• BMB Reports
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• v.48 no.7
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• pp.371-372
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• 2015

MicroRNAs (miRNAs) can regulate the expression of genes that are involved in multiple cellular pathways. However, their targets and mechanism of action associated with the autophagy pathway are not fully investigated yet. EWSR1 (EWS RNA-Binding Protein 1/Ewing Sarcoma Break Point Region 1) gene encodes a RNA/DNA binding protein that is ubiquitously expressed and plays roles in numerous cellular processes. Recently, our group has shown that EWSR1 deficiency leads to developmental failure and accelerated senescence via processing of miRNAs, but its role in the regulation of autophagy remains elusive. In this context, we further investigated and found that EWSR1 deficiency triggers the activation of the DROSHA-mediated microprocessor complex and increases the levels of miR125a and miR351, which directly target Uvrag. Interestingly, the miR125a- and miR351-targeted reduction of Uvrag led to the inhibition of autophagy in both ewsr1 knockout (KO) MEFs and ewsr1 KO mice. In summary, our study demonstrates that EWSR1 is associated with the posttranscriptional regulation of Uvrag via miRNA processing. The regulation of autophagy pathway in miRNAs-Uvrag-dependent manner provides a novel mechanism of EWSR1 deficiency-related cellular dysfunction. [BMB Reports 2015; 48(7): 371-372]

• Journal of the Korea Convergence Society
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• v.8 no.10
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• pp.397-405
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• 2017

This study was to identify hardiness, social support, burnout which might influence burnout in emergency department nurses. Data were collected by self-reporting questionnaires from 115 nurses in 8 emergency department. Data analysis was done with SPSS/Win 21.0 program. Burnout showed significantly negative correlations with hardiness(r=-.390, p<.001), social support(r=-.400, p<.001) and hardiness showed significantly positive correlations with social support(r=.351, p<.001). As results, key factor was hardiness, social support, that continuing to work in emergency department, were significant predictors and accounted for 30.6%. Based on these results, burnout showed statistically significant differences depending on hardiness, social support and wanted department state. It is needed to develop a program in order to improve hardiness and social support of emergency department nurses.

• The Journal of the Convergence on Culture Technology
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• v.8 no.1
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• pp.167-174
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• 2022

The purpose of this study was to evaluate the effect of academic stress, self-efficacy and problem solving ability on subjective happiness of nursing college students. Participants in this study were 348 nursing students from 2 universities in B city. Data analysis was performed using SPSS 22.0 program with real number, percentage, mean, standard deviation, t-test, ANOVA, Pearson correlation coefficient, and multiple regression analysis. The mean score for subjective happiness was 41.91±9.53(range: 9 to 63). Subjective happiness negatively correlated with academic stress(r=-.523, p<.001) and positively correlated with self-efficacy(r=.515, p<.001), problem solving ability(r=.466, p<.001). Significant predictors of subjective happiness included academic stress((β=-.351, p<.001), self-esteem(β=.255, p<.001), and problem solving ability(β=.132, p=.049), and the explanation power was 37.2%. Therefore, we need various program development that can enhance self-efficacy, problem solving ability, and academic stress management in order to improve nursing students' subjective happiness.

• Journal of the Korea Convergence Society
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• v.11 no.2
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• pp.351-360
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• 2020

The purpose of this study is to verify the current states of the comprehensive nursing care services and nursing professionalism the role conflicts and job stresses experienced by the nurses, to investigate the influences affecting the nursing professionalism. The subjects were 174 nurses, the role conflict, job stress, and nursing professionalism have a significant correlation with each other. Data were analyzed by t-test, correlation, regression analysis using SPSS WIN 23.0 program. The result showed that the correlation between nursing professionalism was significant in role conflict(r=-.186, p=.014) and job stress(r=-.389, p<.001). In addition, factors affecting nursing professionalism were in order of role conflict and job stress(F=23.810, p<.001), and explanatory power was 11.8%.

• The Journal of the Korea Contents Association
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• v.21 no.10
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• pp.622-629
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• 2021

This study was attempted to find out the effect of empathy and leadership of nursing college students on happiness. For this study, from November to December 2020, 142 students were participated from C University in U City, using self reported questionnaire. Descriptive statistics, t-test, ANOVA, Scheffe test, Pearson's correlation analysis, and multiple regression analysis were used for data analysis. As results of this study, it was revealed that there was a significant positive correlation between the happiness of nursing students on empathy and leadership(r=.424, p<.001, r=.635, p<.001). Also, the factors affecting the happiness of nursing students were personality(β=-0.284, p<.001), health status(β=-0.375, p<.001, β=-0.178, p<.001), empathy(β=0.351, p<.001) and leadership(β=0.133, p=.039) with a total explanatory power of 58.1%. As the results of this study, in order to increase the happiness of nursing students, it is necessary to develop their empathy skills and leadership. The specific strategies are to develope and apply special programs to develop the empathy skills and leadership.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.5
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• pp.2101-2107
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• 2014

Background: Single nucleotide polymorphisms (SNPs) affecting microRNA (miR) sequences may influence carcinogenesis. Our current study primarily aimed to confirm previously conducted association studies between rs2910164 found on miR-146a, and rs11614913 located on miR-196a2 polymorphisms and cancer phenotypes in the Japanese elderly population. rs2910164 (G/C) and rs11614913 (T/C) polymorphisms were determined by genotyping on the samples collected from 1,351 consecutive autopsy cases registered in the Japanese SNPs for geriatric research (JG-SNP) data base. Cancer samples were systematically reviewed, pathologically verified and assessed with respect to miR-146a and miR-196a2 genotypic variation. The current study covered 726 males and 625 females with a mean age of $80.3{\pm}8.9$ years. The study included 524 subjects without cancer and 827 subjects with at least one type of cancer, such as gastric (n=160), lung (n=148), colorectal (n=116) or others. Males with cancers (n=467) were more numerous than females (n=360). Both rs11614913 (CT: TT adjusted odds ratio (OR) 95% confidence interval (95%CI)=0.98 (0.75-1.28), p=0.873, CC: TT adjusted OR (95%CI)=1.06 (0.76-1.47), p=0.737, CT+CC: TT, adjusted OR (95%CI)=0.99 (0.77-1.29), p=0.990), and rs2910164 (CG: CC adjusted OR (95%CI)=1.12 (0.87-1.44), p=0.383, GG: CC adjusted OR (95%CI)=1.03 (0.71-1.48), p=0.887, CG+GG: CC adjusted OR (95%CI)=1.10 (0.87-1.39), p=0.446) polymorphisms did not show significant association with overall cancer in all subjects. However, "CC" genotype in rs11614913 polymorphism was significantly associated with increased gastric cancer (n=160) in all subjects (CC: CT+TT, adjusted OR (95%CI)=1.50 (1.02-2.22), p=0.040). We found that rs11614913 and rs2910164 do not pose general cancer risk, but rs11614913 may influence gastric cancer in Japanese elderly population. Confirmation of our study results requires further investigations with larger subject populations.

• The Journal of the Convergence on Culture Technology
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• v.9 no.6
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• pp.435-442
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• 2023

This study is a descriptive survey study to confirm the degree of depression, self-efficacy, life stress and smartphone addiction of nursing college students, and to identify their correlations and influencing factors. The study subjects had 15.85 points of depression, 3.19 points of self-efficacy, 2.47 points of life stress, and 39.23 points of smartphone addiction. As a result of analyzing smartphone addiction according to the general characteristics of the subjects, there was no statistically significant difference in grade and major, and there were significant differences in gender(t=-2.540, p=.014), grade(F=3.080, p=.029), smartphone importance(F=16.192, P<0.001), smartphone usage time (F=6.938, P<0.001). The subject's smartphone addiction showed a positive correlation with depression (r=.351, p<0.01), life stress (r=.321, p<.001), and self-efficacy (r=-.383, p<.001) showed a negative correlation. A negative correlation was found between depression and self-efficacy (r=-.529, p<.001), and a positive correlation was found between life stress (r=.568, p<.001). A negative correlation was found between self-efficacy and college life stress (r=-.434, p<.001). Self-efficacy appeared to be an influential factor in the subject's smartphone addiction. The goal is to provide basic data for programs and education to improve college students' self-efficacy.

• Journal of Korean society of Dental Hygiene
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• v.13 no.4
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• pp.639-644
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• 2013

Objectives : The aim of this study is to investigate the influencing factors of oral health behaviors according to oral health education experiences in middle school students. Methods : The subjects were 301 middle school students who lived in Gimhae and Jinhae. All statistical analyses were performed using SPSS. Results : The group with oral health education experience had higher scores in oral health knowledge(p<.01) than the group without oral health education. The group with oral health education experience has higher scores in oral health behavior (p<.01) than the group without oral health education. The group with oral health education experience has higher scores in self-efficiency (p<.01) than the group without oral health education. The experience of oral health education shows positive correlation with oral health knowledge(r=0.184), oral health behavior(r=0.199) and self-efficiency(r=0.199). There existed a positive correlation between oral health knowledge and self-efficiency(r=0.351). Conclusions : It is necessary to provide oral health promotion program in middle school students. The importance of oral health care is closely related to oral health knowledge.

• Journal of Korean Academy of Nursing Administration
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• v.14 no.3
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• pp.344-351
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• 2008

Purpose: The aim of this study was to testify whether clinical performance examination (CPX) was useful to evaluate comprehensive performance for nursing students just prior to graduation. Method: A cross-sectional descriptive study was designed to examine the usefulness. A total of 61 nursing students whose requirement credits were completed for graduation from a C University in G-city, at December, 5, 2007. Data were analyzed by Pearson's Correlation Coefficient and Spearman's rank Correlation Coefficient. Results: This study showed that both of the finals scores with paper and pens and the clinical practicum scores were not correlated with the CPX scores (r=-.031, p=.811; r=.028, p=.831). Consistency of scores between faculties and standardized patients was moderate (r=.752, p=.000). Conclusion: CPX was considered as a different and innovative evaluation from previous testing systems to test the various aspects of performance including knowledge, skill and attitude. Therefore, CPX under high raters' consistency was useful to test nursing students's final performance. Further study would be needed to develop the standard of CPX system.

• Journal of the Korea Society of Computer and Information
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• v.24 no.4
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• pp.145-151
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• 2019

The purpose of this study was to find out whether there was a meaningful change in the learning perception and interpersonal relations of nursing students after completing clinical practice. Participants were 32 nursing students in the third grade. The research data were collected by questionnaire consisting of interpersonal relations and learning perception. The analysis of data was analyzed by SPSS 21 Version. General characteristics were analyzed by descriptive statistics, correlation between variables was analyzed by Pearson's relation, and differences of variables before and after clinical practice were analyzed by paired t-test. The results of the study are as follows. In clinical practice, interpersonal abilities showed a significant correlation with learning outcomes (R =.351, p =.049). The interpersonal abilities of nursing students improved significantly(t =2.264, p =.13) after completion of clinical practice. Nursing college students recognized that their interpersonal abilities had improved after completion of clinical practice, and the improvement of interpersonal abilities was statistically supported. Considering that the interpersonal relationship was an important factor in the clinical practice related stress of the nursing college students, it was meaningful that the interpersonal ability improved after the clinical practice. The positive correlation between interpersonal abilities and learning perceptions in clinical practice of nursing college students suggests future directions for future research. The results of this study will provide basic data on education that will enhance the satisfaction of students' clinical practice and improve their learning outcomes.