• Journal of Chest Surgery
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• 제57권5호
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• pp.492-495
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• 2024

Solitary fibrous tumors (SFTs) are rare neoplasms arising from mesenchymal cells. Although most SFTs are benign, rare cases of metastasis have been reported at various sites. Complete surgical resection is the mainstay of treatment for both primary and recurrent or metastatic SFTs. Herein, we present a case of an SFT initially identified in the anterior mediastinum that later developed multiple metastases, even to the thyroid gland. The patient underwent repeated surgical resection and is currently being followed up in an outpatient setting.

• 한국인터넷방송통신학회논문지
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• 제11권2호
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• pp.41-49
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• 2011

본 논문은 사용자가 작업하는 문서에서 검색하고자 하는 검색어를 빠르고 단순하게, 그리고 다양한 검색의 범위를 조절할 수 있는 검색 방법을 제안하고 구현한 사례를 소개한다. 기존 웹 사이트 검색 방식은 하던 작업을 멈추고 웹 브라우저를 실행하고 사이트에 접속하며 키워드를 입력하는 지루한 과정이 필요하다. 또한 검색의 결과도 장황하며, 사전, 이미지, 동영상 등 동시 검색이 필요한 경우 여러 사이트에서 여러 번 검색하는 불편함이 있다. 본 논문은 사용자가 작업하는 어떤 문서에서도 간단히 검색어를 선택하고 CTRL키와 마우스 왼쪽 버튼을 동시에 누르는 것으로 검색이 이루어지도록 한다. 이를 위해 웹 서비스를 이용할 수 있는 Open API를 이용하여 여러 검색 웹 사이트의 검색 기능을 동시에 통합적으로 활용하는 매쉬업 검색 소프트웨어를 구현한다. 본 논문에서 개발한 검색 소프트웨어는 검색의 단순 즉시성, 결과의 간결성, 검색 범위의 다양성, 기능의 확장성뿐만 아니라 작업하는 어떤 문서에도 검색이 가능한 매쉬업의 좋은 사례로 평가된다.

• BMB Reports
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• 제34권3호
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• pp.194-200
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• 2001

Secreted arginase from Evernia prunastri thallus has been purified 616-fold from the incubation medium. Purified arginase was resolved as only one peak in a capillary electrophoresis with a pI value of 5.35. The protein contained high amounts of acidic amino acids, such as Asx and Glx, and a relatively high quantity of Ser and Gly. The molecular mass of native, purified arginase was estimated as about 26 kDa by SE-HPLC. Substrate saturated kinetic showed a typical Michaelis-Menten relationship with a K_m value of 3.3 mM L-arginine. Atranorin behaved as a mixed activator of the enzyme (apparent $K_m$ = 0.96 mM); whereas evernic and usnic acid were revealed as non competitive inhibitors (apparent $K_m$ values were 3.16 mM and 3.05 mM, respectively). Kinetics of atranorin binding indicated that saturation was reached from 0.18 ${\mu}mol$ of the total atranorin and the occurrence of multiple sites for the ligand. This agrees with a possible aggregation of several enzyme subunits during the interaction process. A value of binding sites of about 12 was obtained. The binding of evernic acid was saturated from 23 nmol of total phenol. The number of binding sites was about 5. The loss of the binding ability of evernic acid could be interpreted as a single negative cooperatively. Usnic acid behaves in a similar way to evernic acid, although the binding saturation occurs at $0.14\;{\mu}moles$ of the ligand. This binding appears to be unspecific, and has 28 usnic acid binding sites to the protein.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2004년도 춘계 종합학술대회 논문집
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• pp.241-260
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• 2004

무역포탈사이트는 중소기업들이 최신의 정보와 통신기술을 통해 효율적으로 국제무역활동을 할 수 있게 하는 도구중 하나라고 할 수 있다. 따라서 중소기업들의 수출경쟁력 제고를 위해서는 무역포탈사이트를 적극적으로 활용할 필요가 있다. 이와 관련하여 본 논문은 기존의 서비스품질에 관한 문헌과 정보기술 이용만족도에 관한 연구 검토를 통해 무역포탈사이트를 사용하는데 있어 이용자들의 만족 요인을 분석하였다. 실증 연구를 위해 서비스품질, 정부정책, 기술, 기업, 비용이 이용만족도에 영향을 미치고 이용만족도는 향후 지속적 이용의도에 영향을 미치는 것으로 연구모형을 설정하였다. 대표적인 무역포탈사이트 이용자들에 대한 실증분석 결과 서비스품질, 정부정책, 비용이 이용자 만족에 유의한 영향을 미치고, 이용자 이용만족은 지속적 사용의도에 유의적인 영향을 미치는 것으로 나타났다. 이러한 분석 결과는 기업의 무역포탈사이트 관리자, 전자무역시스템개발자, 정부정책자 등에게 여러 가지 시사점을 제공하고 있다.

• BMB Reports
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• 제41권5호
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• pp.369-375
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• 2008

Polygonatum cyrtonema Lectin (PCL), which is classified as a monocot mannose-binding lectin, has received great regards for its uniquely biological activities and potentially medical applications in cancer cells. This paper was initially aimed to study apoptosis of PCL on Hela cells. Thus, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) method was carried out. Through observation of cell morphologic changes and Lactate dehydrogenase (LDH) activity-based cytotoxicity assays, PCL induced HeLa cell apoptosis in a dose-dependent manner. To further gain structural basis, multiple alignments, homology modeling and docking experiments were performed to analyze the correlation between its biological activities and mannose-binding sites. Eventually, considering docking data, chemical modification properties on the three mannose-binding sites were analyzed by a series of biological experiments (e.g., hemagglutinating and mitogenic activity assays, fluorescence and Circular Dichrosim (CD) spectroscopy) to profoundly identify the role of some key amino acids in the structure-function relationship of PCL.

• 한국산학기술학회논문지
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• 제15권3호
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• pp.1590-1598
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• 2014

본 연구는 한국 여성의 골다공증 검진부위에 따른 검진결과와 유병률의 차이를 분석함으로써, 연령 증가에 따른 유병부위와 양상 변화를 파악하고자 하였다. 국민건강영양조사 3개년(2008-2010)의 대규모 자료를 활용하여, 전국을 대표하는 50-89세의 여성 4,449명을 연구대상으로 하였다. 연령집단별로 유병부위에 차이를 발견할 수 있었는데, 50대부터 70대까지는 요추 골다공증의 비중이 상대적으로 높은 반면, 80대에는 대퇴(경부 혹은 전체) 골다공증의 비중이 더 높았다. 단일부위 골다공증의 경우, 연령 증가에 따라 요추는 감소하지만 대퇴 경부는 증가했다. 복수부위 골다공증의 비중은 연령 증가와 함께 증가하며, 유병양상은 요추가 대퇴보다 선행하는 것이 일반적으로 판단된다. 따라서 50-70대 여성을 대상으로 대퇴만을 검진하는 경우, 골다공증 환자를 정상 판정하는 음성오류를 범할 가능성이 높다.

• 천문학논총
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• 제30권2호
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• pp.139-143
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• 2015

We describe a survey of nearby core-collapse supernova (SN) explosion sites using integral field spectroscopy (IFS) techniques, which is an extension of the work described in Kuncarayakti et al. (2013). The project aims to constrain SN progenitor properties based on the study of the immediate environment of the SN. The stellar populations present at the SN explosion sites are studied by means of integral field spectroscopy, which enables the acquisition of both spatial and spectral information of the object simultaneously. The spectrum of the SN parent stellar population gives an estimate of its age and metallicity. With this information, the initial mass and metallicity of the once coeval SN progenitor star are derived. While the survey is mostly done in optical, the additional utilization of near-infrared integral field spectroscopy assisted with adaptive optics (AO) enables us to examine the explosion sites in high spatial detail, down to a few parsecs. This work is being carried out using multiple 2-8 m class telescopes equipped with integral field spectrographs in Chile and Hawaii.

• Journal of Trauma and Injury
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• 제34권4호
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• pp.233-241
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• 2021

Purpose: The medical community has been heavily impacted by the coronavirus disease 2019 pandemic. The management of facial trauma patients has been affected by the patient capacity of emergency rooms. In this study, we share our experiences of facial trauma management during the social lockdown period and investigate the epidemiological changes in facial bone fractures. Methods: A total of 997 patients who presented to Ajou University Hospital Emergency Center and were evaluated by plastic or maxillofacial surgeons for facial trauma were included in this retrospective study. Our study design was a comparative study of two groups: the 2019 group (control) and the 2020 group (the experimental group that experienced social lockdown). Results: The total number of emergency room inpatients reflected the national pandemic trends with three peaks in patient numbers. According to these trends, facial bone fractures had two different low points in August 2020 and December 2020. A comparison of the 2019 and 2020 facial bone fractures did not show a statistically significant difference in the total number of patients. An analysis of the causes of trauma showed that domestic accidents increased in 2020 (30.92%; p<0.001). Among the anatomical sites of facial injury in surgical patients, the frontozygomatic complex fracture increased the most in 2020 (p=0.018). Facial injuries with two separate sites of injury or with three or more involved sites also showed a significant increase in 2020 (p<0.001). Conclusions: We demonstrated that the incidence of facial trauma patients correlated with the incidence of patients presenting to the emergency department and that facial trauma is inextricably related to multi-trauma cases. Domestic accidents and facial trauma with multiple anatomically involved sites are increasing trends that need more attention.

• Asian Pacific Journal of Cancer Prevention
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• 제13권2호
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• pp.599-606
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• 2012

The characterization of the whole genome of human papillomavirus type 16 (HPV16) from cervical cancer specimens with multiple infections in comparison with single infection samples as the oncogenic potential of the virus may differ. Cervical carcinoma specimens positive for HPV16 by PCR and INNO-LiPA were randomly selected for whole genome characterization. Two HPV16 single infection and six HPV16 multiple infection specimens were subjected to whole genome analysis by using conserved primers and subsequent sequencing. All HPV16 whole genomes from single infection samples clustered in the European (E) lineage while all multiple infection specimens belonged to the non-European lineage. The variations in nucleotide sequences in E6, E7, E2, L1 and Long control region (LCR) were evaluated. In the E6 region, amino acid changes at L83V were related to increased cancer progression. An amino acid variation N29S within the E7 oncoprotein significantly associated with severity of lesion was also discovered. In all three domains of the E2 gene non synonymous mutations were found. The L1 region showed various mutations which may be related to conformation changes of viral epitopes. Some transcription factor binding sites in the LCR region correlated to virulence were shown on GRE/1, TEF-1, YY14 and Oct-1. HPV16 European variant prone to single infection may harbor a major variation at L83V which significantly increases the risk for developing cervical carcinoma. HPV16 non-European variants prone to multiple infections may require many polymorphisms to enhance the risk of cervical cancer development.

• Journal of Yeungnam Medical Science
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• 제30권2호
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• pp.105-108
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• 2013

Type 1 neurofibromatosis (von Recklinghausen's disease, NF-1) is an autosomal-dominant neurocutaneous-disorder characterized by systemic cafe'-au-lait spots, multiple cutaneous neurofibromas, axillary or inguinal freckling, and Lisch nodules (pigmented iris hamartomas). Approximately 10-25% of NF1 patients have gastrointestinal neoplasms. Gastrointestinal stromal tumor (GIST) in patients with neurofibromatosis is most commonly found in the small bowel and the stomach, and approximately 60% of such patients have multiple tumors or multiple tumor sites. Although, the increased incidence of GIST in patients with neurofibromatosis is well documented in pathology literature in English, but has rarely been documented in Korea. Here, we report a case of multiple GISTs in a 48-year-old woman accompanied by NF1. She was admitted to Yeung-nam University Hospital with complaints of melena and dyspnea. A contrast-enhanced computed tomography (CT) scan revealed that multiple soft tissue masses were occupying the entire peritoneal cavity. An ultrasonogram- guided biopsy was performed and the tumors were found to have been composed of tumor cells that were positive for c-kit protein. The patient was put on Imatinib mesylate treatment, and further follow-up will be carried out.