• Genomics & Informatics
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• 제14권4호
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• pp.196-204
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• 2016

Many researchers have found that one of the most important characteristics of the structure of linkage disequilibrium is that the human genome can be divided into non-overlapping block partitions in which only a small number of haplotypes are observed. The location and distribution of haplotype blocks can be seen as a population property influenced by population genetic events such as selection, mutation, recombination and population structure. In this study, we investigate the effects of the density of markers relative to the full set of all polymorphisms in the region on the results of haplotype partitioning for five popular haplotype block partition methods: three methods in Haploview (confidence interval, four gamete test, and solid spine), MIG++ implemented in PLINK 1.9 and S-MIG++. We used several experimental datasets obtained by sampling subsets of single nucleotide polymorphism (SNP) markers of chromosome 22 region in the 1000 Genomes Project data and also the HapMap phase 3 data to compare the results of haplotype block partitions by five methods. With decreasing sampling ratio down to 20% of the original SNP markers, the total number of haplotype blocks decreases and the length of haplotype blocks increases for all algorithms. When we examined the marker-independence of the haplotype block locations constructed from the datasets of different density, the results using below 50% of the entire SNP markers were very different from the results using the entire SNP markers. We conclude that the haplotype block construction results should be used and interpreted carefully depending on the selection of markers and the purpose of the study.

• 복식
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• 제60권9호
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• pp.95-105
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• 2010

The purpose of this study is in allowing thinking about the design development process which is more towards the visual and perceptional aspects related to the form structure by more diverse methods by typology of idea generation. To accomplish such goal, researches in the psychology, pedagogy, engineering, and consilient studies as well as related precedent researches and reference data in architecture, promotion, industrial design, and other art fields and fashion designs are collected and analyzed to see the study trend. In addition, in the content analysis method based on such, the idea generation was classified into types in consideration of relevancy, usefulness, and suitability with fashion. First, a concentrated thinking of a limited space is a method of leading an optimal design by focusing on solving the cause of a problem within a space which generates the problem. Second, plan thinking per section of structure decomposition is a method of dismantling the design problems per organization, thinking type, factor, and characteristic into sub-modules to re-interpret and re-organize the problems in various aspects. Third, an associated thinking through interpreting relationships among vocabularies is a method of selecting the marginal languages that allow a person to come up with concrete forms and the key words related to fashion to import the characteristics and attributes of the marginal languages and thematic relationship between the two terms to search the relevancy. Lastly, the free integrated thinking of language extension is a method of groping integration between other fields and fashion by free integration among the extended terms by extending the vocabularies through inferring metaphorical expressions founded upon individual's memories or knowledge concepts regarding theme words that do not allow concrete forms to come up.

• 한국콘텐츠학회논문지
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• 제19권4호
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• pp.546-555
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• 2019

본 연구는 K대학교 디자인대학 실내디자인전공의 교육이 산업계의 요구에 부합하는 전문인을 양성하도록 교육과정의 개발절차 및 그 결과를 제시하는 것을 목적으로 했다. 연구의 방법으로는 먼저 내 외부 환경분석을 거쳐 문제점과 발전방향을 수립하였다. 이어서 실내디자인분야 직무모형을 구축하고 직무에 따라 교과목을 도출하여 4년제 교육과정에 따라 교과목을 편성하였다. 실내디자인 직무에 따라 수립한 인재상은 '실내디자인분야 경영 및 마케팅 전문가', '실내디자인분야 공간기획 전문가' 그리고 '실내디자인분야 시공관리 전문가'이다. 세부 직무모형에 따라 40개 교과목을 도출하였다. 1학년은 학부 공통교과목, 2학년은 전공기초, 3학년은 전공심화, 4학년은 전공응용으로 전체 교육과정을 편성하였다. 본 연구에서 실내디자인분야의 산업체 조직구성현황 및 직무표준의 모형을 기준으로 교과목을 개발하는 과정 자체를 제안하고 구체적 결과를 제시한다는 점에서 연구의 실용적 의의를 찾고자 한다.

• Genomics & Informatics
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• 제21권1호
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• pp.3.1-3.10
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• 2023

Characterization as well as prediction of the secondary and tertiary structure of hypothetical proteins from their amino acid sequences uploaded in databases by in silico approach are the critical issues in computational biology. Severe acute respiratory syndrome-associated coronavirus (SARS-CoV), which is responsible for pneumonia alike diseases, possesses a wide range of proteins of which many are still uncharacterized. The current study was conducted to reveal the physicochemical characteristics and structures of an uncharacterized protein Q6S8D9_SARS of SARS-CoV. Following the common flowchart of characterizing a hypothetical protein, several sophisticated computerized tools e.g., ExPASy Protparam, CD Search, SOPMA, PSIPRED, HHpred, etc. were employed to discover the functions and structures of Q6S8D9_SARS. After delineating the secondary and tertiary structures of the protein, some quality evaluating tools e.g., PROCHECK, ProSA-web etc. were performed to assess the structures and later the active site was identified also by CASTp v.3.0. The protein contains more negatively charged residues than positively charged residues and a high aliphatic index value which make the protein more stable. The 2D and 3D structures modeled by several bioinformatics tools ensured that the proteins had domain in it which indicated it was functional protein having the ability to trouble host antiviral inflammatory cytokine and interferon production pathways. Moreover, active site was found in the protein where ligand could bind. The study was aimed to unveil the features and structures of an uncharacterized protein of SARS-CoV which can be a therapeutic target for development of vaccines against the virus. Further research are needed to accomplish the task.

• 벤처창업연구
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• 제9권3호
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• pp.75-88
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• 2014

본 연구는 벤처기업이 겪는 성장통이 경영성과에 미치는 영향과 성장통이 발생하는 요인을 분석하여 벤처기업에 정책적 시사점을 제시하는데 그 목적이 있다. 연평균복합성장률을 사용하여 추출한 경영성과와 성장통을 상관관계분석한 결과 통계적으로 유의적인 부(-)의 관계가 있었다. 성장통에 영향을 미치는 요인을 분석하기 위해 회귀분석을 실시한 7개의 변수 중 CEO의 업무능력과 리더십, 조직 구조적 역량, 조직 문화적 역량은 성장통과 유의미한 관계가 있으나 분석요인 중 CEO의 업무능력은 성장통을 악화시키는 것으로 나타나, 기업이 일정한 성장기에 들어서는 경우 CEO의 개인적 역량에 의존하기보다 관리시스템을 구축하는 것이 필요한 것으로 분석되었다. 또한 기업의 관리역량과 관련된 CEO의 강한 리더십 발휘와 조직구조의 적정한 편제 및 고객 지향적이고 책임감 있는 기업문화의 조성은 성장통을 감소시키는 요인으로 조사되었다.

• 한국병원경영학회지
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• 제12권1호
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• pp.75-99
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• 2007

The purpose of this study was to provide basic materials needed to enhance quality of organizational life by identifying the improvements of labor union management in the perspective of general hospital organization management. The subjects of this study were 428 employees in 8 Hospitals in Metro Capital including Seoul. Materials were collected from administrators, nurses and medical technicians in target hospitals from November 10 to November 30, 2006 through survey questionnaires. The main results of this study were as follows: 1. The commitment level of the subjects according to their characteristics was higher in older employees than the younger ones, large family to support than small family to support and those who had higher positions in labor union. 2. The commitment level of the subjects according to the Job and role related variables were higher those who had higher satisfaction level to their job, role conflict in all hospitals. 3. The commitment level of the subjects according to union related variables, variables jointly controlled by union and employer was statistically significant positive correlation. 4. The results of multiple regression analysis shows that formal and informal socialization, satisfaction with the labor union's were all found as important antecedents of labor union commitment. 5. The results of AMOS shows that structure characteristics of hospital, Job and manager satisfaction, socialization were statistically significant labor union satisfaction. The satisfaction level of labor union was statistically significant labor union commitment To summarize study results, the level of commitment in labor union depends on job satisfaction, managers' attitudes, union satisfaction factors, their colleagues attitudes toward union. Therefore hospital managers should have democratic and flexible attitudes toward labor union. Additionally, as formal and informal socialization is important determinant in union commitment, hospital managers should have countermeasures to enhance the colleague attitude and job satisfaction level of hospital employees. Moreover, as managerial factors of the principal of hospital influence union commitment directly, the attitudes of hospital managers toward union and transparency of hospital management should be improved.

• 건축역사연구
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• 제15권1호
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• pp.7-27
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• 2006

This study aims to identify and analyze the factors that influenced the construction of London Eye which was led by private groups, including characteristics in progress, differentiated value in design, the combination of technology and design, and construction costs. The results of this study were the followings. 1) London Eye provides a new construction method for a landmark in the downtown in that the architects became the clients of the project which might have been hoarded, procuring the construction costs and completing it by themselves. 2) London Eye presents a space utilization method where undeveloped spaces in the downtown are used in three-dimensions by erecting a structure on the river with a minimum land. 3) The process of design, production and erection is propelled the realization of technical intention design with one system and from at the initial stage, the participation of the engineer where the designer is equal with you must accompany. 4) London Eye is endowed with strong shape by a circle in design concept, which is the simplest geometrical figure, and it provides organic relationship between the past and the present by utilizing historical elements in various ways. 5) The construction was completed through four phases including idea phase, promotion phase, turn-key contract phase, and design-build phase. The most critical factor to the success is derived from the direct contact with Involved companies from the production phase. 6) In a project facing many challenges in terms of technology, the design-build method proves to be a more effective method than turn-key contract in that it may more allocate risks and enable coherent implementation of the core concept in design. The organization for the design-build method was composed of three phases including general affairs, responsible contracting by sector, and cooperative system by sector. Since that was a new concept structure, high-level contractors who hadn't had existing cooperative relationships with one another formed new cooperative relationship, while collaborating companies who had long cooperated led the responsible contracting and sub-cooperative system, which resulted in reduction of risks and time. 7) The major factors to change design were the design characteristics, derived from a technically great combination, and the opening time. 8) A new erection method was applied to London Eye, a structure that overcame the limitation in land and period, and the process of installation demonstrated that it is an important value for the construction of a landmark in the city. 9) In spite of many visitors and tremendous operational income, the factors that London Eye fails to free itself from debts include the construction costs expended double than expected, and interest burden to the investments, which occurred in the course of procuring the costs. Absolute limit in time increased the construction costs, resulting in being a great obstacle in the course of operation.

• 토지주택연구
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• 제15권1호
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• pp.99-115
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• 2024

본 연구의 목적은 마르세유의 유로메디테라네의 사업 현황과 특성을 살펴보고, 국내 도시재생사업의 활성화를 위한 정책적 시사점을 도출하는 것이다. 연구결과를 요약하면 다음과 같다. 첫째, 유로메디테라네는 마르세유의 도시재생사업으로, 중앙정부와 지방정부가 공동으로 출자･협력한 거버넌스형 사업추진기구인 EPAEM을 통해 사업을 수행하여, 유로메디테라네가 마르세유의 활성화와 삶의 질 개선에 의미 있는 성과를 보임을 확인할 수 있다. 둘째, 도시재생사업으로서 유로메디테라네의 특성으로는 전면 재개발과 수복재개발 방식을 결합한 복합적 접근방법의 활용, 하드웨어적인 물리적 재생과 소프트웨어적인 경제･문화･환경적 재생을 결합한 통합적 재생의 활용, 거버넌스형 도시재생 사업구조의 활용을 들 수 있다. 마지막으로, 국내 도시재생사업의 활성화를 위한 정책적 시사점으로 도시재생사업 단위의 복합화 및 대형화, 국가차원의 거버넌스형 추진기구의 활용, 적절한 민관 파트너십의 활용을 제안하였다.

• 한국사회복지학
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• 제63권1호
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• pp.57-84
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• 2011

본 연구는 네트워크 내 개별 조직의 연계활동이 아닌 네트워크 수준의 조직간 연계인 전체 네트워크를 분석단위로 하여 전체 네트워크의 효과성을 분석하는 것을 목적으로 한다. 분석자료는 2006년 11월부터 2009년 11월까지 3년에 걸쳐 사회복지공동모금회가 후원하고, 한국사회복지행정학회가 관리운영한 '지역사회네트워크지원사업'의 대상인 10개 지역사회 네트워크 중 3개 사업단을 선정하여 사업수행 결과보고서를 포함한 관련자료와 설문조사(기관장, 중간관리자, 실무자 대상)를 통해 확보하였다. 분석을 위해 각 네트워크의 참여조직과 네트워크 사무국을 대상으로 한 설문을 통하여 조직간 네트워크의 전체적 특징을 파악하였다. 또한, 네트워크 전체의 효과성 분석을 위해 다중이해관계자관점(multiple stakeholders perspective)을 반영하여 전체 네트워크의 구조적 특징과의 관계를 규명하였다. 마지막으로, 네트워크 참여조직과 네트워크 사무국을 대상으로 한 설문조사와 문헌조사를 바탕으로 네트워크의 효과성에 영향을 줄 수 있는 환경적 요인들을 검토하였다. 분석결과 네트워크 참여조직들은 핵심 기관을 중심으로 집중되어 있는 전체적 구조를 보여주고, 네트워크가 안정적일수록 전체 네트워크의 효과성은 높은 것으로 분석되었다. 이 연구는 지역사회 네트워크 효과성 분석을 전체 네트워크 관점에서 시도하고, 개별조직, 네트워크수준, 지역사회수준의 다차원적인 다중이해관계자관점을 반영한 효과성 분석을 시도하였다는 점에서 의의가 있다. 그러나, 연구의 성격상 분석결과를 일반화하기 위해서는 광범위한 후속 연구를 통해 검증을 시도해야 한다는 한계가 있다.

• 한국HCI학회논문지
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• 제9권2호
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• pp.23-31
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• 2014

작가의 내러티브 창작을 지원하는 다양한 소프트웨어들은 일반적으로 작가가 생산하고 필요로 하는 정보의 관리와 상업적 성공을 거둔 내러티브 텍스트에 대한 분석에 주목한다. 이러한 관점에서는 내러티브 창작 과정에서의 독자의 적극적 역할이 간과된다. 작가는 독자의 반응이나 기대를 예상하여, 이를 충족시키거나 배반하면서 내러티브를 구성한다. 사건 전개에 따른 독자의 이해 상황을 파악하고 이를 적절히 조절하는 작가의 활동은 내러티브 전체의 미학적 완성도와 연관되어 있다. 본 논문에서는 서사학의 내러티브 구조 모델과 인지과학의 '사건 색인 상황모델'을 이론적 근거로, 독자의 이해와 관련된 내러티브의 다차원적 특성을 시각적으로 확인하고 조절할 수 있는 창작 지원 시스템 설계를 제안한다. 먼저 사건을 기본 단위로 하여 그 속성을 설정하고 내러티브의 두 시간축에 유기적으로 배열할 수 있는 프레임워크를 설계하고, 이를 실제 영화의 내러티브에 적용하여 전체 구조를 분석하였다. 다음으로, 독자의 이해에 영향을 미치는 상황 모델 차원들의 연속성을 시각화하는 방안과 정보처리 요구량으로써 인지적 복잡도를 분석하는 방안을 제시하고, 사례 영화에 대해 시각화한 결과를 내러티브의 특성과 작가 지원 관점에서 논의하였다.