• 감성과학
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• 제5권2호
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• pp.1-9
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• 2002

향-냄새에 대한 감수성은 종족, 성에 따라 상이하며 냄새에 대한 인지력과 식별력은 가령화에 따라 쇠퇴한다고 한다. 가령화에 따른 향의 평가에 관한 선행보고들은 그 대상이 유아에서 노인에 이르기까지 다양함에도 불구하고 제시 향에 단순 알코올이나 단순 초산염이 주로 사용되었으며, 냄새 인지력이나 식별력 둥 지성적인 측면에서의 평가가 대부분이었다. 본 연구에서는 후각기능이 정상인 19～68세 50명을 대상으로 6종의 천연향에 대해 안정/폐안 상태에서 ECG, 피부저항, 그리고 주관평가를 실시하여 서로 다른 연령층에 따른 변화를 살펴보고자 하였다. 그 결과, 20대, 40대의 청\ulcorner중년층은 lemon을, 60대는 Lavender를 긍정적으로 반응\ulcorner평가하였다. 특히 40대 그룹은 평균 RR 간격, 심박수, 피부저항, 주관평가의 결과에서 가장 높은 상관성을 보여 후각기능이 가장 성숙한 연령대임이 확인되었다. 제시 향에 대해 연령별로 상이하게 반응/평가한 본 연구결과는 연령별로 차별화된 향장품 개발뿐만 아니라 인공냄새 그리고 맛의 개발에도 응용이 가능할 것으로 여겨진다.

• 산업경영시스템학회지
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• 제22권53호
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• pp.69-78
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• 1999

We developed an apparatus for odorous stimuli control to record olfactory evoked potentials from human scalp. The characteristics of the apparatus were as follows. 1. Translating the subjects respiration into electric signals with a sensor attached to the nose. The period and timing of odorous stimuli could be adjusted, so that stimuli could be synchronous with respiration. 2. The respirations translated into electric signals were made constant in amplitude by using an auto gain control circuit. 3. The interstimulus interval of odorous could be arbitrarily selected once every 1 to 9 respirations so that adaptation could be prevented. We obtained olfactory - evoked potentials (OEPs) to odorous stimuli using this apparatus from the site of Cz, whose positive peak latencies were approximately $180{\pm}23ms$. Such response were not recorded if oxygen stimuli were used instead of odorous or with click sounds produced by the switching electromagnetic valve.

• The Korean Journal of Physiology and Pharmacology
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• 제8권1호
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• pp.17-20
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• 2004

PTEN (phosphatase and tensin homolog) is a dual specific phosphatase antagonizing phosphoinositide 3-kinase activity, and has first been cloned as a tumor suppressor for glioma. Although the role of PTEN as a tumor suppressor has been well studied, little is known about signaling mechanisms regulating expression and/or activity of PTEN in the central nervous system. In this study, we investigated whether PTEN expression is regulated by sensory deprivation. P5 rat pups were unilaterally naris-closed, and olfactory bulbs were immunohistochemically analyzed with PTEN antibody at the $7^{th}$ day after naris closure. PTEN immunoreactivity was found to be down-regulated in both glomerular, external plexiform and subependymal cell layers, suggesting that odor deprivation signals down-regulate expression of PTEN in the olfactory bulb. To the best of our knowledge, this is the first report to suggest that PTEN expression is regulated by sensory deprivation signals in neonatal rats.

• Archives of Plastic Surgery
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• 제37권4호
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• pp.433-442
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• 2010

Purpose: Many authors reported about the posttraumatic nasal aesthetic complications. However, the studies for functional or intranasal complications are not enough yet. We identified relatively high prevalence of nasal obstruction and olfactory dysfunction in nasal synechiae, and the synechiae formation was a frequently occurred after the nasal bone reduction. And then, the aim of this study is to identify the usefulness of the treatment of intranasal synechiae. Methods: We reviewed the data from 10 patients with symptomatic intranasal synechiae from June 2007 to June 2009. We enforced evaluation with preoperative CT in all patients but postoperative CT within complicated patients. We studied 10 patients with intranasal synechiae who had persistence postoperative symptoms. We studied the patients who were operated by removal of synechiae and ancillary surgical treatments in the last two years. Results: In the previous report, the incidence of intranasal synechiae was 15% (n=62) and symptomatic synechiae was 16% (10/62). We classified the nasal bone fracture according to Stranc classification. In this paper, the incidence of treated intranasal synechiae was 13% (2/15) in Frontal Impact (FI) Type I, 11% (2/18) in FI Type II, 100% (2/2) in FI Type III, 0% (0/2) in Lateral Impact (LI) Type I, 25% (3/12) in LI Type II, and 33% (1/3) in LI Type III, respectively. After removal of synechiae, all patients improved nasal obstruction and little improved olfactory disturbance. Conclusion: Simple removal of synechiae by scissors improved postoperative symptoms and complications such as nasal obstruction and olfactory dysfunction. After removal of synechiae, all patients improved nasal obstruction, however, little improved anosmia. So, we thought that olfactory dysfunction may result in many intranasal factors. First of all, education of delicate procedure regarding this subject should be empathized accordingly.

• 한국동물생명공학회지
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• 제36권4호
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• pp.292-298
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• 2021

Olfactory receptors (OR) are primarily responsible for the detection of odorant molecules. We previously demonstrated that OR7D4, an OR for androstenone, is expressed in the vomeronasal organ and olfactory epithelium tissue of stallions. Recently, the expression of OR1I1 in the human testes was reported and the possible roles of OR1I1 in the testicular cells were suggested. The objectives of this study were 1) to explore the expression of OR7D4 and OR1I1 in stallion testes, and 2) to define the specific localization of OR7D4 and OR1I1 in the testicular tissues. Stallion testicular tissue samples were used for this study. Western blot was performed to confirm the cross-reactivity of OR7D4 and OR1I1 antibody with stallion testicular tissue samples. OR7D4 and OR1I1 gene expressions were investigated using reverse transcription-polymerase chain reaction (RT-PCR) in stallion testes. Immunofluorescence was performed to investigate the expression of OR7D4 and OR1I1 in stallion testicular tissues. The protein bands for OR7D4 and OR1I1 from the testes were observed at approximately 38 kDa and 43 kDa, respectively. The mRNA of OR7D4 and OR1I1 were detected in stallion testes. Immunolabeling of OR7D4 and OR1I1 in the cytoplasm of both spermatogonia and Leydig cells was observed. In conclusion, androstenone and another odorant chemical, which is recognized by OR1I1, may play an important role in stallion testes.

• Molecules and Cells
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• 제25권1호
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• pp.124-130
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• 2008

Astrocyte ion channels participate in ionic homeostasis in the brain. Inward rectifying potassium channels (Kir channels) in astrocytes have been particularly implicated in $K^+$ homeostasis because of their high open probability at resting potential and their increased conductance at high concentrations of extracellular $K^+$. We examined the expression of the Kir2.1 subunit, one of the Kir channel subunits, in the mouse brain by immunohistochemistry. Kir2.1 channels were widely distributed throughout the brain, with high expression in the olfactory bulb and the cerebellum. Interestingly, they were abundantly expressed in astrocytes of the olfactory bulb, while astrocytes in other brain regions including the hippocampus did not show any detectable expression. However, Kir2.1 channel-expressing cells were dramatically increased in the hippocampus by kainic acid-induced seizure and the cells were glial fibrillary acidic protein (GFAP)-positive, which confirms that astrocytes in the hippocampus express Kir2.1 channels under pathological conditions. Our results imply that Kir2.1 channels in astrocyte may be involved in buffering $K^+$ against accumulated extracellular $K^+$ caused by neuronal hyperexcitability under phathophysiological conditions.

• 산업기술연구
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• 제31권B호
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• pp.45-50
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• 2011

Recently, machine olfactory systems that have been proposed as an artificial substitute of the human olfactory system are being studied by many researchers because they can scent dangerous gases and identify the type of gases in contamination areas instead of the human. In this paper, we present an effective design method for the gas identification system. The design method adopted the sequential combination between genetic algorithms and TSK fuzzy logic system. First, the proposed method allowed the designed gas identification system effectively performing the pattern analysis because it was able to avoid the curse of dimensionality caused by use of a large number of sensors. Secondly, the method led the gas identification system to good performance because it was able to deal with drift characteristics of the sensor data by using description ability of the fuzzy system for nonlinear data. In simulation, we demonstrated the effectiveness of the designed gas identification system by using the simulation results of five types of gases.

• 대한의생명과학회지
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• 제26권1호
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• pp.14-21
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• 2020

Quantitative evaluation of the sense of smell is done by the olfactory event-related potential (OERP) test. OERP consists of N1, P1, N2, P2, and P3, of which N1 and P1 latency are known to be affected by the concentration of odor stimuli associated with the pre-sensory phase and P2 and P3 are the stages at which odors are perceived and are known to change by subjective evaluation of the stimulus. The purpose of this study was to clarify the correlation between the expression of OERP and the subjective evaluation of the object on the fragrance stimulus using various fragrances. Therefore, the study examined the relative waveform power ratio, preference for each scent stimulus, and finally the amplitude and latency change of the components of OERP, N1 and P2. In contrast, it was found that the late P2 response waveform was an effective aroma stimulus recognition waveform in OERP compared to the initial response waveforms.

• 전기학회논문지
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• 제61권8호
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• pp.1164-1171
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• 2012

Recently, machine olfactory systems as an artificial substitute of the human olfactory system are being studied actively because they can scent dangerous gases and identify the type of gases in contamination areas instead of the human. In this paper, we present an effective design method for the gas identification system. Even though dimensionality reduction is the very important part, in pattern analysis, We handled effectively the dimensionality reduction by grouping the sensors of which the measured patterns are similar each other, where genetic algorithms were used for combination optimization. To identify the gas type, we constructed the hierarchical rule base with two frames by using rough set theory. The first frame is to accept measurement characteristics of each sensor and the other one is to reflect the identification patterns of each group. Thus, the proposed methods was able to accomplish effectively dimensionality reduction as well as accurate gas identification. In simulation, we demonstrated the effectiveness of the proposed methods by identifying five types of gases.

• The Korean Journal of Pain
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• 제20권2호
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• pp.154-157
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• 2007

Background: Anosmia can be frustrating for both the patient and physician, with no clear treatment. We prospectively investigated the effects of stellate ganglion block (SGB) in anosmic patients who were unresponsive to conventional steroid therapy. Methods: Thirteen patients with anosmia were treated with SGB. To evaluate the improvement in olfactory function, we evaluated both changes in subjective symptoms and the butanol threshold test. The number of SGB required for improvement in olfactory function was counted. Results: Seven patients (54%) showed improvement of olfactory function with SGB. The average number of SGB for the first response was $7.4{\pm}5.9times$. Conclusions: These results suggest that SGB may be a good treatment modality for patients with anosmia unresponsive to steroid therapy.