• Molecules and Cells
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• v.45 no.7
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• pp.444-453
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• 2022

Multivalent macromolecular interactions underlie dynamic regulation of diverse biological processes in ever-changing cellular states. These interactions often involve binding of multiple proteins to a linear lattice including intrinsically disordered proteins and the chromosomal DNA with many repeating recognition motifs. Quantitative understanding of such multivalent interactions on a linear lattice is crucial for exploring their unique regulatory potentials in the cellular processes. In this review, the distinctive molecular features of the linear lattice system are first discussed with a particular focus on the overlapping nature of potential protein binding sites within a lattice. Then, we introduce two general quantitative frameworks, combinatorial and conditional probability models, dealing with the overlap problem and relating the binding parameters to the experimentally measurable properties of the linear lattice-protein interactions. To this end, we present two specific examples where the quantitative models have been applied and further extended to provide biological insights into specific cellular processes. In the first case, the conditional probability model was extended to highlight the significant impact of nonspecific binding of transcription factors to the chromosomal DNA on gene-specific transcriptional activities. The second case presents the recently developed combinatorial models to unravel the complex organization of target protein binding sites within an intrinsically disordered region (IDR) of a nucleoporin. In particular, these models have suggested a unique function of IDRs as a molecular switch coupling distinct cellular processes. The quantitative models reviewed here are envisioned to further advance for dissection and functional studies of more complex systems including phase-separated biomolecular condensates.

• Nonlinear Functional Analysis and Applications
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• v.26 no.3
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• pp.553-563
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• 2021

As hypergeometric meromorphic multivalent functions of the form $$L^{t,{\rho}}_{{\varpi},{\sigma}}f(\zeta)=\frac{1}{{\zeta}^{\rho}}+{\sum\limits_{{\kappa}=0}^{\infty}}{\frac{(\varpi)_{{\kappa}+2}}{{(\sigma)_{{\kappa}+2}}}}\;{\cdot}\;{\frac{({\rho}-({\kappa}+2{\rho})t)}{{\rho}}}{\alpha}_{\kappa}+_{\rho}{\zeta}^{{\kappa}+{\rho}}$$ contains a new subclass in the punctured unit disk ${\sum_{{\varpi},{\sigma}}^{S,D}}(t,{\kappa},{\rho})$ for -1 ≤ D < S ≤ 1, this paper aims to determine sufficient conditions, distortion properties and radii of starlikeness and convexity for functions in the subclass $L^{t,{\rho}}_{{\varpi},{\sigma}}f(\zeta)$.

• Kyungpook Mathematical Journal
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• v.59 no.4
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• pp.651-663
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• 2019

In this paper, we introduce and study a new subclass of p-valent harmonic functions defined by modified operator and obtain the basic properties such as coefficient characterization, distortion properties, extreme points, convolution properties, convex combination and also we apply integral operator for this class.

• Journal of the Korean Mathematical Society
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• v.53 no.1
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• pp.147-159
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• 2016

In this paper, subordination results of analytic function $f{\in}{\mathcal{A}}_p$ involving linear operator ${\mathcal{K}}^{{\delta},{\lambda}}_{c,p}$ are obtained. By applying the differential subordination method, results are derived under some sufficient subordination conditions. On using some hypergeometric identities, corollaries of the main results are derived. Furthermore, convolution preserving properties for a class of multivalent analytic function associated with the operator ${\mathcal{K}}^{{\delta},{\lambda}}_{c,p}$ are investigated.

• Kyungpook Mathematical Journal
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• v.55 no.4
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• pp.1031-1051
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• 2015

The object of the present paper is to derive some inclusion and subordination results for certain classes of multivalent analytic functions in the open unit disk, which are defined in terms of the Cho-Kwon-Srivastava operator. Some interesting corollaries are derived and the relevant connection of the results obtained in this paper with various known results are also pointed out.

• Kyungpook Mathematical Journal
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• v.54 no.2
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• pp.211-220
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• 2014

In the present investigation, by making use of the familiar concept of neighborhoods of analytic and multivalent functions, we prove several inclusion relations associated with the (n, ${\delta}$)-neighborhoods of certain subclasses of analytic functions of complex order, which are introduced here by means of the Al-Oboudi derivative. Several special cases of the main results are mentioned.

• Kyungpook Mathematical Journal
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• v.51 no.2
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• pp.217-232
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• 2011

Differential subordination and superordination results are obtained for multivalent meromorphic functions associated with the Liu-Srivastava linear operator in the punctured unit disk. These results are derived by investigating appropriate classes of admissible functions. Sandwich-type results are also obtained.

• Kyungpook Mathematical Journal
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• v.52 no.2
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• pp.209-222
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• 2012

In this paper, we obtain some applications of first order differential subordination and superordination results involving the operator $J_{s,b}^{{\lambda},p}$ for certain normalized p-valent analytic functions associated with that operator.

• Kyungpook Mathematical Journal
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• v.52 no.1
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• pp.21-32
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• 2012

In this paper a new subclass of multivalent functions with negative coefficients defined by Cho-Kwon-Srivastava operator is introduced. Coefficient estimate and inclusion relationships involving the neighborhoods of p-valently analytic functions are investigated for this class. Further subordination result and results on partial sums for this class are also found.

• Kyungpook Mathematical Journal
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• v.53 no.1
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• pp.1-12
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• 2013

The purpose of the present paper is to obtain some subordination- and superordination-preserving properties for multivalent function associated the differintegral operators defined on the space of normalized analytic functions in the open unit disk. The sandwich type theorem for the integral operator is also considered.