• Asian Pacific Journal of Cancer Prevention
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• v.16 no.7
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• pp.2793-2800
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• 2015

In molecular-targeted cancer therapy, acquired resistance to gemcitabine is a major clinical problem that reduces its effectiveness, resulting in recurrence and metastasis of cancers. In spite of great efforts to reveal the overall mechanism of acquired gemcitabine resistance, no definitive genetic factors have been identified that are absolutely responsible for the resistance process. Therefore, we performed a cross-platform meta-analysis of three publically available microarray datasets for cancer cell lines with acquired gemcitabine resistance, using the R-based RankProd algorithm, and were able to identify a total of 158 differentially expressed genes (DEGs; 76 up- and 82 down-regulated) that are potentially involved in acquired resistance to gemcitabine. Indeed, the top 20 up- and down-regulated DEGs are largely associated with a common process of carcinogenesis in many cells. For the top 50 up- and down-regulated DEGs, we conducted integrated analyses of a gene regulatory network, a gene co-expression network, and a protein-protein interaction network. The identified DEGs were functionally enriched via Gene Ontology hierarchy and Kyoto Encyclopedia of Genes and Genomes pathway analyses. By systemic combinational analysis of the three molecular networks, we could condense the total number of DEGs to final seven genes. Notably, GJA1, LEF1, and CCND2 were contained within the lists of the top 20 up- or down-regulated DEGs. Our study represents a comprehensive overview of the gene expression patterns associated with acquired gemcitabine resistance and theoretical support for further clinical therapeutic studies.

• Journal of Korean Society for Geospatial Information Science
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• v.18 no.2
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• pp.99-105
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• 2010

Photovoltaic system is the core one among the new and renewable energy of the low Carbon and green growth. Recently, the necessity developing PV is emerging since its of less green hose gas emissions. However, a survey or research on the PV system has been hardly performed. It's not easy to find a appropriate location in consideration of environment. These circumstances encourages a systematic approach for the PV system development. The purpose of this study is to propose a methodology of the location analysis for developing PV system. With this, constraint and location criteria with weights of Analytic Hierarchy Process are established and quantification method of each factor is presented. The location analysis of PV system using the GIS were generalized and the results of analysis for redundant topographic features were presented as 3 criteria of the suitability rank.

• Journal of the Korean Society of Clothing and Textiles
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• v.33 no.1
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• pp.92-103
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• 2009

The study is interested in the consumer's mixed choice of the internet and the offline stores. Therefore the purpose of study is to investigate if the clothing shopping orientation of consumers varies when they shop internet and offline, instead of classifying consumers into internet shoppers and offline shoppers. For the purpose, quantitative survey was carried out using 201 questionnaires from men and women in their twenties. The data were analyzed using factor analysis, Pearson's correlation analysis, Spearman's rank order correlation coefficient, t-test, and frequency analysis. The results are as following. First, the clothing shopping orientation structures of offline and internet stores were different each other. As the result of factor analysis, positive, brand oriented, economic, convenient conformity, convenient impulsive factors were extracted from offline store and rational, enjoying, goal oriented, conformity, brand oriented, convenient impulsive purchase factors were extracted from internet store respectively. Second, as the results of investigating the relationship between the clothing shopping orientation structures of offline and internet stores, positive(off)-enjoying(on), brand oriented(off)-brand oriented(on), convenient conformity(off)-conformity(on) had strong correlation s and the rest were peculiar to the each store type. Specifically, the goal oriented factor peculiar to the internet store was noticeable. Third, as the results of investigating the differences between clothing shopping orientation of offline and internet stores, the ranks of strong orientation dimension were different between two channels. As well, the mean differences were significant in goal oriented, conformity, brand oriented, and convenient impulsive purchase dimensions. This study has the significance that it investigated the variance of clothing shopping orientation according to the mixed selection trend of internet/offline.

• The Korean Journal of Food And Nutrition
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• v.31 no.2
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• pp.284-292
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• 2018

This study was conducted to determine the elements that are required and that need improvement in the contents of dietary life education and the educational environment by analyzing the importance-satisfaction of a dietary life education program for dietary life education trainees. The results of the rank test for the satisfactory elements of dietary life education were in the order of competence of instructors, educational contents, time of education, educational environment and affordability of tuition. The importance-satisfaction analysis of the contents and construction of the dietary life education program showed that "suitable contents for the theme of the class", "contents and construction of practice class", "diversity of practice menu" and "diversity of educational contents" had high importance and satisfaction scores and therefore, could be maintained at their current levels. Meanwhile, "adequacy of class time" and "contents and construction of theory class" showed low importance and satisfaction scores, requiring a little effort. Whereas, "time and construction of group practice", "structure of textbook for class" and "duration of course and number of classes" showed relatively low satisfaction compared to importance, requiring major efforts for improvement. Similarly, analysis of the lecture element from dietary life education showed that "professional lecture by instructors", "lectures suitable for themes" and "lecture applicable in real life" had relatively low satisfaction compared to importance, requiring major efforts for improvement. In addition, analysis of the educational environment from dietary life education showed that "adequacy of lecture room space", "cooking equipment", "diversity of cooking utensils" and "sanitary condition of cooking utensils" also require major efforts for improvement. Therefore, dietary life education should not be executed with a simple delivery of knowledge but with both theory and practice classes to increase its application in real life, and active and specific efforts are required to nurture professional instructors and establish educational strategies.

• The Journal of the Korea Contents Association
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• v.15 no.5
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• pp.475-487
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• 2015

This study measures the managerial efficiency of Korea's 14 public enterprises using bootstrap DEA in 2013. In addition, it examines the factors that affect on the bootstrap bias-corrected efficiency using truncated regression analysis. The results and implications of this study are as follows. First, using bootstrap DEA model analysis, the results showed that the mean technical efficiency was 0.3182, the mean pure technical efficiency was 0.4994 and the mean scale efficiency was 0.6585. The main cause of technical inefficiency was due to pure technical inefficiency. Second, rank test between technical efficiency of general DEA model and bootstrap DEA model was no significant difference under CRS and VRS assumption. Third, the main cause of the inefficiency in 11 DMUs among 14 DMUs were mainly due to the pure technology and three DMUs were because of the scale efficiency. Finally, in the truncated regression analysis, cost of labor, profit, sales, return of equity, and the number of employees appeared as factors affecting the scale efficiency at the 10% significance level.

• Journal of Korea Technology Innovation Society
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• v.7 no.1
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• pp.89-110
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• 2004

Home networks consist of two or more home appliances or communication devices enabling the mutual data communication between appliances such as personal computers, refrigerators, phones, television sets, personal digital assistants(PDA), etc. There are three factors that create demand for the home network services. The first factor is development of technology. Second, on the demand side, consumer demand for the home appliances having access to the Internet is in the increase. Finally, producers need a strategy to deal with the problem of market saturation. Home networks are emerging markets. They are unique in that they unite information technologies with home appliances that provide new services. in this paper we study the main attributes of home network services and analyze consumers' preferences for them. However, it is not quite possible to use the revealed preference approach since the home network market is still at an incipient stage. We therefore use the conjoint analysis method using stated preference data. conjoint analysis has been widely use in the area of marketing for evaluating consumer preferences for new products and services. it presents a hypothetical product to the respondents along with the product's attributes and their levels. The respondents are asked to either rank each alternative or choose between several hypothetical products. By estimating consumers' willingness to pay for the attributes of the home network services and analyzing consumers' preferences, we predict the pattern of the development of the home network services and related technologies along various quality dimensions. Based on the estimation results, we draw policy implications for the national- and company-level strategy.

• Korean Journal of Construction Engineering and Management
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• v.20 no.5
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• pp.125-136
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• 2019

This study investigated checked risk level before bid, actual risk level after award, contingency, and cost growth rate in the 124 international construction projects executed by Korean major companies. This study conducted comparative analysis by product type using rank analysis, ANOVA and correlation analysis. As a result, plant and civil projects have worse risk level than architecture projects not only in before bid but also in after award. Especially, country risk is the worst risk in both plant and civil projects, followed by project risk and capability risk. Also, although plant and civil projects reflect more contingency than architecture projects, contingency is not correlated with the checked risk level before bid. Lastly, the cost growth rate is correlated with the actual risk level in all product types. This study is expected to support in planning better practical risk management for international construction projects.

• Journal of Sasang Constitutional Medicine
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• v.33 no.3
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• pp.127-137
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• 2021

Objectives The purpose of this study was to identify the effects of personality by each Sasang constitution on sleep using Positive Affect and Negative Affect Schedule(PANAS) and NEO-personality inventory(NEO-PI). Methods The subjects of this study were 2,078 people who had information on Sasang constitutional type and personality(PANAS, NEO-PI) among the data established at the Korean Medicine Data Center. Sleep time and sleep quality were investigated through self-written questionnaires. Sleep time was collected by hand-writing, and sleep quality was checked on a 4 point Likert scale. Pearson correlation analysis was conducted to see the correlation between personality and sleep in each constitutional type. Logistic regression was performed using personality as independent variables to find out how much personality affects sleep time. In order to find out how much personality affects sleep quality, regression analysis was performed using personality as independent variables. Results & Conclusions Sleep time was hardly affected by personality. As a result of Pearson correlation analysis, sleep time in all subjects did not show a significant correlation with personality. In logistic regression on sleep time as the dependent variable, no statistically significant results were obtained except for the Negative Affect(NA) in Taeeumin. Sleep quality showed a statistically significant correlation with the negative affect(NA), neuroticism(N), extraversion(E), Physical Component Summary(PCS) and Mental Component Summary(MCS). As a result of regression analysis on sleep quality as the dependent variable, neuroticism(N), negative affect(NA), positive affect(PA), and extraversion(E) were found in the factors affecting sleep quality. Besides, how much personality affected sleep quality might differ in each constitution. In all constitutions, sleep quality was affected by N, but the rank of N was different in each constitution. The sleep quality of Soyangin was not affected by E, and the sleep quality of Taeeumin was specifically affected by O.

• Journal of Gastric Cancer
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• v.21 no.4
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• pp.335-351
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• 2021

Purpose: An underlying factor for the failure of several clinical trials of anti-epidermal growth factor receptor (EGFR) therapies is the lack of an effective method to identify patients who overexpress EGFR protein. The quantitative dot blot method (QDB) was used to measure EGFR protein levels objectively, absolutely, and quantitatively. Its feasibility was evaluated for the prognosis of overall survival (OS) of patients with gastric cancer. Materials and Methods: Slices of 2×5 ㎛ from formalin-fixed paraffin-embedded gastric cancer specimens were used to extract total tissue lysates for QDB measurement. Absolutely quantitated EGFR protein levels were used for the Kaplan-Meier OS analysis. Results: EGFR protein levels ranged from 0 to 772.6 pmol/g (n=246) for all gastric cancer patients. A poor correlation was observed between quantitated EGFR levels and immunohistochemistry scores with ρ=0.024 and P=0.717 in Spearman's correlation analysis. EGFR was identified as an independent negative prognostic biomarker for gastric cancer patients only through absolute quantitation, with a hazard ratio of 1.92 (95% confidence interval, 1.05-3.53; P=0.034) in multivariate Cox regression OS analysis. A cutoff of 208 pmol/g was proposed to stratify patients with a 3-year survival probability of 44% for patients with EGFR levels above the cutoff versus 68% for those below the cutoff based on Kaplan-Meier OS analysis (log rank test, P=0.002). Conclusions: A QDB-based assay was developed for gastric cancer specimens to measure EGFR protein levels absolutely, quantitatively, and objectively. This assay should facilitate clinical trials aimed at evaluation of anti-EGFR therapies retrospectively and prospectively for gastric cancer.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.56 no.4
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• pp.558-568
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• 2023

The spatio-temporal distribution of the sand crab Ovalipes punctatus larvae was investigated in the Korean waters in 2019. Sea surface temperature (SST) was the lowest in February and highest in September. Sea surface salinity (SSS) was the lowest in September and highest in March. Further, sea surface chlorophyll a (SSC) was the highest in September. Larvae were distributed in the South Sea and coastal area of Jeju Island from April to June, and the abundance was the highest in May. The spatio-temporal distribution analysis suggested that larval groups showed a tendency to be dispersed over a wider area as the larvae developed, due to the increase in their swimming ability. The correlation analysis between environmental factors and larval density suggested that larvae appeared in the SST range 11.8-20.9℃ and SSS range 31.5-35.3 psu. The Megalopal stage appeared in a wider range of SST and SSS than other larval stages, possibly due to the increased environmental tolerance before settlement. Results of redundancy analysis (RDA) and Spearman's rank correlation analysis between the larval density by developmental stages and the environmental factors suggested that SST showed a positive correlation and SSC showed a negative correlation in the later stage.