadhesion to the intestine. Swelling and drug release characteristics of mucoadhesive polymeric systems were studied extensively to find out the feasibility for the oral controlled delivery systems. Swelling ratio, expressed as the final height/initial height, has been determined in various pH buffer solutions. Hydrochlorothiazide (HCT) was employed as a model drug for release study. Apparent swelling and drug release rate constants, $K_s$ and $K_r$ respectively, were obtained from the square-root time plot of either swelling ratio or released amount of drug, particularly for the time periods before reaching the equilibrium. As a result, the swelling ratio of HPC/CP solid dispersions was increased as the weight percentage of CP increased. Similarly, the release of HCT from the solid dispersions was dependent on pH changes and CP contents, resulted in the slower release of HCT with the increases of pH and CP contents.

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2003.11a
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• pp.539-543
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• 2003

The objective of this to improve the reliability of the safety evaluation code for Wolsong Tritium Removal Facility(WTRF) which is on the development for environmental assessment. To achieve this, tritium concentrations calculated in the Wolsong Units of this study are compared with that of the existing reference. As the result, the tritium concentration in each Wolsong nuclear power plant unit just before operating WTRF is 60.9Ci/kg, 36.3Ci/kg, 30.0Ci/kg, 26.5Ci/kg under the assumption that the WTRF begins operation in 2005, respectively. This result is almost same with that of the existing reference. But the reducing rate of tritium concentration in the moderator is faster than that of the reference result Finally it is expected to drop below 10Ci/kg after WTRF operation. And this result is also similar with that of the existing reference.

• Journal of Energy Engineering
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• v.20 no.4
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• pp.278-285
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• 2011

Computational modelling and simulation for the charge-discharge characteristics of Lithium-ion batteries have been carried out. The battery system consists of a simplified 2-dimensional single cell for the modelling, in which the thermal modelling on the charge-discharge characteristics was conducted in the temperature range from 288 K through 318 K by using FEMLAB as an engineering PDE solver. While material parameters adopted in the present modelling were dependent on the system temperature, their thermal modelling were applied on the simulations of the charge-discharge period and the rate of transferring charges systematically. The resulting simulation shows that the cycle of the charge-discharge shorten itself by reducing the system temperature, regardless of the charge-discharge rates. In addition, the mass-transport phenomena of Lithium ion have been discussed in connection with the charge-discharge characteristics in the battery.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.9
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• pp.4334-4356
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• 2017

In orthogonal frequency-division multiplexing (OFDM) systems, phase noise introduced by the local oscillators can cause bit error rate (BER) performance degradation. To solve the phase noise problem, a novel orthogonal-polarization-based phase noise self-cancellation (OP-PNSC) scheme is proposed. First, the efficiency of canceling the phase noise of the OP-PNSC scheme in the AWGN channel is investigated. Then, the OP-PNSC scheme in the polarization-dependent loss (PDL) channel is investigated due to power imbalance caused by PDL, and a PDL pre-compensated OP-PNSC (PPC -OP-PNSC) scheme is proposed to mitigate the power imbalance caused by PDL. In addition, the performance of the PPC-OP-PNSC scheme is investigated, where the signal-to-interference-plus-noise ratio (SINR) and spectral efficiency (SE) performances are analyzed. Finally, a comparison between the OP-PNSC and polarization diversity scheme is discussed. The numerical results show that the BER and SINR performances of the OP-PNSC scheme outperform the case with the phase noise compensation and phase noise self-cancellation scheme.

• Journal of Animal Environmental Science
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• v.21 no.3
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• pp.83-92
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• 2015

An attempt to produce more pigs in limited spaces inevitably generalized concentrated feeding operation (CFO). As concentrated pig production practice expanded, concerns on environmental issues grow concurrently. Since odor is the concerned most among those, we attempted to develop means to tackle odor emission from livestock operations. Previously, we excavated few microorganisms from pig manure and, one of them, Bacillus licheniformis was particularly useful to handle odor problem. In this study, we conducted our investigation to further characterize Bacillus licheniformis. Strain identification was conducted using Vitek 2 compact, and the optimal temperature and pH conditions to growth B. licheniformis were searched for by analyzing turbidity on O.D 600 nm. Results of this study can be summarized as these, (1) it was re-verified that the bacterial strain that purified from pig manure was, in fact, Bacillus licheniformis, (2) the bacterial growth was highest when the temperature was kept at $30^{\circ}C$, also (3) growth rate was dependent on media pH as it was high at neutral (6, 7 and 8) but dropped when it was diverged from neutral (4, 5, 9 and 10), and (4) regarding ammonia removal efficiency, B. licheniformis recorded 64% effectiveness after 48 h incubation and reached its highest (80%) at 72 h.

• Journal of KIISE:Software and Applications
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• v.29 no.4
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• pp.278-288
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• 2002

This paper presents a design and implementation of fuzzy retrieval system that could support an associated learning in problem banks. It tries to retrieve some of the problems conceptually related to specific semantics described by user's queries. In particular, the problem retrieval system employs a fuzzy thesaurus which represents relationships between domain dependent vocabularies as fuzzy degrees. It would keep track of characteristics of the associated learning, which should guarantee high recall and acceptable precision for retrieval effectiveness. That is, since the thesaurus could make a vocabulary mismatch problem resolved among query terms and document index terms, this retrieval system could take a chance to effectively support user's associated teaming. Finally, we have evaluated whether the fuzzy retrieval system is appropriate for the associated teaming or not, by means of its precision and recall rate point of view.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.4
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• pp.2628-2638
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• 2015

The purpose of this study was to examine knowledge, attitude, and altruism on blood donation and influential factors in regard to its experience. Data were collected through questionnaires with a convenience sample of 311 healthcare providers. Subjects with blood donation experience accounted for 63.3%. In both nurses and laboratory technologist, the rate of blood donation in male group has higher than that of female group. There were differences in the knowledge of blood donation dependent upon the type of occupation of healthcare providers and the higher age and the longer period of career experience proved to be the significant factor for the level of altruism. The study suggests that more practical, concrete strategies should be identified to participate in blood donation. The further relevant variables need to be investigated since the most determinant motivator for blood donation among healthcare providers was the responsibility to help others.

• Analytical Science and Technology
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• v.8 no.3
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• pp.341-350
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• 1995

$Nd_{14}Fe_{80}B_6$ ribbon alloy was manufactured with using melt-spinning method and analyzed the magnetic properties according to the manufacturing conditions. The microstructure and magnetic properties of melt-spun ribbons are sensitively dependent on the quench rate and annealing conditions. As-quenched $Nd_{14}Fe_{80}B_6$ ribbons with optimum magnetic properties are obtained at wheel speed($v_s$) of about 20m/sec and over quenched ribbons show optimum magnetic properties at $v_s$=22m/see when annealed for 30 minutes at $600^{\circ}C$ under vacuum. The crystallization temperature($T_k$) of $Nd_2Fe_{14}B$ phase is about $595^{\circ}C$ in the DTA analysis.

• Food Science and Biotechnology
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• v.18 no.1
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• pp.103-107
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• 2009

Three traditional Chinese medicines, Agrimonia pilosa Ledeb, Grifola umbellata (pers.) Pilat, and Gambogia, are combined to form a compound extract, AGC. In this study, the in vitro and in vivo inhibitory effects of AGC on human gastric carcinoma MGC-803 cells were demonstrated, and the molecular mechanisms underlying these effects are investigated. Our results indicate that AGC inhibited MGC-803 cell growth in a dose-dependent manner as measured by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, with an $IC_{50}$ of about $6.045{\pm}0.69{\mu}g/mL$. In vivo, AGC inhibited growth of human gastric carcinoma in xenograft tumors in nude mice, and the inhibitory rate reached 55.2% at 300 mg/kg. The pro-apoptotic activity of AGC was attributed to its ability to decrease the expression of Bcl-2 and Pro-caspase3 and increase the expression of Bax. These results demonstrate that AGC can effectively induce programmed cell death and may be a promising anti-tumor drug in human gastric carcinoma.

• Health Policy and Management
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• v.12 no.4
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• pp.1-17
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• 2002

This study was attempted to identify the liquidity trends and determinants of private hospitals in Korea different. Data used in this study were collected from 98 hospitals with complete general data of present conditions as well as financial statements(balance sheets, income statements). They were chosen from hospitals that passed the standardization audit undertaken by the Korean Hospital Association from 1996 to 2000 for the purpose of accrediting training hospitals. The dependent variables in this study were used current ration and quick ratio as a proxy indicator for liquidity. The independent variables were ownership type, hospital type, location, bed size, period of establishment, short-term liabilities to total assets, long-term liabilities to total assets, borrowings to total assets, fixed asset ration, net profit to total assets, operating margin to gross revenue, growth rate of net worth to total assets, total asset turnover, and business risk(volatility of profit). The major findings of this study were as follows. Trends of liquidity(current ratio, quick ratio) had been continuously decreased. Especially, There were very distinct decreasing trends of personal hospitals and less than 300beds, which weakened liquidity. The factors had significant effect on current ratio were short-term debt to total assets(-), fixed asset ratio(-), business risk(+). High short-term debt to total assets, high fixed asset ratio and high business risk significantly decreased in liquidity. The factors that significantly affected on quick ratio were short-term debt to total assets(-), borrowings to total assets(+), fixed asset ratio(-), business risk(+).