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Discordance in Diagnosis of Osteoporosis by Skeletal Site in Korean Women: KNHANES 2008-2010

한국 여성의 골다공증 검진부위에 따른 진단결과 불일치: 국민건강영양조사 2008-2010

  • Lee, Jongseok (Hallym University School of Business Administration) ;
  • Lee, Sungwha (Hallym University School of Business Administration)
  • Received : 2013.09.13
  • Accepted : 2014.03.06
  • Published : 2014.03.31

Abstract

Based on an analysis on the difference on the measurement sites and their relations to osteoporosis diagnosis and prevalence, this study attempts to investigate the patterns of prevalence in skeletal sites in the aging process. The samples were driven by the National Health and Nutrition Examination Survey (2008-2010) on Korean females (n = 4,449) aged from 50 to 89 years. The result shows that the differences on affected sites in the aging process were detected as follow: the osteoporosis prevalence in lumbar spine was relatively high in 50s, 60s and 70s; however, the prevalence in the proximal femur (total hip and femoral neck) was higher in 80s. In terms of the diagnosis identified in a single site, the prevalence in lumbar spine seemed to decrease as age increases; but, the rate went up in the figure of femoral neck. Overall, the osteoporosis prevalence for the diagnosis detected in multiple sites was increased as age goes up. In general, the increase in lumbar osteoporosis prevalence starts earlier than that of femoral neck. The findings of this study also suggests that if the proximal femur site is only used for diagnosing women age in 50s, 60s and 70s, the significant portion of osteoporosis patients could be misdiagnosed as normal.

본 연구는 한국 여성의 골다공증 검진부위에 따른 검진결과와 유병률의 차이를 분석함으로써, 연령 증가에 따른 유병부위와 양상 변화를 파악하고자 하였다. 국민건강영양조사 3개년(2008-2010)의 대규모 자료를 활용하여, 전국을 대표하는 50-89세의 여성 4,449명을 연구대상으로 하였다. 연령집단별로 유병부위에 차이를 발견할 수 있었는데, 50대부터 70대까지는 요추 골다공증의 비중이 상대적으로 높은 반면, 80대에는 대퇴(경부 혹은 전체) 골다공증의 비중이 더 높았다. 단일부위 골다공증의 경우, 연령 증가에 따라 요추는 감소하지만 대퇴 경부는 증가했다. 복수부위 골다공증의 비중은 연령 증가와 함께 증가하며, 유병양상은 요추가 대퇴보다 선행하는 것이 일반적으로 판단된다. 따라서 50-70대 여성을 대상으로 대퇴만을 검진하는 경우, 골다공증 환자를 정상 판정하는 음성오류를 범할 가능성이 높다.

Keywords

References

  1. W. A. Peck, P. Burckhardt, C. Christiansen, H. A. Fleisch, H. K. Genant, C. Gennari, T. J. Martin, "Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis", The American journal of medicine, 94(6), pp.646-650, 1993. DOI: http://dx.doi.org/10.1016/0002-9343(93)90218-E
  2. S. R. Lee, S. R. Kim, K. H. Chung, D. O. Ko, S. H. Cho, Y. C. Ha, B. G. Kim, J. R. Kim, S. Y. Kim, "Mortality and activity after hip fracture: a prospective study", Journal of Korean Orthopedic Association, 40, pp.423-427, 2005. https://doi.org/10.4055/jkoa.2005.40.4.423
  3. J. A. Kanis, L. J. Melton, C. Christiansen, C. C. Johnston, N. Khaltaev, "The diagnosis of osteoporosis", Journal of bone and mineral research, 9(8), pp.1137-41, 1994. DOI: http://dx.doi.org/10.1002/jbmr.5650090802
  4. H. G. Bone, D. Hosking, J. P. Devogelaer, J. R. Tucci, R. D. Emkey, R. P. Tonino, U. A. Liberman, "Ten years' experience with alendronate for osteoporosis in postmenopausal women", the New England journal of medicine, 350(12), pp.1189-1199, 2004. https://doi.org/10.1056/NEJMoa030897
  5. J. A. Kanis, E. V. McCloskey, H. Johansson, C. Cooper, R. Rizzoli, J. Y. Reginster, "European guidance for the diagnosis and management of osteoporosis in postmenopausal women", Osteoporosis international, 24(1), pp.23-57, 2013. DOI: http://dx.doi.org/10.1007/s00198-012-2074-y
  6. E. M. Lewiecki, C. M. Gordon, S. Baim, M. B. Leonard, N. J. Bishop, M-L. Bianchi, H. J. Kalkwarf, C. B. Langman, H. Plotkin, F. Rauch, B. S. Zemel. N. Binkley, J. P. Bilezikian, D. L. Kendler, D. B. Hans, S. Silverman, "International Society for Clinical Densitometry 2007 Adult and Pediatric Official Positions", Bone, 43(6), pp.1115-1121, 2008. DOI: http://dx.doi.org/10.1016/j.bone.2008.08.106
  7. A. Petrie, C. Sabin, Medical Statistics at a Glance (3 ed.), p.115-116, Wiley-Blackwell, 2009.
  8. J. S. Lee, S. Lee, S. Jang, O. H. Ryu, "Age-related Changes in the Prevalence of Osteoporosis According to Gender and Skeletal Site: The Korean National Health and Nutrition Examination Survey 2008-2010", Endocrinology and Metabolism, 28(3), pp.180-191, 2013. DOI: http://dx.doi.org/10.3803/EnM.2013.28.3.180
  9. C. Cooper, L. J. Melton, "Epidemiology of osteoporosis", Trends in Endocrinology &Metabolism, 3(6), pp.224-229, 1992. DOI: http://dx.doi.org/10.1016/1043-2760(92)90032-V
  10. B. Abrahamsen, T. B. Hansen, L. B. Jensen, A. P. Hermann, P. Eiken, "Site of osteodensitometry in perimenopausal women: correlation and limits of agreement between anatomic regions", Journal of bone and mineral research, 12(9), pp.1471-1479, 1997. DOI: http://dx.doi.org/10.1359/jbmr.1997.12.9.1471
  11. G. Woodson, "Dual X-ray absorptiometry T-score concordance and discordance between the hip and spine measurement sites", Journal of clinical densitometry, 3(4), pp.319-324, 2000. DOI: http://dx.doi.org/10.1385/JCD:3:4:319
  12. M. J. Cho, J. S. Ahn, S. B. Chae, S. W. Lee, "Coincidence of Diagnosis of Osteoporosis at the Site of the Proximal Femur, Lumbar Spine and Distal Radius", the Journal of the Korean Hip Society, 24(1), pp.53-58. 2012. DOI: http://dx.doi.org/10.5371/jkhs.2012.24.1.53
  13. W. D. Leslie, J. F. Tsang, P. A. Caetano, L. M. Lix, "Number of Osteoporotic Sites and Fracture Risk Assessment", Journal of Bone and Mineral Research, 22(3), pp.476-483, 2007 DOI: http://dx.doi.org/10.1359/jbmr.061112
  14. D. O'Gradaigh, I. Debiram, S. Love, H. K. Richards, J. E. Compston, "A prospective study of discordance in diagnosis of osteoporosis using spine and proximal femur bone densitometry", Osteoporosis international, 14(1), pp.13-18, 2003. DOI: http://dx.doi.org/10.1007/s00198-002-1311-1