• Clinical and Experimental Pediatrics
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• 제53권10호
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• pp.872-879
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• 2010

Obstructive sleep apnea (OSA) in children is a frequent disease for which optimal diagnostic methods are still being defined. Treatment of OSA in children should include providing space, improving craniofacial growth, resolving all symptoms, and preventing the development of the disease in the adult years. Adenotonsillectomy (T&A) has been the treatment of choice and thought to solve young patient's OSA problem, which is not the case for most adults. Recent reports showed success rates that vary from 27.2% to 82.9%. Children snoring regularly generally have a narrow maxilla compared to children who do not snore. The impairment of nasal breathing with increased nasal resistance has a well-documented negative impact on early childhood maxilla-mandibular development, making the upper airway smaller and might lead to adult OSA. Surgery in young children should be performed as early as possible to prevent the resulting morphologic changes and neurobehavioral, cardiovascular, endocrine, and metabolic complications. Close postoperative follow-up to monitor for residual disease is equally important. As the proportion of obese children has been increasing recently, parents should be informed about the weight gain after T&A. Multidisciplinary evaluation of the anatomic abnormalities in children with OSA leads to better overall treatment outcome.

• 생약학회지
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• 제47권2호
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• pp.137-142
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• 2016

Enterovirus is a common cause of several severe diseases such as myocarditis, hand-foot-mouth disease, and meningitis in children and adult. There are many try to develop new antiviral drug for direct treatment in virus infection. However, synthetic chemical antiviral drug is not working. To overcome this limitation, we examined plant extracts. The antiviral effect of plant extracts was screened by HeLa cell survival assay in coxsackievirus B3 (CVB3) infection. We observed a strong antiviral effect of Poria cocos extract in a dose-dependent manner (1 mg/ml~0.01 mg/ml). P. cocos extract (1 mg/ml) treatment was dramatically decreased virus protease 2A induced eIF4G-I cleavage and virus capsid protein VP1 production. CVB3 positive and negative strand RNA amplification were significantly reduced in P. cocos extract treatment. P. cocos extract completely blocked early time activation of ERK and AKT activity in CVB3 infection. Taken together these data indicate that the treatment of P. cocos extract strongly inhibit CVB3 replication. Poria cocos extract may possible to developed as a therapeutic agent for enterovirus.

• Radiation Oncology Journal
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• 제32권4호
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• pp.262-265
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• 2014

Tamoxifen and radiotherapy are used in breast cancer treatment worldwide. Radiation recall dermatitis (RRD), induced by tamoxifen, has been rarely reported. Herein, we report a RRD case induced by tamoxifen. A 47-year-old woman had a right quadrantectomy and an axillary lymph node dissection due to breast cancer. The tumor was staged pT2N0; it was hormone receptor positive, and human epidermal growth factor receptor 2 negative. The patient received adjuvant chemotherapy followed by tamoxifen and radiotherapy. After 22 months of tamoxifen, the patient developed a localized heating sensation, tenderness, edema, and redness at the irradiated area of the right breast. The symptoms improved within 1 week without treatment. Three weeks later, however, the patient developed similar symptoms in the same area of the breast. She continued tamoxifen before and during dermatitis, and symptoms resolved within 1 week.

• 음성과학
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• 제15권2호
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• pp.145-156
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• 2008

The purpose of this study was to investigate the reason why puberphonia patients revisit hospitals after completion of its treatment and the effect of visual voice therapy on voice improvement. The subject the study included are two puberphonia patients who had been diagnosed by laryngologists. The patients who were diagnosed as puberphonia by the laryngologist and treated by the a speech pathologist, completed their treatment and revisited hospital. The study used laryngoscopy, acoustic and aerodynamic analysis before and after voice treatment to investigate what change happens and why generalization of treatment effect did not occur naturally in the daily life. Their voices of pre-therapy and post-therapy were analyzed on the aspects of acoustics, aerodynamics and laryngeal endoscopy. As a result, it was found that fundamental frequency(Fo) was significantly lowered in respect of acoustic change and maximum phonation time(MPT) was increased to some extent in respect of aerodynamic change. In addition, there was a laryngoscopic change and commissure glottic chink disappeared generally in the phonation. The reason why the generalization did not occur naturally in one’s daily routine was mainly due to the fact that high-pitched voicing was used for a long time. Other than that reason, negative reaction or attitude of surrounding people and lack of confidence were to blame for failure of generalization.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2003년도 추계학술대회
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• pp.1086-1091
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• 2003

The problem of residual stresses and fatigue behavior in welded structures is the main concern of welding research fields. The residual stresses and distortions of structures by welding exert negative effect on the safety of mechanical structures. Postweld heat treatment is usually carried out to relieve this residual stresses of welded joints. In this paper the influence of postweld heat treatment on fatigue life of butt-welded joint was investigated. To predict the effect of PWHT, an analytical model is developed by finite element and local strain approach and the result of fatigue life analysis is compared to experimental results. It is demonstrated that fatigue life estimates closely approximate the experimental results and PWHT provides some increase of fatigue lives in long-life fatigue region and no increase in short-life fatigue region because of the residual stress relaxation under tensile loads.

• 대한물리치료과학회지
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• 제4권3호
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• pp.491-498
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• 1997

This Research has been made through the questionnaire(enquete) sent to parents whose children are under cerebral palsy treatment in the hospitals of Daejon, Daegu and Pusan area and in other social welfare organizations such as Korea C.P. Welfare institution and Social Welfare Corporation during the period of Februay to August 1997. Form this research, we have obtained following results : 1. Mostly, the blood type of parents of cerebral palsy children is "0" type in father side (24 persons : 30%) and "A" type in mother side(28 persons : 35%), 2. For their(parents) baby-delivery, it shows that the nature delivery was adoped in most cases i. e. 50 persons(62.5%). 3. The birth weight of cerebral palsy children appears to be less than 2.4Kg in most cases(24 persons : 30%) 4. Most of parents positively want to take a medical treatment for their children with hope, but parents of 5 patients(6.3%) have a negative attitude against medical treatment and its cure. 5. Parents of 25 patients (31.7%) appear to have a sense of shame about the fact that their children are C.P. patients. 6. The 65 parents(81.3%) are depending on medical treatment and physical therapy as a means of cure.

• Molecules and Cells
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• 제39권2호
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• pp.163-168
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• 2016

Caffeine has both positive and negative effects on physiological functions in a dose-dependent manner. C. elegans has been used as an animal model to investigate the effects of caffeine on development. Caffeine treatment at a high dose (30 mM) showed detrimental effects and caused early larval arrest. We performed a comparative proteomic analysis to investigate the mode of action of high-dose caffeine treatment in C. elegans and found that the stress response proteins, heat shock protein (HSP)-4 (endoplasmic reticulum [ER] chaperone), HSP-6 (mitochondrial chaperone), and HSP-16 (cytosolic chaperone), were induced and their expression was regulated at the transcriptional level. These findings suggest that high-dose caffeine intake causes a strong stress response and activates all three stress-response pathways in the worms, including the ER-, mitochondrial-, and cytosolic pathways. RNA interference of each hsp gene or in triple combination retarded growth. In addition, caffeine treatment stimulated a food-avoidance behavior (aversion phenotype), which was enhanced by RNAi depletion of the hsp-4 gene. Therefore, up-regulation of hsp genes after caffeine treatment appeared to be the major responses to alleviate stress and protect against developmental arrest.

• 한국동물위생학회지
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• 제40권2호
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• pp.143-147
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• 2017

A Korean domestic short hair (1-year-old, male) presented with 2 to 3 weeks of seizures, aggressive behavior, vomiting, anorexia, and lethargy. The frequency of seizure had gradually increased from once a week to once every 3 hours. Physical and neurologic examination, diagnostic screening tests, including complete blood count (CBC), serum chemistry, electrolyte, coagulation test, X-ray, ultrasonography, and urinalysis were performed. Feline Leukemia Virus (FeLV), Feline Immunodeficiency Virus (FIV) and Toxoplasma spp. All tested negative, but the Feline Corona Virus (FCoV) kit revealed a positive result. To determine the exact diagnosis, magnetic resonance imaging (MRI) was performed but yielded no specific findings. The patient was then diagnosed with idiopathic epilepsy and treatment of phenobarbital was initiated. A month's treatment with phenobarbital proved ineffective as symptoms worsened. Zonisamide was then selected as an additional anticonvulsant. After adding zonisamide, symptoms improved, and seizures abated for 15 months. This is the first case report in South Korea describing the use of phenobarbital and zonisamide in the treatment of a cat with idiopathic epilepsy.

• Journal of Microbiology and Biotechnology
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• 제12권4호
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• pp.643-648
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• 2002

For wastewater treatment and utilization of the biomass, a photosynthetic bacterium was isolated based on its cell growth rate, cell mass, and assimilating ability of organic acids. The isolate was a Gram-negative rod-shaped bacterium that contained a single polar flagellum and formed a lamellar intracytoplasmic membrane (ICM) system, including bacteriochlorophyll $\alpha$. The major isoprenoid quinone component was identified as ubiquinone Q-10, and the fatty acid composition was characterized as to contain relatively large amount of C-16:0 (18.74%) and C-18:1 (59.23%). Based on its morphology, phototrophic properties, quinone component, and fatty acid composition, the isolate appeared to be closely related to the Rhodopseudomonas subgroup of purple nonsulfur bacteria. A phylogenetic analysis of the isolate using its 16S rRNA gene sequence data also supported the phenotypic findings, and classified the isolate closely related to Rhodopseudomonas palustris. Accordingly, the nomenclature of the isolate was proposed as Rhodopseudomonas palustris KUGB306. A bench-scale photosynthetic bacteria (PSB) reactor using the isolate was designed and operated for the treatment of soybean curd wastewater.

• 대한간호학회지
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• 제33권1호
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• pp.71-78
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• 2003

Purpose: The study was done to identify the relationship of treatment side effects, family support, and quality of life in patients with cancer, and factors influencing quality of life. Method: A convenience sample of 106 patients who were receiving cancer treatment at W hospital were interviewed using the Side Effects scale by Hur, Family Support scale by Kang, and QOL scale by Ro. Result: Results indicate that women experienced more severe side effects than men. There was a negative relationship between side effects and quality of life, and a positive relationship between family support and quality of life. The most bothersome side effects were changes in taste and appetite, followed by general weakness and fatigue. Side effects such as loss of hair, nausea, dizziness, numbness, pins and needles in fingers and toes, and dry mouth were also experienced. General weakness and family support were analysed as to whether they were factors influencing quality of life. Conclusion: The results revealed that relieving general weakness should be given high priority in nursing interventions for patients undergoing cancer treatment. In addition, nursing programs should be developed that can reinforce family support.