• BMB Reports
• /
• 제48권7호
• /
• pp.371-372
• /
• 2015

MicroRNAs (miRNAs) can regulate the expression of genes that are involved in multiple cellular pathways. However, their targets and mechanism of action associated with the autophagy pathway are not fully investigated yet. EWSR1 (EWS RNA-Binding Protein 1/Ewing Sarcoma Break Point Region 1) gene encodes a RNA/DNA binding protein that is ubiquitously expressed and plays roles in numerous cellular processes. Recently, our group has shown that EWSR1 deficiency leads to developmental failure and accelerated senescence via processing of miRNAs, but its role in the regulation of autophagy remains elusive. In this context, we further investigated and found that EWSR1 deficiency triggers the activation of the DROSHA-mediated microprocessor complex and increases the levels of miR125a and miR351, which directly target Uvrag. Interestingly, the miR125a- and miR351-targeted reduction of Uvrag led to the inhibition of autophagy in both ewsr1 knockout (KO) MEFs and ewsr1 KO mice. In summary, our study demonstrates that EWSR1 is associated with the posttranscriptional regulation of Uvrag via miRNA processing. The regulation of autophagy pathway in miRNAs-Uvrag-dependent manner provides a novel mechanism of EWSR1 deficiency-related cellular dysfunction. [BMB Reports 2015; 48(7): 371-372]

• 한국융합학회논문지
• /
• 제8권10호
• /
• pp.397-405
• /
• 2017

본 연구의 목적은 응급실 간호사의 강인성과 사회적 지지 및 소진의 정도를 파악하고 소진에 미치는 영향 요인을 확인하고자 시도되었다. 연구방법은 자가보고식 조사연구이며, 연구대상은 일지역 종합병원 응급실에서 6개월 이상 근무하고 있는 간호사를 선정하였다. 자료수집은 강인성, 사회적 지지, 소진 측정도구 설문지를 활용하였고, 수집된 설문지 중 115개를 SPSS/Win 21.0 program을 이용하여 분석하였다. 연구결과, 강인성 점수는 평균 2.59점(1.80-3.67점), 사회적 지지 3.29점(1.00-5.00점), 소진 3.16점(1.73-4.63점)이었다. 소진은 강인성 (r=-.390, p<.001), 사회적 지지(r=-.400, p<.001)와 부적 상관성이 있었고 강인성은 사회적 지지(r=.351, p<.001)와 정적 상관성이 있었다. 소진에 영향을 미치는 요인은 강인성(${\beta}=-.325$, p<.001), 사회적 지지(${\beta}=-.213$, p=.023), 응급실 계속희망 여부(${\beta}=-.295$, p=.001)였고 소진에 대한 설명력은 30.6%였다. 따라서 응급실 간호사의 소진 감소를 위해 응급실 근무자는 희망자로 배치하고 강인성과 사회적 지지를 높일 수 있는 프로그램을 개발하고 운영할 것을 권한다.

• 문화기술의 융합
• /
• 제8권1호
• /
• pp.167-174
• /
• 2022

본 연구는 간호대학생을 대상으로 주관적 행복감의 정도를 알아보고, 학업스트레스, 자기효능감, 문제해결능력이 주관적 행복감에 미치는 영향을 확인하기 위하여 시도되었다. 연구참여자는 B시 2개 대학의 간호대학생 348명을 대상으로 실시하였다. 자료분석은 SPSS 22.0 프로그램을 이용하여 실수, 백분율, 평균, 표준편차, t-test, ANOVA, 피어슨 상관계수, 다중회귀분석으로 분석하였다. 대상자의 주관적 행복감은 41.91±9.53점이었다. 주관적 행복감은 학업스트레스(r=-.523, p<.001)와 부적상관관계, 자기효능감(r=.515, p<.001), 문제해결능력(r=.466, p<.001)과 정적상관관계를 나타냈다. 주관적 행복감에 영향을 미치는 요인은 학업스트레스(β=-.351, p<.001), 자기효능감(β=.255, p<.001), 문제해결능력(β=.132, p=.049)으로 나타났고, 설명력은 37.2%로 확인되었다. 본 연구결과를 통하여 간호대학생의 주관적 행복감을 향상하기 위하여 학업스트레스를 줄이고, 자기효능감과 문제해결능력을 높일 수 있는 다양한 프로그램 개발이 필요하다.

• 한국융합학회논문지
• /
• 제11권2호
• /
• pp.351-360
• /
• 2020

본 연구의 목적은 간호·간병통합서비스 병동 간호사의 입장에서 근무 실태를 파악하고 역할갈등 및 직무스트레스가 간호전문직관에 미치는 요인을 파악하기 위함이다. 상관성 조사연구설계를 이용하여 C 지역 간호·간병통합서비스를 제공하는 간호사 174명을 대상으로 Likert식 척도를 이용하여 역할갈등, 직무스트레스, 간호전문직관을 측정하였다. 자료분석은 SPSS WIN 23.0 프로그램을 이용하여 t-test, correlation, regression 분석을 실시하였다. 연구결과 간호·간병통합서비스 병동 간호사의 간호전문직관과 독립변수간의 상관계수는 역할갈등(r=-.186, p=.014), 직무스트레스(r=-.389, p<.001)로 유의하였다. 간호전문직관에 영향을 미치는 요인은 직무스트레스, 역할갈등 순으로 나타났으며(F=23.810, p<.001), 설명력은 11.8%였다.

• 한국콘텐츠학회논문지
• /
• 제21권10호
• /
• pp.622-629
• /
• 2021

본 연구는 간호대학생의 공감과 리더십이 행복감에 미치는 영향을 알아보고자 시도되었다. 본 연구는 2020년 11월부터 12월까지 울산시 소재 C대학의 간호대학생 142명을 대상으로 구조화된 설문을 통해 데이터를 수집하였다. 자료의 분석은 기술통계, t-test, ANOVA, Scheffe test, Pearson's 상관관계 분석, 다중회귀분석을 이용하였다. 연구의 결과 간호대학생의 행복감은 공감과 리더십에 유의한 양의 상관관계(r=.429, p<.001, r=.635, p<.001)가 있었다. 다중회귀분석의 결과, 간호대학생의 행복감에 영향을 미치는 요인은 성향(β=-0.284, p<.001), 본인의 건강상태(β=-0.375, p<.001, β=-0.178, p<.001), 공감(β=0.351, p<.001)과 리더십(β=0.133, p=.039)이었고 설명력은 58.1%였다. 본 연구의 결과로 간호대학생의 행복감을 높여주기 위해 공감과 리더십을 높여주는 것이 필요하며, 공감능력, 리더십 프로그램의 개발과 적용을 통해 학생들의 공감능력과 리더십을 높여주어야 한다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권5호
• /
• pp.2101-2107
• /
• 2014

Background: Single nucleotide polymorphisms (SNPs) affecting microRNA (miR) sequences may influence carcinogenesis. Our current study primarily aimed to confirm previously conducted association studies between rs2910164 found on miR-146a, and rs11614913 located on miR-196a2 polymorphisms and cancer phenotypes in the Japanese elderly population. rs2910164 (G/C) and rs11614913 (T/C) polymorphisms were determined by genotyping on the samples collected from 1,351 consecutive autopsy cases registered in the Japanese SNPs for geriatric research (JG-SNP) data base. Cancer samples were systematically reviewed, pathologically verified and assessed with respect to miR-146a and miR-196a2 genotypic variation. The current study covered 726 males and 625 females with a mean age of $80.3{\pm}8.9$ years. The study included 524 subjects without cancer and 827 subjects with at least one type of cancer, such as gastric (n=160), lung (n=148), colorectal (n=116) or others. Males with cancers (n=467) were more numerous than females (n=360). Both rs11614913 (CT: TT adjusted odds ratio (OR) 95% confidence interval (95%CI)=0.98 (0.75-1.28), p=0.873, CC: TT adjusted OR (95%CI)=1.06 (0.76-1.47), p=0.737, CT+CC: TT, adjusted OR (95%CI)=0.99 (0.77-1.29), p=0.990), and rs2910164 (CG: CC adjusted OR (95%CI)=1.12 (0.87-1.44), p=0.383, GG: CC adjusted OR (95%CI)=1.03 (0.71-1.48), p=0.887, CG+GG: CC adjusted OR (95%CI)=1.10 (0.87-1.39), p=0.446) polymorphisms did not show significant association with overall cancer in all subjects. However, "CC" genotype in rs11614913 polymorphism was significantly associated with increased gastric cancer (n=160) in all subjects (CC: CT+TT, adjusted OR (95%CI)=1.50 (1.02-2.22), p=0.040). We found that rs11614913 and rs2910164 do not pose general cancer risk, but rs11614913 may influence gastric cancer in Japanese elderly population. Confirmation of our study results requires further investigations with larger subject populations.

• 문화기술의 융합
• /
• 제9권6호
• /
• pp.435-442
• /
• 2023

본 연구는 간호대학생의 우울, 자기효능감, 생활스트레스와 스마트폰 중독의 정도를 확인하고 이들의 상관관계 및 영향요인을 파악하기 위한 서술적 조사연구이다. 연구대상자의 우울 15.85점, 자기효능감 3.19점, 생활스트레스 2.47점, 스마트폰 중독 39.23점으로 나타났다. 일반적 특성에 따른 스마트폰 중독을 분석한 결과는 연령에서는 통계적으로 유의한 차이가 없는 것으로 나타났으며, 성별(t=-2.540, p=.014), 학년(F=3.080, p=.029), 스마트폰 중요도(F=16.192, p<.001), 스마트폰 사용시간(F=6.938, p<.001)에서는 유의한 차이가 있었다. 대상자의 스마트폰 중독은 우울(r=.351, p<0.01), 생활스트레스(r=.321, p<.001)와는 정적상관관계가 나타났으며, 자기효능감,(r=-.383, p<.001)은 부적 상관관계가 나타났다. 우울과 자기효능감(r=-.529, p<.001)은 부적 상관관계가 나타났으며, 생활스트레스(r=.568, p<.001)은 정적 상관관계가 나타났다. 자기효능감과 생활스트레스는(r=-.434, p<.001)부적 상관관계가 나타났다. 대상자의 스마트폰 중독의 영향요인으로는 자기효능감이 나타났다. 대학생의 자기효능감을 향상시키기 위한 프로그램 및 교육의 기초자료를 제공하고자 한다.

• 한국치위생학회지
• /
• 제13권4호
• /
• pp.639-644
• /
• 2013

Objectives : The aim of this study is to investigate the influencing factors of oral health behaviors according to oral health education experiences in middle school students. Methods : The subjects were 301 middle school students who lived in Gimhae and Jinhae. All statistical analyses were performed using SPSS. Results : The group with oral health education experience had higher scores in oral health knowledge(p<.01) than the group without oral health education. The group with oral health education experience has higher scores in oral health behavior (p<.01) than the group without oral health education. The group with oral health education experience has higher scores in self-efficiency (p<.01) than the group without oral health education. The experience of oral health education shows positive correlation with oral health knowledge(r=0.184), oral health behavior(r=0.199) and self-efficiency(r=0.199). There existed a positive correlation between oral health knowledge and self-efficiency(r=0.351). Conclusions : It is necessary to provide oral health promotion program in middle school students. The importance of oral health care is closely related to oral health knowledge.

• 간호행정학회지
• /
• 제14권3호
• /
• pp.344-351
• /
• 2008

Purpose: The aim of this study was to testify whether clinical performance examination (CPX) was useful to evaluate comprehensive performance for nursing students just prior to graduation. Method: A cross-sectional descriptive study was designed to examine the usefulness. A total of 61 nursing students whose requirement credits were completed for graduation from a C University in G-city, at December, 5, 2007. Data were analyzed by Pearson's Correlation Coefficient and Spearman's rank Correlation Coefficient. Results: This study showed that both of the finals scores with paper and pens and the clinical practicum scores were not correlated with the CPX scores (r=-.031, p=.811; r=.028, p=.831). Consistency of scores between faculties and standardized patients was moderate (r=.752, p=.000). Conclusion: CPX was considered as a different and innovative evaluation from previous testing systems to test the various aspects of performance including knowledge, skill and attitude. Therefore, CPX under high raters' consistency was useful to test nursing students's final performance. Further study would be needed to develop the standard of CPX system.

• 한국컴퓨터정보학회논문지
• /
• 제24권4호
• /
• pp.145-151
• /
• 2019

The purpose of this study was to find out whether there was a meaningful change in the learning perception and interpersonal relations of nursing students after completing clinical practice. Participants were 32 nursing students in the third grade. The research data were collected by questionnaire consisting of interpersonal relations and learning perception. The analysis of data was analyzed by SPSS 21 Version. General characteristics were analyzed by descriptive statistics, correlation between variables was analyzed by Pearson's relation, and differences of variables before and after clinical practice were analyzed by paired t-test. The results of the study are as follows. In clinical practice, interpersonal abilities showed a significant correlation with learning outcomes (R =.351, p =.049). The interpersonal abilities of nursing students improved significantly(t =2.264, p =.13) after completion of clinical practice. Nursing college students recognized that their interpersonal abilities had improved after completion of clinical practice, and the improvement of interpersonal abilities was statistically supported. Considering that the interpersonal relationship was an important factor in the clinical practice related stress of the nursing college students, it was meaningful that the interpersonal ability improved after the clinical practice. The positive correlation between interpersonal abilities and learning perceptions in clinical practice of nursing college students suggests future directions for future research. The results of this study will provide basic data on education that will enhance the satisfaction of students' clinical practice and improve their learning outcomes.