Journal of Pharmaceutical Investigation
- Volume 24 Issue 3
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- Pages.155-165
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- 1994
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Mucoadhesion, Swelling and Drug Release Characteristics of Hydroxypropylcellulose/Carbopol Solid Dispersions
히드록시프로필셀룰로오스/카르보폴 고체분산체의 점막부착성과 팽윤 및 약물방출특성
- Kim, Sang-Heon (College of Pharmacy, Chung-Ang University) ;
- Yang, Su-Geun (College of Pharmacy, Chung-Ang University) ;
- Shin, Dong-Sun (College of Pharmacy, Chung-Ang University) ;
- Lee, Min-Suk (College of Pharmacy, Chung-Ang University) ;
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Choi, Young-Wook
(College of Pharmacy, Chung-Ang University)
- Published : 1994.09.20
Abstract
Some mucoadhesive polymers such as hydroxypropylcelluose (HPC) and carbopol-934 (CP) have been employed for the preparation of mucoadhesive polymeric systems, and their physical properties including mucoadhesion, swelling, and drug release were evaluated. A new simple experimental technique that can quantitatively measure the bioadhesive properties of various polymeric systems has been developed by the methods of detachment force test. As the polymeric systems, the discs of freeze-dried HPC/CP solid dispersions were prepared. The mucosa used in these tests were upper, middle, and lower parts of small intestine of male rats weighing
Keywords
- Hydroxypropylcelluose;
- Carbopol-934;
- Solid dispersion;
- Mucoadhesion;
- Swelling;
- Drug release;
- Detachment force